PhosphoNET

           
Protein Info 
   
Short Name:  SERGEF
Full Name:  Secretion-regulating guanine nucleotide exchange factor
Alias:  Deafness locus associated putative guanine nucleotide exchange factor; Deafness locus-associated guanine nucleotide exchange factor; DELGEF; GNEFR; Guanine nucleotide exchange factor-related protein; Secretion-regulating guanine nucleotide exchange factor;
Type:  Guanine nucleotide exchange factor, Ras
Mass (Da):  48981
Number AA:  458
UniProt ID:  Q9UGK8
International Prot ID:  Isoform1 - IPI00015919
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0005087  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0050709  GO:0007165   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MEREPSASEAAPA
Site 2S8MEREPSASEAAPAAA
Site 3S50NDFCKPRSVRRITGG
Site 4T55PRSVRRITGGGGHSA
Site 5Y91GHTEDIPYFTPCKSL
Site 6T93TEDIPYFTPCKSLFG
Site 7S124TENGQVLSCGSNSFG
Site 8S127GQVLSCGSNSFGQLG
Site 9S183QWGTGLASCGRRLCP
Site 10T207AKEPSRVTGLENSKA
Site 11S226AGSDHSASLTDAGEV
Site 12T228SDHSASLTDAGEVYV
Site 13Y234LTDAGEVYVWGSNKH
Site 14Y294FTWGRADYGQLGRKL
Site 15Y304LGRKLETYEGWKLEK
Site 16S314WKLEKQDSFLPCSRP
Site 17S319QDSFLPCSRPPNSMP
Site 18S324PCSRPPNSMPSSPHC
Site 19S327RPPNSMPSSPHCLTG
Site 20S328PPNSMPSSPHCLTGA
Site 21T333PSSPHCLTGATEVSC
Site 22Y416VQDPKVTYLSPDAIE
Site 23S418DPKVTYLSPDAIEDT
Site 24T425SPDAIEDTESQKAMD
Site 25S427DAIEDTESQKAMDKE
Site 26S442RNWKERQSETSTQSQ
Site 27S445KERQSETSTQSQSDW
Site 28T446ERQSETSTQSQSDWS
Site 29S448QSETSTQSQSDWSRN
Site 30S450ETSTQSQSDWSRNGG
Site 31S453TQSQSDWSRNGGL__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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