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Updated November 2019
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Protein Info
Short Name:
TJP2
Full Name:
Tight junction protein Zonula occludens protein 2
Alias:
Friedreich ataxia region gene X104; Tight junction protein 2; Tight junction protein 2 (zona occludens 2); Tight junction protein ZO-2; X104; ZO2; ZO-2; Zona occludens 2 protein; Zona occludens protein 2; Zonula occludens 2 protein; Zonula occludens protein 2
Type:
Adapter/scaffold protein
Mass (Da):
133972
Number AA:
1190
UniProt ID:
Q9UDY2
International Prot ID:
IPI00003843
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005912
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004385
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
F
P
P
R
R
E
L
S
G
W
L
R
A
P
G
Site 2
Y32
E
E
L
I
W
E
Q
Y
T
V
T
L
Q
K
D
Site 3
T35
I
W
E
Q
Y
T
V
T
L
Q
K
D
S
K
R
Site 4
S40
T
V
T
L
Q
K
D
S
K
R
G
F
G
I
A
Site 5
S49
R
G
F
G
I
A
V
S
G
G
R
D
N
P
H
Site 6
T62
P
H
F
E
N
G
E
T
S
I
V
I
S
D
V
Site 7
T91
R
V
V
M
V
N
G
T
P
M
E
D
V
L
H
Site 8
S99
P
M
E
D
V
L
H
S
F
A
V
Q
Q
L
R
Site 9
S130
Q
V
A
A
L
Q
A
S
P
P
L
D
Q
D
D
Site 10
S150
M
D
E
F
D
G
R
S
F
R
S
G
Y
S
E
Site 11
S153
F
D
G
R
S
F
R
S
G
Y
S
E
R
S
R
Site 12
Y155
G
R
S
F
R
S
G
Y
S
E
R
S
R
L
N
Site 13
S156
R
S
F
R
S
G
Y
S
E
R
S
R
L
N
S
Site 14
S159
R
S
G
Y
S
E
R
S
R
L
N
S
H
G
G
Site 15
S163
S
E
R
S
R
L
N
S
H
G
G
R
S
R
S
Site 16
S168
L
N
S
H
G
G
R
S
R
S
W
E
D
S
P
Site 17
S170
S
H
G
G
R
S
R
S
W
E
D
S
P
E
R
Site 18
S174
R
S
R
S
W
E
D
S
P
E
R
G
R
P
H
Site 19
S186
R
P
H
E
R
A
R
S
R
E
R
D
L
S
R
Site 20
S192
R
S
R
E
R
D
L
S
R
D
R
S
R
G
R
Site 21
S196
R
D
L
S
R
D
R
S
R
G
R
S
L
E
R
Site 22
S200
R
D
R
S
R
G
R
S
L
E
R
G
L
D
Q
Site 23
T212
L
D
Q
D
H
A
R
T
R
D
R
S
R
G
R
Site 24
S216
H
A
R
T
R
D
R
S
R
G
R
S
L
E
R
Site 25
S220
R
D
R
S
R
G
R
S
L
E
R
G
L
D
H
Site 26
S232
L
D
H
D
F
G
P
S
R
D
R
D
R
D
R
Site 27
S240
R
D
R
D
R
D
R
S
R
G
R
S
I
D
Q
Site 28
S244
R
D
R
S
R
G
R
S
I
D
Q
D
Y
E
R
Site 29
Y249
G
R
S
I
D
Q
D
Y
E
R
A
Y
H
R
A
Site 30
Y253
D
Q
D
Y
E
R
A
Y
H
R
A
Y
D
P
D
Site 31
Y257
E
R
A
Y
H
R
A
Y
D
P
D
Y
E
R
A
Site 32
Y261
H
R
A
Y
D
P
D
Y
E
R
A
Y
S
P
E
Site 33
Y265
D
P
D
Y
E
R
A
Y
S
P
E
Y
R
R
G
Site 34
S266
P
D
Y
E
R
A
Y
S
P
E
Y
R
R
G
A
Site 35
Y269
E
R
A
Y
S
P
E
Y
R
R
G
A
R
H
D
Site 36
S279
G
A
R
H
D
A
R
S
R
G
P
R
S
R
S
Site 37
S284
A
R
S
R
G
P
R
S
R
S
R
E
H
P
H
Site 38
S286
S
R
G
P
R
S
R
S
R
E
H
P
H
S
R
Site 39
S292
R
S
R
E
H
P
H
S
R
S
P
S
P
E
P
Site 40
S294
R
E
H
P
H
S
R
S
P
S
P
E
P
R
G
Site 41
S296
H
P
H
S
R
S
P
S
P
E
P
R
G
R
P
Site 42
S313
I
G
V
L
L
M
K
S
R
A
N
E
E
Y
G
Site 43
Y319
K
S
R
A
N
E
E
Y
G
L
R
L
G
S
Q
Site 44
S325
E
Y
G
L
R
L
G
S
Q
I
F
V
K
E
M
Site 45
T339
M
T
R
T
G
L
A
T
K
D
G
N
L
H
E
Site 46
T358
L
K
I
N
G
T
V
T
E
N
M
S
L
T
D
Site 47
S362
G
T
V
T
E
N
M
S
L
T
D
A
R
K
L
Site 48
T364
V
T
E
N
M
S
L
T
D
A
R
K
L
I
E
Site 49
S385
Q
L
V
V
L
R
D
S
Q
Q
T
L
I
N
I
Site 50
T388
V
L
R
D
S
Q
Q
T
L
I
N
I
P
S
L
Site 51
S394
Q
T
L
I
N
I
P
S
L
N
D
S
D
S
E
Site 52
S398
N
I
P
S
L
N
D
S
D
S
E
I
E
D
I
Site 53
S400
P
S
L
N
D
S
D
S
E
I
E
D
I
S
E
Site 54
S406
D
S
E
I
E
D
I
S
E
I
E
S
N
R
S
Site 55
S410
E
D
I
S
E
I
E
S
N
R
S
F
S
P
E
Site 56
S413
S
E
I
E
S
N
R
S
F
S
P
E
E
R
R
Site 57
S415
I
E
S
N
R
S
F
S
P
E
E
R
R
H
Q
Site 58
Y423
P
E
E
R
R
H
Q
Y
S
D
Y
D
Y
H
S
Site 59
S424
E
E
R
R
H
Q
Y
S
D
Y
D
Y
H
S
S
Site 60
Y426
R
R
H
Q
Y
S
D
Y
D
Y
H
S
S
S
E
Site 61
Y428
H
Q
Y
S
D
Y
D
Y
H
S
S
S
E
K
L
Site 62
S430
Y
S
D
Y
D
Y
H
S
S
S
E
K
L
K
E
Site 63
S431
S
D
Y
D
Y
H
S
S
S
E
K
L
K
E
R
Site 64
S432
D
Y
D
Y
H
S
S
S
E
K
L
K
E
R
P
Site 65
S440
E
K
L
K
E
R
P
S
S
R
E
D
T
P
S
Site 66
S441
K
L
K
E
R
P
S
S
R
E
D
T
P
S
R
Site 67
T445
R
P
S
S
R
E
D
T
P
S
R
L
S
R
M
Site 68
S447
S
S
R
E
D
T
P
S
R
L
S
R
M
G
A
Site 69
S450
E
D
T
P
S
R
L
S
R
M
G
A
T
P
T
Site 70
T455
R
L
S
R
M
G
A
T
P
T
P
F
K
S
T
Site 71
T457
S
R
M
G
A
T
P
T
P
F
K
S
T
G
D
Site 72
S461
A
T
P
T
P
F
K
S
T
G
D
I
A
G
T
Site 73
T462
T
P
T
P
F
K
S
T
G
D
I
A
G
T
V
Site 74
T468
S
T
G
D
I
A
G
T
V
V
P
E
T
N
K
Site 75
Y479
E
T
N
K
E
P
R
Y
Q
E
E
P
P
A
P
Site 76
T494
Q
P
K
A
A
P
R
T
F
L
R
P
S
P
E
Site 77
S499
P
R
T
F
L
R
P
S
P
E
D
E
A
I
Y
Site 78
Y506
S
P
E
D
E
A
I
Y
G
P
N
T
K
M
V
Site 79
T510
E
A
I
Y
G
P
N
T
K
M
V
R
F
K
K
Site 80
S520
V
R
F
K
K
G
D
S
V
G
L
R
L
A
G
Site 81
S543
A
G
I
Q
E
G
T
S
A
E
Q
E
G
L
Q
Site 82
Y574
V
R
E
D
A
V
L
Y
L
L
E
I
P
K
G
Site 83
T585
I
P
K
G
E
M
V
T
I
L
A
Q
S
R
A
Site 84
S590
M
V
T
I
L
A
Q
S
R
A
D
V
Y
R
D
Site 85
Y595
A
Q
S
R
A
D
V
Y
R
D
I
L
A
C
G
Site 86
S611
G
D
S
F
F
I
R
S
H
F
E
C
E
K
E
Site 87
T619
H
F
E
C
E
K
E
T
P
Q
S
L
A
F
T
Site 88
S622
C
E
K
E
T
P
Q
S
L
A
F
T
R
G
E
Site 89
Y638
F
R
V
V
D
T
L
Y
D
G
K
L
G
N
W
Site 90
S663
K
G
L
I
P
N
K
S
R
A
E
Q
M
A
S
Site 91
S670
S
R
A
E
Q
M
A
S
V
Q
N
A
Q
R
D
Site 92
S702
V
K
K
N
L
R
K
S
R
E
D
L
T
A
V
Site 93
T707
R
K
S
R
E
D
L
T
A
V
V
S
V
S
T
Site 94
S711
E
D
L
T
A
V
V
S
V
S
T
K
F
P
A
Site 95
S713
L
T
A
V
V
S
V
S
T
K
F
P
A
Y
E
Site 96
Y719
V
S
T
K
F
P
A
Y
E
R
V
L
L
R
E
Site 97
T760
D
W
F
Q
T
A
K
T
E
P
K
D
A
G
S
Site 98
S767
T
E
P
K
D
A
G
S
E
K
S
T
G
V
V
Site 99
S770
K
D
A
G
S
E
K
S
T
G
V
V
R
L
N
Site 100
T771
D
A
G
S
E
K
S
T
G
V
V
R
L
N
T
Site 101
T778
T
G
V
V
R
L
N
T
V
R
Q
I
I
E
Q
Site 102
S817
V
I
F
F
N
P
D
S
R
Q
G
V
K
T
M
Site 103
T823
D
S
R
Q
G
V
K
T
M
R
Q
R
L
N
P
Site 104
T831
M
R
Q
R
L
N
P
T
S
N
K
S
S
R
K
Site 105
S832
R
Q
R
L
N
P
T
S
N
K
S
S
R
K
L
Site 106
S835
L
N
P
T
S
N
K
S
S
R
K
L
F
D
Q
Site 107
S836
N
P
T
S
N
K
S
S
R
K
L
F
D
Q
A
Site 108
S862
T
A
T
I
N
L
N
S
A
N
D
S
W
F
G
Site 109
S866
N
L
N
S
A
N
D
S
W
F
G
S
L
K
D
Site 110
S870
A
N
D
S
W
F
G
S
L
K
D
T
I
Q
H
Site 111
S886
Q
G
E
A
V
W
V
S
E
G
K
M
E
G
M
Site 112
S902
D
D
P
E
D
R
M
S
Y
L
T
A
M
G
A
Site 113
Y903
D
P
E
D
R
M
S
Y
L
T
A
M
G
A
D
Site 114
T905
E
D
R
M
S
Y
L
T
A
M
G
A
D
Y
L
Site 115
Y911
L
T
A
M
G
A
D
Y
L
S
C
D
S
R
L
Site 116
S913
A
M
G
A
D
Y
L
S
C
D
S
R
L
I
S
Site 117
S916
A
D
Y
L
S
C
D
S
R
L
I
S
D
F
E
Site 118
S920
S
C
D
S
R
L
I
S
D
F
E
D
T
D
G
Site 119
T925
L
I
S
D
F
E
D
T
D
G
E
G
G
A
Y
Site 120
Y932
T
D
G
E
G
G
A
Y
T
D
N
E
L
D
E
Site 121
T933
D
G
E
G
G
A
Y
T
D
N
E
L
D
E
P
Site 122
S947
P
A
E
E
P
L
V
S
S
I
T
R
S
S
E
Site 123
S948
A
E
E
P
L
V
S
S
I
T
R
S
S
E
P
Site 124
T950
E
P
L
V
S
S
I
T
R
S
S
E
P
V
Q
Site 125
S952
L
V
S
S
I
T
R
S
S
E
P
V
Q
H
E
Site 126
S953
V
S
S
I
T
R
S
S
E
P
V
Q
H
E
E
Site 127
S961
E
P
V
Q
H
E
E
S
I
R
K
P
S
P
E
Site 128
S966
E
E
S
I
R
K
P
S
P
E
P
R
A
Q
M
Site 129
S978
A
Q
M
R
R
A
A
S
S
D
Q
L
R
D
N
Site 130
S979
Q
M
R
R
A
A
S
S
D
Q
L
R
D
N
S
Site 131
S986
S
D
Q
L
R
D
N
S
P
P
P
A
F
K
P
Site 132
T1000
P
E
P
P
K
A
K
T
Q
N
K
E
E
S
Y
Site 133
S1006
K
T
Q
N
K
E
E
S
Y
D
F
S
K
S
Y
Site 134
Y1007
T
Q
N
K
E
E
S
Y
D
F
S
K
S
Y
E
Site 135
S1010
K
E
E
S
Y
D
F
S
K
S
Y
E
Y
K
S
Site 136
S1012
E
S
Y
D
F
S
K
S
Y
E
Y
K
S
N
P
Site 137
Y1013
S
Y
D
F
S
K
S
Y
E
Y
K
S
N
P
S
Site 138
Y1015
D
F
S
K
S
Y
E
Y
K
S
N
P
S
A
V
Site 139
S1017
S
K
S
Y
E
Y
K
S
N
P
S
A
V
A
G
Site 140
T1027
S
A
V
A
G
N
E
T
P
G
A
S
T
K
G
Site 141
S1031
G
N
E
T
P
G
A
S
T
K
G
Y
P
P
P
Site 142
Y1035
P
G
A
S
T
K
G
Y
P
P
P
V
A
A
K
Site 143
T1044
P
P
V
A
A
K
P
T
F
G
R
S
I
L
K
Site 144
S1048
A
K
P
T
F
G
R
S
I
L
K
P
S
T
P
Site 145
S1053
G
R
S
I
L
K
P
S
T
P
I
P
P
Q
E
Site 146
T1054
R
S
I
L
K
P
S
T
P
I
P
P
Q
E
G
Site 147
S1067
E
G
E
E
V
G
E
S
S
E
E
Q
D
N
A
Site 148
S1068
G
E
E
V
G
E
S
S
E
E
Q
D
N
A
P
Site 149
S1077
E
Q
D
N
A
P
K
S
V
L
G
K
V
K
I
Site 150
Y1118
A
Q
K
H
P
D
I
Y
A
V
P
I
K
T
H
Site 151
T1124
I
Y
A
V
P
I
K
T
H
K
P
D
P
G
T
Site 152
T1131
T
H
K
P
D
P
G
T
P
Q
H
T
S
S
R
Site 153
T1135
D
P
G
T
P
Q
H
T
S
S
R
P
P
E
P
Site 154
S1136
P
G
T
P
Q
H
T
S
S
R
P
P
E
P
Q
Site 155
S1137
G
T
P
Q
H
T
S
S
R
P
P
E
P
Q
K
Site 156
S1147
P
E
P
Q
K
A
P
S
R
P
Y
Q
D
T
R
Site 157
Y1150
Q
K
A
P
S
R
P
Y
Q
D
T
R
G
S
Y
Site 158
T1153
P
S
R
P
Y
Q
D
T
R
G
S
Y
G
S
D
Site 159
S1156
P
Y
Q
D
T
R
G
S
Y
G
S
D
A
E
E
Site 160
Y1157
Y
Q
D
T
R
G
S
Y
G
S
D
A
E
E
E
Site 161
S1159
D
T
R
G
S
Y
G
S
D
A
E
E
E
E
Y
Site 162
Y1166
S
D
A
E
E
E
E
Y
R
Q
Q
L
S
E
H
Site 163
S1171
E
E
Y
R
Q
Q
L
S
E
H
S
K
R
G
Y
Site 164
S1174
R
Q
Q
L
S
E
H
S
K
R
G
Y
Y
G
Q
Site 165
Y1178
S
E
H
S
K
R
G
Y
Y
G
Q
S
A
R
Y
Site 166
Y1179
E
H
S
K
R
G
Y
Y
G
Q
S
A
R
Y
R
Site 167
S1182
K
R
G
Y
Y
G
Q
S
A
R
Y
R
D
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation