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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC9A2
Full Name:
Sodium/hydrogen exchanger 2
Alias:
Exchanger 2; NHE2; NHE-2; SL9A2; Solute carrier family 9 member 2
Type:
Membrane, Integral membrane protein
Mass (Da):
91520
Number AA:
812
UniProt ID:
Q9UBY0
International Prot ID:
IPI00002841
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0015385
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
P
L
G
N
W
R
S
L
R
A
P
L
P
P
Site 2
T45
N
A
P
R
A
M
G
T
S
S
S
P
P
S
P
Site 3
S46
A
P
R
A
M
G
T
S
S
S
P
P
S
P
A
Site 4
S47
P
R
A
M
G
T
S
S
S
P
P
S
P
A
S
Site 5
S48
R
A
M
G
T
S
S
S
P
P
S
P
A
S
V
Site 6
S51
G
T
S
S
S
P
P
S
P
A
S
V
V
A
P
Site 7
S54
S
S
P
P
S
P
A
S
V
V
A
P
G
T
T
Site 8
T72
E
S
R
L
P
V
F
T
L
D
Y
P
H
V
Q
Site 9
S132
I
F
G
V
D
E
K
S
P
P
A
M
K
T
D
Site 10
Y144
K
T
D
V
F
F
L
Y
L
L
P
P
I
V
L
Site 11
Y155
P
I
V
L
D
A
G
Y
F
M
P
T
R
P
F
Site 12
Y346
C
A
M
T
M
N
K
Y
V
E
E
N
V
S
Q
Site 13
S352
K
Y
V
E
E
N
V
S
Q
K
S
Y
T
T
I
Site 14
S355
E
E
N
V
S
Q
K
S
Y
T
T
I
K
Y
F
Site 15
Y356
E
N
V
S
Q
K
S
Y
T
T
I
K
Y
F
M
Site 16
Y361
K
S
Y
T
T
I
K
Y
F
M
K
M
L
S
S
Site 17
T421
Q
V
I
N
R
F
R
T
I
P
L
T
F
K
D
Site 18
S491
E
F
L
D
V
K
R
S
N
K
K
Q
Q
A
V
Site 19
S499
N
K
K
Q
Q
A
V
S
E
E
I
Y
C
R
L
Site 20
Y503
Q
A
V
S
E
E
I
Y
C
R
L
F
D
H
V
Site 21
Y537
F
K
K
F
D
D
K
Y
L
R
K
L
L
I
R
Site 22
S550
I
R
E
N
Q
P
K
S
S
I
V
S
L
Y
K
Site 23
S554
Q
P
K
S
S
I
V
S
L
Y
K
K
L
E
I
Site 24
S581
S
T
V
P
T
F
A
S
L
N
D
C
R
E
E
Site 25
T594
E
E
K
I
R
K
V
T
S
S
E
T
D
E
I
Site 26
S596
K
I
R
K
V
T
S
S
E
T
D
E
I
R
E
Site 27
Y610
E
L
L
S
R
N
L
Y
Q
I
R
Q
R
T
L
Site 28
T616
L
Y
Q
I
R
Q
R
T
L
S
Y
N
R
H
S
Site 29
S618
Q
I
R
Q
R
T
L
S
Y
N
R
H
S
L
T
Site 30
Y619
I
R
Q
R
T
L
S
Y
N
R
H
S
L
T
A
Site 31
S623
T
L
S
Y
N
R
H
S
L
T
A
D
T
S
E
Site 32
T625
S
Y
N
R
H
S
L
T
A
D
T
S
E
R
Q
Site 33
S629
H
S
L
T
A
D
T
S
E
R
Q
A
K
E
I
Site 34
S643
I
L
I
R
R
R
H
S
L
R
E
S
I
R
K
Site 35
S647
R
R
H
S
L
R
E
S
I
R
K
D
S
S
L
Site 36
S652
R
E
S
I
R
K
D
S
S
L
N
R
E
H
R
Site 37
S653
E
S
I
R
K
D
S
S
L
N
R
E
H
R
A
Site 38
S661
L
N
R
E
H
R
A
S
T
S
T
S
R
Y
L
Site 39
T662
N
R
E
H
R
A
S
T
S
T
S
R
Y
L
S
Site 40
S663
R
E
H
R
A
S
T
S
T
S
R
Y
L
S
L
Site 41
T664
E
H
R
A
S
T
S
T
S
R
Y
L
S
L
P
Site 42
S665
H
R
A
S
T
S
T
S
R
Y
L
S
L
P
K
Site 43
S669
T
S
T
S
R
Y
L
S
L
P
K
N
T
K
L
Site 44
T685
E
K
L
Q
K
R
R
T
I
S
I
A
D
G
N
Site 45
S687
L
Q
K
R
R
T
I
S
I
A
D
G
N
S
S
Site 46
S694
S
I
A
D
G
N
S
S
D
S
D
A
D
A
G
Site 47
S696
A
D
G
N
S
S
D
S
D
A
D
A
G
T
T
Site 48
S720
R
F
L
P
E
Q
F
S
K
K
S
P
Q
S
Y
Site 49
S723
P
E
Q
F
S
K
K
S
P
Q
S
Y
K
M
E
Site 50
S726
F
S
K
K
S
P
Q
S
Y
K
M
E
W
K
N
Site 51
S739
K
N
E
V
D
V
D
S
G
R
D
M
P
S
T
Site 52
S745
D
S
G
R
D
M
P
S
T
P
P
T
P
H
S
Site 53
T746
S
G
R
D
M
P
S
T
P
P
T
P
H
S
R
Site 54
T749
D
M
P
S
T
P
P
T
P
H
S
R
E
K
G
Site 55
S752
S
T
P
P
T
P
H
S
R
E
K
G
T
Q
T
Site 56
S769
L
L
Q
Q
P
L
L
S
K
D
Q
S
G
S
E
Site 57
S773
P
L
L
S
K
D
Q
S
G
S
E
R
E
D
S
Site 58
S775
L
S
K
D
Q
S
G
S
E
R
E
D
S
L
T
Site 59
S780
S
G
S
E
R
E
D
S
L
T
E
G
I
P
P
Site 60
T782
S
E
R
E
D
S
L
T
E
G
I
P
P
K
P
Site 61
S798
P
R
L
V
W
R
A
S
E
P
G
S
R
K
A
Site 62
S802
W
R
A
S
E
P
G
S
R
K
A
R
F
G
S
Site 63
S809
S
R
K
A
R
F
G
S
E
K
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation