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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DBF4
Full Name:
Protein DBF4 homologue A
Alias:
Activator of S phase kinase; ASK; ASK/H37; Chif; Chiffon; DBF4A; MUDBF4; ZDBF1; Zinc finger, DBF-type containing 1
Type:
Protein kinase, regulatory subunit
Mass (Da):
76858
Number AA:
674
UniProt ID:
Q9UBU7
International Prot ID:
IPI00170805
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005634
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008047
GO:0003676
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0000082
GO:0000074
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
G
A
M
R
I
H
S
K
G
H
F
Q
G
G
Site 2
S28
K
N
E
K
N
R
P
S
L
K
S
L
K
T
D
Site 3
S31
K
N
R
P
S
L
K
S
L
K
T
D
N
R
P
Site 4
T34
P
S
L
K
S
L
K
T
D
N
R
P
E
K
S
Site 5
S41
T
D
N
R
P
E
K
S
K
C
K
P
L
W
G
Site 6
S61
D
L
P
S
V
T
I
S
E
K
L
Q
K
D
I
Site 7
S80
G
R
V
E
E
F
L
S
K
D
I
S
Y
L
I
Site 8
S84
E
F
L
S
K
D
I
S
Y
L
I
S
N
K
K
Site 9
Y85
F
L
S
K
D
I
S
Y
L
I
S
N
K
K
E
Site 10
S88
K
D
I
S
Y
L
I
S
N
K
K
E
A
K
F
Site 11
T98
K
E
A
K
F
A
Q
T
L
G
R
I
S
P
V
Site 12
S103
A
Q
T
L
G
R
I
S
P
V
P
S
P
E
S
Site 13
S107
G
R
I
S
P
V
P
S
P
E
S
A
Y
T
A
Site 14
S110
S
P
V
P
S
P
E
S
A
Y
T
A
E
T
T
Site 15
T113
P
S
P
E
S
A
Y
T
A
E
T
T
S
P
H
Site 16
T116
E
S
A
Y
T
A
E
T
T
S
P
H
P
S
H
Site 17
S118
A
Y
T
A
E
T
T
S
P
H
P
S
H
D
G
Site 18
S122
E
T
T
S
P
H
P
S
H
D
G
S
S
F
K
Site 19
S126
P
H
P
S
H
D
G
S
S
F
K
S
P
D
T
Site 20
S127
H
P
S
H
D
G
S
S
F
K
S
P
D
T
V
Site 21
S130
H
D
G
S
S
F
K
S
P
D
T
V
C
L
S
Site 22
T133
S
S
F
K
S
P
D
T
V
C
L
S
R
G
K
Site 23
S155
K
D
H
D
F
I
P
S
N
S
I
L
S
N
A
Site 24
S157
H
D
F
I
P
S
N
S
I
L
S
N
A
L
S
Site 25
Y177
L
H
I
D
D
I
R
Y
Y
I
E
Q
K
K
K
Site 26
Y178
H
I
D
D
I
R
Y
Y
I
E
Q
K
K
K
E
Site 27
Y187
E
Q
K
K
K
E
L
Y
L
L
K
K
S
S
T
Site 28
S193
L
Y
L
L
K
K
S
S
T
S
V
R
D
G
G
Site 29
T194
Y
L
L
K
K
S
S
T
S
V
R
D
G
G
K
Site 30
S195
L
L
K
K
S
S
T
S
V
R
D
G
G
K
R
Site 31
S205
D
G
G
K
R
V
G
S
G
A
Q
K
T
R
T
Site 32
T210
V
G
S
G
A
Q
K
T
R
T
G
R
L
K
K
Site 33
T212
S
G
A
Q
K
T
R
T
G
R
L
K
K
P
F
Site 34
Y229
V
E
D
M
S
Q
L
Y
R
P
F
Y
L
Q
L
Site 35
Y233
S
Q
L
Y
R
P
F
Y
L
Q
L
T
N
M
P
Site 36
S251
Y
S
I
Q
K
P
C
S
P
F
D
V
D
K
P
Site 37
S259
P
F
D
V
D
K
P
S
S
M
Q
K
Q
T
Q
Site 38
S260
F
D
V
D
K
P
S
S
M
Q
K
Q
T
Q
V
Site 39
T273
Q
V
K
L
R
I
Q
T
D
G
D
K
Y
G
G
Site 40
Y278
I
Q
T
D
G
D
K
Y
G
G
T
S
I
Q
L
Site 41
T281
D
G
D
K
Y
G
G
T
S
I
Q
L
Q
L
K
Site 42
S282
G
D
K
Y
G
G
T
S
I
Q
L
Q
L
K
E
Site 43
Y295
K
E
K
K
K
K
G
Y
C
E
C
C
L
Q
K
Site 44
Y303
C
E
C
C
L
Q
K
Y
E
D
L
E
T
H
L
Site 45
T308
Q
K
Y
E
D
L
E
T
H
L
L
S
E
Q
H
Site 46
S312
D
L
E
T
H
L
L
S
E
Q
H
R
N
F
A
Site 47
Y341
L
V
F
D
F
V
E
Y
E
K
D
T
P
K
K
Site 48
T345
F
V
E
Y
E
K
D
T
P
K
K
K
R
I
K
Site 49
Y353
P
K
K
K
R
I
K
Y
S
V
G
S
L
S
P
Site 50
S354
K
K
K
R
I
K
Y
S
V
G
S
L
S
P
V
Site 51
S357
R
I
K
Y
S
V
G
S
L
S
P
V
S
A
S
Site 52
S359
K
Y
S
V
G
S
L
S
P
V
S
A
S
V
L
Site 53
S362
V
G
S
L
S
P
V
S
A
S
V
L
K
K
T
Site 54
S364
S
L
S
P
V
S
A
S
V
L
K
K
T
E
Q
Site 55
S381
K
V
E
L
Q
H
I
S
Q
K
D
C
Q
E
D
Site 56
T390
K
D
C
Q
E
D
D
T
T
V
K
E
Q
N
F
Site 57
T391
D
C
Q
E
D
D
T
T
V
K
E
Q
N
F
L
Site 58
Y399
V
K
E
Q
N
F
L
Y
K
E
T
Q
E
T
E
Site 59
T402
Q
N
F
L
Y
K
E
T
Q
E
T
E
K
K
L
Site 60
T405
L
Y
K
E
T
Q
E
T
E
K
K
L
L
F
I
Site 61
S413
E
K
K
L
L
F
I
S
E
P
I
P
H
P
S
Site 62
S420
S
E
P
I
P
H
P
S
N
E
L
R
G
L
N
Site 63
S431
R
G
L
N
E
K
M
S
N
K
C
S
M
L
S
Site 64
S435
E
K
M
S
N
K
C
S
M
L
S
T
A
E
D
Site 65
T439
N
K
C
S
M
L
S
T
A
E
D
D
I
R
Q
Site 66
T449
D
D
I
R
Q
N
F
T
Q
L
P
L
H
K
N
Site 67
S470
D
I
S
E
H
T
L
S
E
N
D
L
E
E
L
Site 68
Y482
E
E
L
R
V
D
H
Y
K
C
N
I
Q
A
S
Site 69
S493
I
Q
A
S
V
H
V
S
D
F
S
T
D
N
S
Site 70
S496
S
V
H
V
S
D
F
S
T
D
N
S
G
S
Q
Site 71
T497
V
H
V
S
D
F
S
T
D
N
S
G
S
Q
P
Site 72
S500
S
D
F
S
T
D
N
S
G
S
Q
P
K
Q
K
Site 73
S502
F
S
T
D
N
S
G
S
Q
P
K
Q
K
S
D
Site 74
S508
G
S
Q
P
K
Q
K
S
D
T
V
L
F
P
A
Site 75
T510
Q
P
K
Q
K
S
D
T
V
L
F
P
A
K
D
Site 76
S525
L
K
E
K
D
L
H
S
I
F
T
H
D
S
G
Site 77
S531
H
S
I
F
T
H
D
S
G
L
I
T
I
N
S
Site 78
T535
T
H
D
S
G
L
I
T
I
N
S
S
Q
E
H
Site 79
S538
S
G
L
I
T
I
N
S
S
Q
E
H
L
T
V
Site 80
S539
G
L
I
T
I
N
S
S
Q
E
H
L
T
V
Q
Site 81
T544
N
S
S
Q
E
H
L
T
V
Q
A
K
A
P
F
Site 82
T553
Q
A
K
A
P
F
H
T
P
P
E
E
P
N
E
Site 83
S568
C
D
F
K
N
M
D
S
L
P
S
G
K
I
H
Site 84
T604
D
K
R
T
E
F
I
T
Q
E
E
N
R
I
C
Site 85
S612
Q
E
E
N
R
I
C
S
S
P
V
Q
S
L
L
Site 86
S613
E
E
N
R
I
C
S
S
P
V
Q
S
L
L
D
Site 87
T624
S
L
L
D
L
F
Q
T
S
E
E
K
S
E
F
Site 88
S625
L
L
D
L
F
Q
T
S
E
E
K
S
E
F
L
Site 89
S629
F
Q
T
S
E
E
K
S
E
F
L
G
F
T
S
Site 90
S636
S
E
F
L
G
F
T
S
Y
T
E
K
S
G
I
Site 91
Y637
E
F
L
G
F
T
S
Y
T
E
K
S
G
I
C
Site 92
S655
D
I
W
E
E
E
N
S
D
N
L
L
T
A
F
Site 93
T660
E
N
S
D
N
L
L
T
A
F
F
S
S
P
S
Site 94
S664
N
L
L
T
A
F
F
S
S
P
S
T
S
T
F
Site 95
S665
L
L
T
A
F
F
S
S
P
S
T
S
T
F
T
Site 96
T670
F
S
S
P
S
T
S
T
F
T
G
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation