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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPS6KB2
Full Name:
Ribosomal protein S6 kinase beta-2
Alias:
14 beta; EC 2.7.11.1; KS6B2; S6 kinase-related kinase; S6K2; S6K-beta 2; SRK; STK14B
Type:
Protein-serine kinase, AGC group, RSK family, p70 subfamily
Mass (Da):
53483
Number AA:
482
UniProt ID:
Q9UBS0
International Prot ID:
IPI00217069
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Ribosomal protein S6 kinase beta-2; Ribosomal protein S6 kinase 2 S423 phosphosite-specific antibody AB-PK747#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK747#PKAIa (15-23) KinSub - cAMP-dependent protein kinase inhibitor alpha (C15-I23) peptide; PKA protein kinase substrate peptide - Powder PE-01ADK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADK95#S6KBSubtide - p70S6Kb (RPS6KB2) protein kinase substrate peptide - Powder PE-01BJI85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJI85#Ribosomal protein S6 kinase beta-2 / Ribosomal protein S6 kinase 2 (A420-K426, human) pS423 phosphopeptide - Powder PE-04AGI95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AGI95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
V
F
D
L
D
L
E
T
E
E
G
S
E
G
E
Site 2
S15
D
L
E
T
E
E
G
S
E
G
E
G
E
P
E
Site 3
S24
G
E
G
E
P
E
L
S
P
A
D
A
C
P
L
Site 4
Y45
G
L
E
P
V
G
H
Y
E
E
V
E
L
T
E
Site 5
T51
H
Y
E
E
V
E
L
T
E
T
S
V
N
V
G
Site 6
T53
E
E
V
E
L
T
E
T
S
V
N
V
G
P
E
Site 7
S54
E
V
E
L
T
E
T
S
V
N
V
G
P
E
R
Site 8
Y78
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
Site 9
T90
Q
V
R
K
V
Q
G
T
N
L
G
K
I
Y
A
Site 10
Y96
G
T
N
L
G
K
I
Y
A
M
K
V
L
R
K
Site 11
T113
I
V
R
N
A
K
D
T
A
H
T
R
A
E
R
Site 12
S125
A
E
R
N
I
L
E
S
V
K
H
P
F
I
V
Site 13
Y136
P
F
I
V
E
L
A
Y
A
F
Q
T
G
G
K
Site 14
Y192
L
H
S
Q
G
I
I
Y
R
D
L
K
P
E
N
Site 15
S203
K
P
E
N
I
M
L
S
S
Q
G
H
I
K
L
Site 16
S204
P
E
N
I
M
L
S
S
Q
G
H
I
K
L
T
Site 17
T211
S
Q
G
H
I
K
L
T
D
F
G
L
C
K
E
Site 18
S219
D
F
G
L
C
K
E
S
I
H
E
G
A
V
T
Site 19
T226
S
I
H
E
G
A
V
T
H
T
F
C
G
T
I
Site 20
T228
H
E
G
A
V
T
H
T
F
C
G
T
I
E
Y
Site 21
S266
M
Y
D
M
L
T
G
S
P
P
F
T
A
E
N
Site 22
T270
L
T
G
S
P
P
F
T
A
E
N
R
K
K
T
Site 23
T277
T
A
E
N
R
K
K
T
M
D
K
I
I
R
G
Site 24
Y291
G
K
L
A
L
P
P
Y
L
T
P
D
A
R
D
Site 25
S309
K
F
L
K
R
N
P
S
Q
R
I
G
G
G
P
Site 26
S351
P
F
R
P
C
L
Q
S
E
E
D
V
S
Q
F
Site 27
S356
L
Q
S
E
E
D
V
S
Q
F
D
T
R
F
T
Site 28
T360
E
D
V
S
Q
F
D
T
R
F
T
R
Q
T
P
Site 29
T363
S
Q
F
D
T
R
F
T
R
Q
T
P
V
D
S
Site 30
T366
D
T
R
F
T
R
Q
T
P
V
D
S
P
D
D
Site 31
S370
T
R
Q
T
P
V
D
S
P
D
D
T
A
L
S
Site 32
T374
P
V
D
S
P
D
D
T
A
L
S
E
S
A
N
Site 33
S377
S
P
D
D
T
A
L
S
E
S
A
N
Q
A
F
Site 34
T388
N
Q
A
F
L
G
F
T
Y
V
A
P
S
V
L
Site 35
S403
D
S
I
K
E
G
F
S
F
Q
P
K
L
R
S
Site 36
S410
S
F
Q
P
K
L
R
S
P
R
R
L
N
S
S
Site 37
S416
R
S
P
R
R
L
N
S
S
P
R
V
P
V
S
Site 38
S417
S
P
R
R
L
N
S
S
P
R
V
P
V
S
P
Site 39
S423
S
S
P
R
V
P
V
S
P
L
K
F
S
P
F
Ribosomal protein S6 kinase beta-2; Ribosomal protein S6 kinase 2 S423 phosphosite-specific antibody AB-PK747#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK747#Ribosomal protein S6 kinase beta-2 / Ribosomal protein S6 kinase 2 (A420-K426, human) pS423 phosphopeptide - Powder PE-04AGI95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AGI95
Site 40
S428
P
V
S
P
L
K
F
S
P
F
E
G
F
R
P
Site 41
S436
P
F
E
G
F
R
P
S
P
S
L
P
E
P
T
Site 42
S438
E
G
F
R
P
S
P
S
L
P
E
P
T
E
L
Site 43
T443
S
P
S
L
P
E
P
T
E
L
P
L
P
P
L
Site 44
T458
L
P
P
P
P
P
S
T
T
A
P
L
P
I
R
Site 45
S468
P
L
P
I
R
P
P
S
G
T
K
K
S
K
R
Site 46
T470
P
I
R
P
P
S
G
T
K
K
S
K
R
G
R
Site 47
S473
P
P
S
G
T
K
K
S
K
R
G
R
G
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation