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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEY2
Full Name:
Alias:
Cardiovascular helix-loop-helix factor 1;Class B basic helix-loop-helix protein 32;HES-related repressor protein 2;Hairy and enhancer of split-related protein 2;Hairy-related transcription factor 2;Protein gridlock homolog
Type:
Mass (Da):
35808
Number AA:
337
UniProt ID:
Q9UBP5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
K
R
P
C
E
E
T
T
S
E
S
D
M
D
Site 2
S10
R
P
C
E
E
T
T
S
E
S
D
M
D
E
T
Site 3
S12
C
E
E
T
T
S
E
S
D
M
D
E
T
I
D
Site 4
T17
S
E
S
D
M
D
E
T
I
D
V
G
S
E
N
Site 5
S22
D
E
T
I
D
V
G
S
E
N
N
Y
S
G
Q
Site 6
Y26
D
V
G
S
E
N
N
Y
S
G
Q
S
T
S
S
Site 7
S27
V
G
S
E
N
N
Y
S
G
Q
S
T
S
S
V
Site 8
S30
E
N
N
Y
S
G
Q
S
T
S
S
V
I
R
L
Site 9
T31
N
N
Y
S
G
Q
S
T
S
S
V
I
R
L
N
Site 10
S32
N
Y
S
G
Q
S
T
S
S
V
I
R
L
N
S
Site 11
S33
Y
S
G
Q
S
T
S
S
V
I
R
L
N
S
P
Site 12
S39
S
S
V
I
R
L
N
S
P
T
T
T
S
Q
I
Site 13
T42
I
R
L
N
S
P
T
T
T
S
Q
I
M
A
R
Site 14
S67
R
R
D
R
I
N
N
S
L
S
E
L
R
R
L
Site 15
S69
D
R
I
N
N
S
L
S
E
L
R
R
L
V
P
Site 16
T77
E
L
R
R
L
V
P
T
A
F
E
K
Q
G
S
Site 17
S84
T
A
F
E
K
Q
G
S
A
K
L
E
K
A
E
Site 18
T96
K
A
E
I
L
Q
M
T
V
D
H
L
K
M
L
Site 19
S138
T
E
V
A
R
Y
L
S
S
V
E
G
L
D
S
Site 20
S139
E
V
A
R
Y
L
S
S
V
E
G
L
D
S
S
Site 21
S145
S
S
V
E
G
L
D
S
S
D
P
L
R
V
R
Site 22
S146
S
V
E
G
L
D
S
S
D
P
L
R
V
R
L
Site 23
S158
V
R
L
V
S
H
L
S
T
C
A
T
Q
R
E
Site 24
T159
R
L
V
S
H
L
S
T
C
A
T
Q
R
E
A
Site 25
T162
S
H
L
S
T
C
A
T
Q
R
E
A
A
A
M
Site 26
S205
Q
P
N
G
L
H
A
S
E
S
T
P
C
R
L
Site 27
S207
N
G
L
H
A
S
E
S
T
P
C
R
L
S
T
Site 28
T208
G
L
H
A
S
E
S
T
P
C
R
L
S
T
T
Site 29
S213
E
S
T
P
C
R
L
S
T
T
S
E
V
P
P
Site 30
T214
S
T
P
C
R
L
S
T
T
S
E
V
P
P
A
Site 31
S216
P
C
R
L
S
T
T
S
E
V
P
P
A
H
G
Site 32
S236
A
T
F
A
H
A
D
S
A
L
R
M
P
S
T
Site 33
S242
D
S
A
L
R
M
P
S
T
G
S
V
A
P
C
Site 34
S310
I
S
P
P
L
S
V
S
A
T
S
S
P
Q
Q
Site 35
T312
P
P
L
S
V
S
A
T
S
S
P
Q
Q
T
S
Site 36
S314
L
S
V
S
A
T
S
S
P
Q
Q
T
S
S
G
Site 37
T318
A
T
S
S
P
Q
Q
T
S
S
G
T
N
N
K
Site 38
S320
S
S
P
Q
Q
T
S
S
G
T
N
N
K
P
Y
Site 39
Y327
S
G
T
N
N
K
P
Y
R
P
W
G
T
E
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation