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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO1A
Full Name:
Myosin-Ia
Alias:
BBMI; BBM-I; Brush border myosin I; Brush border myosin-I; Deafness, autosomal dominant 48; DFNA48; MIHC; MYHL; Myosin I heavy
Type:
Motor protein
Mass (Da):
118401
Number AA:
1043
UniProt ID:
Q9UBC5
International Prot ID:
IPI00294386
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005903
GO:0030864
GO:0031941
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0007605
GO:0051648
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
R
Y
E
N
K
E
I
Y
T
Y
I
G
N
V
V
Site 2
Y40
E
N
K
E
I
Y
T
Y
I
G
N
V
V
I
S
Site 3
Y57
P
Y
Q
Q
L
P
I
Y
G
P
E
F
I
A
K
Site 4
Y65
G
P
E
F
I
A
K
Y
Q
D
Y
T
F
Y
E
Site 5
Y68
F
I
A
K
Y
Q
D
Y
T
F
Y
E
L
K
P
Site 6
Y71
K
Y
Q
D
Y
T
F
Y
E
L
K
P
H
I
Y
Site 7
Y78
Y
E
L
K
P
H
I
Y
A
L
A
N
V
A
Y
Site 8
Y85
Y
A
L
A
N
V
A
Y
Q
S
L
R
D
R
D
Site 9
S87
L
A
N
V
A
Y
Q
S
L
R
D
R
D
R
D
Site 10
T100
R
D
Q
C
I
L
I
T
G
E
S
G
S
G
K
Site 11
S103
C
I
L
I
T
G
E
S
G
S
G
K
T
E
A
Site 12
S105
L
I
T
G
E
S
G
S
G
K
T
E
A
S
K
Site 13
T108
G
E
S
G
S
G
K
T
E
A
S
K
L
V
M
Site 14
S130
G
K
G
E
Q
V
N
S
V
K
E
Q
L
L
Q
Site 15
S138
V
K
E
Q
L
L
Q
S
N
P
V
L
E
A
F
Site 16
T150
E
A
F
G
N
A
K
T
I
R
N
N
N
S
S
Site 17
S156
K
T
I
R
N
N
N
S
S
R
F
G
K
Y
M
Site 18
Y162
N
S
S
R
F
G
K
Y
M
D
I
E
F
D
F
Site 19
Y202
E
R
N
F
H
I
F
Y
Q
L
L
A
G
A
D
Site 20
T222
A
L
K
L
E
R
D
T
T
G
Y
A
Y
L
N
Site 21
T223
L
K
L
E
R
D
T
T
G
Y
A
Y
L
N
H
Site 22
Y225
L
E
R
D
T
T
G
Y
A
Y
L
N
H
E
V
Site 23
Y227
R
D
T
T
G
Y
A
Y
L
N
H
E
V
S
R
Site 24
S233
A
Y
L
N
H
E
V
S
R
V
D
G
M
D
D
Site 25
S242
V
D
G
M
D
D
A
S
S
F
R
A
V
Q
S
Site 26
S243
D
G
M
D
D
A
S
S
F
R
A
V
Q
S
A
Site 27
S291
Q
A
S
G
I
P
A
S
G
I
R
D
G
R
G
Site 28
S310
G
E
M
V
G
L
N
S
E
E
V
E
R
A
L
Site 29
S319
E
V
E
R
A
L
C
S
R
T
M
E
T
A
K
Site 30
Y340
L
N
V
M
Q
A
Q
Y
A
R
D
A
L
A
K
Site 31
Y350
D
A
L
A
K
N
I
Y
S
R
L
F
D
W
I
Site 32
Y382
V
M
G
V
L
D
I
Y
G
F
E
I
L
E
D
Site 33
S391
F
E
I
L
E
D
N
S
F
E
Q
F
V
I
N
Site 34
Y399
F
E
Q
F
V
I
N
Y
C
N
E
K
L
Q
Q
Site 35
Y420
L
K
E
E
Q
E
E
Y
K
R
E
G
I
P
W
Site 36
Y432
I
P
W
T
K
V
D
Y
F
D
N
G
I
I
C
Site 37
T467
P
G
V
V
S
D
S
T
F
L
A
K
L
N
Q
Site 38
S477
A
K
L
N
Q
L
F
S
K
H
G
H
Y
E
S
Site 39
Y482
L
F
S
K
H
G
H
Y
E
S
K
V
T
Q
N
Site 40
S484
S
K
H
G
H
Y
E
S
K
V
T
Q
N
A
Q
Site 41
T487
G
H
Y
E
S
K
V
T
Q
N
A
Q
R
Q
Y
Site 42
Y494
T
Q
N
A
Q
R
Q
Y
D
H
T
M
G
L
S
Site 43
T497
A
Q
R
Q
Y
D
H
T
M
G
L
S
C
F
R
Site 44
Y514
H
Y
A
G
K
V
T
Y
N
V
T
S
F
I
D
Site 45
S545
A
Q
H
P
L
L
R
S
L
F
P
E
G
N
P
Site 46
S556
E
G
N
P
K
Q
A
S
L
K
R
P
P
T
A
Site 47
T562
A
S
L
K
R
P
P
T
A
G
A
Q
F
K
S
Site 48
Y579
A
I
L
M
K
N
L
Y
S
K
S
P
N
Y
I
Site 49
S580
I
L
M
K
N
L
Y
S
K
S
P
N
Y
I
R
Site 50
Y585
L
Y
S
K
S
P
N
Y
I
R
C
I
K
P
N
Site 51
S602
Q
Q
R
G
Q
F
S
S
D
L
V
A
T
Q
A
Site 52
Y625
V
R
V
R
R
A
G
Y
A
H
R
Q
G
Y
G
Site 53
Y631
G
Y
A
H
R
Q
G
Y
G
P
F
L
E
R
Y
Site 54
Y638
Y
G
P
F
L
E
R
Y
R
L
L
S
R
S
T
Site 55
S642
L
E
R
Y
R
L
L
S
R
S
T
W
P
H
W
Site 56
S665
E
K
V
L
G
E
L
S
M
S
S
G
E
L
A
Site 57
S682
K
T
K
I
F
I
R
S
P
K
T
L
F
Y
L
Site 58
T685
I
F
I
R
S
P
K
T
L
F
Y
L
E
E
Q
Site 59
Y688
R
S
P
K
T
L
F
Y
L
E
E
Q
R
R
L
Site 60
Y717
G
W
R
C
R
T
H
Y
Q
L
M
R
K
S
Q
Site 61
Y763
G
W
K
A
R
K
N
Y
R
K
Y
F
R
S
E
Site 62
Y766
A
R
K
N
Y
R
K
Y
F
R
S
E
A
A
L
Site 63
S769
N
Y
R
K
Y
F
R
S
E
A
A
L
T
L
A
Site 64
T804
S
T
N
V
L
D
K
T
W
P
A
A
P
Y
K
Site 65
Y810
K
T
W
P
A
A
P
Y
K
C
L
S
T
A
N
Site 66
S814
A
A
P
Y
K
C
L
S
T
A
N
Q
E
L
Q
Site 67
Y825
Q
E
L
Q
Q
L
F
Y
Q
W
K
C
K
R
F
Site 68
S837
K
R
F
R
D
Q
L
S
P
K
Q
V
E
I
L
Site 69
S860
L
F
K
G
K
K
A
S
Y
P
Q
S
V
P
I
Site 70
Y861
F
K
G
K
K
A
S
Y
P
Q
S
V
P
I
P
Site 71
S864
K
K
A
S
Y
P
Q
S
V
P
I
P
F
C
G
Site 72
Y873
P
I
P
F
C
G
D
Y
I
G
L
Q
G
N
P
Site 73
T909
V
N
R
G
N
G
K
T
S
S
R
I
L
L
L
Site 74
S910
N
R
G
N
G
K
T
S
S
R
I
L
L
L
T
Site 75
S911
R
G
N
G
K
T
S
S
R
I
L
L
L
T
K
Site 76
T924
T
K
G
H
V
I
L
T
D
T
K
K
S
Q
A
Site 77
S954
S
L
K
D
G
L
F
S
L
H
L
S
E
M
S
Site 78
S961
S
L
H
L
S
E
M
S
S
V
G
S
K
G
D
Site 79
S962
L
H
L
S
E
M
S
S
V
G
S
K
G
D
F
Site 80
T991
Y
R
A
V
L
D
A
T
Q
R
Q
L
T
V
T
Site 81
T996
D
A
T
Q
R
Q
L
T
V
T
V
T
E
K
F
Site 82
T998
T
Q
R
Q
L
T
V
T
V
T
E
K
F
S
V
Site 83
T1000
R
Q
L
T
V
T
V
T
E
K
F
S
V
R
F
Site 84
S1004
V
T
V
T
E
K
F
S
V
R
F
K
E
N
S
Site 85
S1011
S
V
R
F
K
E
N
S
V
A
V
K
V
V
Q
Site 86
S1026
G
P
A
G
G
D
N
S
K
L
R
Y
K
K
K
Site 87
Y1030
G
D
N
S
K
L
R
Y
K
K
K
G
S
H
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation