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Updated November 2019
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Protein Info
Short Name:
RERE
Full Name:
Arginine-glutamic acid dipeptide repeats protein
Alias:
ARG; arginine-glutamic acid dipeptide (RE) repeats; ARP; ATN1L; atrophin 1-like; atrophin-1-related; DNB1; KIAA0458
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
172424
Number AA:
1566
UniProt ID:
Q9P2R6
International Prot ID:
IPI00185027
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008267
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0007275
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
K
R
D
K
A
R
E
S
E
N
S
R
P
R
R
Site 2
S35
K
A
R
E
S
E
N
S
R
P
R
R
S
C
T
Site 3
S40
E
N
S
R
P
R
R
S
C
T
L
E
G
G
A
Site 4
T42
S
R
P
R
R
S
C
T
L
E
G
G
A
K
N
Site 5
S53
G
A
K
N
Y
A
E
S
D
H
S
E
D
E
D
Site 6
S56
N
Y
A
E
S
D
H
S
E
D
E
D
N
D
N
Site 7
S65
D
E
D
N
D
N
N
S
A
T
A
E
E
S
T
Site 8
T67
D
N
D
N
N
S
A
T
A
E
E
S
T
K
K
Site 9
S84
K
K
P
P
K
K
K
S
R
Y
E
R
T
D
T
Site 10
Y86
P
P
K
K
K
S
R
Y
E
R
T
D
T
G
E
Site 11
T91
S
R
Y
E
R
T
D
T
G
E
I
T
S
Y
I
Site 12
Y97
D
T
G
E
I
T
S
Y
I
T
E
D
D
V
V
Site 13
Y105
I
T
E
D
D
V
V
Y
R
P
G
D
C
V
Y
Site 14
Y112
Y
R
P
G
D
C
V
Y
I
E
S
R
R
P
N
Site 15
T120
I
E
S
R
R
P
N
T
P
Y
F
I
C
S
I
Site 16
Y122
S
R
R
P
N
T
P
Y
F
I
C
S
I
Q
D
Site 17
S142
N
S
Q
A
C
C
R
S
P
T
P
A
L
C
D
Site 18
T144
Q
A
C
C
R
S
P
T
P
A
L
C
D
P
P
Site 19
S159
A
C
S
L
P
V
A
S
Q
P
P
Q
H
L
S
Site 20
S166
S
Q
P
P
Q
H
L
S
E
A
G
R
G
P
V
Site 21
S175
A
G
R
G
P
V
G
S
K
R
D
H
L
L
M
Site 22
Y187
L
L
M
N
V
K
W
Y
Y
R
Q
S
E
V
P
Site 23
S196
R
Q
S
E
V
P
D
S
V
Y
Q
H
L
V
Q
Site 24
Y198
S
E
V
P
D
S
V
Y
Q
H
L
V
Q
D
R
Site 25
S211
D
R
H
N
E
N
D
S
G
R
E
L
V
I
T
Site 26
T218
S
G
R
E
L
V
I
T
D
P
V
I
K
N
R
Site 27
Y232
R
E
L
F
I
S
D
Y
V
D
T
Y
H
A
A
Site 28
Y236
I
S
D
Y
V
D
T
Y
H
A
A
A
L
R
G
Site 29
T276
I
L
G
Y
N
P
E
T
R
R
L
N
S
T
Q
Site 30
S281
P
E
T
R
R
L
N
S
T
Q
G
E
I
R
V
Site 31
T282
E
T
R
R
L
N
S
T
Q
G
E
I
R
V
G
Site 32
S304
P
D
L
Q
P
F
P
S
P
D
G
D
T
V
T
Site 33
T309
F
P
S
P
D
G
D
T
V
T
Q
H
E
E
L
Site 34
T311
S
P
D
G
D
T
V
T
Q
H
E
E
L
V
W
Site 35
Y330
N
D
C
D
L
L
M
Y
L
R
A
A
R
S
M
Site 36
S336
M
Y
L
R
A
A
R
S
M
A
A
F
A
G
M
Site 37
S348
A
G
M
C
D
G
G
S
T
E
D
G
C
V
A
Site 38
T349
G
M
C
D
G
G
S
T
E
D
G
C
V
A
A
Site 39
S357
E
D
G
C
V
A
A
S
R
D
D
T
T
L
N
Site 40
T361
V
A
A
S
R
D
D
T
T
L
N
A
L
N
T
Site 41
T362
A
A
S
R
D
D
T
T
L
N
A
L
N
T
L
Site 42
T368
T
T
L
N
A
L
N
T
L
H
E
S
G
Y
D
Site 43
Y374
N
T
L
H
E
S
G
Y
D
A
G
K
A
L
Q
Site 44
T397
K
L
I
E
K
C
W
T
E
D
E
V
K
R
F
Site 45
Y411
F
V
K
G
L
R
Q
Y
G
K
N
F
F
R
I
Site 46
Y435
T
G
E
L
I
T
F
Y
Y
Y
W
K
K
T
P
Site 47
Y436
G
E
L
I
T
F
Y
Y
Y
W
K
K
T
P
E
Site 48
Y437
E
L
I
T
F
Y
Y
Y
W
K
K
T
P
E
A
Site 49
T441
F
Y
Y
Y
W
K
K
T
P
E
A
A
S
S
R
Site 50
S446
K
K
T
P
E
A
A
S
S
R
A
H
R
R
H
Site 51
S447
K
T
P
E
A
A
S
S
R
A
H
R
R
H
R
Site 52
T464
A
V
F
R
R
I
K
T
R
T
A
S
T
P
V
Site 53
T466
F
R
R
I
K
T
R
T
A
S
T
P
V
N
T
Site 54
S468
R
I
K
T
R
T
A
S
T
P
V
N
T
P
S
Site 55
T469
I
K
T
R
T
A
S
T
P
V
N
T
P
S
R
Site 56
T473
T
A
S
T
P
V
N
T
P
S
R
P
P
S
S
Site 57
S475
S
T
P
V
N
T
P
S
R
P
P
S
S
E
F
Site 58
S479
N
T
P
S
R
P
P
S
S
E
F
L
D
L
S
Site 59
S480
T
P
S
R
P
P
S
S
E
F
L
D
L
S
S
Site 60
S486
S
S
E
F
L
D
L
S
S
A
S
E
D
D
F
Site 61
S487
S
E
F
L
D
L
S
S
A
S
E
D
D
F
D
Site 62
S495
A
S
E
D
D
F
D
S
E
D
S
E
Q
E
L
Site 63
S498
D
D
F
D
S
E
D
S
E
Q
E
L
K
G
Y
Site 64
Y505
S
E
Q
E
L
K
G
Y
A
C
R
H
C
F
T
Site 65
Y539
C
R
I
H
F
K
K
Y
G
E
L
P
P
I
E
Site 66
S567
K
E
E
D
D
G
L
S
G
K
H
S
M
R
T
Site 67
S571
D
G
L
S
G
K
H
S
M
R
T
R
R
S
R
Site 68
T574
S
G
K
H
S
M
R
T
R
R
S
R
G
S
M
Site 69
S577
H
S
M
R
T
R
R
S
R
G
S
M
S
T
L
Site 70
S580
R
T
R
R
S
R
G
S
M
S
T
L
R
S
G
Site 71
S582
R
R
S
R
G
S
M
S
T
L
R
S
G
R
K
Site 72
T583
R
S
R
G
S
M
S
T
L
R
S
G
R
K
K
Site 73
S586
G
S
M
S
T
L
R
S
G
R
K
K
Q
P
A
Site 74
S594
G
R
K
K
Q
P
A
S
P
D
G
R
T
S
P
Site 75
T599
P
A
S
P
D
G
R
T
S
P
I
N
E
D
I
Site 76
S600
A
S
P
D
G
R
T
S
P
I
N
E
D
I
R
Site 77
S608
P
I
N
E
D
I
R
S
S
G
R
N
S
P
S
Site 78
S609
I
N
E
D
I
R
S
S
G
R
N
S
P
S
A
Site 79
S613
I
R
S
S
G
R
N
S
P
S
A
A
S
T
S
Site 80
S615
S
S
G
R
N
S
P
S
A
A
S
T
S
S
N
Site 81
S618
R
N
S
P
S
A
A
S
T
S
S
N
D
S
K
Site 82
T619
N
S
P
S
A
A
S
T
S
S
N
D
S
K
A
Site 83
S620
S
P
S
A
A
S
T
S
S
N
D
S
K
A
E
Site 84
S621
P
S
A
A
S
T
S
S
N
D
S
K
A
E
T
Site 85
S624
A
S
T
S
S
N
D
S
K
A
E
T
V
K
K
Site 86
T628
S
N
D
S
K
A
E
T
V
K
K
S
A
K
K
Site 87
S641
K
K
V
K
E
E
A
S
S
P
L
K
S
N
K
Site 88
S642
K
V
K
E
E
A
S
S
P
L
K
S
N
K
R
Site 89
S646
E
A
S
S
P
L
K
S
N
K
R
Q
R
E
K
Site 90
S656
R
Q
R
E
K
V
A
S
D
T
E
E
A
D
R
Site 91
T664
D
T
E
E
A
D
R
T
S
S
K
K
T
K
T
Site 92
S665
T
E
E
A
D
R
T
S
S
K
K
T
K
T
Q
Site 93
S666
E
E
A
D
R
T
S
S
K
K
T
K
T
Q
E
Site 94
T671
T
S
S
K
K
T
K
T
Q
E
I
S
R
P
N
Site 95
S675
K
T
K
T
Q
E
I
S
R
P
N
S
P
S
E
Site 96
S679
Q
E
I
S
R
P
N
S
P
S
E
G
E
G
E
Site 97
S681
I
S
R
P
N
S
P
S
E
G
E
G
E
S
S
Site 98
S687
P
S
E
G
E
G
E
S
S
D
S
R
S
V
N
Site 99
S688
S
E
G
E
G
E
S
S
D
S
R
S
V
N
D
Site 100
S690
G
E
G
E
S
S
D
S
R
S
V
N
D
E
G
Site 101
S692
G
E
S
S
D
S
R
S
V
N
D
E
G
S
S
Site 102
S698
R
S
V
N
D
E
G
S
S
D
P
K
D
I
D
Site 103
S699
S
V
N
D
E
G
S
S
D
P
K
D
I
D
Q
Site 104
S710
D
I
D
Q
D
N
R
S
T
S
P
S
I
P
S
Site 105
T711
I
D
Q
D
N
R
S
T
S
P
S
I
P
S
P
Site 106
S712
D
Q
D
N
R
S
T
S
P
S
I
P
S
P
Q
Site 107
S714
D
N
R
S
T
S
P
S
I
P
S
P
Q
D
N
Site 108
S717
S
T
S
P
S
I
P
S
P
Q
D
N
E
S
D
Site 109
S723
P
S
P
Q
D
N
E
S
D
S
D
S
S
A
Q
Site 110
S725
P
Q
D
N
E
S
D
S
D
S
S
A
Q
Q
Q
Site 111
S727
D
N
E
S
D
S
D
S
S
A
Q
Q
Q
M
L
Site 112
T748
L
Q
A
P
T
G
V
T
P
A
P
S
S
A
P
Site 113
S752
T
G
V
T
P
A
P
S
S
A
P
P
G
T
P
Site 114
S753
G
V
T
P
A
P
S
S
A
P
P
G
T
P
Q
Site 115
T758
P
S
S
A
P
P
G
T
P
Q
L
P
T
P
G
Site 116
T763
P
G
T
P
Q
L
P
T
P
G
P
T
P
S
A
Site 117
T767
Q
L
P
T
P
G
P
T
P
S
A
T
A
V
P
Site 118
S769
P
T
P
G
P
T
P
S
A
T
A
V
P
P
Q
Site 119
T771
P
G
P
T
P
S
A
T
A
V
P
P
Q
G
S
Site 120
S778
T
A
V
P
P
Q
G
S
P
T
A
S
Q
A
P
Site 121
T780
V
P
P
Q
G
S
P
T
A
S
Q
A
P
N
Q
Site 122
S782
P
Q
G
S
P
T
A
S
Q
A
P
N
Q
P
Q
Site 123
S813
L
H
P
Q
R
P
P
S
P
H
P
P
P
H
P
Site 124
S821
P
H
P
P
P
H
P
S
P
H
P
P
L
Q
P
Site 125
T830
H
P
P
L
Q
P
L
T
G
S
A
G
Q
P
S
Site 126
S832
P
L
Q
P
L
T
G
S
A
G
Q
P
S
A
P
Site 127
S837
T
G
S
A
G
Q
P
S
A
P
S
H
A
Q
P
Site 128
S840
A
G
Q
P
S
A
P
S
H
A
Q
P
P
L
H
Site 129
S856
Q
G
P
P
G
P
H
S
L
Q
A
G
P
L
L
Site 130
S879
F
G
L
P
P
Q
A
S
Q
G
Q
A
P
L
G
Site 131
S888
G
Q
A
P
L
G
T
S
P
A
A
A
Y
P
H
Site 132
Y893
G
T
S
P
A
A
A
Y
P
H
T
S
L
Q
L
Site 133
S897
A
A
A
Y
P
H
T
S
L
Q
L
P
A
S
Q
Site 134
S903
T
S
L
Q
L
P
A
S
Q
S
A
L
Q
S
Q
Site 135
S905
L
Q
L
P
A
S
Q
S
A
L
Q
S
Q
Q
P
Site 136
S909
A
S
Q
S
A
L
Q
S
Q
Q
P
P
R
E
Q
Site 137
T933
P
H
I
K
P
P
P
T
T
P
I
P
Q
L
P
Site 138
T934
H
I
K
P
P
P
T
T
P
I
P
Q
L
P
A
Site 139
S952
H
K
H
P
P
H
L
S
G
P
S
P
F
S
M
Site 140
S955
P
P
H
L
S
G
P
S
P
F
S
M
N
A
N
Site 141
S958
L
S
G
P
S
P
F
S
M
N
A
N
L
P
P
Site 142
S973
P
P
A
L
K
P
L
S
S
L
S
T
H
H
P
Site 143
S974
P
A
L
K
P
L
S
S
L
S
T
H
H
P
P
Site 144
S976
L
K
P
L
S
S
L
S
T
H
H
P
P
S
A
Site 145
T977
K
P
L
S
S
L
S
T
H
H
P
P
S
A
H
Site 146
S982
L
S
T
H
H
P
P
S
A
H
P
P
P
L
Q
Site 147
S994
P
L
Q
L
M
P
Q
S
Q
P
L
P
S
S
P
Site 148
S999
P
Q
S
Q
P
L
P
S
S
P
A
Q
P
P
G
Site 149
S1000
Q
S
Q
P
L
P
S
S
P
A
Q
P
P
G
L
Site 150
T1008
P
A
Q
P
P
G
L
T
Q
S
Q
N
L
P
P
Site 151
S1010
Q
P
P
G
L
T
Q
S
Q
N
L
P
P
P
P
Site 152
S1019
N
L
P
P
P
P
A
S
H
P
P
T
G
L
H
Site 153
T1023
P
P
A
S
H
P
P
T
G
L
H
Q
V
A
P
Site 154
T1048
P
G
G
P
P
P
I
T
P
P
T
C
P
S
T
Site 155
T1051
P
P
P
I
T
P
P
T
C
P
S
T
S
T
P
Site 156
S1054
I
T
P
P
T
C
P
S
T
S
T
P
P
A
G
Site 157
T1055
T
P
P
T
C
P
S
T
S
T
P
P
A
G
P
Site 158
S1056
P
P
T
C
P
S
T
S
T
P
P
A
G
P
G
Site 159
T1057
P
T
C
P
S
T
S
T
P
P
A
G
P
G
T
Site 160
T1064
T
P
P
A
G
P
G
T
S
A
Q
P
P
C
S
Site 161
S1065
P
P
A
G
P
G
T
S
A
Q
P
P
C
S
G
Site 162
S1071
T
S
A
Q
P
P
C
S
G
A
A
A
S
G
G
Site 163
T1090
G
S
S
C
P
L
P
T
V
Q
I
K
E
E
A
Site 164
S1106
D
D
A
E
E
P
E
S
P
P
P
P
P
R
S
Site 165
S1113
S
P
P
P
P
P
R
S
P
S
P
E
P
T
V
Site 166
S1115
P
P
P
P
R
S
P
S
P
E
P
T
V
V
D
Site 167
T1119
R
S
P
S
P
E
P
T
V
V
D
T
P
S
H
Site 168
T1123
P
E
P
T
V
V
D
T
P
S
H
A
S
Q
S
Site 169
S1125
P
T
V
V
D
T
P
S
H
A
S
Q
S
A
R
Site 170
S1128
V
D
T
P
S
H
A
S
Q
S
A
R
F
Y
K
Site 171
S1130
T
P
S
H
A
S
Q
S
A
R
F
Y
K
H
L
Site 172
Y1134
A
S
Q
S
A
R
F
Y
K
H
L
D
R
G
Y
Site 173
Y1141
Y
K
H
L
D
R
G
Y
N
S
C
A
R
T
D
Site 174
S1143
H
L
D
R
G
Y
N
S
C
A
R
T
D
L
Y
Site 175
Y1150
S
C
A
R
T
D
L
Y
F
M
P
L
A
G
S
Site 176
S1157
Y
F
M
P
L
A
G
S
K
L
A
K
K
R
E
Site 177
S1209
A
E
R
A
A
K
A
S
S
S
A
H
E
G
R
Site 178
S1211
R
A
A
K
A
S
S
S
A
H
E
G
R
L
S
Site 179
S1218
S
A
H
E
G
R
L
S
D
P
Q
L
S
G
P
Site 180
S1223
R
L
S
D
P
Q
L
S
G
P
G
H
M
R
P
Site 181
S1231
G
P
G
H
M
R
P
S
F
E
P
P
P
T
T
Site 182
T1237
P
S
F
E
P
P
P
T
T
I
A
A
V
P
P
Site 183
T1238
S
F
E
P
P
P
T
T
I
A
A
V
P
P
Y
Site 184
T1250
P
P
Y
I
G
P
D
T
P
A
L
R
T
L
S
Site 185
S1257
T
P
A
L
R
T
L
S
E
Y
A
R
P
H
V
Site 186
Y1259
A
L
R
T
L
S
E
Y
A
R
P
H
V
M
S
Site 187
S1266
Y
A
R
P
H
V
M
S
P
T
N
R
N
H
P
Site 188
T1268
R
P
H
V
M
S
P
T
N
R
N
H
P
F
Y
Site 189
Y1275
T
N
R
N
H
P
F
Y
M
P
L
N
P
T
D
Site 190
Y1287
P
T
D
P
L
L
A
Y
H
M
P
G
L
Y
N
Site 191
Y1293
A
Y
H
M
P
G
L
Y
N
V
D
P
T
I
R
Site 192
T1298
G
L
Y
N
V
D
P
T
I
R
E
R
E
L
R
Site 193
S1351
M
E
H
F
A
R
H
S
A
L
T
I
P
P
T
Site 194
S1366
A
G
P
H
P
F
A
S
F
H
P
G
L
N
P
Site 195
S1391
P
Q
L
R
P
E
M
S
Y
P
D
R
L
A
A
Site 196
Y1392
Q
L
R
P
E
M
S
Y
P
D
R
L
A
A
E
Site 197
S1408
I
H
A
E
R
M
A
S
L
T
S
D
P
L
A
Site 198
T1410
A
E
R
M
A
S
L
T
S
D
P
L
A
R
L
Site 199
T1460
H
P
L
V
D
P
L
T
A
G
P
H
L
A
R
Site 200
Y1470
P
H
L
A
R
F
P
Y
P
P
G
T
L
P
N
Site 201
T1474
R
F
P
Y
P
P
G
T
L
P
N
P
L
L
G
Site 202
T1497
L
R
H
P
V
F
G
T
P
Y
P
R
D
L
P
Site 203
Y1499
H
P
V
F
G
T
P
Y
P
R
D
L
P
G
A
Site 204
S1512
G
A
I
P
P
P
M
S
A
A
H
Q
L
Q
A
Site 205
S1550
M
H
G
G
H
L
P
S
Q
E
D
Y
Y
S
R
Site 206
Y1554
H
L
P
S
Q
E
D
Y
Y
S
R
L
K
K
E
Site 207
Y1555
L
P
S
Q
E
D
Y
Y
S
R
L
K
K
E
G
Site 208
S1556
P
S
Q
E
D
Y
Y
S
R
L
K
K
E
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation