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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHDC5
Full Name:
Kelch domain-containing protein 5
Alias:
KIAA1340; KLDC5
Type:
Uncharacterized
Mass (Da):
56868
Number AA:
505
UniProt ID:
Q9P2K6
International Prot ID:
IPI00220056
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
I
R
L
E
D
R
C
Y
P
V
S
K
R
K
L
Site 2
S19
E
D
R
C
Y
P
V
S
K
R
K
L
I
E
Q
Site 3
S27
K
R
K
L
I
E
Q
S
D
Y
F
R
A
L
Y
Site 4
Y29
K
L
I
E
Q
S
D
Y
F
R
A
L
Y
R
S
Site 5
Y34
S
D
Y
F
R
A
L
Y
R
S
G
M
R
E
A
Site 6
S36
Y
F
R
A
L
Y
R
S
G
M
R
E
A
L
S
Site 7
S43
S
G
M
R
E
A
L
S
Q
E
A
G
G
P
E
Site 8
S100
D
E
E
M
D
E
V
S
L
L
S
E
L
V
E
Site 9
Y140
M
Y
R
L
A
Q
V
Y
G
L
P
D
L
Q
E
Site 10
S171
P
Q
F
H
L
L
G
S
P
P
Q
A
P
G
D
Site 11
S180
P
Q
A
P
G
D
V
S
L
K
Q
R
L
R
E
Site 12
Y212
G
P
L
A
P
H
P
Y
Q
G
E
P
P
S
M
Site 13
S218
P
Y
Q
G
E
P
P
S
M
L
R
Y
E
E
M
Site 14
Y222
E
P
P
S
M
L
R
Y
E
E
M
T
E
R
W
Site 15
Y246
D
L
V
N
V
R
G
Y
G
S
A
I
L
D
N
Site 16
S265
V
G
G
Y
R
I
T
S
Q
E
I
S
A
A
H
Site 17
S269
R
I
T
S
Q
E
I
S
A
A
H
S
Y
N
P
Site 18
S273
Q
E
I
S
A
A
H
S
Y
N
P
S
T
N
E
Site 19
S277
A
A
H
S
Y
N
P
S
T
N
E
W
L
Q
V
Site 20
S312
A
I
G
G
Q
A
V
S
N
V
E
C
Y
N
P
Site 21
S388
I
R
K
Q
Q
M
V
S
V
E
E
T
I
Y
I
Site 22
S409
E
L
G
P
N
R
R
S
S
Q
S
E
D
M
L
Site 23
S410
L
G
P
N
R
R
S
S
Q
S
E
D
M
L
T
Site 24
S412
P
N
R
R
S
S
Q
S
E
D
M
L
T
V
Q
Site 25
T417
S
Q
S
E
D
M
L
T
V
Q
S
Y
N
T
V
Site 26
Y421
D
M
L
T
V
Q
S
Y
N
T
V
T
R
Q
W
Site 27
T423
L
T
V
Q
S
Y
N
T
V
T
R
Q
W
L
Y
Site 28
Y430
T
V
T
R
Q
W
L
Y
L
K
E
N
T
S
K
Site 29
S436
L
Y
L
K
E
N
T
S
K
S
G
L
N
L
T
Site 30
S438
L
K
E
N
T
S
K
S
G
L
N
L
T
C
A
Site 31
T443
S
K
S
G
L
N
L
T
C
A
L
H
N
D
G
Site 32
Y452
A
L
H
N
D
G
I
Y
I
M
S
R
D
V
T
Site 33
S455
N
D
G
I
Y
I
M
S
R
D
V
T
L
S
T
Site 34
T459
Y
I
M
S
R
D
V
T
L
S
T
S
L
E
H
Site 35
S461
M
S
R
D
V
T
L
S
T
S
L
E
H
R
V
Site 36
S463
R
D
V
T
L
S
T
S
L
E
H
R
V
F
L
Site 37
Y472
E
H
R
V
F
L
K
Y
N
I
F
S
D
S
W
Site 38
Y498
N
L
L
V
S
S
L
Y
L
P
N
K
A
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation