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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNDC16
Full Name:
Thioredoxin domain-containing protein 16
Alias:
Type:
Mass (Da):
93572
Number AA:
825
UniProt ID:
Q9P2K2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
F
Y
M
P
T
V
N
S
L
P
E
L
S
P
Q
Site 2
S32
V
N
S
L
P
E
L
S
P
Q
K
Y
F
S
T
Site 3
Y36
P
E
L
S
P
Q
K
Y
F
S
T
L
Q
P
G
Site 4
T39
S
P
Q
K
Y
F
S
T
L
Q
P
G
K
A
S
Site 5
Y49
P
G
K
A
S
L
A
Y
F
C
Q
A
D
S
P
Site 6
S59
Q
A
D
S
P
R
T
S
V
F
L
E
E
L
N
Site 7
Y92
V
K
E
E
I
S
R
Y
C
G
K
E
K
D
L
Site 8
Y103
E
K
D
L
M
K
A
Y
L
F
K
G
N
I
L
Site 9
S203
A
L
L
E
S
I
G
S
E
D
V
E
Y
A
H
Site 10
Y208
I
G
S
E
D
V
E
Y
A
H
L
Y
F
F
H
Site 11
T223
C
K
L
V
L
D
L
T
Q
Q
C
R
R
T
L
Site 12
T229
L
T
Q
Q
C
R
R
T
L
M
E
Q
P
L
T
Site 13
T264
E
D
P
Q
Q
V
S
T
V
H
L
Q
L
G
L
Site 14
T289
T
Y
E
A
D
R
R
T
A
E
W
V
A
W
R
Site 15
T379
Q
D
D
E
V
A
E
T
V
F
R
D
R
K
R
Site 16
T393
R
K
L
P
L
E
L
T
V
E
L
T
E
E
T
Site 17
T404
T
E
E
T
F
N
A
T
V
M
A
S
D
S
I
Site 18
S478
K
K
G
E
N
P
V
S
Y
A
G
M
L
G
T
Site 19
Y479
K
G
E
N
P
V
S
Y
A
G
M
L
G
T
E
Site 20
S505
S
Y
P
V
N
I
T
S
I
Q
E
A
E
E
Y
Site 21
Y512
S
I
Q
E
A
E
E
Y
L
S
G
E
L
Y
K
Site 22
S514
Q
E
A
E
E
Y
L
S
G
E
L
Y
K
D
L
Site 23
Y518
E
Y
L
S
G
E
L
Y
K
D
L
I
L
Y
S
Site 24
Y524
L
Y
K
D
L
I
L
Y
S
S
V
S
V
L
G
Site 25
S545
K
T
A
K
E
D
F
S
E
A
G
N
Y
L
K
Site 26
Y550
D
F
S
E
A
G
N
Y
L
K
G
Y
V
I
T
Site 27
Y572
V
L
L
L
S
T
K
Y
A
A
S
L
P
A
L
Site 28
S575
L
S
T
K
Y
A
A
S
L
P
A
L
L
L
A
Site 29
S591
H
T
E
G
K
I
E
S
I
P
L
A
S
T
H
Site 30
T618
L
E
M
F
P
E
I
T
V
E
N
L
P
S
Y
Site 31
S624
I
T
V
E
N
L
P
S
Y
F
R
L
Q
K
P
Site 32
Y625
T
V
E
N
L
P
S
Y
F
R
L
Q
K
P
L
Site 33
T640
L
I
L
F
S
D
G
T
V
N
P
Q
Y
K
K
Site 34
Y645
D
G
T
V
N
P
Q
Y
K
K
A
I
L
T
L
Site 35
T651
Q
Y
K
K
A
I
L
T
L
V
K
Q
K
Y
L
Site 36
Y657
L
T
L
V
K
Q
K
Y
L
D
S
F
T
P
C
Site 37
T662
Q
K
Y
L
D
S
F
T
P
C
W
L
N
L
K
Site 38
T732
A
G
L
E
N
H
I
T
I
L
P
A
Q
E
W
Site 39
Y746
W
K
P
P
L
P
A
Y
D
F
L
S
M
I
D
Site 40
T756
L
S
M
I
D
A
A
T
S
Q
R
G
T
R
K
Site 41
S757
S
M
I
D
A
A
T
S
Q
R
G
T
R
K
V
Site 42
T761
A
A
T
S
Q
R
G
T
R
K
V
P
K
C
M
Site 43
S785
K
E
Q
H
E
D
K
S
A
V
R
K
E
P
I
Site 44
T794
V
R
K
E
P
I
E
T
L
R
I
K
H
W
N
Site 45
S812
W
F
K
E
A
E
K
S
F
R
R
D
K
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation