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Updated November 2019
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Protein Info
Short Name:
CC2D2A
Full Name:
Coiled-coil and C2 domain-containing protein 2A
Alias:
Type:
Mass (Da):
186185
Number AA:
1620
UniProt ID:
Q9P2K1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
M
G
R
Q
N
K
N
S
K
V
R
R
Q
P
R
Site 2
T44
P
R
K
K
Q
P
P
T
A
V
P
K
E
M
V
Site 3
S52
A
V
P
K
E
M
V
S
E
K
S
H
L
G
N
Site 4
S55
K
E
M
V
S
E
K
S
H
L
G
N
P
Q
E
Site 5
T70
P
V
Q
E
E
P
K
T
R
L
L
S
M
T
V
Site 6
S74
E
P
K
T
R
L
L
S
M
T
V
R
R
G
P
Site 7
T76
K
T
R
L
L
S
M
T
V
R
R
G
P
R
S
Site 8
S83
T
V
R
R
G
P
R
S
L
P
P
I
P
S
T
Site 9
S89
R
S
L
P
P
I
P
S
T
S
R
T
G
F
A
Site 10
T90
S
L
P
P
I
P
S
T
S
R
T
G
F
A
E
Site 11
T93
P
I
P
S
T
S
R
T
G
F
A
E
F
S
M
Site 12
S99
R
T
G
F
A
E
F
S
M
R
G
R
M
R
E
Site 13
S113
E
K
L
Q
A
A
R
S
K
A
E
S
A
L
L
Site 14
S117
A
A
R
S
K
A
E
S
A
L
L
Q
E
I
P
Site 15
T125
A
L
L
Q
E
I
P
T
P
R
P
R
R
L
R
Site 16
S133
P
R
P
R
R
L
R
S
P
S
K
K
E
L
E
Site 17
S135
P
R
R
L
R
S
P
S
K
K
E
L
E
T
E
Site 18
T154
P
G
K
E
V
E
R
T
Q
Q
E
V
D
S
Q
Site 19
S160
R
T
Q
Q
E
V
D
S
Q
S
Y
S
R
V
K
Site 20
S162
Q
Q
E
V
D
S
Q
S
Y
S
R
V
K
F
H
Site 21
Y163
Q
E
V
D
S
Q
S
Y
S
R
V
K
F
H
D
Site 22
S164
E
V
D
S
Q
S
Y
S
R
V
K
F
H
D
S
Site 23
S171
S
R
V
K
F
H
D
S
A
R
K
I
K
P
K
Site 24
S206
F
D
P
E
P
E
G
S
E
E
K
P
K
A
R
Site 25
T218
K
A
R
H
R
A
G
T
N
Q
E
E
E
E
G
Site 26
Y272
V
A
V
R
P
A
D
Y
E
S
I
H
D
R
L
Site 27
S290
R
E
M
L
F
I
P
S
R
Q
T
V
P
T
Y
Site 28
T293
L
F
I
P
S
R
Q
T
V
P
T
Y
K
K
L
Site 29
T296
P
S
R
Q
T
V
P
T
Y
K
K
L
P
E
N
Site 30
Y297
S
R
Q
T
V
P
T
Y
K
K
L
P
E
N
V
Site 31
Y315
F
L
E
D
E
G
L
Y
T
G
V
R
P
E
V
Site 32
T316
L
E
D
E
G
L
Y
T
G
V
R
P
E
V
A
Site 33
T325
V
R
P
E
V
A
R
T
N
Q
N
I
M
E
N
Site 34
S362
N
P
I
K
P
F
P
S
R
P
P
V
L
T
Q
Site 35
T368
P
S
R
P
P
V
L
T
Q
E
Q
S
I
K
A
Site 36
S372
P
V
L
T
Q
E
Q
S
I
K
A
E
L
E
T
Site 37
Y381
K
A
E
L
E
T
L
Y
K
K
A
V
K
Y
V
Site 38
Y387
L
Y
K
K
A
V
K
Y
V
H
S
S
Q
H
V
Site 39
S391
A
V
K
Y
V
H
S
S
Q
H
V
I
R
S
G
Site 40
S397
S
S
Q
H
V
I
R
S
G
D
P
P
G
N
F
Site 41
Y438
L
A
Q
L
Y
D
Q
Y
L
A
R
H
Q
R
N
Site 42
T480
S
L
D
T
I
Q
K
T
I
N
E
Y
K
S
E
Site 43
S486
K
T
I
N
E
Y
K
S
E
I
R
Q
T
R
K
Site 44
T491
Y
K
S
E
I
R
Q
T
R
K
F
R
D
A
E
Site 45
T504
A
E
Q
E
K
D
R
T
L
L
K
T
I
I
K
Site 46
T508
K
D
R
T
L
L
K
T
I
I
K
V
W
K
E
Site 47
S518
K
V
W
K
E
M
K
S
L
R
E
F
Q
R
F
Site 48
T526
L
R
E
F
Q
R
F
T
N
T
P
L
K
L
V
Site 49
T528
E
F
Q
R
F
T
N
T
P
L
K
L
V
L
R
Site 50
S557
A
E
I
Q
A
E
I
S
E
L
L
E
E
H
T
Site 51
Y611
G
D
E
I
A
E
P
Y
P
E
E
D
L
V
K
Site 52
S620
E
E
D
L
V
K
P
S
P
P
E
P
T
D
R
Site 53
S641
V
R
E
R
A
A
Q
S
R
R
R
P
W
E
P
Site 54
T649
R
R
R
P
W
E
P
T
L
V
P
E
L
S
L
Site 55
S659
P
E
L
S
L
A
G
S
V
T
P
N
D
Q
C
Site 56
T661
L
S
L
A
G
S
V
T
P
N
D
Q
C
P
R
Site 57
S672
Q
C
P
R
A
E
V
S
R
R
E
D
V
K
K
Site 58
Y683
D
V
K
K
R
S
V
Y
L
K
V
L
F
N
N
Site 59
S694
L
F
N
N
K
E
V
S
R
T
V
S
R
P
L
Site 60
T696
N
N
K
E
V
S
R
T
V
S
R
P
L
G
A
Site 61
S698
K
E
V
S
R
T
V
S
R
P
L
G
A
D
F
Site 62
T725
V
N
W
P
E
S
L
T
L
Q
V
Y
E
T
V
Site 63
Y729
E
S
L
T
L
Q
V
Y
E
T
V
G
H
S
S
Site 64
T731
L
T
L
Q
V
Y
E
T
V
G
H
S
S
P
T
Site 65
S736
Y
E
T
V
G
H
S
S
P
T
L
L
A
E
V
Site 66
T759
V
V
T
G
R
A
P
T
E
E
V
E
F
S
S
Site 67
S765
P
T
E
E
V
E
F
S
S
N
Q
H
V
T
L
Site 68
S779
L
D
H
E
G
V
G
S
G
V
P
F
S
F
E
Site 69
S784
V
G
S
G
V
P
F
S
F
E
A
D
G
S
N
Site 70
S790
F
S
F
E
A
D
G
S
N
Q
L
T
L
M
T
Site 71
T794
A
D
G
S
N
Q
L
T
L
M
T
S
G
K
V
Site 72
T797
S
N
Q
L
T
L
M
T
S
G
K
V
S
H
S
Site 73
S798
N
Q
L
T
L
M
T
S
G
K
V
S
H
S
V
Site 74
S804
T
S
G
K
V
S
H
S
V
A
W
A
I
G
E
Site 75
S839
K
K
A
D
A
I
S
S
I
G
T
S
G
L
T
Site 76
S843
A
I
S
S
I
G
T
S
G
L
T
D
M
K
K
Site 77
T846
S
I
G
T
S
G
L
T
D
M
K
K
L
A
K
Site 78
S879
Q
L
I
S
V
A
T
S
G
E
S
Y
V
P
D
Site 79
S901
Q
Q
E
F
N
F
V
S
D
Q
E
L
N
R
S
Site 80
S908
S
D
Q
E
L
N
R
S
K
R
F
R
L
L
H
Site 81
S918
F
R
L
L
H
L
R
S
Q
E
V
P
E
F
R
Site 82
Y927
E
V
P
E
F
R
N
Y
K
Q
V
P
V
Y
D
Site 83
Y933
N
Y
K
Q
V
P
V
Y
D
R
E
I
M
E
K
Site 84
Y945
M
E
K
V
F
Q
D
Y
E
K
R
L
R
D
R
Site 85
T957
R
D
R
N
V
I
E
T
K
E
H
I
D
T
H
Site 86
T963
E
T
K
E
H
I
D
T
H
R
A
I
V
A
K
Site 87
Y971
H
R
A
I
V
A
K
Y
L
Q
Q
V
R
E
S
Site 88
S1061
P
V
R
K
P
A
V
S
K
F
Q
Q
P
S
R
Site 89
S1067
V
S
K
F
Q
Q
P
S
R
S
S
R
M
F
S
Site 90
S1069
K
F
Q
Q
P
S
R
S
S
R
M
F
S
E
K
Site 91
S1070
F
Q
Q
P
S
R
S
S
R
M
F
S
E
K
H
Site 92
S1074
S
R
S
S
R
M
F
S
E
K
H
A
A
S
P
Site 93
S1080
F
S
E
K
H
A
A
S
P
S
T
Y
S
P
T
Site 94
S1082
E
K
H
A
A
S
P
S
T
Y
S
P
T
H
N
Site 95
T1083
K
H
A
A
S
P
S
T
Y
S
P
T
H
N
A
Site 96
Y1084
H
A
A
S
P
S
T
Y
S
P
T
H
N
A
D
Site 97
S1085
A
A
S
P
S
T
Y
S
P
T
H
N
A
D
Y
Site 98
Y1092
S
P
T
H
N
A
D
Y
P
L
G
Q
V
L
V
Site 99
T1114
F
Q
R
T
V
C
H
T
T
T
A
E
G
P
N
Site 100
S1123
T
A
E
G
P
N
P
S
W
N
E
E
L
E
L
Site 101
Y1139
F
R
A
P
N
G
D
Y
S
T
A
S
L
Q
S
Site 102
S1140
R
A
P
N
G
D
Y
S
T
A
S
L
Q
S
V
Site 103
T1141
A
P
N
G
D
Y
S
T
A
S
L
Q
S
V
K
Site 104
S1143
N
G
D
Y
S
T
A
S
L
Q
S
V
K
D
V
Site 105
S1172
E
D
D
R
E
R
G
S
G
I
H
T
R
I
E
Site 106
T1176
E
R
G
S
G
I
H
T
R
I
E
R
H
W
L
Site 107
Y1194
K
M
P
F
S
T
I
Y
F
Q
A
R
I
D
G
Site 108
T1202
F
Q
A
R
I
D
G
T
F
K
I
D
I
P
P
Site 109
S1228
I
L
E
R
G
F
D
S
V
R
S
L
S
E
G
Site 110
S1231
R
G
F
D
S
V
R
S
L
S
E
G
S
Y
I
Site 111
S1233
F
D
S
V
R
S
L
S
E
G
S
Y
I
T
L
Site 112
S1253
P
Q
L
V
P
G
E
S
I
R
E
K
F
E
S
Site 113
S1260
S
I
R
E
K
F
E
S
Q
E
D
E
K
L
L
Site 114
T1289
P
N
R
Q
C
L
T
T
V
I
D
I
S
G
K
Site 115
T1301
S
G
K
T
V
F
I
T
R
Y
L
K
P
L
N
Site 116
Y1303
K
T
V
F
I
T
R
Y
L
K
P
L
N
P
P
Site 117
Y1317
P
Q
E
L
L
N
V
Y
P
N
N
L
Q
A
T
Site 118
Y1398
I
P
E
G
P
T
A
Y
V
L
T
W
E
Q
G
Site 119
T1401
G
P
T
A
Y
V
L
T
W
E
Q
G
R
Y
L
Site 120
Y1446
I
W
F
N
I
Q
R
Y
E
S
P
L
R
I
N
Site 121
S1448
F
N
I
Q
R
Y
E
S
P
L
R
I
N
F
D
Site 122
T1457
L
R
I
N
F
D
V
T
R
P
K
L
W
K
S
Site 123
S1464
T
R
P
K
L
W
K
S
F
F
S
R
S
L
P
Site 124
S1469
W
K
S
F
F
S
R
S
L
P
Y
P
G
L
S
Site 125
Y1472
F
F
S
R
S
L
P
Y
P
G
L
S
S
V
Q
Site 126
S1476
S
L
P
Y
P
G
L
S
S
V
Q
P
E
E
L
Site 127
S1477
L
P
Y
P
G
L
S
S
V
Q
P
E
E
L
I
Site 128
Y1485
V
Q
P
E
E
L
I
Y
Q
R
S
D
K
A
A
Site 129
S1488
E
E
L
I
Y
Q
R
S
D
K
A
A
A
A
E
Site 130
S1537
F
L
P
L
L
E
K
S
Q
G
E
D
V
E
D
Site 131
Y1557
L
L
K
Q
L
G
D
Y
R
F
S
G
F
P
L
Site 132
S1560
Q
L
G
D
Y
R
F
S
G
F
P
L
H
M
P
Site 133
S1569
F
P
L
H
M
P
Y
S
E
V
K
P
L
I
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation