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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LARS
Full Name:
Leucyl-tRNA synthetase, cytoplasmic
Alias:
FLJ10595; FLJ21788; HSPC192; LARS1; Leucine tRNA ligase 1, cytoplasmic; Leucine-tRNA ligase; Leucine--tRNA ligase; Leucyl-tRNA synthetase; LeuRS; LEUS; RNTLS; SYLC
Type:
EC 6.1.1.4; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis
Mass (Da):
134466
Number AA:
1176
UniProt ID:
Q9P2J5
International Prot ID:
IPI00103994
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004823
PhosphoSite+
KinaseNET
Biological Process:
GO:0006429
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
E
R
K
G
T
A
K
V
D
F
L
K
Site 2
T26
E
I
Q
Q
K
W
D
T
E
R
V
F
E
V
N
Site 3
S35
R
V
F
E
V
N
A
S
N
L
E
K
Q
T
S
Site 4
S42
S
N
L
E
K
Q
T
S
K
G
K
Y
F
V
T
Site 5
Y46
K
Q
T
S
K
G
K
Y
F
V
T
F
P
Y
P
Site 6
T49
S
K
G
K
Y
F
V
T
F
P
Y
P
Y
M
N
Site 7
Y52
K
Y
F
V
T
F
P
Y
P
Y
M
N
G
R
L
Site 8
T64
G
R
L
H
L
G
H
T
F
S
L
S
K
C
E
Site 9
Y76
K
C
E
F
A
V
G
Y
Q
R
L
K
G
K
C
Site 10
Y111
L
K
R
E
I
E
L
Y
G
C
P
P
D
F
P
Site 11
T127
E
E
E
E
E
E
E
T
S
V
K
T
E
D
I
Site 12
S128
E
E
E
E
E
E
T
S
V
K
T
E
D
I
I
Site 13
S145
D
K
A
K
G
K
K
S
K
A
A
A
K
A
G
Site 14
S153
K
A
A
A
K
A
G
S
S
K
Y
Q
W
G
I
Site 15
S154
A
A
A
K
A
G
S
S
K
Y
Q
W
G
I
M
Site 16
Y156
A
K
A
G
S
S
K
Y
Q
W
G
I
M
K
S
Site 17
S163
Y
Q
W
G
I
M
K
S
L
G
L
S
D
E
E
Site 18
Y183
E
A
E
H
W
L
D
Y
F
P
P
L
A
I
Q
Site 19
S204
L
K
V
D
W
R
R
S
F
I
T
T
D
V
N
Site 20
T208
W
R
R
S
F
I
T
T
D
V
N
P
Y
Y
D
Site 21
Y213
I
T
T
D
V
N
P
Y
Y
D
S
F
V
R
W
Site 22
Y214
T
T
D
V
N
P
Y
Y
D
S
F
V
R
W
Q
Site 23
T224
F
V
R
W
Q
F
L
T
L
R
E
R
N
K
I
Site 24
Y237
K
I
K
F
G
K
R
Y
T
I
Y
S
P
K
D
Site 25
T238
I
K
F
G
K
R
Y
T
I
Y
S
P
K
D
G
Site 26
Y240
F
G
K
R
Y
T
I
Y
S
P
K
D
G
Q
P
Site 27
S241
G
K
R
Y
T
I
Y
S
P
K
D
G
Q
P
C
Site 28
T255
C
M
D
H
D
R
Q
T
G
E
G
V
G
P
Q
Site 29
Y264
E
G
V
G
P
Q
E
Y
T
L
L
K
L
K
V
Site 30
Y275
K
L
K
V
L
E
P
Y
P
S
K
L
S
G
L
Site 31
S277
K
V
L
E
P
Y
P
S
K
L
S
G
L
K
G
Site 32
T298
A
A
T
L
R
P
E
T
M
F
G
Q
T
N
C
Site 33
Y313
W
V
R
P
D
M
K
Y
I
G
F
E
T
V
N
Site 34
S335
Q
K
A
A
R
N
M
S
Y
Q
G
F
T
K
D
Site 35
T386
T
I
K
E
D
K
G
T
G
V
V
T
S
V
P
Site 36
T390
D
K
G
T
G
V
V
T
S
V
P
S
D
S
P
Site 37
S391
K
G
T
G
V
V
T
S
V
P
S
D
S
P
D
Site 38
S394
G
V
V
T
S
V
P
S
D
S
P
D
D
I
A
Site 39
Y416
K
Q
A
L
R
A
K
Y
G
I
R
D
D
M
V
Site 40
Y468
A
E
A
K
E
K
I
Y
L
K
G
F
Y
E
G
Site 41
Y473
K
I
Y
L
K
G
F
Y
E
G
I
M
L
V
D
Site 42
Y507
D
A
G
D
A
L
I
Y
M
E
P
E
K
Q
V
Site 43
S516
E
P
E
K
Q
V
M
S
R
S
S
D
E
C
V
Site 44
S519
K
Q
V
M
S
R
S
S
D
E
C
V
V
A
L
Site 45
Y531
V
A
L
C
D
Q
W
Y
L
D
Y
G
E
E
N
Site 46
S544
E
N
W
K
K
Q
T
S
Q
C
L
K
N
L
E
Site 47
T552
Q
C
L
K
N
L
E
T
F
C
E
E
T
R
R
Site 48
T564
T
R
R
N
F
E
A
T
L
G
W
L
Q
E
H
Site 49
Y577
E
H
A
C
S
R
T
Y
G
L
G
T
H
L
P
Site 50
T581
S
R
T
Y
G
L
G
T
H
L
P
W
D
E
Q
Site 51
S593
D
E
Q
W
L
I
E
S
L
S
D
S
T
I
Y
Site 52
S621
N
L
H
G
Q
A
E
S
P
L
G
I
R
P
Q
Site 53
Y637
M
T
K
E
V
W
D
Y
V
F
F
K
E
A
P
Site 54
T648
K
E
A
P
F
P
K
T
Q
I
A
K
E
K
L
Site 55
Y666
K
Q
E
F
E
F
W
Y
P
V
D
L
R
V
S
Site 56
S673
Y
P
V
D
L
R
V
S
G
K
D
L
V
P
N
Site 57
Y685
V
P
N
H
L
S
Y
Y
L
Y
N
H
V
A
M
Site 58
S714
N
G
H
L
L
L
N
S
E
K
M
S
K
S
T
Site 59
S718
L
L
N
S
E
K
M
S
K
S
T
G
N
F
L
Site 60
S720
N
S
E
K
M
S
K
S
T
G
N
F
L
T
L
Site 61
S735
T
Q
A
I
D
K
F
S
A
D
G
M
R
L
A
Site 62
S783
E
M
V
A
N
W
D
S
L
R
S
G
P
A
S
Site 63
S786
A
N
W
D
S
L
R
S
G
P
A
S
T
F
N
Site 64
S790
S
L
R
S
G
P
A
S
T
F
N
D
R
V
F
Site 65
T791
L
R
S
G
P
A
S
T
F
N
D
R
V
F
A
Site 66
Y812
I
I
K
T
D
Q
N
Y
E
K
M
M
F
K
E
Site 67
Y835
F
Q
A
A
K
D
K
Y
R
E
L
A
V
E
G
Site 68
T872
H
L
C
E
H
I
W
T
L
L
G
K
P
D
S
Site 69
S879
T
L
L
G
K
P
D
S
I
M
N
A
S
W
P
Site 70
Y901
V
L
I
H
S
S
Q
Y
L
M
E
V
T
H
D
Site 71
Y916
L
R
L
R
L
K
N
Y
M
M
P
A
K
G
K
Site 72
Y939
K
P
S
H
C
T
I
Y
V
A
K
N
Y
P
P
Site 73
S974
P
D
N
K
V
I
A
S
E
L
G
S
M
P
E
Site 74
S978
V
I
A
S
E
L
G
S
M
P
E
L
K
K
Y
Site 75
Y985
S
M
P
E
L
K
K
Y
M
K
K
V
M
P
F
Site 76
S1042
H
I
E
V
K
F
A
S
E
A
E
D
K
I
R
Site 77
S1070
I
E
P
G
V
S
V
S
L
V
N
P
Q
P
S
Site 78
S1077
S
L
V
N
P
Q
P
S
N
G
H
F
S
T
K
Site 79
S1095
R
Q
G
D
N
C
D
S
I
I
R
R
L
M
K
Site 80
S1111
N
R
G
I
K
D
L
S
K
V
K
L
M
R
F
Site 81
T1139
G
K
E
Y
T
E
K
T
P
I
S
E
H
A
V
Site 82
S1142
Y
T
E
K
T
P
I
S
E
H
A
V
F
N
V
Site 83
T1159
M
S
K
K
I
H
L
T
E
N
G
I
R
V
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation