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Updated November 2019
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Protein Info
Short Name:
KIAA1377
Full Name:
Uncharacterized protein KIAA1377
Alias:
Type:
Mass (Da):
125870
Number AA:
1117
UniProt ID:
Q9P2H0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
L
A
G
R
P
G
T
R
S
A
V
G
E
L
Site 2
S10
A
G
R
P
G
T
R
S
A
V
G
E
L
G
T
Site 3
T17
S
A
V
G
E
L
G
T
E
S
S
D
N
L
D
Site 4
S20
G
E
L
G
T
E
S
S
D
N
L
D
R
A
P
Site 5
S33
A
P
L
G
P
R
E
S
G
G
H
H
R
P
G
Site 6
S41
G
G
H
H
R
P
G
S
Y
L
D
M
K
I
H
Site 7
Y42
G
H
H
R
P
G
S
Y
L
D
M
K
I
H
L
Site 8
Y74
C
R
N
R
A
R
K
Y
F
V
E
S
N
R
R
Site 9
S78
A
R
K
Y
F
V
E
S
N
R
R
K
K
A
F
Site 10
S126
Q
R
A
H
V
P
L
S
Q
R
R
K
A
V
S
Site 11
S133
S
Q
R
R
K
A
V
S
R
K
P
V
P
P
L
Site 12
S154
I
Q
E
S
N
L
K
S
E
V
N
L
P
F
S
Site 13
S161
S
E
V
N
L
P
F
S
R
R
P
T
I
N
W
Site 14
T165
L
P
F
S
R
R
P
T
I
N
W
R
A
I
D
Site 15
S177
A
I
D
S
A
L
P
S
A
L
S
K
N
D
H
Site 16
S180
S
A
L
P
S
A
L
S
K
N
D
H
K
H
Q
Site 17
T207
M
N
E
N
M
R
A
T
L
A
T
S
K
N
V
Site 18
S232
L
L
E
D
Q
H
L
S
N
L
Q
K
F
C
D
Site 19
S247
E
V
N
Q
I
T
N
S
E
T
L
S
S
I
D
Site 20
T249
N
Q
I
T
N
S
E
T
L
S
S
I
D
S
L
Site 21
S251
I
T
N
S
E
T
L
S
S
I
D
S
L
E
A
Site 22
S252
T
N
S
E
T
L
S
S
I
D
S
L
E
A
T
Site 23
S255
E
T
L
S
S
I
D
S
L
E
A
T
E
H
E
Site 24
T259
S
I
D
S
L
E
A
T
E
H
E
E
I
Y
L
Site 25
Y265
A
T
E
H
E
E
I
Y
L
T
L
N
K
E
H
Site 26
T267
E
H
E
E
I
Y
L
T
L
N
K
E
H
S
T
Site 27
S273
L
T
L
N
K
E
H
S
T
S
I
Q
R
N
T
Site 28
S275
L
N
K
E
H
S
T
S
I
Q
R
N
T
I
S
Site 29
T280
S
T
S
I
Q
R
N
T
I
S
L
K
P
A
N
Site 30
S282
S
I
Q
R
N
T
I
S
L
K
P
A
N
M
Q
Site 31
S290
L
K
P
A
N
M
Q
S
T
N
L
S
C
F
D
Site 32
S294
N
M
Q
S
T
N
L
S
C
F
D
E
D
K
L
Site 33
T321
T
N
L
D
A
S
N
T
Q
N
V
T
A
F
S
Site 34
S328
T
Q
N
V
T
A
F
S
D
I
L
S
K
S
N
Site 35
S334
F
S
D
I
L
S
K
S
N
V
L
P
S
W
E
Site 36
S339
S
K
S
N
V
L
P
S
W
E
Y
F
N
S
K
Site 37
Y342
N
V
L
P
S
W
E
Y
F
N
S
K
E
Q
N
Site 38
S345
P
S
W
E
Y
F
N
S
K
E
Q
N
P
S
P
Site 39
S351
N
S
K
E
Q
N
P
S
P
L
N
G
T
V
E
Site 40
T356
N
P
S
P
L
N
G
T
V
E
R
A
T
N
T
Site 41
T361
N
G
T
V
E
R
A
T
N
T
A
N
N
S
V
Site 42
S367
A
T
N
T
A
N
N
S
V
P
F
V
S
S
P
Site 43
T386
L
D
K
K
C
E
K
T
S
E
T
S
T
M
R
Site 44
T391
E
K
T
S
E
T
S
T
M
R
T
T
D
S
T
Site 45
T394
S
E
T
S
T
M
R
T
T
D
S
T
S
G
A
Site 46
T395
E
T
S
T
M
R
T
T
D
S
T
S
G
A
F
Site 47
S397
S
T
M
R
T
T
D
S
T
S
G
A
F
K
R
Site 48
T398
T
M
R
T
T
D
S
T
S
G
A
F
K
R
E
Site 49
S399
M
R
T
T
D
S
T
S
G
A
F
K
R
E
R
Site 50
T410
K
R
E
R
P
L
V
T
E
S
P
T
F
K
F
Site 51
S412
E
R
P
L
V
T
E
S
P
T
F
K
F
S
K
Site 52
T414
P
L
V
T
E
S
P
T
F
K
F
S
K
S
Q
Site 53
S418
E
S
P
T
F
K
F
S
K
S
Q
S
T
S
D
Site 54
S420
P
T
F
K
F
S
K
S
Q
S
T
S
D
S
L
Site 55
S422
F
K
F
S
K
S
Q
S
T
S
D
S
L
T
Q
Site 56
S424
F
S
K
S
Q
S
T
S
D
S
L
T
Q
E
V
Site 57
S426
K
S
Q
S
T
S
D
S
L
T
Q
E
V
A
T
Site 58
T428
Q
S
T
S
D
S
L
T
Q
E
V
A
T
F
P
Site 59
T433
S
L
T
Q
E
V
A
T
F
P
D
Q
E
K
Y
Site 60
T450
L
N
Q
E
N
G
T
T
S
I
P
T
S
C
V
Site 61
S451
N
Q
E
N
G
T
T
S
I
P
T
S
C
V
P
Site 62
S467
A
T
P
L
V
L
P
S
N
I
Q
S
A
R
P
Site 63
S471
V
L
P
S
N
I
Q
S
A
R
P
S
A
K
N
Site 64
S475
N
I
Q
S
A
R
P
S
A
K
N
S
I
H
I
Site 65
S479
A
R
P
S
A
K
N
S
I
H
I
K
E
I
D
Site 66
Y507
G
K
E
E
E
I
K
Y
F
N
C
N
K
E
E
Site 67
S519
K
E
E
L
P
L
F
S
D
S
F
Q
D
A
Y
Site 68
S521
E
L
P
L
F
S
D
S
F
Q
D
A
Y
I
P
Site 69
Y526
S
D
S
F
Q
D
A
Y
I
P
H
N
P
D
S
Site 70
S533
Y
I
P
H
N
P
D
S
K
D
E
K
Q
K
L
Site 71
S545
Q
K
L
A
E
T
S
S
L
S
N
V
T
S
N
Site 72
S547
L
A
E
T
S
S
L
S
N
V
T
S
N
Y
D
Site 73
S551
S
S
L
S
N
V
T
S
N
Y
D
F
V
G
Q
Site 74
Y553
L
S
N
V
T
S
N
Y
D
F
V
G
Q
H
K
Site 75
Y564
G
Q
H
K
K
M
K
Y
N
I
H
E
R
N
G
Site 76
S577
N
G
V
R
F
L
K
S
I
L
K
K
E
S
K
Site 77
Y585
I
L
K
K
E
S
K
Y
E
H
G
Y
L
K
A
Site 78
Y589
E
S
K
Y
E
H
G
Y
L
K
A
L
I
I
N
Site 79
S598
K
A
L
I
I
N
Q
S
F
K
F
G
N
Q
K
Site 80
S612
K
A
A
A
I
R
D
S
I
E
L
T
K
E
K
Site 81
T616
I
R
D
S
I
E
L
T
K
E
K
G
A
E
I
Site 82
T626
K
G
A
E
I
P
K
T
I
K
K
L
R
W
F
Site 83
T636
K
L
R
W
F
D
E
T
S
N
I
E
N
N
A
Site 84
S648
N
N
A
E
N
S
H
S
L
K
N
K
T
G
T
Site 85
T653
S
H
S
L
K
N
K
T
G
T
T
Q
Q
H
S
Site 86
S660
T
G
T
T
Q
Q
H
S
Q
Q
F
H
I
Q
S
Site 87
S667
S
Q
Q
F
H
I
Q
S
G
A
G
S
N
I
I
Site 88
S689
N
S
A
D
T
K
K
S
R
E
D
S
I
S
E
Site 89
S693
T
K
K
S
R
E
D
S
I
S
E
N
V
T
T
Site 90
S695
K
S
R
E
D
S
I
S
E
N
V
T
T
L
G
Site 91
T699
D
S
I
S
E
N
V
T
T
L
G
G
S
G
A
Site 92
T700
S
I
S
E
N
V
T
T
L
G
G
S
G
A
D
Site 93
S729
A
K
H
A
W
P
A
S
K
K
E
E
S
K
I
Site 94
S734
P
A
S
K
K
E
E
S
K
I
P
V
H
D
D
Site 95
S742
K
I
P
V
H
D
D
S
K
T
K
Q
G
K
P
Site 96
T744
P
V
H
D
D
S
K
T
K
Q
G
K
P
Q
R
Site 97
S762
K
I
I
R
K
P
G
S
A
K
V
Q
S
G
F
Site 98
S767
P
G
S
A
K
V
Q
S
G
F
I
C
T
N
R
Site 99
S785
V
I
Q
P
Q
S
A
S
K
V
N
I
F
T
Q
Site 100
S806
I
P
C
P
P
P
Q
S
T
S
N
I
R
S
G
Site 101
S808
C
P
P
P
Q
S
T
S
N
I
R
S
G
K
N
Site 102
S812
Q
S
T
S
N
I
R
S
G
K
N
I
Q
V
S
Site 103
S819
S
G
K
N
I
Q
V
S
Q
C
Q
P
V
T
P
Site 104
T825
V
S
Q
C
Q
P
V
T
P
E
N
P
Q
N
I
Site 105
T834
E
N
P
Q
N
I
I
T
H
N
S
F
N
S
K
Site 106
S857
L
N
Q
W
N
Q
E
S
S
S
P
L
S
N
A
Site 107
S858
N
Q
W
N
Q
E
S
S
S
P
L
S
N
A
C
Site 108
S859
Q
W
N
Q
E
S
S
S
P
L
S
N
A
C
S
Site 109
S862
Q
E
S
S
S
P
L
S
N
A
C
S
D
L
V
Site 110
S877
T
V
I
P
S
L
P
S
Y
C
S
S
E
C
Q
Site 111
Y878
V
I
P
S
L
P
S
Y
C
S
S
E
C
Q
T
Site 112
S880
P
S
L
P
S
Y
C
S
S
E
C
Q
T
F
A
Site 113
S881
S
L
P
S
Y
C
S
S
E
C
Q
T
F
A
K
Site 114
T904
A
V
A
R
Q
D
A
T
L
Y
C
T
Q
R
S
Site 115
Y906
A
R
Q
D
A
T
L
Y
C
T
Q
R
S
P
V
Site 116
T908
Q
D
A
T
L
Y
C
T
Q
R
S
P
V
C
E
Site 117
S911
T
L
Y
C
T
Q
R
S
P
V
C
E
E
S
Y
Site 118
S917
R
S
P
V
C
E
E
S
Y
P
S
V
T
L
R
Site 119
Y918
S
P
V
C
E
E
S
Y
P
S
V
T
L
R
T
Site 120
S920
V
C
E
E
S
Y
P
S
V
T
L
R
T
A
E
Site 121
T948
L
H
Q
N
K
R
A
T
G
S
T
V
M
R
R
Site 122
T951
N
K
R
A
T
G
S
T
V
M
R
R
K
R
I
Site 123
T961
R
R
K
R
I
A
E
T
K
R
R
N
I
L
E
Site 124
S976
Q
K
R
Q
N
P
G
S
V
G
Q
K
Y
S
E
Site 125
Y981
P
G
S
V
G
Q
K
Y
S
E
Q
I
N
N
F
Site 126
S982
G
S
V
G
Q
K
Y
S
E
Q
I
N
N
F
G
Site 127
S991
Q
I
N
N
F
G
Q
S
V
L
L
S
S
S
E
Site 128
S995
F
G
Q
S
V
L
L
S
S
S
E
P
K
Q
T
Site 129
S997
Q
S
V
L
L
S
S
S
E
P
K
Q
T
T
R
Site 130
T1002
S
S
S
E
P
K
Q
T
T
R
G
T
S
Y
I
Site 131
T1003
S
S
E
P
K
Q
T
T
R
G
T
S
Y
I
E
Site 132
T1006
P
K
Q
T
T
R
G
T
S
Y
I
E
E
V
S
Site 133
S1007
K
Q
T
T
R
G
T
S
Y
I
E
E
V
S
D
Site 134
S1013
T
S
Y
I
E
E
V
S
D
S
T
S
E
F
L
Site 135
S1015
Y
I
E
E
V
S
D
S
T
S
E
F
L
M
A
Site 136
S1017
E
E
V
S
D
S
T
S
E
F
L
M
A
E
N
Site 137
S1029
A
E
N
L
V
K
A
S
V
P
E
D
E
I
L
Site 138
T1037
V
P
E
D
E
I
L
T
V
L
N
S
K
Q
I
Site 139
S1041
E
I
L
T
V
L
N
S
K
Q
I
Q
K
S
N
Site 140
S1047
N
S
K
Q
I
Q
K
S
N
L
P
L
N
K
T
Site 141
T1054
S
N
L
P
L
N
K
T
Q
Q
F
N
I
C
T
Site 142
S1063
Q
F
N
I
C
T
L
S
A
E
E
Q
K
I
L
Site 143
S1072
E
E
Q
K
I
L
E
S
L
N
D
L
N
E
R
Site 144
Y1082
D
L
N
E
R
L
H
Y
I
Q
E
S
I
C
K
Site 145
S1092
E
S
I
C
K
N
P
S
I
K
N
T
L
Q
I
Site 146
S1111
E
K
R
E
D
R
T
S
S
C
R
D
K
R
_
Site 147
S1112
K
R
E
D
R
T
S
S
C
R
D
K
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation