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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL8
Full Name:
Kelch-like protein 8
Alias:
Type:
Mass (Da):
68802
Number AA:
620
UniProt ID:
Q9P2G9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
D
S
M
S
S
K
Q
A
R
N
H
Site 2
S32
Q
Q
I
K
N
R
S
S
I
S
D
G
D
G
E
Site 3
S41
S
D
G
D
G
E
D
S
F
I
F
E
A
N
E
Site 4
Y61
H
G
S
L
L
R
F
Y
E
N
G
E
L
C
D
Site 5
S75
D
V
T
L
K
V
G
S
K
L
I
S
C
H
K
Site 6
S98
Y
F
R
A
M
F
L
S
E
M
A
E
A
K
Q
Site 7
T106
E
M
A
E
A
K
Q
T
L
I
E
I
R
D
F
Site 8
T133
Y
S
S
R
L
T
L
T
V
D
N
V
Q
P
L
Site 9
S178
A
V
R
A
F
A
E
S
H
N
R
I
D
L
M
Site 10
Y191
L
M
D
M
A
D
Q
Y
A
C
D
H
F
T
E
Site 11
S207
V
E
C
E
D
F
V
S
V
S
P
Q
H
L
H
Site 12
S209
C
E
D
F
V
S
V
S
P
Q
H
L
H
K
L
Site 13
S218
Q
H
L
H
K
L
L
S
S
S
D
L
N
I
E
Site 14
S220
L
H
K
L
L
S
S
S
D
L
N
I
E
N
E
Site 15
Y231
I
E
N
E
K
Q
V
Y
N
A
A
I
K
W
L
Site 16
T252
H
S
K
W
L
D
E
T
L
A
Q
V
R
L
P
Site 17
Y292
L
L
D
E
A
R
N
Y
H
L
H
L
S
S
R
Site 18
S297
R
N
Y
H
L
H
L
S
S
R
A
V
P
D
F
Site 19
Y306
R
A
V
P
D
F
E
Y
S
I
R
T
T
P
R
Site 20
S307
A
V
P
D
F
E
Y
S
I
R
T
T
P
R
K
Site 21
T311
F
E
Y
S
I
R
T
T
P
R
K
H
T
A
G
Site 22
T316
R
T
T
P
R
K
H
T
A
G
V
L
F
C
V
Site 23
S329
C
V
G
G
R
G
G
S
G
D
P
F
R
S
I
Site 24
S335
G
S
G
D
P
F
R
S
I
E
C
Y
S
I
N
Site 25
Y339
P
F
R
S
I
E
C
Y
S
I
N
K
N
S
W
Site 26
S354
F
F
G
P
E
M
N
S
R
R
R
H
V
G
V
Site 27
S363
R
R
H
V
G
V
I
S
V
E
G
K
V
Y
A
Site 28
Y369
I
S
V
E
G
K
V
Y
A
V
G
G
H
D
G
Site 29
S382
D
G
N
E
H
L
G
S
M
E
M
F
D
P
L
Site 30
T425
I
G
G
L
D
D
N
T
C
F
N
D
V
E
R
Site 31
S437
V
E
R
Y
D
I
E
S
D
Q
W
S
T
V
A
Site 32
T442
I
E
S
D
Q
W
S
T
V
A
P
M
N
T
P
Site 33
T448
S
T
V
A
P
M
N
T
P
R
G
G
V
G
S
Site 34
S473
G
G
N
D
G
M
A
S
L
S
S
V
E
R
Y
Site 35
S475
N
D
G
M
A
S
L
S
S
V
E
R
Y
D
P
Site 36
S476
D
G
M
A
S
L
S
S
V
E
R
Y
D
P
H
Site 37
Y480
S
L
S
S
V
E
R
Y
D
P
H
L
D
K
W
Site 38
S503
R
R
A
G
N
G
V
S
K
L
H
G
C
L
Y
Site 39
S519
V
G
G
F
D
D
N
S
P
L
S
S
V
E
R
Site 40
S522
F
D
D
N
S
P
L
S
S
V
E
R
Y
D
P
Site 41
S523
D
D
N
S
P
L
S
S
V
E
R
Y
D
P
R
Site 42
Y527
P
L
S
S
V
E
R
Y
D
P
R
S
N
K
W
Site 43
Y536
P
R
S
N
K
W
D
Y
V
A
A
L
T
T
P
Site 44
Y567
G
G
H
N
G
N
A
Y
L
N
T
V
E
A
F
Site 45
T570
N
G
N
A
Y
L
N
T
V
E
A
F
D
P
V
Site 46
S586
N
R
W
E
L
V
G
S
V
S
H
C
R
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation