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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKIB1
Full Name:
Ankyrin repeat and IBR domain-containing protein 1
Alias:
AKIB1
Type:
Mass (Da):
122002
Number AA:
1089
UniProt ID:
Q9P2G1
International Prot ID:
IPI00292914
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
E
N
L
A
C
Q
I
Y
E
N
N
P
Q
L
K
Site 2
S33
N
N
P
Q
L
K
E
S
L
D
P
N
T
S
Y
Site 3
T38
K
E
S
L
D
P
N
T
S
Y
G
E
P
Y
Q
Site 4
S39
E
S
L
D
P
N
T
S
Y
G
E
P
Y
Q
H
Site 5
Y40
S
L
D
P
N
T
S
Y
G
E
P
Y
Q
H
N
Site 6
Y44
N
T
S
Y
G
E
P
Y
Q
H
N
T
P
L
H
Site 7
T48
G
E
P
Y
Q
H
N
T
P
L
H
Y
A
A
R
Site 8
Y52
Q
H
N
T
P
L
H
Y
A
A
R
H
G
M
N
Site 9
T64
G
M
N
K
I
L
G
T
F
L
G
R
D
G
N
Site 10
S95
M
G
P
Q
I
M
I
S
E
G
A
L
H
P
R
Site 11
T107
H
P
R
L
A
R
P
T
E
D
D
F
R
R
A
Site 12
Y133
A
K
L
D
Q
G
E
Y
E
R
A
A
I
D
A
Site 13
T147
A
V
D
N
K
K
N
T
P
L
H
Y
A
A
A
Site 14
Y151
K
K
N
T
P
L
H
Y
A
A
A
S
G
M
K
Site 15
T180
A
E
N
E
N
K
D
T
P
C
D
C
A
E
K
Site 16
S199
D
L
A
L
N
L
E
S
Q
M
V
F
S
R
D
Site 17
S204
L
E
S
Q
M
V
F
S
R
D
P
E
A
E
E
Site 18
Y216
A
E
E
I
E
A
E
Y
A
A
L
D
K
R
E
Site 19
Y225
A
L
D
K
R
E
P
Y
E
G
L
R
P
Q
D
Site 20
T290
R
S
G
V
Q
M
P
T
P
P
P
S
G
Y
N
Site 21
S294
Q
M
P
T
P
P
P
S
G
Y
N
A
W
D
T
Site 22
Y296
P
T
P
P
P
S
G
Y
N
A
W
D
T
L
P
Site 23
T301
S
G
Y
N
A
W
D
T
L
P
S
P
R
T
P
Site 24
S304
N
A
W
D
T
L
P
S
P
R
T
P
R
T
T
Site 25
T307
D
T
L
P
S
P
R
T
P
R
T
T
R
S
S
Site 26
T310
P
S
P
R
T
P
R
T
T
R
S
S
V
T
S
Site 27
T311
S
P
R
T
P
R
T
T
R
S
S
V
T
S
P
Site 28
S313
R
T
P
R
T
T
R
S
S
V
T
S
P
D
E
Site 29
S314
T
P
R
T
T
R
S
S
V
T
S
P
D
E
I
Site 30
S317
T
T
R
S
S
V
T
S
P
D
E
I
S
L
S
Site 31
S322
V
T
S
P
D
E
I
S
L
S
P
G
D
L
D
Site 32
S324
S
P
D
E
I
S
L
S
P
G
D
L
D
T
S
Site 33
S397
D
I
I
E
S
V
V
S
K
E
M
D
K
R
Y
Site 34
Y404
S
K
E
M
D
K
R
Y
L
Q
F
D
I
K
A
Site 35
T424
P
A
I
K
W
C
P
T
P
G
C
D
R
A
V
Site 36
T434
C
D
R
A
V
R
L
T
K
Q
G
S
N
T
S
Site 37
S438
V
R
L
T
K
Q
G
S
N
T
S
G
S
D
T
Site 38
S441
T
K
Q
G
S
N
T
S
G
S
D
T
L
S
F
Site 39
S443
Q
G
S
N
T
S
G
S
D
T
L
S
F
P
L
Site 40
T445
S
N
T
S
G
S
D
T
L
S
F
P
L
L
R
Site 41
S447
T
S
G
S
D
T
L
S
F
P
L
L
R
A
P
Site 42
S524
K
P
C
A
N
C
K
S
P
I
Q
K
N
E
G
Site 43
S557
E
E
W
K
K
H
S
S
S
T
G
G
Y
Y
R
Site 44
Y562
H
S
S
S
T
G
G
Y
Y
R
C
T
R
Y
E
Site 45
Y563
S
S
S
T
G
G
Y
Y
R
C
T
R
Y
E
V
Site 46
Y568
G
Y
Y
R
C
T
R
Y
E
V
I
Q
H
V
E
Site 47
T582
E
E
Q
S
K
E
M
T
V
E
A
E
K
K
H
Site 48
Y601
E
L
D
R
F
M
H
Y
Y
T
R
F
K
N
H
Site 49
Y602
L
D
R
F
M
H
Y
Y
T
R
F
K
N
H
E
Site 50
T636
L
S
R
A
L
K
E
T
E
G
G
C
P
D
T
Site 51
T643
T
E
G
G
C
P
D
T
T
F
I
E
D
A
V
Site 52
T644
E
G
G
C
P
D
T
T
F
I
E
D
A
V
H
Site 53
Y664
R
R
I
L
K
C
S
Y
P
Y
G
F
F
L
E
Site 54
S674
G
F
F
L
E
P
K
S
T
K
K
E
I
F
E
Site 55
T675
F
F
L
E
P
K
S
T
K
K
E
I
F
E
L
Site 56
T685
E
I
F
E
L
M
Q
T
D
L
E
M
V
T
E
Site 57
Y702
A
Q
K
V
N
R
P
Y
L
R
T
P
R
H
K
Site 58
T705
V
N
R
P
Y
L
R
T
P
R
H
K
I
I
K
Site 59
S727
K
R
Q
E
F
L
A
S
V
A
R
G
V
A
P
Site 60
S737
R
G
V
A
P
A
D
S
P
E
A
P
R
R
S
Site 61
S744
S
P
E
A
P
R
R
S
F
A
G
G
T
W
D
Site 62
Y754
G
G
T
W
D
W
E
Y
L
G
F
A
S
P
E
Site 63
S759
W
E
Y
L
G
F
A
S
P
E
E
Y
A
E
F
Site 64
Y763
G
F
A
S
P
E
E
Y
A
E
F
Q
Y
R
R
Site 65
Y768
E
E
Y
A
E
F
Q
Y
R
R
R
H
R
Q
R
Site 66
S782
R
R
R
G
D
V
H
S
L
L
S
N
P
P
D
Site 67
S785
G
D
V
H
S
L
L
S
N
P
P
D
P
D
E
Site 68
S794
P
P
D
P
D
E
P
S
E
S
T
L
D
I
P
Site 69
S796
D
P
D
E
P
S
E
S
T
L
D
I
P
E
G
Site 70
S805
L
D
I
P
E
G
G
S
S
S
R
R
P
G
T
Site 71
S806
D
I
P
E
G
G
S
S
S
R
R
P
G
T
S
Site 72
S807
I
P
E
G
G
S
S
S
R
R
P
G
T
S
V
Site 73
T812
S
S
S
R
R
P
G
T
S
V
V
S
S
A
S
Site 74
S813
S
S
R
R
P
G
T
S
V
V
S
S
A
S
M
Site 75
S821
V
V
S
S
A
S
M
S
V
L
H
S
S
S
L
Site 76
S825
A
S
M
S
V
L
H
S
S
S
L
R
D
Y
T
Site 77
S826
S
M
S
V
L
H
S
S
S
L
R
D
Y
T
P
Site 78
S827
M
S
V
L
H
S
S
S
L
R
D
Y
T
P
A
Site 79
Y831
H
S
S
S
L
R
D
Y
T
P
A
S
R
S
E
Site 80
T832
S
S
S
L
R
D
Y
T
P
A
S
R
S
E
N
Site 81
S835
L
R
D
Y
T
P
A
S
R
S
E
N
Q
D
S
Site 82
S842
S
R
S
E
N
Q
D
S
L
Q
A
L
S
S
L
Site 83
S848
D
S
L
Q
A
L
S
S
L
D
E
D
D
P
N
Site 84
S867
I
Q
L
S
L
Q
E
S
G
L
A
L
D
E
E
Site 85
S880
E
E
T
R
D
F
L
S
N
E
A
S
L
G
A
Site 86
S891
S
L
G
A
I
G
T
S
L
P
S
R
L
D
S
Site 87
S894
A
I
G
T
S
L
P
S
R
L
D
S
V
P
R
Site 88
S898
S
L
P
S
R
L
D
S
V
P
R
N
T
D
S
Site 89
T903
L
D
S
V
P
R
N
T
D
S
P
R
A
A
L
Site 90
S905
S
V
P
R
N
T
D
S
P
R
A
A
L
S
S
Site 91
S911
D
S
P
R
A
A
L
S
S
S
E
L
L
E
L
Site 92
S912
S
P
R
A
A
L
S
S
S
E
L
L
E
L
G
Site 93
S913
P
R
A
A
L
S
S
S
E
L
L
E
L
G
D
Site 94
S933
G
A
E
N
D
P
F
S
T
D
T
L
S
S
H
Site 95
T934
A
E
N
D
P
F
S
T
D
T
L
S
S
H
P
Site 96
T936
N
D
P
F
S
T
D
T
L
S
S
H
P
L
S
Site 97
S938
P
F
S
T
D
T
L
S
S
H
P
L
S
E
A
Site 98
S939
F
S
T
D
T
L
S
S
H
P
L
S
E
A
R
Site 99
S943
T
L
S
S
H
P
L
S
E
A
R
S
D
F
C
Site 100
S947
H
P
L
S
E
A
R
S
D
F
C
P
S
S
S
Site 101
S952
A
R
S
D
F
C
P
S
S
S
D
P
D
S
A
Site 102
S953
R
S
D
F
C
P
S
S
S
D
P
D
S
A
G
Site 103
S954
S
D
F
C
P
S
S
S
D
P
D
S
A
G
Q
Site 104
S958
P
S
S
S
D
P
D
S
A
G
Q
D
P
N
I
Site 105
S999
T
T
E
I
S
A
D
S
Q
L
P
C
I
K
D
Site 106
S1022
E
L
V
L
P
E
D
S
M
F
E
D
A
S
V
Site 107
S1028
D
S
M
F
E
D
A
S
V
S
E
G
R
G
T
Site 108
S1030
M
F
E
D
A
S
V
S
E
G
R
G
T
Q
I
Site 109
T1035
S
V
S
E
G
R
G
T
Q
I
E
E
N
P
L
Site 110
S1053
I
L
A
G
E
A
A
S
Q
A
G
D
S
G
N
Site 111
S1069
A
A
N
R
G
D
G
S
D
V
S
S
Q
T
P
Site 112
S1072
R
G
D
G
S
D
V
S
S
Q
T
P
Q
T
S
Site 113
S1073
G
D
G
S
D
V
S
S
Q
T
P
Q
T
S
S
Site 114
T1075
G
S
D
V
S
S
Q
T
P
Q
T
S
S
D
W
Site 115
T1078
V
S
S
Q
T
P
Q
T
S
S
D
W
L
E
Q
Site 116
S1080
S
Q
T
P
Q
T
S
S
D
W
L
E
Q
V
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation