PhosphoNET

           
Protein Info 
   
Short Name:  MARCH-IV
Full Name:  E3 ubiquitin-protein ligase MARCH4
Alias:  EC 6.3.2.-; MARCH-IV; MARH4; Membrane-associated RING finger protein 4
Type:  Ubiquitin conjugating system
Mass (Da):  45528
Number AA:  410
UniProt ID:  Q9P2E8
International Prot ID:  IPI00002144
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0016021   Uniprot OncoNet
Molecular Function:  GO:0016874  GO:0008270   PhosphoSite+ KinaseNET
Biological Process:  GO:0019941     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S113PPPPLPPSSVEDDWG
Site 2S114PPPLPPSSVEDDWGG
Site 3T124DDWGGPATEPPASLL
Site 4S129PATEPPASLLSSASS
Site 5S132EPPASLLSSASSDDF
Site 6S133PPASLLSSASSDDFC
Site 7S135ASLLSSASSDDFCKE
Site 8S136SLLSSASSDDFCKEK
Site 9T144DDFCKEKTEDRYSLG
Site 10Y148KEKTEDRYSLGSSLD
Site 11S149EKTEDRYSLGSSLDS
Site 12S152EDRYSLGSSLDSGMR
Site 13S153DRYSLGSSLDSGMRT
Site 14S156SLGSSLDSGMRTPLC
Site 15S177PEQGELLSPCRCDGS
Site 16S297LIIHEGPSVYRIFKR
Site 17T320KVLNYDKTKDLEDQK
Site 18T332DQKAGGRTNPRTSSS
Site 19T336GGRTNPRTSSSTQAN
Site 20S337GRTNPRTSSSTQANI
Site 21S338RTNPRTSSSTQANIP
Site 22S339TNPRTSSSTQANIPS
Site 23T340NPRTSSSTQANIPSS
Site 24S346STQANIPSSEEETAG
Site 25S347TQANIPSSEEETAGT
Site 26T354SEEETAGTPAPEQGP
Site 27S369AQAAGHPSGPLSHHH
Site 28S386YTILHILSHLRPHEQ
Site 29S395LRPHEQRSPPGSSRE
Site 30S399EQRSPPGSSRELVMR
Site 31T408RELVMRVTTV_____
Site 32T409ELVMRVTTV______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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