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Updated November 2019
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Protein Info
Short Name:
KIAA1409
Full Name:
Protein unc-79 homolog
Alias:
FLJ43337; K1409; LOC57578
Type:
Mass (Da):
295294
Number AA:
2635
UniProt ID:
Q9P2D8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
K
A
E
Q
F
A
S
K
I
R
Y
L
Q
E
Site 2
Y14
Q
F
A
S
K
I
R
Y
L
Q
E
Y
H
N
R
Site 3
Y18
K
I
R
Y
L
Q
E
Y
H
N
R
V
L
H
N
Site 4
Y27
N
R
V
L
H
N
I
Y
P
V
P
S
G
T
D
Site 5
T38
S
G
T
D
I
A
N
T
L
K
Y
F
S
Q
T
Site 6
Y41
D
I
A
N
T
L
K
Y
F
S
Q
T
L
L
S
Site 7
S48
Y
F
S
Q
T
L
L
S
I
L
S
R
T
G
K
Site 8
S51
Q
T
L
L
S
I
L
S
R
T
G
K
K
E
N
Site 9
S82
V
P
F
P
L
T
P
S
L
R
P
Q
V
S
S
Site 10
S88
P
S
L
R
P
Q
V
S
S
I
N
P
T
V
T
Site 11
S89
S
L
R
P
Q
V
S
S
I
N
P
T
V
T
R
Site 12
T93
Q
V
S
S
I
N
P
T
V
T
R
S
L
L
Y
Site 13
S108
S
V
L
R
D
A
P
S
E
R
G
P
Q
S
R
Site 14
S114
P
S
E
R
G
P
Q
S
R
D
A
Q
L
S
D
Site 15
S120
Q
S
R
D
A
Q
L
S
D
Y
P
S
L
D
Y
Site 16
Y122
R
D
A
Q
L
S
D
Y
P
S
L
D
Y
Q
G
Site 17
S124
A
Q
L
S
D
Y
P
S
L
D
Y
Q
G
L
Y
Site 18
Y127
S
D
Y
P
S
L
D
Y
Q
G
L
Y
V
T
L
Site 19
S209
L
P
M
A
I
L
G
S
S
R
R
E
G
V
P
Site 20
S210
P
M
A
I
L
G
S
S
R
R
E
G
V
P
A
Site 21
Y239
Q
Y
T
S
N
P
V
Y
H
C
Q
L
L
E
C
Site 22
Y250
L
L
E
C
L
M
K
Y
K
Q
E
V
W
K
D
Site 23
Y280
A
V
Q
M
L
F
H
Y
W
P
N
L
K
P
P
Site 24
S291
L
K
P
P
G
A
I
S
E
Y
R
G
L
Q
Y
Site 25
Y298
S
E
Y
R
G
L
Q
Y
T
A
W
N
P
I
H
Site 26
Y340
G
D
K
P
P
P
L
Y
L
C
E
E
C
S
E
Site 27
S354
E
R
I
A
G
D
H
S
E
W
L
I
D
V
L
Site 28
Y403
H
G
N
R
P
V
R
Y
C
K
R
C
H
S
N
Site 29
S413
R
C
H
S
N
H
H
S
N
E
V
G
A
A
A
Site 30
Y425
A
A
A
E
T
H
L
Y
Q
T
S
P
P
P
I
Site 31
S428
E
T
H
L
Y
Q
T
S
P
P
P
I
N
T
R
Site 32
S476
R
R
R
Q
L
G
L
S
S
S
H
H
S
L
D
Site 33
S477
R
R
Q
L
G
L
S
S
S
H
H
S
L
D
N
Site 34
S478
R
Q
L
G
L
S
S
S
H
H
S
L
D
N
A
Site 35
S481
G
L
S
S
S
H
H
S
L
D
N
A
D
F
D
Site 36
S501
K
H
D
Q
R
L
L
S
Q
F
G
I
W
F
L
Site 37
S515
L
V
S
L
C
T
P
S
E
N
T
P
T
E
S
Site 38
T518
L
C
T
P
S
E
N
T
P
T
E
S
L
A
R
Site 39
T520
T
P
S
E
N
T
P
T
E
S
L
A
R
L
V
Site 40
S522
S
E
N
T
P
T
E
S
L
A
R
L
V
A
M
Site 41
S547
M
M
D
D
E
V
G
S
L
V
E
K
L
K
P
Site 42
Y589
E
F
A
R
V
G
G
Y
W
D
K
S
C
S
T
Site 43
T634
E
W
L
E
A
I
R
T
E
V
P
D
N
Q
L
Site 44
T675
G
F
I
S
C
R
F
T
G
Y
P
S
S
V
Q
Site 45
Y677
I
S
C
R
F
T
G
Y
P
S
S
V
Q
E
Q
Site 46
S680
R
F
T
G
Y
P
S
S
V
Q
E
Q
A
L
L
Site 47
S714
M
F
S
D
G
V
N
S
V
K
E
L
A
N
Q
Site 48
S724
E
L
A
N
Q
R
K
S
R
V
S
E
L
A
G
Site 49
S727
N
Q
R
K
S
R
V
S
E
L
A
G
N
L
A
Site 50
S735
E
L
A
G
N
L
A
S
R
R
V
S
V
A
S
Site 51
S739
N
L
A
S
R
R
V
S
V
A
S
D
P
G
R
Site 52
S742
S
R
R
V
S
V
A
S
D
P
G
R
R
V
Q
Site 53
S754
R
V
Q
H
N
M
L
S
P
F
H
S
P
F
Q
Site 54
S758
N
M
L
S
P
F
H
S
P
F
Q
S
P
F
R
Site 55
S762
P
F
H
S
P
F
Q
S
P
F
R
S
P
L
R
Site 56
S766
P
F
Q
S
P
F
R
S
P
L
R
S
P
F
R
Site 57
S770
P
F
R
S
P
L
R
S
P
F
R
S
P
F
K
Site 58
S774
P
L
R
S
P
F
R
S
P
F
K
N
F
G
H
Site 59
T890
E
S
R
L
V
E
P
T
D
S
L
E
D
S
L
Site 60
S892
R
L
V
E
P
T
D
S
L
E
D
S
L
L
S
Site 61
S896
P
T
D
S
L
E
D
S
L
L
S
S
R
P
E
Site 62
S899
S
L
E
D
S
L
L
S
S
R
P
E
F
I
I
Site 63
S918
E
E
E
E
N
P
A
S
K
H
G
E
N
P
G
Site 64
Y990
C
L
H
G
E
C
L
Y
I
A
R
K
D
H
P
Site 65
S1018
S
L
W
R
V
V
K
S
E
F
S
Q
L
S
S
Site 66
T1136
C
L
D
F
Q
F
D
T
V
V
K
D
R
P
T
Site 67
S1162
K
Q
D
I
P
A
L
S
W
E
F
F
V
N
R
Site 68
S1174
V
N
R
F
E
T
L
S
L
E
A
Q
L
H
L
Site 69
S1204
R
T
N
V
A
N
L
S
D
A
A
L
W
K
I
Site 70
S1223
F
A
R
N
R
Q
K
S
V
R
S
L
R
D
S
Site 71
S1226
N
R
Q
K
S
V
R
S
L
R
D
S
V
K
G
Site 72
S1230
S
V
R
S
L
R
D
S
V
K
G
P
V
E
S
Site 73
S1237
S
V
K
G
P
V
E
S
K
R
A
L
S
L
P
Site 74
S1242
V
E
S
K
R
A
L
S
L
P
E
T
L
T
S
Site 75
T1246
R
A
L
S
L
P
E
T
L
T
S
K
I
R
Q
Site 76
S1249
S
L
P
E
T
L
T
S
K
I
R
Q
Q
S
P
Site 77
S1255
T
S
K
I
R
Q
Q
S
P
E
N
D
N
T
I
Site 78
T1261
Q
S
P
E
N
D
N
T
I
K
D
L
L
P
E
Site 79
S1293
K
F
M
A
K
D
E
S
S
A
E
S
D
I
S
Site 80
S1294
F
M
A
K
D
E
S
S
A
E
S
D
I
S
S
Site 81
S1297
K
D
E
S
S
A
E
S
D
I
S
S
A
K
A
Site 82
S1300
S
S
A
E
S
D
I
S
S
A
K
A
F
N
T
Site 83
S1301
S
A
E
S
D
I
S
S
A
K
A
F
N
T
V
Site 84
T1307
S
S
A
K
A
F
N
T
V
K
R
H
L
Y
V
Site 85
Y1313
N
T
V
K
R
H
L
Y
V
L
L
G
Y
D
Q
Site 86
Y1318
H
L
Y
V
L
L
G
Y
D
Q
Q
E
G
C
F
Site 87
Y1351
G
I
A
Q
V
M
D
Y
N
I
N
L
G
K
H
Site 88
Y1378
S
C
P
Q
L
R
H
Y
F
Q
Q
P
P
R
C
Site 89
S1386
F
Q
Q
P
P
R
C
S
L
W
S
L
K
P
H
Site 90
S1389
P
P
R
C
S
L
W
S
L
K
P
H
I
R
Q
Site 91
Y1411
V
I
L
Y
K
Y
P
Y
R
D
C
D
I
S
K
Site 92
Y1435
V
N
T
L
N
A
Q
Y
H
S
C
K
P
H
A
Site 93
T1443
H
S
C
K
P
H
A
T
A
G
P
L
Y
S
D
Site 94
Y1448
H
A
T
A
G
P
L
Y
S
D
N
S
N
I
S
Site 95
S1449
A
T
A
G
P
L
Y
S
D
N
S
N
I
S
R
Site 96
S1452
G
P
L
Y
S
D
N
S
N
I
S
R
Y
S
E
Site 97
S1458
N
S
N
I
S
R
Y
S
E
K
E
K
G
E
I
Site 98
Y1470
G
E
I
E
L
A
E
Y
R
E
T
G
A
L
Q
Site 99
T1473
E
L
A
E
Y
R
E
T
G
A
L
Q
D
S
L
Site 100
S1479
E
T
G
A
L
Q
D
S
L
L
H
C
V
R
E
Site 101
S1488
L
H
C
V
R
E
E
S
I
P
K
K
K
L
R
Site 102
S1496
I
P
K
K
K
L
R
S
F
K
Q
K
S
L
D
Site 103
S1501
L
R
S
F
K
Q
K
S
L
D
I
G
N
A
D
Site 104
T1513
N
A
D
S
L
L
F
T
L
D
E
H
R
R
K
Site 105
S1521
L
D
E
H
R
R
K
S
C
I
D
R
C
D
I
Site 106
T1533
C
D
I
E
K
P
P
T
Q
A
A
Y
I
A
Q
Site 107
Y1537
K
P
P
T
Q
A
A
Y
I
A
Q
R
P
N
D
Site 108
S1552
P
G
R
S
R
Q
N
S
A
T
R
P
D
N
S
Site 109
T1554
R
S
R
Q
N
S
A
T
R
P
D
N
S
E
I
Site 110
S1559
S
A
T
R
P
D
N
S
E
I
P
E
N
P
A
Site 111
T1588
V
R
L
N
C
M
E
T
F
E
V
K
V
D
S
Site 112
S1595
T
F
E
V
K
V
D
S
P
V
K
P
A
P
K
Site 113
S1611
D
L
D
L
I
D
L
S
S
D
S
T
S
G
P
Site 114
S1612
L
D
L
I
D
L
S
S
D
S
T
S
G
P
E
Site 115
S1614
L
I
D
L
S
S
D
S
T
S
G
P
E
K
H
Site 116
T1615
I
D
L
S
S
D
S
T
S
G
P
E
K
H
S
Site 117
S1616
D
L
S
S
D
S
T
S
G
P
E
K
H
S
I
Site 118
S1622
T
S
G
P
E
K
H
S
I
L
S
T
S
D
S
Site 119
S1625
P
E
K
H
S
I
L
S
T
S
D
S
D
S
L
Site 120
T1626
E
K
H
S
I
L
S
T
S
D
S
D
S
L
V
Site 121
S1627
K
H
S
I
L
S
T
S
D
S
D
S
L
V
F
Site 122
S1629
S
I
L
S
T
S
D
S
D
S
L
V
F
E
P
Site 123
S1631
L
S
T
S
D
S
D
S
L
V
F
E
P
L
P
Site 124
S1645
P
P
L
R
I
V
E
S
D
E
E
E
E
T
M
Site 125
T1651
E
S
D
E
E
E
E
T
M
N
Q
G
D
D
G
Site 126
S1666
P
S
G
K
N
A
A
S
S
P
S
V
P
S
H
Site 127
S1667
S
G
K
N
A
A
S
S
P
S
V
P
S
H
P
Site 128
S1669
K
N
A
A
S
S
P
S
V
P
S
H
P
S
V
Site 129
S1672
A
S
S
P
S
V
P
S
H
P
S
V
L
S
L
Site 130
S1688
T
A
P
L
V
Q
V
S
V
E
D
C
S
K
D
Site 131
S1693
Q
V
S
V
E
D
C
S
K
D
F
S
S
K
D
Site 132
S1697
E
D
C
S
K
D
F
S
S
K
D
S
G
N
N
Site 133
S1698
D
C
S
K
D
F
S
S
K
D
S
G
N
N
Q
Site 134
S1701
K
D
F
S
S
K
D
S
G
N
N
Q
S
A
G
Site 135
S1706
K
D
S
G
N
N
Q
S
A
G
N
T
D
S
A
Site 136
T1710
N
N
Q
S
A
G
N
T
D
S
A
L
I
T
L
Site 137
S1712
Q
S
A
G
N
T
D
S
A
L
I
T
L
E
D
Site 138
T1716
N
T
D
S
A
L
I
T
L
E
D
P
M
D
A
Site 139
S1727
P
M
D
A
E
G
S
S
K
P
E
E
L
P
E
Site 140
S1736
P
E
E
L
P
E
F
S
C
G
S
P
L
T
L
Site 141
S1739
L
P
E
F
S
C
G
S
P
L
T
L
K
Q
K
Site 142
T1742
F
S
C
G
S
P
L
T
L
K
Q
K
R
D
L
Site 143
S1753
K
R
D
L
L
Q
K
S
F
A
L
P
E
M
S
Site 144
S1760
S
F
A
L
P
E
M
S
L
D
D
H
P
D
P
Site 145
T1769
D
D
H
P
D
P
G
T
E
G
E
K
P
G
E
Site 146
S1780
K
P
G
E
L
M
P
S
S
G
A
K
T
V
L
Site 147
S1800
D
A
E
N
P
T
E
S
E
K
P
D
T
S
A
Site 148
T1805
T
E
S
E
K
P
D
T
S
A
E
S
D
T
E
Site 149
S1806
E
S
E
K
P
D
T
S
A
E
S
D
T
E
Q
Site 150
S1827
E
E
D
G
A
E
E
S
E
F
K
I
Q
I
V
Site 151
S1846
K
Q
R
K
I
A
V
S
A
I
Q
R
E
Y
L
Site 152
S1856
Q
R
E
Y
L
D
I
S
F
N
I
L
D
K
L
Site 153
S1872
E
Q
K
D
P
D
P
S
T
K
G
L
S
T
L
Site 154
T1873
Q
K
D
P
D
P
S
T
K
G
L
S
T
L
E
Site 155
T1878
P
S
T
K
G
L
S
T
L
E
M
P
R
E
S
Site 156
S1885
T
L
E
M
P
R
E
S
S
S
A
P
T
L
D
Site 157
S1886
L
E
M
P
R
E
S
S
S
A
P
T
L
D
A
Site 158
S1887
E
M
P
R
E
S
S
S
A
P
T
L
D
A
G
Site 159
T1890
R
E
S
S
S
A
P
T
L
D
A
G
V
P
E
Site 160
T1898
L
D
A
G
V
P
E
T
S
S
H
S
S
I
S
Site 161
S1899
D
A
G
V
P
E
T
S
S
H
S
S
I
S
T
Site 162
S1900
A
G
V
P
E
T
S
S
H
S
S
I
S
T
Q
Site 163
S1902
V
P
E
T
S
S
H
S
S
I
S
T
Q
Y
R
Site 164
S1903
P
E
T
S
S
H
S
S
I
S
T
Q
Y
R
Q
Site 165
S1905
T
S
S
H
S
S
I
S
T
Q
Y
R
Q
M
K
Site 166
T1906
S
S
H
S
S
I
S
T
Q
Y
R
Q
M
K
R
Site 167
S1915
Y
R
Q
M
K
R
G
S
L
G
V
L
T
M
S
Site 168
T1920
R
G
S
L
G
V
L
T
M
S
Q
L
M
K
R
Site 169
S1922
S
L
G
V
L
T
M
S
Q
L
M
K
R
Q
L
Site 170
S1933
K
R
Q
L
E
H
Q
S
S
A
P
H
N
I
S
Site 171
S1934
R
Q
L
E
H
Q
S
S
A
P
H
N
I
S
N
Site 172
T1975
P
L
R
M
R
G
A
T
K
S
S
L
L
S
A
Site 173
S1977
R
M
R
G
A
T
K
S
S
L
L
S
A
P
S
Site 174
S1978
M
R
G
A
T
K
S
S
L
L
S
A
P
S
I
Site 175
Y2018
C
G
A
I
L
E
E
Y
D
E
E
T
L
G
L
Site 176
S2057
Q
S
V
G
R
L
A
S
S
T
T
F
S
N
Q
Site 177
S2058
S
V
G
R
L
A
S
S
T
T
F
S
N
Q
A
Site 178
T2059
V
G
R
L
A
S
S
T
T
F
S
N
Q
A
E
Site 179
T2060
G
R
L
A
S
S
T
T
F
S
N
Q
A
E
S
Site 180
S2062
L
A
S
S
T
T
F
S
N
Q
A
E
S
M
M
Site 181
T2107
Q
S
T
I
K
D
G
T
F
L
R
T
L
A
S
Site 182
T2111
K
D
G
T
F
L
R
T
L
A
S
S
L
M
D
Site 183
S2165
M
E
A
L
P
M
D
S
P
S
S
L
W
T
T
Site 184
S2167
A
L
P
M
D
S
P
S
S
L
W
T
T
I
S
Site 185
S2168
L
P
M
D
S
P
S
S
L
W
T
T
I
S
N
Site 186
T2171
D
S
P
S
S
L
W
T
T
I
S
N
Q
F
Q
Site 187
T2172
S
P
S
S
L
W
T
T
I
S
N
Q
F
Q
T
Site 188
T2213
K
I
P
S
T
N
A
T
R
S
L
L
E
P
F
Site 189
S2215
P
S
T
N
A
T
R
S
L
L
E
P
F
S
K
Site 190
Y2246
V
E
L
C
G
L
C
Y
R
A
F
T
K
E
R
Site 191
T2250
G
L
C
Y
R
A
F
T
K
E
R
D
K
F
Y
Site 192
Y2257
T
K
E
R
D
K
F
Y
L
S
R
S
V
V
L
Site 193
S2259
E
R
D
K
F
Y
L
S
R
S
V
V
L
E
L
Site 194
S2274
L
Q
A
L
K
L
K
S
P
L
P
D
T
N
L
Site 195
T2337
D
F
M
A
D
M
H
T
L
T
K
L
K
S
H
Site 196
T2339
M
A
D
M
H
T
L
T
K
L
K
S
H
M
K
Site 197
S2343
H
T
L
T
K
L
K
S
H
M
K
T
C
S
Q
Site 198
T2347
K
L
K
S
H
M
K
T
C
S
Q
P
L
H
E
Site 199
S2349
K
S
H
M
K
T
C
S
Q
P
L
H
E
D
T
Site 200
T2356
S
Q
P
L
H
E
D
T
F
G
G
H
L
K
V
Site 201
Y2387
D
N
K
A
V
I
R
Y
L
P
W
L
Y
H
P
Site 202
Y2392
I
R
Y
L
P
W
L
Y
H
P
P
S
A
M
Q
Site 203
T2464
G
F
P
E
Q
S
K
T
S
V
L
H
M
C
S
Site 204
S2590
Q
N
H
V
N
H
H
S
L
R
T
L
P
G
S
Site 205
T2593
V
N
H
H
S
L
R
T
L
P
G
S
G
Q
S
Site 206
S2597
S
L
R
T
L
P
G
S
G
Q
S
S
A
G
L
Site 207
S2600
T
L
P
G
S
G
Q
S
S
A
G
L
A
A
L
Site 208
T2614
L
R
K
W
L
Q
C
T
Q
F
K
M
A
Q
V
Site 209
S2626
A
Q
V
E
I
Q
S
S
E
A
A
S
Q
F
Y
Site 210
S2630
I
Q
S
S
E
A
A
S
Q
F
Y
P
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation