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Updated November 2019
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Protein Info
Short Name:
FAM135A
Full Name:
Protein FAM135A
Alias:
f135a; fam135a; family with sequence similarity 135, member a; FLJ20176; kiaa1411
Type:
Mass (Da):
169821
Number AA:
1515
UniProt ID:
Q9P2D6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
S
V
E
L
N
K
F
Y
N
V
D
L
F
Q
R
Site 2
Y28
D
L
F
Q
R
G
F
Y
Q
I
R
A
S
M
K
Site 3
S33
G
F
Y
Q
I
R
A
S
M
K
I
P
S
R
I
Site 4
T71
D
S
L
I
C
S
K
T
F
Q
I
L
Y
K
N
Site 5
Y76
S
K
T
F
Q
I
L
Y
K
N
E
E
V
V
L
Site 6
T103
D
E
R
K
I
E
E
T
L
E
E
M
N
F
L
Site 7
S112
E
E
M
N
F
L
L
S
L
D
L
H
F
T
D
Site 8
T118
L
S
L
D
L
H
F
T
D
G
D
Y
S
A
D
Site 9
Y122
L
H
F
T
D
G
D
Y
S
A
D
D
L
N
A
Site 10
S123
H
F
T
D
G
D
Y
S
A
D
D
L
N
A
L
Site 11
T137
L
Q
L
I
S
S
R
T
L
K
L
H
F
S
P
Site 12
S143
R
T
L
K
L
H
F
S
P
H
R
G
L
H
H
Site 13
S181
A
L
H
Q
P
L
I
S
F
P
R
P
V
K
T
Site 14
S202
A
P
A
Q
N
K
D
S
V
I
P
T
L
E
S
Site 15
S209
S
V
I
P
T
L
E
S
V
V
F
G
I
N
Y
Site 16
Y216
S
V
V
F
G
I
N
Y
T
K
Q
L
S
P
D
Site 17
T217
V
V
F
G
I
N
Y
T
K
Q
L
S
P
D
G
Site 18
S221
I
N
Y
T
K
Q
L
S
P
D
G
C
S
F
I
Site 19
T263
H
S
Y
F
I
T
V
T
E
E
I
P
S
C
Q
Site 20
S268
T
V
T
E
E
I
P
S
C
Q
K
L
E
L
E
Site 21
T284
M
D
V
E
A
R
L
T
E
L
C
E
E
V
K
Site 22
T341
L
L
A
Q
E
H
H
T
L
R
V
R
R
F
S
Site 23
S387
K
N
T
S
F
C
S
S
L
P
P
L
P
I
E
Site 24
S396
P
P
L
P
I
E
C
S
E
L
D
G
D
L
N
Site 25
S404
E
L
D
G
D
L
N
S
L
P
I
I
F
E
D
Site 26
Y413
P
I
I
F
E
D
R
Y
L
D
S
V
T
E
D
Site 27
S416
F
E
D
R
Y
L
D
S
V
T
E
D
L
D
A
Site 28
S434
G
I
Q
N
L
Q
R
S
E
S
S
K
M
D
K
Site 29
S436
Q
N
L
Q
R
S
E
S
S
K
M
D
K
Y
E
Site 30
Y442
E
S
S
K
M
D
K
Y
E
T
E
E
S
S
V
Site 31
T444
S
K
M
D
K
Y
E
T
E
E
S
S
V
A
G
Site 32
S447
D
K
Y
E
T
E
E
S
S
V
A
G
L
S
S
Site 33
S448
K
Y
E
T
E
E
S
S
V
A
G
L
S
S
P
Site 34
S453
E
S
S
V
A
G
L
S
S
P
E
L
K
V
R
Site 35
S454
S
S
V
A
G
L
S
S
P
E
L
K
V
R
P
Site 36
S465
K
V
R
P
A
G
A
S
S
I
W
Y
T
E
G
Site 37
Y469
A
G
A
S
S
I
W
Y
T
E
G
E
K
Q
L
Site 38
T470
G
A
S
S
I
W
Y
T
E
G
E
K
Q
L
T
Site 39
T477
T
E
G
E
K
Q
L
T
K
S
L
K
G
K
N
Site 40
S479
G
E
K
Q
L
T
K
S
L
K
G
K
N
E
E
Site 41
S490
K
N
E
E
S
N
K
S
K
V
K
V
T
K
L
Site 42
T500
K
V
T
K
L
M
K
T
M
K
S
E
N
T
K
Site 43
S503
K
L
M
K
T
M
K
S
E
N
T
K
K
L
I
Site 44
S514
K
K
L
I
K
Q
N
S
K
D
S
V
V
L
V
Site 45
S517
I
K
Q
N
S
K
D
S
V
V
L
V
G
Y
K
Site 46
S528
V
G
Y
K
C
L
K
S
T
A
S
N
D
L
I
Site 47
S531
K
C
L
K
S
T
A
S
N
D
L
I
K
C
F
Site 48
S543
K
C
F
E
G
N
P
S
H
S
Q
K
E
G
L
Site 49
S545
F
E
G
N
P
S
H
S
Q
K
E
G
L
D
P
Site 50
T553
Q
K
E
G
L
D
P
T
I
C
G
Y
N
F
D
Site 51
Y564
Y
N
F
D
P
K
T
Y
M
R
Q
T
S
Q
K
Site 52
T568
P
K
T
Y
M
R
Q
T
S
Q
K
E
A
S
C
Site 53
S569
K
T
Y
M
R
Q
T
S
Q
K
E
A
S
C
L
Site 54
T578
K
E
A
S
C
L
P
T
N
T
E
R
T
E
Q
Site 55
T583
L
P
T
N
T
E
R
T
E
Q
K
S
P
D
I
Site 56
S587
T
E
R
T
E
Q
K
S
P
D
I
E
N
V
Q
Site 57
S621
I
S
G
K
L
D
I
S
Q
D
D
S
E
I
T
Site 58
S625
L
D
I
S
Q
D
D
S
E
I
T
Q
M
E
H
Site 59
S636
Q
M
E
H
N
L
A
S
R
R
S
S
D
D
C
Site 60
S639
H
N
L
A
S
R
R
S
S
D
D
C
H
D
H
Site 61
S640
N
L
A
S
R
R
S
S
D
D
C
H
D
H
Q
Site 62
T648
D
D
C
H
D
H
Q
T
T
P
S
L
G
V
R
Site 63
T649
D
C
H
D
H
Q
T
T
P
S
L
G
V
R
T
Site 64
S651
H
D
H
Q
T
T
P
S
L
G
V
R
T
I
E
Site 65
S662
R
T
I
E
I
K
P
S
N
K
D
P
F
S
G
Site 66
S668
P
S
N
K
D
P
F
S
G
E
N
I
T
V
K
Site 67
T673
P
F
S
G
E
N
I
T
V
K
L
G
P
W
T
Site 68
S698
N
L
L
P
N
F
E
S
L
E
S
N
G
K
S
Site 69
S701
P
N
F
E
S
L
E
S
N
G
K
S
K
S
I
Site 70
S705
S
L
E
S
N
G
K
S
K
S
I
E
I
T
F
Site 71
S707
E
S
N
G
K
S
K
S
I
E
I
T
F
E
K
Site 72
T711
K
S
K
S
I
E
I
T
F
E
K
E
A
L
Q
Site 73
S724
L
Q
E
A
K
C
L
S
I
G
E
S
L
T
K
Site 74
S728
K
C
L
S
I
G
E
S
L
T
K
L
R
S
N
Site 75
T730
L
S
I
G
E
S
L
T
K
L
R
S
N
L
P
Site 76
S734
E
S
L
T
K
L
R
S
N
L
P
A
P
S
T
Site 77
S740
R
S
N
L
P
A
P
S
T
K
E
Y
H
V
V
Site 78
T741
S
N
L
P
A
P
S
T
K
E
Y
H
V
V
V
Site 79
Y744
P
A
P
S
T
K
E
Y
H
V
V
V
S
G
D
Site 80
S759
T
I
K
L
P
D
I
S
A
T
Y
A
S
S
R
Site 81
T761
K
L
P
D
I
S
A
T
Y
A
S
S
R
F
S
Site 82
Y762
L
P
D
I
S
A
T
Y
A
S
S
R
F
S
D
Site 83
S764
D
I
S
A
T
Y
A
S
S
R
F
S
D
S
G
Site 84
S765
I
S
A
T
Y
A
S
S
R
F
S
D
S
G
V
Site 85
S768
T
Y
A
S
S
R
F
S
D
S
G
V
E
S
E
Site 86
S770
A
S
S
R
F
S
D
S
G
V
E
S
E
P
S
Site 87
S774
F
S
D
S
G
V
E
S
E
P
S
S
F
A
T
Site 88
S777
S
G
V
E
S
E
P
S
S
F
A
T
H
P
N
Site 89
S778
G
V
E
S
E
P
S
S
F
A
T
H
P
N
T
Site 90
T781
S
E
P
S
S
F
A
T
H
P
N
T
D
L
V
Site 91
T791
N
T
D
L
V
F
E
T
V
Q
G
Q
G
P
C
Site 92
S800
Q
G
Q
G
P
C
N
S
E
R
L
F
P
Q
L
Site 93
Y813
Q
L
L
M
K
P
D
Y
N
V
K
F
S
L
G
Site 94
T824
F
S
L
G
N
H
C
T
E
S
T
S
A
I
S
Site 95
S826
L
G
N
H
C
T
E
S
T
S
A
I
S
E
I
Site 96
S831
T
E
S
T
S
A
I
S
E
I
Q
S
S
L
T
Site 97
S835
S
A
I
S
E
I
Q
S
S
L
T
S
I
N
S
Site 98
T838
S
E
I
Q
S
S
L
T
S
I
N
S
L
P
S
Site 99
S839
E
I
Q
S
S
L
T
S
I
N
S
L
P
S
D
Site 100
S842
S
S
L
T
S
I
N
S
L
P
S
D
D
E
L
Site 101
S845
T
S
I
N
S
L
P
S
D
D
E
L
S
P
D
Site 102
S850
L
P
S
D
D
E
L
S
P
D
E
N
S
K
K
Site 103
S855
E
L
S
P
D
E
N
S
K
K
S
V
V
P
E
Site 104
S858
P
D
E
N
S
K
K
S
V
V
P
E
C
H
L
Site 105
S868
P
E
C
H
L
N
D
S
K
T
V
L
N
L
G
Site 106
T870
C
H
L
N
D
S
K
T
V
L
N
L
G
T
T
Site 107
T876
K
T
V
L
N
L
G
T
T
D
L
P
K
C
D
Site 108
T885
D
L
P
K
C
D
D
T
K
K
S
S
I
T
L
Site 109
S888
K
C
D
D
T
K
K
S
S
I
T
L
Q
Q
Q
Site 110
S900
Q
Q
Q
S
V
V
F
S
G
N
L
D
N
E
T
Site 111
T907
S
G
N
L
D
N
E
T
V
A
I
H
S
L
N
Site 112
S912
N
E
T
V
A
I
H
S
L
N
S
S
I
K
D
Site 113
S916
A
I
H
S
L
N
S
S
I
K
D
P
L
Q
F
Site 114
S926
D
P
L
Q
F
V
F
S
D
E
E
T
S
S
D
Site 115
T930
F
V
F
S
D
E
E
T
S
S
D
V
K
S
S
Site 116
S931
V
F
S
D
E
E
T
S
S
D
V
K
S
S
C
Site 117
S932
F
S
D
E
E
T
S
S
D
V
K
S
S
C
S
Site 118
S936
E
T
S
S
D
V
K
S
S
C
S
S
K
P
N
Site 119
S937
T
S
S
D
V
K
S
S
C
S
S
K
P
N
L
Site 120
S939
S
D
V
K
S
S
C
S
S
K
P
N
L
D
T
Site 121
S940
D
V
K
S
S
C
S
S
K
P
N
L
D
T
M
Site 122
T946
S
S
K
P
N
L
D
T
M
C
K
G
F
Q
S
Site 123
S953
T
M
C
K
G
F
Q
S
P
D
K
S
N
N
S
Site 124
S957
G
F
Q
S
P
D
K
S
N
N
S
T
G
T
A
Site 125
T961
P
D
K
S
N
N
S
T
G
T
A
I
T
L
N
Site 126
S985
C
V
I
S
G
S
I
S
S
N
T
D
V
S
E
Site 127
S986
V
I
S
G
S
I
S
S
N
T
D
V
S
E
D
Site 128
T988
S
G
S
I
S
S
N
T
D
V
S
E
D
R
T
Site 129
S991
I
S
S
N
T
D
V
S
E
D
R
T
M
K
K
Site 130
T995
T
D
V
S
E
D
R
T
M
K
K
N
S
D
V
Site 131
T1006
N
S
D
V
L
N
L
T
Q
M
Y
S
E
I
P
Site 132
S1010
L
N
L
T
Q
M
Y
S
E
I
P
T
V
E
S
Site 133
T1014
Q
M
Y
S
E
I
P
T
V
E
S
E
T
H
L
Site 134
S1017
S
E
I
P
T
V
E
S
E
T
H
L
G
T
S
Site 135
T1023
E
S
E
T
H
L
G
T
S
D
P
F
S
A
S
Site 136
S1024
S
E
T
H
L
G
T
S
D
P
F
S
A
S
T
Site 137
S1028
L
G
T
S
D
P
F
S
A
S
T
D
I
V
K
Site 138
Y1042
K
Q
G
L
V
E
N
Y
F
G
S
Q
S
S
T
Site 139
S1045
L
V
E
N
Y
F
G
S
Q
S
S
T
D
I
S
Site 140
S1047
E
N
Y
F
G
S
Q
S
S
T
D
I
S
D
T
Site 141
S1048
N
Y
F
G
S
Q
S
S
T
D
I
S
D
T
C
Site 142
T1049
Y
F
G
S
Q
S
S
T
D
I
S
D
T
C
A
Site 143
S1052
S
Q
S
S
T
D
I
S
D
T
C
A
V
S
Y
Site 144
T1054
S
S
T
D
I
S
D
T
C
A
V
S
Y
S
N
Site 145
S1060
D
T
C
A
V
S
Y
S
N
A
L
S
P
Q
K
Site 146
S1064
V
S
Y
S
N
A
L
S
P
Q
K
E
T
S
E
Site 147
S1070
L
S
P
Q
K
E
T
S
E
K
E
I
S
N
L
Site 148
S1075
E
T
S
E
K
E
I
S
N
L
Q
Q
E
Q
D
Site 149
Y1105
G
Y
Y
E
E
T
D
Y
S
A
L
D
G
T
I
Site 150
S1106
Y
Y
E
E
T
D
Y
S
A
L
D
G
T
I
N
Site 151
Y1116
D
G
T
I
N
A
H
Y
T
S
R
D
E
L
M
Site 152
T1117
G
T
I
N
A
H
Y
T
S
R
D
E
L
M
E
Site 153
T1128
E
L
M
E
E
R
L
T
K
S
E
K
I
N
S
Site 154
S1130
M
E
E
R
L
T
K
S
E
K
I
N
S
D
Y
Site 155
S1135
T
K
S
E
K
I
N
S
D
Y
L
R
D
G
I
Site 156
Y1137
S
E
K
I
N
S
D
Y
L
R
D
G
I
N
M
Site 157
S1154
V
C
T
S
G
C
L
S
F
P
S
A
P
R
E
Site 158
S1157
S
G
C
L
S
F
P
S
A
P
R
E
S
P
C
Site 159
S1162
F
P
S
A
P
R
E
S
P
C
N
V
K
Y
S
Site 160
Y1168
E
S
P
C
N
V
K
Y
S
S
K
S
K
F
D
Site 161
S1170
P
C
N
V
K
Y
S
S
K
S
K
F
D
A
I
Site 162
S1172
N
V
K
Y
S
S
K
S
K
F
D
A
I
T
K
Site 163
T1178
K
S
K
F
D
A
I
T
K
Q
P
S
S
T
S
Site 164
S1183
A
I
T
K
Q
P
S
S
T
S
Y
N
F
T
S
Site 165
S1185
T
K
Q
P
S
S
T
S
Y
N
F
T
S
S
I
Site 166
Y1186
K
Q
P
S
S
T
S
Y
N
F
T
S
S
I
S
Site 167
T1189
S
S
T
S
Y
N
F
T
S
S
I
S
W
Y
E
Site 168
S1190
S
T
S
Y
N
F
T
S
S
I
S
W
Y
E
S
Site 169
S1191
T
S
Y
N
F
T
S
S
I
S
W
Y
E
S
S
Site 170
S1193
Y
N
F
T
S
S
I
S
W
Y
E
S
S
P
K
Site 171
Y1195
F
T
S
S
I
S
W
Y
E
S
S
P
K
P
Q
Site 172
S1197
S
S
I
S
W
Y
E
S
S
P
K
P
Q
I
Q
Site 173
S1198
S
I
S
W
Y
E
S
S
P
K
P
Q
I
Q
A
Site 174
Y1235
L
L
A
S
S
V
P
Y
F
S
V
E
E
E
D
Site 175
S1237
A
S
S
V
P
Y
F
S
V
E
E
E
D
G
S
Site 176
S1244
S
V
E
E
E
D
G
S
E
D
G
V
H
L
I
Site 177
S1285
G
R
I
D
F
L
M
S
E
R
N
Q
N
D
T
Site 178
T1292
S
E
R
N
Q
N
D
T
F
A
D
F
D
S
M
Site 179
S1298
D
T
F
A
D
F
D
S
M
T
D
R
L
L
D
Site 180
T1300
F
A
D
F
D
S
M
T
D
R
L
L
D
E
I
Site 181
T1338
L
I
I
R
S
V
L
T
R
P
R
F
K
Y
Y
Site 182
Y1344
L
T
R
P
R
F
K
Y
Y
L
N
K
L
H
T
Site 183
Y1345
T
R
P
R
F
K
Y
Y
L
N
K
L
H
T
F
Site 184
T1351
Y
Y
L
N
K
L
H
T
F
L
S
L
S
G
P
Site 185
S1354
N
K
L
H
T
F
L
S
L
S
G
P
H
L
G
Site 186
Y1364
G
P
H
L
G
T
L
Y
N
S
S
A
L
V
N
Site 187
S1383
F
M
Q
K
W
K
K
S
G
S
L
L
Q
L
T
Site 188
S1385
Q
K
W
K
K
S
G
S
L
L
Q
L
T
C
R
Site 189
T1390
S
G
S
L
L
Q
L
T
C
R
D
H
S
D
P
Site 190
S1395
Q
L
T
C
R
D
H
S
D
P
R
Q
T
F
L
Site 191
T1400
D
H
S
D
P
R
Q
T
F
L
Y
K
L
S
N
Site 192
Y1403
D
P
R
Q
T
F
L
Y
K
L
S
N
K
A
G
Site 193
S1406
Q
T
F
L
Y
K
L
S
N
K
A
G
L
H
Y
Site 194
Y1427
V
G
S
L
Q
D
R
Y
V
P
Y
H
S
A
R
Site 195
Y1430
L
Q
D
R
Y
V
P
Y
H
S
A
R
I
E
M
Site 196
T1440
A
R
I
E
M
C
K
T
A
L
K
D
K
Q
S
Site 197
S1447
T
A
L
K
D
K
Q
S
G
Q
I
Y
S
E
M
Site 198
Y1451
D
K
Q
S
G
Q
I
Y
S
E
M
I
H
N
L
Site 199
S1465
L
L
R
P
V
L
Q
S
K
D
C
N
L
V
R
Site 200
S1485
A
L
P
N
T
A
D
S
L
I
G
R
A
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation