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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1414
Full Name:
HEAT repeat-containing protein 5B
Alias:
DKFZp686P15184; HEAT repeat containing 5B; HTR5B; LOC54497
Type:
Unknown function
Mass (Da):
224302
Number AA:
2071
UniProt ID:
Q9P2D3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T57
K
K
L
V
E
Q
L
T
G
L
I
S
S
S
P
Site 2
S61
E
Q
L
T
G
L
I
S
S
S
P
G
P
P
T
Site 3
S63
L
T
G
L
I
S
S
S
P
G
P
P
T
R
K
Site 4
T87
Y
S
I
G
D
T
F
T
V
F
Q
T
L
D
K
Site 5
T105
I
I
R
N
K
D
D
T
A
A
Y
L
P
T
K
Site 6
Y108
N
K
D
D
T
A
A
Y
L
P
T
K
L
A
A
Site 7
T137
L
G
S
A
F
P
E
T
V
N
N
L
L
K
S
Site 8
S144
T
V
N
N
L
L
K
S
L
K
S
A
E
S
Q
Site 9
S147
N
L
L
K
S
L
K
S
A
E
S
Q
G
R
S
Site 10
S150
K
S
L
K
S
A
E
S
Q
G
R
S
E
I
L
Site 11
S154
S
A
E
S
Q
G
R
S
E
I
L
M
S
L
Q
Site 12
S159
G
R
S
E
I
L
M
S
L
Q
K
V
L
S
G
Site 13
S165
M
S
L
Q
K
V
L
S
G
L
G
G
A
A
A
Site 14
S173
G
L
G
G
A
A
A
S
S
H
R
D
I
Y
K
Site 15
S174
L
G
G
A
A
A
S
S
H
R
D
I
Y
K
N
Site 16
Y179
A
S
S
H
R
D
I
Y
K
N
A
R
S
L
L
Site 17
S184
D
I
Y
K
N
A
R
S
L
L
T
D
R
S
M
Site 18
T187
K
N
A
R
S
L
L
T
D
R
S
M
A
V
R
Site 19
Y232
K
A
L
E
N
S
N
Y
G
V
R
V
A
V
S
Site 20
T266
R
Q
N
V
K
R
A
T
F
D
E
V
L
E
L
Site 21
T276
E
V
L
E
L
M
A
T
G
F
L
R
G
G
S
Site 22
S283
T
G
F
L
R
G
G
S
G
F
L
K
S
G
G
Site 23
S288
G
G
S
G
F
L
K
S
G
G
E
M
L
K
V
Site 24
S298
E
M
L
K
V
G
G
S
V
N
R
E
V
R
V
Site 25
S326
G
G
Q
W
L
E
R
S
F
A
T
F
L
S
H
Site 26
S339
S
H
V
L
D
L
V
S
H
P
R
A
T
Q
T
Site 27
T344
L
V
S
H
P
R
A
T
Q
T
H
V
E
A
V
Site 28
Y352
Q
T
H
V
E
A
V
Y
S
R
R
C
V
S
F
Site 29
S400
E
A
V
V
N
D
T
S
G
E
N
K
S
G
A
Site 30
S405
D
T
S
G
E
N
K
S
G
A
A
D
I
A
A
Site 31
S436
Q
S
L
N
A
T
A
S
P
L
I
Q
E
A
S
Site 32
T496
E
R
L
N
N
L
K
T
S
P
E
A
V
S
G
Site 33
S497
R
L
N
N
L
K
T
S
P
E
A
V
S
G
Y
Site 34
S548
A
A
Q
N
S
R
L
S
L
Q
R
T
Q
A
G
Site 35
T552
S
R
L
S
L
Q
R
T
Q
A
G
W
L
L
L
Site 36
T564
L
L
L
G
A
L
M
T
L
G
P
S
V
V
R
Site 37
S568
A
L
M
T
L
G
P
S
V
V
R
Y
H
L
P
Site 38
S588
W
R
N
V
F
P
R
S
L
K
E
L
E
A
E
Site 39
S601
A
E
K
A
R
G
D
S
F
T
W
Q
V
T
L
Site 40
T603
K
A
R
G
D
S
F
T
W
Q
V
T
L
E
G
Site 41
S665
H
G
A
H
L
K
A
S
A
A
M
V
R
L
R
Site 42
T684
L
A
L
L
P
P
K
T
Y
E
G
S
F
N
A
Site 43
Y685
A
L
L
P
P
K
T
Y
E
G
S
F
N
A
L
Site 44
S688
P
P
K
T
Y
E
G
S
F
N
A
L
L
R
E
Site 45
T701
R
E
L
V
A
E
F
T
L
T
D
N
S
A
N
Site 46
T703
L
V
A
E
F
T
L
T
D
N
S
A
N
T
T
Site 47
S706
E
F
T
L
T
D
N
S
A
N
T
T
T
S
L
Site 48
T710
T
D
N
S
A
N
T
T
T
S
L
L
R
S
L
Site 49
S712
N
S
A
N
T
T
T
S
L
L
R
S
L
C
H
Site 50
S716
T
T
T
S
L
L
R
S
L
C
H
Y
D
D
S
Site 51
T733
L
G
S
W
L
Q
E
T
D
H
K
S
I
E
D
Site 52
S737
L
Q
E
T
D
H
K
S
I
E
D
Q
L
Q
P
Site 53
S746
E
D
Q
L
Q
P
N
S
A
S
G
S
G
A
L
Site 54
S748
Q
L
Q
P
N
S
A
S
G
S
G
A
L
E
H
Site 55
S750
Q
P
N
S
A
S
G
S
G
A
L
E
H
D
P
Site 56
S758
G
A
L
E
H
D
P
S
S
I
Y
L
R
I
P
Site 57
S759
A
L
E
H
D
P
S
S
I
Y
L
R
I
P
A
Site 58
Y761
E
H
D
P
S
S
I
Y
L
R
I
P
A
G
E
Site 59
T828
A
V
Q
L
N
I
F
T
A
V
L
S
A
L
K
Site 60
S832
N
I
F
T
A
V
L
S
A
L
K
G
L
A
E
Site 61
S842
K
G
L
A
E
N
K
S
T
L
G
P
E
E
V
Site 62
T843
G
L
A
E
N
K
S
T
L
G
P
E
E
V
R
Site 63
S852
G
P
E
E
V
R
K
S
A
L
T
L
V
M
G
Site 64
S896
I
A
R
M
A
Q
Y
S
F
D
K
L
K
S
A
Site 65
S902
Y
S
F
D
K
L
K
S
A
R
D
V
V
S
R
Site 66
S908
K
S
A
R
D
V
V
S
R
T
G
H
S
L
A
Site 67
S928
R
Y
V
G
G
I
G
S
G
Q
H
L
K
T
S
Site 68
S948
A
L
A
Q
D
G
T
S
P
E
V
Q
T
W
S
Site 69
Y970
V
D
S
S
G
P
M
Y
R
G
Y
V
E
P
T
Site 70
Y973
S
G
P
M
Y
R
G
Y
V
E
P
T
L
S
L
Site 71
S1022
Q
G
N
G
A
T
T
S
T
I
R
S
S
C
L
Site 72
S1039
C
A
I
T
Q
D
H
S
D
S
L
V
Q
A
A
Site 73
Y1104
E
A
A
E
V
C
E
Y
A
M
S
L
A
K
N
Site 74
S1107
E
V
C
E
Y
A
M
S
L
A
K
N
T
G
D
Site 75
S1117
K
N
T
G
D
K
E
S
S
S
A
N
V
S
P
Site 76
S1118
N
T
G
D
K
E
S
S
S
A
N
V
S
P
F
Site 77
S1119
T
G
D
K
E
S
S
S
A
N
V
S
P
F
A
Site 78
S1123
E
S
S
S
A
N
V
S
P
F
A
P
G
V
S
Site 79
S1130
S
P
F
A
P
G
V
S
S
R
T
D
I
H
C
Site 80
S1131
P
F
A
P
G
V
S
S
R
T
D
I
H
C
R
Site 81
T1161
F
G
M
L
D
R
E
T
D
R
K
L
C
S
D
Site 82
S1167
E
T
D
R
K
L
C
S
D
I
H
D
T
L
G
Site 83
T1206
S
S
D
M
S
T
A
T
L
L
S
S
G
K
D
Site 84
S1210
S
T
A
T
L
L
S
S
G
K
D
E
E
A
E
Site 85
T1226
K
D
E
M
D
D
D
T
M
F
T
T
L
G
E
Site 86
S1237
T
L
G
E
E
D
K
S
K
P
F
V
A
P
R
Site 87
T1284
S
A
K
L
R
N
P
T
N
D
L
L
V
L
H
Site 88
S1327
D
I
I
K
K
F
A
S
V
P
E
P
E
F
P
Site 89
S1355
A
A
L
R
P
A
F
S
Q
D
T
P
S
D
I
Site 90
T1358
R
P
A
F
S
Q
D
T
P
S
D
I
I
A
K
Site 91
S1360
A
F
S
Q
D
T
P
S
D
I
I
A
K
A
C
Site 92
S1380
W
I
G
S
G
V
V
S
D
L
N
D
L
R
R
Site 93
S1394
R
V
H
N
L
L
V
S
S
L
D
K
V
Q
A
Site 94
S1407
Q
A
G
K
G
S
S
S
Q
L
Y
R
E
S
A
Site 95
Y1410
K
G
S
S
S
Q
L
Y
R
E
S
A
T
T
M
Site 96
S1413
S
S
Q
L
Y
R
E
S
A
T
T
M
E
K
L
Site 97
T1451
P
K
R
A
I
K
N
T
D
D
D
D
D
D
C
Site 98
T1460
D
D
D
D
D
C
G
T
I
D
E
L
P
P
D
Site 99
S1501
L
T
L
P
A
E
F
S
S
Q
L
P
P
D
G
Site 100
S1502
T
L
P
A
E
F
S
S
Q
L
P
P
D
G
G
Site 101
T1513
P
D
G
G
A
F
Y
T
P
E
T
I
D
T
A
Site 102
T1519
Y
T
P
E
T
I
D
T
A
R
L
H
Y
R
N
Site 103
Y1524
I
D
T
A
R
L
H
Y
R
N
S
W
A
P
I
Site 104
S1527
A
R
L
H
Y
R
N
S
W
A
P
I
L
H
A
Site 105
T1545
W
L
N
S
T
G
F
T
C
S
E
S
T
E
A
Site 106
S1547
N
S
T
G
F
T
C
S
E
S
T
E
A
A
A
Site 107
S1562
I
S
G
L
Q
K
R
S
T
S
V
N
L
N
Q
Site 108
T1563
S
G
L
Q
K
R
S
T
S
V
N
L
N
Q
A
Site 109
S1564
G
L
Q
K
R
S
T
S
V
N
L
N
Q
A
S
Site 110
S1579
G
A
V
G
S
A
K
S
L
P
E
I
N
K
D
Site 111
S1601
V
S
I
Q
F
L
C
S
P
R
P
E
E
P
I
Site 112
Y1626
H
T
L
L
D
S
P
Y
A
R
V
H
I
A
E
Site 113
Y1675
I
V
R
A
A
Q
D
Y
L
Q
E
K
R
N
T
Site 114
T1682
Y
L
Q
E
K
R
N
T
L
N
E
D
D
M
E
Site 115
T1694
D
M
E
K
E
A
C
T
V
L
G
E
G
G
D
Site 116
S1702
V
L
G
E
G
G
D
S
G
G
L
I
P
G
K
Site 117
S1731
V
R
H
M
P
H
L
S
T
K
V
S
D
S
P
Site 118
T1732
R
H
M
P
H
L
S
T
K
V
S
D
S
P
S
Site 119
S1735
P
H
L
S
T
K
V
S
D
S
P
S
H
I
A
Site 120
S1737
L
S
T
K
V
S
D
S
P
S
H
I
A
T
K
Site 121
S1739
T
K
V
S
D
S
P
S
H
I
A
T
K
T
R
Site 122
T1743
D
S
P
S
H
I
A
T
K
T
R
L
S
E
E
Site 123
S1748
I
A
T
K
T
R
L
S
E
E
S
A
R
L
V
Site 124
S1751
K
T
R
L
S
E
E
S
A
R
L
V
A
A
T
Site 125
T1792
I
A
R
I
L
K
D
T
A
I
K
S
A
D
N
Site 126
S1796
L
K
D
T
A
I
K
S
A
D
N
Q
V
P
P
Site 127
S1806
N
Q
V
P
P
P
V
S
A
A
L
Q
G
I
K
Site 128
T1823
V
T
L
S
M
A
K
T
E
A
G
V
Q
K
Q
Site 129
T1832
A
G
V
Q
K
Q
W
T
A
L
I
R
S
T
L
Site 130
Y1845
T
L
A
C
I
L
E
Y
S
Q
P
E
D
S
V
Site 131
S1846
L
A
C
I
L
E
Y
S
Q
P
E
D
S
V
P
Site 132
S1851
E
Y
S
Q
P
E
D
S
V
P
T
P
D
E
V
Site 133
T1854
Q
P
E
D
S
V
P
T
P
D
E
V
S
M
L
Site 134
S1910
K
C
Y
Q
L
L
L
S
V
F
Q
H
S
N
R
Site 135
S1915
L
L
S
V
F
Q
H
S
N
R
A
L
S
T
P
Site 136
S1920
Q
H
S
N
R
A
L
S
T
P
Y
I
H
S
L
Site 137
T1921
H
S
N
R
A
L
S
T
P
Y
I
H
S
L
A
Site 138
S1945
V
E
R
N
R
P
A
S
N
I
E
L
L
A
V
Site 139
S1991
S
Y
L
L
D
E
N
S
F
A
S
A
S
S
A
Site 140
S1994
L
D
E
N
S
F
A
S
A
S
S
A
S
K
D
Site 141
S1996
E
N
S
F
A
S
A
S
S
A
S
K
D
L
H
Site 142
S1997
N
S
F
A
S
A
S
S
A
S
K
D
L
H
E
Site 143
T2037
E
L
K
V
R
L
E
T
A
V
R
A
S
Q
A
Site 144
S2042
L
E
T
A
V
R
A
S
Q
A
S
K
A
K
A
Site 145
S2045
A
V
R
A
S
Q
A
S
K
A
K
A
A
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation