KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CHD7
Full Name:
Chromodomain-helicase-DNA-binding protein 7
Alias:
ATP-dependent helicase CHD7; Chromodomain helicase DNA binding protein 7; FLJ20357; FLJ20361; KIAA1416
Type:
EC 3.6.1.-; DNA binding protein; Helicase
Mass (Da):
335927
Number AA:
2997
UniProt ID:
Q9P2D1
International Prot ID:
IPI00794880
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0030217
GO:0007417
GO:0006333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
D
P
G
M
M
S
L
F
G
E
D
G
N
Site 2
S18
G
E
D
G
N
I
F
S
E
G
L
E
G
L
G
Site 3
Y29
E
G
L
G
E
C
G
Y
P
E
N
P
V
N
P
Site 4
S49
P
I
D
Q
G
F
A
S
L
Q
P
S
L
H
H
Site 5
S53
G
F
A
S
L
Q
P
S
L
H
H
P
S
T
N
Site 6
T59
P
S
L
H
H
P
S
T
N
Q
N
Q
T
K
L
Site 7
Y72
K
L
T
H
F
D
H
Y
N
Q
Y
E
Q
Q
K
Site 8
S91
D
Q
P
N
R
M
M
S
N
T
P
G
N
G
L
Site 9
T93
P
N
R
M
M
S
N
T
P
G
N
G
L
A
S
Site 10
S100
T
P
G
N
G
L
A
S
P
H
S
Q
Y
H
T
Site 11
S103
N
G
L
A
S
P
H
S
Q
Y
H
T
P
P
V
Site 12
Y105
L
A
S
P
H
S
Q
Y
H
T
P
P
V
P
Q
Site 13
T107
S
P
H
S
Q
Y
H
T
P
P
V
P
Q
V
P
Site 14
S118
P
Q
V
P
H
G
G
S
G
G
G
Q
M
G
V
Site 15
Y126
G
G
G
Q
M
G
V
Y
P
G
M
Q
N
E
R
Site 16
S137
Q
N
E
R
H
G
Q
S
F
V
D
S
S
S
M
Site 17
S141
H
G
Q
S
F
V
D
S
S
S
M
W
G
P
R
Site 18
S142
G
Q
S
F
V
D
S
S
S
M
W
G
P
R
A
Site 19
S143
Q
S
F
V
D
S
S
S
M
W
G
P
R
A
V
Site 20
Y160
P
D
Q
I
R
A
P
Y
Q
Q
Q
Q
P
Q
P
Site 21
S175
Q
P
P
Q
P
A
P
S
G
P
P
A
Q
G
H
Site 22
Y192
H
M
Q
Q
M
G
S
Y
M
A
R
G
D
F
S
Site 23
S211
G
Q
P
Q
Q
R
M
S
Q
F
S
Q
G
Q
E
Site 24
S214
Q
Q
R
M
S
Q
F
S
Q
G
Q
E
G
L
N
Site 25
T229
Q
G
N
P
F
I
A
T
S
G
P
G
H
L
S
Site 26
S230
G
N
P
F
I
A
T
S
G
P
G
H
L
S
H
Site 27
S236
T
S
G
P
G
H
L
S
H
V
P
Q
Q
S
P
Site 28
S242
L
S
H
V
P
Q
Q
S
P
S
M
A
P
S
L
Site 29
S244
H
V
P
Q
Q
S
P
S
M
A
P
S
L
R
H
Site 30
S248
Q
S
P
S
M
A
P
S
L
R
H
S
V
Q
Q
Site 31
T262
Q
F
H
H
H
P
S
T
A
L
H
G
E
S
V
Site 32
S268
S
T
A
L
H
G
E
S
V
A
H
S
P
R
F
Site 33
S272
H
G
E
S
V
A
H
S
P
R
F
S
P
N
P
Site 34
S276
V
A
H
S
P
R
F
S
P
N
P
P
Q
Q
G
Site 35
T289
Q
G
A
V
R
P
Q
T
L
N
F
S
S
R
S
Site 36
S293
R
P
Q
T
L
N
F
S
S
R
S
Q
T
V
P
Site 37
S294
P
Q
T
L
N
F
S
S
R
S
Q
T
V
P
S
Site 38
S296
T
L
N
F
S
S
R
S
Q
T
V
P
S
P
T
Site 39
T298
N
F
S
S
R
S
Q
T
V
P
S
P
T
I
N
Site 40
S301
S
R
S
Q
T
V
P
S
P
T
I
N
N
S
G
Site 41
T303
S
Q
T
V
P
S
P
T
I
N
N
S
G
Q
Y
Site 42
S307
P
S
P
T
I
N
N
S
G
Q
Y
S
R
Y
P
Site 43
S311
I
N
N
S
G
Q
Y
S
R
Y
P
Y
S
N
L
Site 44
Y313
N
S
G
Q
Y
S
R
Y
P
Y
S
N
L
N
Q
Site 45
Y315
G
Q
Y
S
R
Y
P
Y
S
N
L
N
Q
G
L
Site 46
S316
Q
Y
S
R
Y
P
Y
S
N
L
N
Q
G
L
V
Site 47
T338
N
L
G
L
T
N
N
T
P
M
N
Q
S
V
P
Site 48
S343
N
N
T
P
M
N
Q
S
V
P
R
Y
P
N
A
Site 49
Y347
M
N
Q
S
V
P
R
Y
P
N
A
V
G
F
P
Site 50
S355
P
N
A
V
G
F
P
S
N
S
G
Q
G
L
M
Site 51
S357
A
V
G
F
P
S
N
S
G
Q
G
L
M
H
Q
Site 52
T378
G
S
L
N
Q
M
N
T
Q
T
M
H
P
S
Q
Site 53
T380
L
N
Q
M
N
T
Q
T
M
H
P
S
Q
P
Q
Site 54
S384
N
T
Q
T
M
H
P
S
Q
P
Q
G
T
Y
A
Site 55
Y390
P
S
Q
P
Q
G
T
Y
A
S
P
P
P
M
S
Site 56
S392
Q
P
Q
G
T
Y
A
S
P
P
P
M
S
P
M
Site 57
S397
Y
A
S
P
P
P
M
S
P
M
K
A
M
S
N
Site 58
S403
M
S
P
M
K
A
M
S
N
P
A
G
T
P
P
Site 59
T408
A
M
S
N
P
A
G
T
P
P
P
Q
V
R
P
Site 60
S417
P
P
Q
V
R
P
G
S
A
G
I
P
M
E
V
Site 61
S426
G
I
P
M
E
V
G
S
Y
P
N
M
P
H
P
Site 62
Y427
I
P
M
E
V
G
S
Y
P
N
M
P
H
P
Q
Site 63
S458
G
P
R
N
M
Q
Q
S
R
P
F
I
G
M
S
Site 64
S466
R
P
F
I
G
M
S
S
A
P
R
E
L
T
G
Site 65
T472
S
S
A
P
R
E
L
T
G
H
M
R
P
N
G
Site 66
S507
Q
H
P
G
Q
Q
P
S
F
Q
Q
L
P
T
C
Site 67
T513
P
S
F
Q
Q
L
P
T
C
P
P
L
Q
P
H
Site 68
S527
H
P
G
L
H
H
Q
S
S
P
P
H
P
H
H
Site 69
S528
P
G
L
H
H
Q
S
S
P
P
H
P
H
H
Q
Site 70
S543
P
W
A
Q
L
H
P
S
P
Q
N
T
P
Q
K
Site 71
T547
L
H
P
S
P
Q
N
T
P
Q
K
V
P
V
H
Site 72
S557
K
V
P
V
H
Q
H
S
P
S
E
P
F
L
E
Site 73
S559
P
V
H
Q
H
S
P
S
E
P
F
L
E
K
P
Site 74
T571
E
K
P
V
P
D
M
T
Q
V
S
G
P
N
A
Site 75
S574
V
P
D
M
T
Q
V
S
G
P
N
A
Q
L
V
Site 76
S583
P
N
A
Q
L
V
K
S
D
D
Y
L
P
S
I
Site 77
Y586
Q
L
V
K
S
D
D
Y
L
P
S
I
E
Q
Q
Site 78
S589
K
S
D
D
Y
L
P
S
I
E
Q
Q
P
Q
Q
Site 79
S612
H
I
V
A
E
D
P
S
K
G
F
G
K
D
D
Site 80
S633
N
Q
E
L
N
R
N
S
L
D
G
S
Q
E
E
Site 81
S637
N
R
N
S
L
D
G
S
Q
E
E
K
K
K
K
Site 82
S647
E
K
K
K
K
K
R
S
K
A
K
K
D
P
K
Site 83
T670
K
E
P
K
E
P
K
T
P
K
A
P
K
I
P
Site 84
T687
P
K
E
K
K
A
K
T
A
T
P
K
P
K
S
Site 85
T689
E
K
K
A
K
T
A
T
P
K
P
K
S
S
K
Site 86
S694
T
A
T
P
K
P
K
S
S
K
K
S
S
N
K
Site 87
S695
A
T
P
K
P
K
S
S
K
K
S
S
N
K
K
Site 88
S698
K
P
K
S
S
K
K
S
S
N
K
K
P
D
S
Site 89
S699
P
K
S
S
K
K
S
S
N
K
K
P
D
S
E
Site 90
S705
S
S
N
K
K
P
D
S
E
A
S
A
L
K
K
Site 91
S708
K
K
P
D
S
E
A
S
A
L
K
K
K
V
N
Site 92
T719
K
K
V
N
K
G
K
T
E
G
S
E
N
S
D
Site 93
S725
K
T
E
G
S
E
N
S
D
L
D
K
T
P
P
Site 94
T730
E
N
S
D
L
D
K
T
P
P
P
S
P
P
P
Site 95
S734
L
D
K
T
P
P
P
S
P
P
P
E
E
D
E
Site 96
S750
P
G
V
Q
K
R
R
S
S
R
Q
V
K
R
K
Site 97
S751
G
V
Q
K
R
R
S
S
R
Q
V
K
R
K
R
Site 98
Y759
R
Q
V
K
R
K
R
Y
T
E
D
L
E
F
K
Site 99
T760
Q
V
K
R
K
R
Y
T
E
D
L
E
F
K
I
Site 100
S768
E
D
L
E
F
K
I
S
D
E
E
A
D
D
A
Site 101
S782
A
D
A
A
G
R
D
S
P
S
N
T
S
Q
S
Site 102
S784
A
A
G
R
D
S
P
S
N
T
S
Q
S
E
Q
Site 103
T786
G
R
D
S
P
S
N
T
S
Q
S
E
Q
Q
E
Site 104
S787
R
D
S
P
S
N
T
S
Q
S
E
Q
Q
E
S
Site 105
S789
S
P
S
N
T
S
Q
S
E
Q
Q
E
S
V
D
Site 106
S794
S
Q
S
E
Q
Q
E
S
V
D
A
E
G
P
V
Site 107
S807
P
V
V
E
K
I
M
S
S
R
S
V
K
K
Q
Site 108
S810
E
K
I
M
S
S
R
S
V
K
K
Q
K
E
S
Site 109
Y827
E
V
E
I
E
E
F
Y
V
K
Y
K
N
F
S
Site 110
Y830
I
E
E
F
Y
V
K
Y
K
N
F
S
Y
L
H
Site 111
S870
Q
G
Q
N
K
F
L
S
E
I
E
D
E
L
F
Site 112
Y881
D
E
L
F
N
P
D
Y
V
E
V
D
R
I
M
Site 113
T894
I
M
D
F
A
R
S
T
D
D
R
G
E
P
V
Site 114
T902
D
D
R
G
E
P
V
T
H
Y
L
V
K
W
C
Site 115
Y904
R
G
E
P
V
T
H
Y
L
V
K
W
C
S
L
Site 116
S916
C
S
L
P
Y
E
D
S
T
W
E
R
R
Q
D
Site 117
T917
S
L
P
Y
E
D
S
T
W
E
R
R
Q
D
I
Site 118
S937
E
E
F
E
K
L
M
S
R
E
P
E
T
E
R
Site 119
T942
L
M
S
R
E
P
E
T
E
R
V
E
R
P
P
Site 120
S956
P
A
D
D
W
K
K
S
E
S
S
R
E
Y
K
Site 121
S958
D
D
W
K
K
S
E
S
S
R
E
Y
K
N
N
Site 122
S959
D
W
K
K
S
E
S
S
R
E
Y
K
N
N
N
Site 123
Y962
K
S
E
S
S
R
E
Y
K
N
N
N
K
L
R
Site 124
Y971
N
N
N
K
L
R
E
Y
Q
L
E
G
V
N
W
Site 125
Y984
N
W
L
L
F
N
W
Y
N
M
R
N
C
I
L
Site 126
T1039
E
R
E
F
R
T
W
T
E
L
N
V
V
V
Y
Site 127
Y1046
T
E
L
N
V
V
V
Y
H
G
S
Q
A
S
R
Site 128
S1049
N
V
V
V
Y
H
G
S
Q
A
S
R
R
T
I
Site 129
S1052
V
Y
H
G
S
Q
A
S
R
R
T
I
Q
L
Y
Site 130
T1055
G
S
Q
A
S
R
R
T
I
Q
L
Y
E
M
Y
Site 131
Y1059
S
R
R
T
I
Q
L
Y
E
M
Y
F
K
D
P
Site 132
Y1062
T
I
Q
L
Y
E
M
Y
F
K
D
P
Q
G
R
Site 133
T1089
T
T
F
E
M
I
L
T
D
C
P
E
L
R
N
Site 134
T1135
H
K
V
L
L
T
G
T
P
L
Q
N
T
V
E
Site 135
T1140
T
G
T
P
L
Q
N
T
V
E
E
L
F
S
L
Site 136
S1154
L
L
H
F
L
E
P
S
R
F
P
S
E
T
T
Site 137
S1158
L
E
P
S
R
F
P
S
E
T
T
F
M
Q
E
Site 138
T1160
P
S
R
F
P
S
E
T
T
F
M
Q
E
F
G
Site 139
T1161
S
R
F
P
S
E
T
T
F
M
Q
E
F
G
D
Site 140
T1171
Q
E
F
G
D
L
K
T
E
E
Q
V
Q
K
L
Site 141
T1211
T
I
I
E
V
E
L
T
N
I
Q
K
K
Y
Y
Site 142
Y1217
L
T
N
I
Q
K
K
Y
Y
R
A
I
L
E
K
Site 143
Y1218
T
N
I
Q
K
K
Y
Y
R
A
I
L
E
K
N
Site 144
S1230
E
K
N
F
T
F
L
S
K
G
G
G
Q
A
N
Site 145
Y1256
R
K
C
C
N
H
P
Y
L
I
N
G
A
E
E
Site 146
T1272
I
L
E
E
F
K
E
T
H
N
A
E
S
P
D
Site 147
S1277
K
E
T
H
N
A
E
S
P
D
F
Q
L
Q
A
Site 148
Y1325
C
L
D
I
L
E
D
Y
L
I
Q
R
R
Y
P
Site 149
Y1331
D
Y
L
I
Q
R
R
Y
P
Y
E
R
I
D
G
Site 150
Y1333
L
I
Q
R
R
Y
P
Y
E
R
I
D
G
R
V
Site 151
S1353
Q
A
A
I
D
R
F
S
K
P
D
S
D
R
F
Site 152
S1357
D
R
F
S
K
P
D
S
D
R
F
V
F
L
L
Site 153
S1408
H
R
I
G
Q
S
K
S
V
K
I
Y
R
L
I
Site 154
Y1412
Q
S
K
S
V
K
I
Y
R
L
I
T
R
N
S
Site 155
T1416
V
K
I
Y
R
L
I
T
R
N
S
Y
E
R
E
Site 156
S1419
Y
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
Site 157
Y1420
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
K
Site 158
S1429
R
E
M
F
D
K
A
S
L
K
L
G
L
D
K
Site 159
S1443
K
A
V
L
Q
S
M
S
G
R
E
N
A
T
N
Site 160
T1449
M
S
G
R
E
N
A
T
N
G
V
Q
Q
L
S
Site 161
S1456
T
N
G
V
Q
Q
L
S
K
K
E
I
E
D
L
Site 162
S1480
M
D
E
E
D
E
G
S
K
F
C
E
E
D
I
Site 163
T1495
D
Q
I
L
L
R
R
T
H
T
I
T
I
E
S
Site 164
T1497
I
L
L
R
R
T
H
T
I
T
I
E
S
E
G
Site 165
T1499
L
R
R
T
H
T
I
T
I
E
S
E
G
K
G
Site 166
S1502
T
H
T
I
T
I
E
S
E
G
K
G
S
T
F
Site 167
T1508
E
S
E
G
K
G
S
T
F
A
K
A
S
F
V
Site 168
S1513
G
S
T
F
A
K
A
S
F
V
A
S
G
N
R
Site 169
S1517
A
K
A
S
F
V
A
S
G
N
R
T
D
I
S
Site 170
T1521
F
V
A
S
G
N
R
T
D
I
S
L
D
D
P
Site 171
S1524
S
G
N
R
T
D
I
S
L
D
D
P
N
F
W
Site 172
T1555
R
N
N
L
V
I
D
T
P
R
V
R
K
Q
T
Site 173
T1562
T
P
R
V
R
K
Q
T
R
L
Y
S
A
V
K
Site 174
Y1565
V
R
K
Q
T
R
L
Y
S
A
V
K
E
D
E
Site 175
S1566
R
K
Q
T
R
L
Y
S
A
V
K
E
D
E
L
Site 176
S1577
E
D
E
L
M
E
F
S
D
L
E
S
D
S
E
Site 177
S1581
M
E
F
S
D
L
E
S
D
S
E
E
K
P
C
Site 178
S1583
F
S
D
L
E
S
D
S
E
E
K
P
C
A
K
Site 179
S1598
P
R
R
P
Q
D
K
S
Q
G
Y
A
R
S
E
Site 180
Y1601
P
Q
D
K
S
Q
G
Y
A
R
S
E
C
F
R
Site 181
S1604
K
S
Q
G
Y
A
R
S
E
C
F
R
V
E
K
Site 182
S1626
G
R
W
T
D
I
L
S
H
G
R
Y
K
R
Q
Site 183
Y1630
D
I
L
S
H
G
R
Y
K
R
Q
L
T
E
Q
Site 184
T1635
G
R
Y
K
R
Q
L
T
E
Q
D
V
E
T
I
Site 185
Y1654
L
V
Y
C
L
N
H
Y
K
G
D
E
N
I
K
Site 186
T1669
S
F
I
W
D
L
I
T
P
T
A
D
G
Q
T
Site 187
S1686
L
V
N
H
S
G
L
S
A
P
V
P
R
G
R
Site 188
S1702
G
K
K
V
K
A
Q
S
T
Q
P
V
V
Q
D
Site 189
S1726
D
A
L
F
Q
E
D
S
Y
K
K
H
L
K
H
Site 190
Y1727
A
L
F
Q
E
D
S
Y
K
K
H
L
K
H
H
Site 191
S1766
K
I
L
E
G
A
D
S
S
E
A
D
V
W
I
Site 192
S1793
W
D
K
E
A
D
K
S
L
L
I
G
V
F
K
Site 193
Y1803
I
G
V
F
K
H
G
Y
E
K
Y
N
S
M
R
Site 194
Y1806
F
K
H
G
Y
E
K
Y
N
S
M
R
A
D
P
Site 195
S1808
H
G
Y
E
K
Y
N
S
M
R
A
D
P
A
L
Site 196
T1836
I
A
A
E
Q
R
G
T
D
M
L
A
D
G
G
Site 197
Y1857
R
E
D
E
D
P
E
Y
K
P
T
R
T
P
F
Site 198
T1860
E
D
P
E
Y
K
P
T
R
T
P
F
K
D
E
Site 199
T1862
P
E
Y
K
P
T
R
T
P
F
K
D
E
I
D
Site 200
S1874
E
I
D
E
F
A
N
S
P
S
E
D
K
E
E
Site 201
S1876
D
E
F
A
N
S
P
S
E
D
K
E
E
S
M
Site 202
T1888
E
S
M
E
I
H
A
T
G
K
H
S
E
S
N
Site 203
Y1902
N
A
E
L
G
Q
L
Y
W
P
N
T
S
T
L
Site 204
T1906
G
Q
L
Y
W
P
N
T
S
T
L
T
T
R
L
Site 205
T1908
L
Y
W
P
N
T
S
T
L
T
T
R
L
R
R
Site 206
T1911
P
N
T
S
T
L
T
T
R
L
R
R
L
I
T
Site 207
T1918
T
R
L
R
R
L
I
T
A
Y
Q
R
S
Y
K
Site 208
Y1920
L
R
R
L
I
T
A
Y
Q
R
S
Y
K
R
Q
Site 209
Y1924
I
T
A
Y
Q
R
S
Y
K
R
Q
Q
M
R
Q
Site 210
T1937
R
Q
E
A
L
M
K
T
D
R
R
R
R
R
P
Site 211
S1960
A
E
R
E
A
I
I
S
E
K
R
Q
K
W
T
Site 212
Y1975
R
R
E
E
A
D
F
Y
R
V
V
S
T
F
G
Site 213
S2007
F
A
R
L
D
K
K
S
D
E
S
L
E
K
Y
Site 214
S2010
L
D
K
K
S
D
E
S
L
E
K
Y
F
S
C
Site 215
Y2014
S
D
E
S
L
E
K
Y
F
S
C
F
V
A
M
Site 216
S2040
D
D
E
P
P
D
L
S
S
I
I
E
P
I
T
Site 217
S2041
D
E
P
P
D
L
S
S
I
I
E
P
I
T
E
Site 218
T2047
S
S
I
I
E
P
I
T
E
E
R
A
S
R
T
Site 219
S2052
P
I
T
E
E
R
A
S
R
T
L
Y
R
I
E
Site 220
Y2056
E
R
A
S
R
T
L
Y
R
I
E
L
L
R
K
Site 221
S2084
R
L
K
L
C
Q
P
S
L
D
L
P
E
W
W
Site 222
T2112
A
K
H
G
V
S
R
T
D
Y
H
I
L
N
D
Site 223
Y2114
H
G
V
S
R
T
D
Y
H
I
L
N
D
P
E
Site 224
S2123
I
L
N
D
P
E
L
S
F
L
D
A
H
K
N
Site 225
T2140
Q
N
R
G
A
G
N
T
S
S
L
N
P
L
A
Site 226
S2141
N
R
G
A
G
N
T
S
S
L
N
P
L
A
V
Site 227
S2142
R
G
A
G
N
T
S
S
L
N
P
L
A
V
G
Site 228
T2153
L
A
V
G
F
V
Q
T
P
P
V
I
S
S
A
Site 229
T2196
G
K
E
E
E
E
E
T
D
G
S
G
K
E
S
Site 230
S2199
E
E
E
E
T
D
G
S
G
K
E
S
K
Q
E
Site 231
S2203
T
D
G
S
G
K
E
S
K
Q
E
C
E
A
E
Site 232
S2212
Q
E
C
E
A
E
A
S
S
V
K
N
E
L
K
Site 233
T2227
G
V
E
V
G
A
D
T
G
S
K
S
I
S
E
Site 234
S2229
E
V
G
A
D
T
G
S
K
S
I
S
E
K
G
Site 235
S2231
G
A
D
T
G
S
K
S
I
S
E
K
G
S
E
Site 236
S2233
D
T
G
S
K
S
I
S
E
K
G
S
E
E
D
Site 237
S2237
K
S
I
S
E
K
G
S
E
E
D
E
E
E
K
Site 238
S2251
K
L
E
D
D
D
K
S
E
E
S
S
Q
P
E
Site 239
S2254
D
D
D
K
S
E
E
S
S
Q
P
E
A
G
A
Site 240
S2255
D
D
K
S
E
E
S
S
Q
P
E
A
G
A
V
Site 241
S2272
G
K
N
F
D
E
E
S
N
A
S
M
S
T
A
Site 242
S2275
F
D
E
E
S
N
A
S
M
S
T
A
R
D
E
Site 243
S2277
E
E
S
N
A
S
M
S
T
A
R
D
E
T
R
Site 244
T2278
E
S
N
A
S
M
S
T
A
R
D
E
T
R
D
Site 245
T2283
M
S
T
A
R
D
E
T
R
D
G
F
Y
M
E
Site 246
Y2288
D
E
T
R
D
G
F
Y
M
E
D
G
D
P
S
Site 247
S2295
Y
M
E
D
G
D
P
S
V
A
Q
L
L
H
E
Site 248
T2304
A
Q
L
L
H
E
R
T
F
A
F
S
F
W
P
Site 249
T2350
Q
G
L
I
P
G
Y
T
P
T
T
V
D
S
P
Site 250
T2352
L
I
P
G
Y
T
P
T
T
V
D
S
P
L
Q
Site 251
T2353
I
P
G
Y
T
P
T
T
V
D
S
P
L
Q
K
Site 252
S2356
Y
T
P
T
T
V
D
S
P
L
Q
K
R
S
F
Site 253
S2362
D
S
P
L
Q
K
R
S
F
A
E
L
S
M
V
Site 254
S2367
K
R
S
F
A
E
L
S
M
V
G
Q
A
S
I
Site 255
S2375
M
V
G
Q
A
S
I
S
G
S
E
D
I
T
T
Site 256
S2377
G
Q
A
S
I
S
G
S
E
D
I
T
T
S
P
Site 257
T2381
I
S
G
S
E
D
I
T
T
S
P
Q
L
S
K
Site 258
T2382
S
G
S
E
D
I
T
T
S
P
Q
L
S
K
E
Site 259
S2383
G
S
E
D
I
T
T
S
P
Q
L
S
K
E
D
Site 260
S2387
I
T
T
S
P
Q
L
S
K
E
D
A
L
N
L
Site 261
S2395
K
E
D
A
L
N
L
S
V
P
R
Q
R
R
R
Site 262
S2430
M
V
A
Q
L
R
E
S
Q
V
V
S
E
N
G
Site 263
S2434
L
R
E
S
Q
V
V
S
E
N
G
Q
E
K
V
Site 264
S2445
Q
E
K
V
V
D
L
S
K
A
S
R
E
A
T
Site 265
T2452
S
K
A
S
R
E
A
T
S
S
T
S
N
F
S
Site 266
S2453
K
A
S
R
E
A
T
S
S
T
S
N
F
S
S
Site 267
S2454
A
S
R
E
A
T
S
S
T
S
N
F
S
S
L
Site 268
T2455
S
R
E
A
T
S
S
T
S
N
F
S
S
L
S
Site 269
S2456
R
E
A
T
S
S
T
S
N
F
S
S
L
S
S
Site 270
S2459
T
S
S
T
S
N
F
S
S
L
S
S
K
F
I
Site 271
S2460
S
S
T
S
N
F
S
S
L
S
S
K
F
I
L
Site 272
S2462
T
S
N
F
S
S
L
S
S
K
F
I
L
P
N
Site 273
S2471
K
F
I
L
P
N
V
S
T
P
V
S
D
A
F
Site 274
T2472
F
I
L
P
N
V
S
T
P
V
S
D
A
F
K
Site 275
S2475
P
N
V
S
T
P
V
S
D
A
F
K
T
Q
M
Site 276
T2480
P
V
S
D
A
F
K
T
Q
M
E
L
L
Q
A
Site 277
S2490
E
L
L
Q
A
G
L
S
R
T
P
T
R
H
L
Site 278
T2492
L
Q
A
G
L
S
R
T
P
T
R
H
L
L
N
Site 279
T2494
A
G
L
S
R
T
P
T
R
H
L
L
N
G
S
Site 280
S2501
T
R
H
L
L
N
G
S
L
V
D
G
E
P
P
Site 281
S2528
G
L
D
L
L
F
M
S
H
K
R
T
S
L
S
Site 282
S2533
F
M
S
H
K
R
T
S
L
S
A
E
D
A
E
Site 283
S2535
S
H
K
R
T
S
L
S
A
E
D
A
E
V
T
Site 284
T2551
A
F
E
E
D
I
E
T
P
P
T
R
N
I
P
Site 285
T2554
E
D
I
E
T
P
P
T
R
N
I
P
S
P
G
Site 286
S2559
P
P
T
R
N
I
P
S
P
G
Q
L
D
P
D
Site 287
T2567
P
G
Q
L
D
P
D
T
R
I
P
V
I
N
L
Site 288
T2600
E
W
L
K
L
H
P
T
Y
T
V
D
M
P
S
Site 289
Y2601
W
L
K
L
H
P
T
Y
T
V
D
M
P
S
Y
Site 290
T2602
L
K
L
H
P
T
Y
T
V
D
M
P
S
Y
V
Site 291
S2607
T
Y
T
V
D
M
P
S
Y
V
P
K
N
A
D
Site 292
Y2608
Y
T
V
D
M
P
S
Y
V
P
K
N
A
D
V
Site 293
S2619
N
A
D
V
L
F
S
S
F
Q
K
P
K
Q
K
Site 294
T2640
P
N
K
L
D
I
N
T
L
T
G
E
E
R
V
Site 295
T2686
F
A
V
A
P
D
W
T
D
I
V
K
Q
S
G
Site 296
S2698
Q
S
G
F
V
P
E
S
M
F
D
R
L
L
T
Site 297
T2705
S
M
F
D
R
L
L
T
G
P
V
V
R
G
E
Site 298
S2715
V
V
R
G
E
G
A
S
R
R
G
R
R
P
K
Site 299
S2723
R
R
G
R
R
P
K
S
E
I
A
R
A
A
A
Site 300
S2766
Q
N
L
Q
N
L
Q
S
L
Q
L
A
G
L
M
Site 301
S2821
G
L
L
N
N
P
L
S
A
A
T
G
N
T
T
Site 302
T2828
S
A
A
T
G
N
T
T
T
A
S
S
Q
G
E
Site 303
S2831
T
G
N
T
T
T
A
S
S
Q
G
E
P
E
D
Site 304
S2839
S
Q
G
E
P
E
D
S
T
S
K
G
E
E
K
Site 305
T2840
Q
G
E
P
E
D
S
T
S
K
G
E
E
K
G
Site 306
S2841
G
E
P
E
D
S
T
S
K
G
E
E
K
G
N
Site 307
S2857
N
E
D
E
N
K
D
S
E
K
S
T
D
A
V
Site 308
S2860
E
N
K
D
S
E
K
S
T
D
A
V
S
A
A
Site 309
T2861
N
K
D
S
E
K
S
T
D
A
V
S
A
A
D
Site 310
S2865
E
K
S
T
D
A
V
S
A
A
D
S
A
N
G
Site 311
T2878
N
G
S
V
G
A
A
T
A
P
A
G
L
P
S
Site 312
S2885
T
A
P
A
G
L
P
S
N
P
L
A
F
N
P
Site 313
T2952
G
P
F
K
D
G
E
T
L
E
G
S
D
A
E
Site 314
S2956
D
G
E
T
L
E
G
S
D
A
E
E
S
L
D
Site 315
S2961
E
G
S
D
A
E
E
S
L
D
K
T
A
E
S
Site 316
T2965
A
E
E
S
L
D
K
T
A
E
S
S
L
L
E
Site 317
S2983
A
Q
G
E
E
L
D
S
L
D
G
G
D
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation