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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM181
Full Name:
Transmembrane protein 181
Alias:
G protein-coupled receptor 178; GPR178; KIAA1423; TM181
Type:
Membrane protein, integral
Mass (Da):
69325
Number AA:
612
UniProt ID:
Q9P2C4
International Prot ID:
IPI00856096
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
A
A
P
S
P
T
Q
A
S
S
R
Site 2
T8
M
G
A
A
P
S
P
T
Q
A
S
S
R
G
G
Site 3
S11
A
P
S
P
T
Q
A
S
S
R
G
G
G
P
G
Site 4
S12
P
S
P
T
Q
A
S
S
R
G
G
G
P
G
P
Site 5
T23
G
P
G
P
P
A
P
T
R
A
V
S
S
S
S
Site 6
S27
P
A
P
T
R
A
V
S
S
S
S
R
A
R
G
Site 7
S28
A
P
T
R
A
V
S
S
S
S
R
A
R
G
G
Site 8
S29
P
T
R
A
V
S
S
S
S
R
A
R
G
G
A
Site 9
S30
T
R
A
V
S
S
S
S
R
A
R
G
G
A
L
Site 10
S38
R
A
R
G
G
A
L
S
A
L
G
P
S
P
A
Site 11
T49
P
S
P
A
R
P
L
T
T
S
P
A
P
A
P
Site 12
S51
P
A
R
P
L
T
T
S
P
A
P
A
P
P
P
Site 13
S60
A
P
A
P
P
P
R
S
R
P
A
R
Q
Q
P
Site 14
T82
R
G
G
A
G
G
D
T
K
G
G
A
A
G
P
Site 15
Y101
L
R
G
M
D
A
E
Y
P
A
F
E
P
P
L
Site 16
S110
A
F
E
P
P
L
C
S
E
L
K
H
L
C
R
Site 17
Y123
C
R
R
L
R
E
A
Y
R
E
L
K
E
D
L
Site 18
T131
R
E
L
K
E
D
L
T
P
F
K
D
D
R
Y
Site 19
Y138
T
P
F
K
D
D
R
Y
Y
R
L
A
P
M
R
Site 20
Y139
P
F
K
D
D
R
Y
Y
R
L
A
P
M
R
L
Site 21
Y147
R
L
A
P
M
R
L
Y
T
L
S
K
R
H
F
Site 22
S182
G
P
K
V
I
Q
T
S
A
A
N
F
S
L
N
Site 23
S187
Q
T
S
A
A
N
F
S
L
N
N
S
K
K
L
Site 24
S191
A
N
F
S
L
N
N
S
K
K
L
K
P
I
Q
Site 25
S201
L
K
P
I
Q
I
L
S
N
P
L
S
T
Y
N
Site 26
S205
Q
I
L
S
N
P
L
S
T
Y
N
Q
Q
L
W
Site 27
S222
C
V
V
E
L
D
Q
S
K
E
T
S
I
K
T
Site 28
S226
L
D
Q
S
K
E
T
S
I
K
T
S
F
P
M
Site 29
T229
S
K
E
T
S
I
K
T
S
F
P
M
T
V
K
Site 30
S230
K
E
T
S
I
K
T
S
F
P
M
T
V
K
V
Site 31
Y248
A
Q
D
G
T
T
M
Y
I
H
N
K
V
H
N
Site 32
T259
K
V
H
N
R
T
R
T
L
T
C
A
G
K
C
Site 33
T261
H
N
R
T
R
T
L
T
C
A
G
K
C
A
E
Site 34
S339
A
H
S
L
R
K
F
S
M
R
D
W
G
I
E
Site 35
T412
Q
G
E
R
K
C
L
T
F
Y
L
P
K
F
F
Site 36
Y445
N
E
L
H
D
P
M
Y
Q
Y
R
V
D
T
G
Site 37
Y447
L
H
D
P
M
Y
Q
Y
R
V
D
T
G
N
F
Site 38
Y488
S
E
L
R
H
M
P
Y
V
D
L
R
L
K
F
Site 39
S529
D
N
F
V
A
E
L
S
T
H
Y
Q
N
S
A
Site 40
S535
L
S
T
H
Y
Q
N
S
A
E
F
L
S
F
Y
Site 41
Y564
S
P
S
K
N
A
L
Y
E
S
Q
L
K
D
N
Site 42
S566
S
K
N
A
L
Y
E
S
Q
L
K
D
N
P
A
Site 43
S575
L
K
D
N
P
A
F
S
M
L
N
D
S
D
D
Site 44
S580
A
F
S
M
L
N
D
S
D
D
D
V
I
Y
G
Site 45
Y586
D
S
D
D
D
V
I
Y
G
S
D
Y
E
E
M
Site 46
S588
D
D
D
V
I
Y
G
S
D
Y
E
E
M
P
L
Site 47
Y590
D
V
I
Y
G
S
D
Y
E
E
M
P
L
Q
N
Site 48
Y605
G
Q
A
I
R
A
K
Y
K
E
E
S
D
S
D
Site 49
S609
R
A
K
Y
K
E
E
S
D
S
D
_
_
_
_
Site 50
S611
K
Y
K
E
E
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation