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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MST4
Full Name:
Serine/threonine-protein kinase MST4
Alias:
EC 2.7.11.1; MASK; Serine/threonine protein kinase MST4
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE20 family; YSK subfamily
Mass (Da):
46529
Number AA:
416
UniProt ID:
Q9P289
International Prot ID:
IPI00292827
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006468
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
H
S
P
V
A
V
Q
V
P
Site 2
T25
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
Site 3
S34
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
Site 4
T46
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
Site 5
S75
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
Site 6
S79
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
Site 7
S80
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
Site 8
Y81
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Site 9
Y85
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
Site 10
Y86
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
Site 11
Y89
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
Site 12
Y101
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
Site 13
Y134
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
Site 14
S137
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
Site 15
T170
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
Site 16
T172
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
Site 17
T178
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
Site 18
T182
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
Site 19
S194
A
P
E
V
I
Q
Q
S
A
Y
D
S
K
A
D
Site 20
Y196
E
V
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
Site 21
S198
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
Site 22
S220
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
Site 23
T238
I
P
K
N
N
P
P
T
L
V
G
D
F
T
K
Site 24
S260
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
Site 25
T264
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
Site 26
S282
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
Site 27
S300
R
W
K
A
E
G
H
S
D
D
E
S
D
S
E
Site 28
S304
E
G
H
S
D
D
E
S
D
S
E
G
S
D
S
Site 29
S306
H
S
D
D
E
S
D
S
E
G
S
D
S
E
S
Site 30
S309
D
E
S
D
S
E
G
S
D
S
E
S
T
S
R
Site 31
S311
S
D
S
E
G
S
D
S
E
S
T
S
R
E
N
Site 32
S313
S
E
G
S
D
S
E
S
T
S
R
E
N
N
T
Site 33
S315
G
S
D
S
E
S
T
S
R
E
N
N
T
H
P
Site 34
T320
S
T
S
R
E
N
N
T
H
P
E
W
S
F
T
Site 35
S325
N
N
T
H
P
E
W
S
F
T
T
V
R
K
K
Site 36
T327
T
H
P
E
W
S
F
T
T
V
R
K
K
P
D
Site 37
T328
H
P
E
W
S
F
T
T
V
R
K
K
P
D
P
Site 38
S411
I
E
K
F
Q
K
C
S
A
D
E
S
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation