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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS18
Full Name:
Vacuolar protein sorting-associated protein 18 homolog
Alias:
KIAA1475; PEP3; Vacuolar protein sorting 18; Vacuolar protein sorting-associated 18
Type:
Mass (Da):
110186
Number AA:
973
UniProt ID:
Q9P253
International Prot ID:
IPI00001985
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030897
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007032
GO:0007040
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
S
I
L
D
E
Y
E
N
S
L
S
R
S
Site 2
S11
I
L
D
E
Y
E
N
S
L
S
R
S
A
V
L
Site 3
S13
D
E
Y
E
N
S
L
S
R
S
A
V
L
Q
P
Site 4
S15
Y
E
N
S
L
S
R
S
A
V
L
Q
P
G
C
Site 5
S30
P
S
V
G
I
P
H
S
G
Y
V
N
A
Q
L
Site 6
Y32
V
G
I
P
H
S
G
Y
V
N
A
Q
L
E
K
Site 7
T52
T
K
Q
R
I
D
F
T
P
S
E
R
I
T
S
Site 8
S54
Q
R
I
D
F
T
P
S
E
R
I
T
S
L
V
Site 9
T58
F
T
P
S
E
R
I
T
S
L
V
V
S
S
N
Site 10
S59
T
P
S
E
R
I
T
S
L
V
V
S
S
N
Q
Site 11
S70
S
S
N
Q
L
C
M
S
L
G
K
D
T
L
L
Site 12
Y123
L
S
S
T
E
V
L
Y
V
N
R
N
G
Q
K
Site 13
T153
G
W
N
K
A
L
G
T
E
S
S
T
G
P
I
Site 14
S177
F
E
A
E
L
S
A
S
E
G
G
L
F
G
P
Site 15
Y194
D
L
Y
F
R
P
L
Y
V
L
N
E
E
G
G
Site 16
S207
G
G
P
A
P
V
C
S
L
E
A
E
R
G
P
Site 17
S218
E
R
G
P
D
G
R
S
F
V
I
A
T
T
R
Site 18
T223
G
R
S
F
V
I
A
T
T
R
Q
R
L
F
Q
Site 19
T252
S
G
L
F
A
A
Y
T
D
H
P
P
P
F
R
Site 20
S263
P
P
F
R
E
F
P
S
N
L
G
Y
S
E
L
Site 21
Y273
G
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
Site 22
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Site 23
S304
L
D
C
G
R
P
D
S
L
L
S
E
E
R
V
Site 24
S307
G
R
P
D
S
L
L
S
E
E
R
V
W
E
Y
Site 25
Y314
S
E
E
R
V
W
E
Y
P
E
G
V
G
P
G
Site 26
S373
L
K
H
M
V
K
D
S
S
T
G
Q
L
W
A
Site 27
Y381
S
T
G
Q
L
W
A
Y
T
E
R
A
V
F
R
Site 28
T382
T
G
Q
L
W
A
Y
T
E
R
A
V
F
R
Y
Site 29
Y389
T
E
R
A
V
F
R
Y
H
V
Q
R
E
A
R
Site 30
Y402
A
R
D
V
W
R
T
Y
L
D
M
N
R
F
D
Site 31
Y414
R
F
D
L
A
K
E
Y
C
R
E
R
P
D
C
Site 32
T424
E
R
P
D
C
L
D
T
V
L
A
R
E
A
D
Site 33
Y439
F
C
F
R
Q
R
R
Y
L
E
S
A
R
C
Y
Site 34
S442
R
Q
R
R
Y
L
E
S
A
R
C
Y
A
L
T
Site 35
Y446
Y
L
E
S
A
R
C
Y
A
L
T
Q
S
Y
F
Site 36
T449
S
A
R
C
Y
A
L
T
Q
S
Y
F
E
E
I
Site 37
S479
F
L
Q
R
K
L
A
S
L
K
P
A
E
R
T
Site 38
T514
Q
G
D
P
E
A
L
T
L
Y
R
E
T
K
E
Site 39
Y516
D
P
E
A
L
T
L
Y
R
E
T
K
E
C
F
Site 40
T519
A
L
T
L
Y
R
E
T
K
E
C
F
R
T
F
Site 41
T525
E
T
K
E
C
F
R
T
F
L
S
S
P
R
H
Site 42
S528
E
C
F
R
T
F
L
S
S
P
R
H
K
E
W
Site 43
S529
C
F
R
T
F
L
S
S
P
R
H
K
E
W
L
Site 44
S539
H
K
E
W
L
F
A
S
R
A
S
I
H
E
L
Site 45
S549
S
I
H
E
L
L
A
S
H
G
D
T
E
H
M
Site 46
Y572
D
Y
E
R
V
V
A
Y
H
C
Q
H
E
A
Y
Site 47
S643
G
G
E
V
Q
Q
V
S
Q
A
I
R
Y
M
E
Site 48
S669
A
I
H
N
Y
L
L
S
L
Y
A
R
G
R
P
Site 49
Y671
H
N
Y
L
L
S
L
Y
A
R
G
R
P
D
S
Site 50
S678
Y
A
R
G
R
P
D
S
L
L
A
Y
L
E
Q
Site 51
Y682
R
P
D
S
L
L
A
Y
L
E
Q
A
G
A
S
Site 52
S689
Y
L
E
Q
A
G
A
S
P
H
R
V
H
Y
D
Site 53
Y695
A
S
P
H
R
V
H
Y
D
L
K
Y
A
L
R
Site 54
Y699
R
V
H
Y
D
L
K
Y
A
L
R
L
C
A
E
Site 55
Y717
H
R
A
C
V
H
V
Y
K
V
L
E
L
Y
E
Site 56
T772
Q
E
E
E
D
V
Q
T
A
M
A
C
L
A
S
Site 57
T797
P
F
F
P
D
F
V
T
I
D
H
F
K
E
A
Site 58
Y812
I
C
S
S
L
K
A
Y
N
H
H
I
Q
E
L
Site 59
S829
E
M
E
E
A
T
A
S
A
Q
R
I
R
R
D
Site 60
Y844
L
Q
E
L
R
G
R
Y
G
T
V
E
P
Q
D
Site 61
T846
E
L
R
G
R
Y
G
T
V
E
P
Q
D
K
C
Site 62
Y890
V
R
P
G
L
P
A
Y
K
Q
A
R
L
E
E
Site 63
S912
A
P
P
P
A
K
G
S
A
R
A
K
E
A
E
Site 64
T924
E
A
E
G
G
A
A
T
A
G
P
S
R
E
Q
Site 65
Y965
P
F
I
D
P
Q
R
Y
E
E
E
Q
L
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation