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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP23
Full Name:
Rho GTPase-activating protein 23
Alias:
KIAA1501; RHG23; Rho GTPase activating protein 23; Rho-type GTPase-activating protein 23
Type:
GTPase-activating protein for G protein
Mass (Da):
162192
Number AA:
1491
UniProt ID:
Q9P227
International Prot ID:
IPI00101969
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
L
G
P
R
D
G
C
S
P
R
R
P
F
P
W
Site 2
T43
F
P
W
Q
G
P
R
T
L
L
L
Y
K
S
P
Site 3
Y47
G
P
R
T
L
L
L
Y
K
S
P
Q
D
G
F
Site 4
S49
R
T
L
L
L
Y
K
S
P
Q
D
G
F
G
F
Site 5
Y64
T
L
R
H
F
I
V
Y
P
P
E
S
A
V
H
Site 6
S73
P
E
S
A
V
H
C
S
L
K
E
E
E
N
G
Site 7
S87
G
G
R
G
G
G
P
S
P
R
Y
R
L
E
P
Site 8
Y90
G
G
G
P
S
P
R
Y
R
L
E
P
M
D
T
Site 9
T97
Y
R
L
E
P
M
D
T
I
F
V
K
N
V
K
Site 10
T116
A
H
R
A
G
L
R
T
G
D
R
L
V
K
V
Site 11
T146
L
I
Q
N
S
D
D
T
L
E
L
S
I
M
P
Site 12
S150
S
D
D
T
L
E
L
S
I
M
P
K
D
E
D
Site 13
S164
D
I
L
Q
L
A
Y
S
Q
D
A
Y
L
K
G
Site 14
Y168
L
A
Y
S
Q
D
A
Y
L
K
G
N
E
P
Y
Site 15
S176
L
K
G
N
E
P
Y
S
G
E
A
R
S
I
P
Site 16
S181
P
Y
S
G
E
A
R
S
I
P
E
P
P
P
I
Site 17
Y190
P
E
P
P
P
I
C
Y
P
R
K
T
Y
A
P
Site 18
T194
P
I
C
Y
P
R
K
T
Y
A
P
P
A
R
A
Site 19
Y195
I
C
Y
P
R
K
T
Y
A
P
P
A
R
A
S
Site 20
S202
Y
A
P
P
A
R
A
S
T
R
A
T
M
V
P
Site 21
T203
A
P
P
A
R
A
S
T
R
A
T
M
V
P
E
Site 22
T206
A
R
A
S
T
R
A
T
M
V
P
E
P
T
S
Site 23
T212
A
T
M
V
P
E
P
T
S
A
L
P
S
D
P
Site 24
S213
T
M
V
P
E
P
T
S
A
L
P
S
D
P
R
Site 25
S217
E
P
T
S
A
L
P
S
D
P
R
S
P
A
A
Site 26
S221
A
L
P
S
D
P
R
S
P
A
A
W
S
D
P
Site 27
S226
P
R
S
P
A
A
W
S
D
P
G
L
R
V
P
Site 28
S243
A
R
A
H
L
D
N
S
S
L
G
M
S
Q
P
Site 29
S244
R
A
H
L
D
N
S
S
L
G
M
S
Q
P
R
Site 30
S248
D
N
S
S
L
G
M
S
Q
P
R
P
S
P
G
Site 31
S253
G
M
S
Q
P
R
P
S
P
G
A
F
P
H
L
Site 32
S261
P
G
A
F
P
H
L
S
S
E
P
R
T
P
R
Site 33
S262
G
A
F
P
H
L
S
S
E
P
R
T
P
R
A
Site 34
T266
H
L
S
S
E
P
R
T
P
R
A
F
P
E
P
Site 35
S275
R
A
F
P
E
P
G
S
R
V
P
P
S
R
L
Site 36
S280
P
G
S
R
V
P
P
S
R
L
E
C
Q
Q
A
Site 37
S293
Q
A
L
S
H
W
L
S
N
Q
V
P
R
R
A
Site 38
S314
A
M
A
P
R
A
R
S
A
S
Q
D
R
L
E
Site 39
S316
A
P
R
A
R
S
A
S
Q
D
R
L
E
E
V
Site 40
S332
A
P
R
P
W
P
C
S
T
S
Q
D
A
L
S
Site 41
S334
R
P
W
P
C
S
T
S
Q
D
A
L
S
Q
L
Site 42
S339
S
T
S
Q
D
A
L
S
Q
L
G
Q
E
G
W
Site 43
S351
E
G
W
H
R
A
R
S
D
D
Y
L
S
R
A
Site 44
Y354
H
R
A
R
S
D
D
Y
L
S
R
A
T
R
S
Site 45
S356
A
R
S
D
D
Y
L
S
R
A
T
R
S
A
E
Site 46
T359
D
D
Y
L
S
R
A
T
R
S
A
E
A
L
G
Site 47
S361
Y
L
S
R
A
T
R
S
A
E
A
L
G
P
G
Site 48
S372
L
G
P
G
A
L
V
S
P
R
F
E
R
C
G
Site 49
S382
F
E
R
C
G
W
A
S
Q
R
S
S
A
R
T
Site 50
S385
C
G
W
A
S
Q
R
S
S
A
R
T
P
A
C
Site 51
S386
G
W
A
S
Q
R
S
S
A
R
T
P
A
C
P
Site 52
T389
S
Q
R
S
S
A
R
T
P
A
C
P
T
R
D
Site 53
S406
G
P
Q
A
P
P
P
S
G
L
Q
G
L
D
D
Site 54
Y416
Q
G
L
D
D
L
G
Y
I
G
Y
R
S
Y
S
Site 55
Y419
D
D
L
G
Y
I
G
Y
R
S
Y
S
P
S
F
Site 56
S421
L
G
Y
I
G
Y
R
S
Y
S
P
S
F
Q
R
Site 57
Y422
G
Y
I
G
Y
R
S
Y
S
P
S
F
Q
R
R
Site 58
S423
Y
I
G
Y
R
S
Y
S
P
S
F
Q
R
R
T
Site 59
S425
G
Y
R
S
Y
S
P
S
F
Q
R
R
T
G
L
Site 60
T430
S
P
S
F
Q
R
R
T
G
L
L
H
A
L
S
Site 61
S437
T
G
L
L
H
A
L
S
F
R
D
S
P
F
G
Site 62
S441
H
A
L
S
F
R
D
S
P
F
G
G
L
P
T
Site 63
T448
S
P
F
G
G
L
P
T
F
N
L
A
Q
S
P
Site 64
S454
P
T
F
N
L
A
Q
S
P
A
S
F
P
P
E
Site 65
S457
N
L
A
Q
S
P
A
S
F
P
P
E
A
S
E
Site 66
S463
A
S
F
P
P
E
A
S
E
P
P
R
V
V
R
Site 67
S474
R
V
V
R
P
E
P
S
T
R
A
L
E
P
P
Site 68
T475
V
V
R
P
E
P
S
T
R
A
L
E
P
P
A
Site 69
T497
V
L
R
Q
K
P
P
T
G
R
K
V
Q
L
T
Site 70
T504
T
G
R
K
V
Q
L
T
P
A
R
Q
M
N
L
Site 71
S517
N
L
G
F
G
D
E
S
P
E
P
E
A
S
G
Site 72
S523
E
S
P
E
P
E
A
S
G
R
G
E
R
L
G
Site 73
T538
R
K
V
A
P
L
A
T
T
E
D
S
L
A
S
Site 74
T553
I
P
F
I
D
E
P
T
S
P
S
I
D
L
Q
Site 75
S554
P
F
I
D
E
P
T
S
P
S
I
D
L
Q
A
Site 76
S572
P
A
S
A
V
V
S
S
A
M
N
S
A
P
V
Site 77
S576
V
V
S
S
A
M
N
S
A
P
V
L
G
T
S
Site 78
T582
N
S
A
P
V
L
G
T
S
P
S
S
P
T
F
Site 79
S583
S
A
P
V
L
G
T
S
P
S
S
P
T
F
T
Site 80
S585
P
V
L
G
T
S
P
S
S
P
T
F
T
F
T
Site 81
S586
V
L
G
T
S
P
S
S
P
T
F
T
F
T
L
Site 82
T588
G
T
S
P
S
S
P
T
F
T
F
T
L
G
R
Site 83
T590
S
P
S
S
P
T
F
T
F
T
L
G
R
H
Y
Site 84
T592
S
S
P
T
F
T
F
T
L
G
R
H
Y
S
Q
Site 85
Y597
T
F
T
L
G
R
H
Y
S
Q
D
C
S
S
I
Site 86
S598
F
T
L
G
R
H
Y
S
Q
D
C
S
S
I
K
Site 87
S602
R
H
Y
S
Q
D
C
S
S
I
K
A
G
R
R
Site 88
S603
H
Y
S
Q
D
C
S
S
I
K
A
G
R
R
S
Site 89
S610
S
I
K
A
G
R
R
S
S
Y
L
L
A
I
T
Site 90
S611
I
K
A
G
R
R
S
S
Y
L
L
A
I
T
T
Site 91
Y612
K
A
G
R
R
S
S
Y
L
L
A
I
T
T
E
Site 92
T617
S
S
Y
L
L
A
I
T
T
E
R
S
K
S
C
Site 93
T618
S
Y
L
L
A
I
T
T
E
R
S
K
S
C
D
Site 94
S621
L
A
I
T
T
E
R
S
K
S
C
D
D
G
L
Site 95
S623
I
T
T
E
R
S
K
S
C
D
D
G
L
N
T
Site 96
T630
S
C
D
D
G
L
N
T
F
R
D
E
G
R
V
Site 97
S647
R
L
P
N
R
I
P
S
L
R
M
L
R
S
F
Site 98
S653
P
S
L
R
M
L
R
S
F
F
T
D
G
S
L
Site 99
T656
R
M
L
R
S
F
F
T
D
G
S
L
D
S
W
Site 100
S659
R
S
F
F
T
D
G
S
L
D
S
W
G
T
S
Site 101
S662
F
T
D
G
S
L
D
S
W
G
T
S
E
D
A
Site 102
S666
S
L
D
S
W
G
T
S
E
D
A
D
A
P
S
Site 103
S673
S
E
D
A
D
A
P
S
K
R
H
S
T
S
D
Site 104
S677
D
A
P
S
K
R
H
S
T
S
D
L
S
D
A
Site 105
T678
A
P
S
K
R
H
S
T
S
D
L
S
D
A
T
Site 106
S682
R
H
S
T
S
D
L
S
D
A
T
F
S
D
I
Site 107
T685
T
S
D
L
S
D
A
T
F
S
D
I
R
R
E
Site 108
S687
D
L
S
D
A
T
F
S
D
I
R
R
E
G
W
Site 109
Y696
I
R
R
E
G
W
L
Y
Y
K
Q
I
L
T
K
Site 110
Y697
R
R
E
G
W
L
Y
Y
K
Q
I
L
T
K
K
Site 111
S710
K
K
G
K
K
A
G
S
G
L
R
Q
W
K
R
Site 112
Y719
L
R
Q
W
K
R
V
Y
A
A
L
R
A
R
S
Site 113
S726
Y
A
A
L
R
A
R
S
L
S
L
S
K
E
R
Site 114
S728
A
L
R
A
R
S
L
S
L
S
K
E
R
R
E
Site 115
S730
R
A
R
S
L
S
L
S
K
E
R
R
E
P
G
Site 116
S766
G
S
C
L
V
D
I
S
Y
S
E
T
K
R
R
Site 117
Y767
S
C
L
V
D
I
S
Y
S
E
T
K
R
R
H
Site 118
S768
C
L
V
D
I
S
Y
S
E
T
K
R
R
H
V
Site 119
T770
V
D
I
S
Y
S
E
T
K
R
R
H
V
F
R
Site 120
T779
R
R
H
V
F
R
L
T
T
A
D
F
C
E
Y
Site 121
T780
R
H
V
F
R
L
T
T
A
D
F
C
E
Y
L
Site 122
Y786
T
T
A
D
F
C
E
Y
L
F
Q
A
E
D
R
Site 123
S807
I
R
A
I
R
E
N
S
R
A
E
G
E
D
P
Site 124
Y829
I
S
K
K
L
N
D
Y
R
K
V
S
H
S
S
Site 125
S833
L
N
D
Y
R
K
V
S
H
S
S
G
P
K
A
Site 126
S835
D
Y
R
K
V
S
H
S
S
G
P
K
A
D
S
Site 127
S836
Y
R
K
V
S
H
S
S
G
P
K
A
D
S
S
Site 128
S842
S
S
G
P
K
A
D
S
S
P
K
G
S
R
G
Site 129
S843
S
G
P
K
A
D
S
S
P
K
G
S
R
G
L
Site 130
S847
A
D
S
S
P
K
G
S
R
G
L
G
G
L
K
Site 131
S855
R
G
L
G
G
L
K
S
E
F
L
K
Q
S
A
Site 132
S861
K
S
E
F
L
K
Q
S
A
A
R
G
L
R
T
Site 133
S875
T
Q
D
L
P
A
G
S
K
D
D
S
A
A
A
Site 134
S879
P
A
G
S
K
D
D
S
A
A
A
P
K
T
P
Site 135
T938
E
A
R
G
L
E
S
T
G
I
Y
R
V
P
G
Site 136
Y941
G
L
E
S
T
G
I
Y
R
V
P
G
N
N
A
Site 137
S952
G
N
N
A
V
V
S
S
L
Q
E
Q
L
N
R
Site 138
S978
W
Q
D
L
N
V
I
S
S
L
L
K
S
F
F
Site 139
S979
Q
D
L
N
V
I
S
S
L
L
K
S
F
F
R
Site 140
T994
K
L
P
E
P
L
F
T
D
D
K
Y
N
D
F
Site 141
Y998
P
L
F
T
D
D
K
Y
N
D
F
I
E
A
N
Site 142
T1016
D
A
R
E
R
M
R
T
L
R
K
L
I
R
D
Site 143
Y1029
R
D
L
P
G
H
Y
Y
E
T
L
K
F
L
V
Site 144
T1041
F
L
V
G
H
L
K
T
I
A
D
H
S
E
K
Site 145
S1046
L
K
T
I
A
D
H
S
E
K
N
K
M
E
P
Site 146
S1068
G
P
T
L
V
R
T
S
E
D
N
M
T
D
M
Site 147
Y1083
V
T
H
M
P
D
R
Y
K
I
V
E
T
L
I
Site 148
T1107
E
E
D
K
G
E
R
T
P
V
G
D
K
E
P
Site 149
Y1122
Q
A
V
P
N
I
E
Y
L
L
P
N
I
G
R
Site 150
T1130
L
L
P
N
I
G
R
T
V
P
P
G
D
P
G
Site 151
S1138
V
P
P
G
D
P
G
S
D
S
T
T
C
S
S
Site 152
S1140
P
G
D
P
G
S
D
S
T
T
C
S
S
A
K
Site 153
T1141
G
D
P
G
S
D
S
T
T
C
S
S
A
K
S
Site 154
T1142
D
P
G
S
D
S
T
T
C
S
S
A
K
S
K
Site 155
S1144
G
S
D
S
T
T
C
S
S
A
K
S
K
G
S
Site 156
S1145
S
D
S
T
T
C
S
S
A
K
S
K
G
S
W
Site 157
S1148
T
T
C
S
S
A
K
S
K
G
S
W
A
P
K
Site 158
S1151
S
S
A
K
S
K
G
S
W
A
P
K
K
E
P
Site 159
S1187
R
E
A
R
G
L
G
S
S
T
D
D
D
S
E
Site 160
S1188
E
A
R
G
L
G
S
S
T
D
D
D
S
E
Q
Site 161
T1189
A
R
G
L
G
S
S
T
D
D
D
S
E
Q
E
Site 162
S1193
G
S
S
T
D
D
D
S
E
Q
E
A
H
K
P
Site 163
T1209
A
G
A
T
A
P
G
T
Q
E
R
P
Q
G
P
Site 164
S1230
P
E
A
P
G
R
L
S
P
P
A
A
P
E
E
Site 165
T1243
E
E
R
P
A
A
D
T
R
S
I
V
S
G
Y
Site 166
S1245
R
P
A
A
D
T
R
S
I
V
S
G
Y
S
T
Site 167
S1248
A
D
T
R
S
I
V
S
G
Y
S
T
L
S
T
Site 168
S1251
R
S
I
V
S
G
Y
S
T
L
S
T
M
D
R
Site 169
T1252
S
I
V
S
G
Y
S
T
L
S
T
M
D
R
S
Site 170
S1254
V
S
G
Y
S
T
L
S
T
M
D
R
S
V
C
Site 171
T1255
S
G
Y
S
T
L
S
T
M
D
R
S
V
C
S
Site 172
S1259
T
L
S
T
M
D
R
S
V
C
S
G
A
S
G
Site 173
S1265
R
S
V
C
S
G
A
S
G
R
R
A
G
A
G
Site 174
S1283
D
D
E
R
S
E
L
S
H
V
E
T
D
T
E
Site 175
T1287
S
E
L
S
H
V
E
T
D
T
E
G
A
A
G
Site 176
T1289
L
S
H
V
E
T
D
T
E
G
A
A
G
A
G
Site 177
T1302
A
G
P
G
G
R
L
T
R
R
P
S
F
S
S
Site 178
S1306
G
R
L
T
R
R
P
S
F
S
S
H
H
L
M
Site 179
S1308
L
T
R
R
P
S
F
S
S
H
H
L
M
P
C
Site 180
S1309
T
R
R
P
S
F
S
S
H
H
L
M
P
C
D
Site 181
T1317
H
H
L
M
P
C
D
T
L
A
R
R
R
L
A
Site 182
S1346
R
A
P
E
P
P
G
S
A
S
S
S
S
Q
E
Site 183
S1348
P
E
P
P
G
S
A
S
S
S
S
Q
E
S
L
Site 184
S1349
E
P
P
G
S
A
S
S
S
S
Q
E
S
L
R
Site 185
S1350
P
P
G
S
A
S
S
S
S
Q
E
S
L
R
P
Site 186
S1351
P
G
S
A
S
S
S
S
Q
E
S
L
R
P
P
Site 187
S1354
A
S
S
S
S
Q
E
S
L
R
P
P
A
A
A
Site 188
S1364
P
P
A
A
A
L
A
S
R
P
S
R
M
E
A
Site 189
S1367
A
A
L
A
S
R
P
S
R
M
E
A
L
R
L
Site 190
S1393
V
R
L
R
R
P
L
S
P
E
T
R
R
R
R
Site 191
T1396
R
R
P
L
S
P
E
T
R
R
R
R
S
S
W
Site 192
S1401
P
E
T
R
R
R
R
S
S
W
R
R
H
T
V
Site 193
S1402
E
T
R
R
R
R
S
S
W
R
R
H
T
V
V
Site 194
T1407
R
S
S
W
R
R
H
T
V
V
V
Q
S
P
L
Site 195
S1412
R
H
T
V
V
V
Q
S
P
L
T
D
L
N
F
Site 196
S1440
P
A
G
A
R
A
H
S
D
N
K
D
S
G
L
Site 197
S1445
A
H
S
D
N
K
D
S
G
L
S
S
L
E
S
Site 198
S1448
D
N
K
D
S
G
L
S
S
L
E
S
T
K
A
Site 199
S1449
N
K
D
S
G
L
S
S
L
E
S
T
K
A
R
Site 200
S1452
S
G
L
S
S
L
E
S
T
K
A
R
A
P
S
Site 201
T1453
G
L
S
S
L
E
S
T
K
A
R
A
P
S
S
Site 202
S1459
S
T
K
A
R
A
P
S
S
A
A
S
Q
P
P
Site 203
S1460
T
K
A
R
A
P
S
S
A
A
S
Q
P
P
A
Site 204
S1463
R
A
P
S
S
A
A
S
Q
P
P
A
P
G
D
Site 205
S1473
P
A
P
G
D
T
G
S
L
Q
S
Q
P
P
R
Site 206
S1476
G
D
T
G
S
L
Q
S
Q
P
P
R
R
S
A
Site 207
S1482
Q
S
Q
P
P
R
R
S
A
A
S
R
L
H
Q
Site 208
S1485
P
P
R
R
S
A
A
S
R
L
H
Q
C
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation