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Updated November 2019
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Protein Info
Short Name:
PLCE1
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1
Alias:
KIAA1516; Nephrosis type 3; NPHS3; Pancreas-enriched phospholipase C; Phosphoinositide-specific phospholipase C epsilon-1; Phospholipase C, epsilon 1; PLCE; PLC-epsilon-1
Type:
Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
258710
Number AA:
UniProt ID:
Q9P212
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0005829
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0017016
GO:0005509
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0000187
GO:0007200
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
R
K
V
V
S
A
Q
S
A
A
D
E
S
S
E
Site 2
S30
Q
S
A
A
D
E
S
S
E
K
V
S
D
I
N
Site 3
S34
D
E
S
S
E
K
V
S
D
I
N
I
S
K
A
Site 4
T43
I
N
I
S
K
A
H
T
V
R
R
S
G
E
T
Site 5
S47
K
A
H
T
V
R
R
S
G
E
T
S
H
T
I
Site 6
S51
V
R
R
S
G
E
T
S
H
T
I
S
Q
L
N
Site 7
T53
R
S
G
E
T
S
H
T
I
S
Q
L
N
K
L
Site 8
S55
G
E
T
S
H
T
I
S
Q
L
N
K
L
K
E
Site 9
S65
N
K
L
K
E
E
P
S
G
S
N
L
P
K
I
Site 10
S67
L
K
E
E
P
S
G
S
N
L
P
K
I
L
S
Site 11
S74
S
N
L
P
K
I
L
S
I
A
R
E
K
I
V
Site 12
S82
I
A
R
E
K
I
V
S
D
E
N
S
N
E
K
Site 13
S86
K
I
V
S
D
E
N
S
N
E
K
C
W
E
K
Site 14
Y123
G
L
P
Q
R
Q
F
Y
E
M
Y
N
S
V
A
Site 15
Y126
Q
R
Q
F
Y
E
M
Y
N
S
V
A
E
E
D
Site 16
T138
E
E
D
L
C
L
E
T
G
I
P
S
P
L
E
Site 17
S142
C
L
E
T
G
I
P
S
P
L
E
R
K
V
F
Site 18
S160
Q
L
E
L
D
R
P
S
M
G
I
S
P
L
G
Site 19
S164
D
R
P
S
M
G
I
S
P
L
G
N
Q
S
V
Site 20
S170
I
S
P
L
G
N
Q
S
V
I
I
E
T
G
R
Site 21
S182
T
G
R
A
H
P
D
S
R
R
A
V
F
H
F
Site 22
Y191
R
A
V
F
H
F
H
Y
E
V
D
R
R
M
S
Site 23
S198
Y
E
V
D
R
R
M
S
D
T
F
C
T
L
S
Site 24
T200
V
D
R
R
M
S
D
T
F
C
T
L
S
E
N
Site 25
S205
S
D
T
F
C
T
L
S
E
N
L
I
L
D
D
Site 26
Y230
E
E
K
Q
K
K
N
Y
V
A
Y
T
C
K
L
Site 27
Y263
C
D
T
L
N
D
K
Y
F
C
F
E
G
S
C
Site 28
Y277
C
E
K
V
D
M
V
Y
S
G
D
S
F
C
R
Site 29
S278
E
K
V
D
M
V
Y
S
G
D
S
F
C
R
K
Site 30
T288
S
F
C
R
K
D
F
T
D
S
Q
A
A
K
T
Site 31
S290
C
R
K
D
F
T
D
S
Q
A
A
K
T
F
L
Site 32
T295
T
D
S
Q
A
A
K
T
F
L
S
H
F
E
D
Site 33
S298
Q
A
A
K
T
F
L
S
H
F
E
D
F
P
D
Site 34
S317
V
E
E
D
A
F
K
S
K
K
E
R
S
T
L
Site 35
T323
K
S
K
K
E
R
S
T
L
L
V
R
R
F
C
Site 36
S339
N
D
R
E
V
K
K
S
V
Y
T
G
T
R
A
Site 37
S362
H
I
G
L
T
A
W
S
Y
I
D
Q
K
R
N
Site 38
Y363
I
G
L
T
A
W
S
Y
I
D
Q
K
R
N
G
Site 39
S383
G
R
V
M
E
P
P
S
T
V
E
I
R
Q
D
Site 40
T384
R
V
M
E
P
P
S
T
V
E
I
R
Q
D
G
Site 41
S392
V
E
I
R
Q
D
G
S
Q
R
L
S
E
A
Q
Site 42
S396
Q
D
G
S
Q
R
L
S
E
A
Q
W
Y
P
I
Site 43
Y401
R
L
S
E
A
Q
W
Y
P
I
Y
N
A
V
R
Site 44
Y404
E
A
Q
W
Y
P
I
Y
N
A
V
R
R
E
E
Site 45
T412
N
A
V
R
R
E
E
T
E
N
T
V
G
S
L
Site 46
T415
R
R
E
E
T
E
N
T
V
G
S
L
L
H
F
Site 47
S418
E
T
E
N
T
V
G
S
L
L
H
F
L
T
K
Site 48
S429
F
L
T
K
L
P
A
S
E
T
A
H
G
R
I
Site 49
S437
E
T
A
H
G
R
I
S
V
G
P
C
L
K
Q
Site 50
T449
L
K
Q
C
V
R
D
T
V
C
E
Y
R
A
T
Site 51
T456
T
V
C
E
Y
R
A
T
L
Q
R
T
S
I
S
Site 52
S461
R
A
T
L
Q
R
T
S
I
S
Q
Y
I
T
G
Site 53
S463
T
L
Q
R
T
S
I
S
Q
Y
I
T
G
S
L
Site 54
Y465
Q
R
T
S
I
S
Q
Y
I
T
G
S
L
L
E
Site 55
S485
G
A
R
S
G
L
L
S
T
F
G
G
S
T
G
Site 56
T486
A
R
S
G
L
L
S
T
F
G
G
S
T
G
R
Site 57
S490
L
L
S
T
F
G
G
S
T
G
R
M
M
L
K
Site 58
S504
K
E
R
Q
P
G
P
S
V
A
N
S
N
A
L
Site 59
S508
P
G
P
S
V
A
N
S
N
A
L
P
S
S
S
Site 60
S513
A
N
S
N
A
L
P
S
S
S
A
G
I
S
K
Site 61
S514
N
S
N
A
L
P
S
S
S
A
G
I
S
K
E
Site 62
S515
S
N
A
L
P
S
S
S
A
G
I
S
K
E
L
Site 63
S519
P
S
S
S
A
G
I
S
K
E
L
I
D
L
Q
Site 64
S537
Q
F
P
E
E
V
A
S
I
L
M
E
Q
E
Q
Site 65
T545
I
L
M
E
Q
E
Q
T
I
Y
R
R
V
L
P
Site 66
Y547
M
E
Q
E
Q
T
I
Y
R
R
V
L
P
V
D
Site 67
T565
F
L
T
R
D
L
G
T
P
E
C
Q
S
S
L
Site 68
S571
G
T
P
E
C
Q
S
S
L
P
C
L
K
A
S
Site 69
T586
I
S
A
S
I
L
T
T
Q
N
G
E
H
N
A
Site 70
Y627
E
K
R
E
V
F
S
Y
L
V
H
V
A
K
C
Site 71
S653
E
F
L
A
G
L
R
S
R
K
V
L
K
M
W
Site 72
T670
M
D
Q
S
D
I
E
T
M
R
S
L
K
D
A
Site 73
S673
S
D
I
E
T
M
R
S
L
K
D
A
M
A
Q
Site 74
Y687
Q
H
E
S
S
C
E
Y
R
K
V
V
T
R
A
Site 75
Y730
L
M
K
L
C
P
R
Y
N
S
Q
E
E
T
L
Site 76
S732
K
L
C
P
R
Y
N
S
Q
E
E
T
L
E
F
Site 77
T736
R
Y
N
S
Q
E
E
T
L
E
F
V
A
D
Y
Site 78
Y743
T
L
E
F
V
A
D
Y
S
G
Q
D
N
F
L
Site 79
S761
G
Q
N
G
L
K
N
S
E
K
E
S
T
V
N
Site 80
S765
L
K
N
S
E
K
E
S
T
V
N
S
I
F
Q
Site 81
T766
K
N
S
E
K
E
S
T
V
N
S
I
F
Q
V
Site 82
S769
E
K
E
S
T
V
N
S
I
F
Q
V
I
R
S
Site 83
S776
S
I
F
Q
V
I
R
S
C
N
R
S
L
E
T
Site 84
S780
V
I
R
S
C
N
R
S
L
E
T
D
E
E
D
Site 85
S788
L
E
T
D
E
E
D
S
P
S
E
G
N
S
S
Site 86
S790
T
D
E
E
D
S
P
S
E
G
N
S
S
R
K
Site 87
S794
D
S
P
S
E
G
N
S
S
R
K
S
S
L
K
Site 88
S795
S
P
S
E
G
N
S
S
R
K
S
S
L
K
D
Site 89
S798
E
G
N
S
S
R
K
S
S
L
K
D
K
S
R
Site 90
S799
G
N
S
S
R
K
S
S
L
K
D
K
S
R
W
Site 91
S804
K
S
S
L
K
D
K
S
R
W
Q
F
I
I
G
Site 92
S816
I
I
G
D
L
L
D
S
D
N
D
I
F
E
Q
Site 93
S824
D
N
D
I
F
E
Q
S
K
E
Y
D
S
H
G
Site 94
Y827
I
F
E
Q
S
K
E
Y
D
S
H
G
S
E
D
Site 95
S829
E
Q
S
K
E
Y
D
S
H
G
S
E
D
S
Q
Site 96
S835
D
S
H
G
S
E
D
S
Q
K
A
F
D
H
G
Site 97
T866
Q
F
L
L
Q
G
A
T
V
I
H
Y
D
Q
D
Site 98
Y870
Q
G
A
T
V
I
H
Y
D
Q
D
T
H
L
S
Site 99
T874
V
I
H
Y
D
Q
D
T
H
L
S
A
R
C
F
Site 100
S889
L
Q
L
Q
P
D
N
S
T
L
T
W
V
K
P
Site 101
T898
L
T
W
V
K
P
T
T
A
S
P
A
S
S
K
Site 102
S900
W
V
K
P
T
T
A
S
P
A
S
S
K
A
K
Site 103
S903
P
T
T
A
S
P
A
S
S
K
A
K
L
G
V
Site 104
T914
K
L
G
V
L
N
N
T
A
E
P
G
K
F
P
Site 105
T955
H
P
G
I
D
I
H
T
V
C
V
Q
N
K
L
Site 106
S964
C
V
Q
N
K
L
G
S
M
F
L
S
E
T
G
Site 107
Y976
E
T
G
V
T
L
L
Y
G
L
Q
T
T
D
N
Site 108
T981
L
L
Y
G
L
Q
T
T
D
N
R
L
L
H
F
Site 109
Y1027
Q
Q
W
L
R
K
Q
Y
V
S
L
Y
Q
E
D
Site 110
S1029
W
L
R
K
Q
Y
V
S
L
Y
Q
E
D
G
R
Site 111
Y1031
R
K
Q
Y
V
S
L
Y
Q
E
D
G
R
Y
E
Site 112
Y1037
L
Y
Q
E
D
G
R
Y
E
G
P
T
L
A
H
Site 113
T1041
D
G
R
Y
E
G
P
T
L
A
H
A
V
E
L
Site 114
S1055
L
F
G
G
R
R
W
S
A
R
N
P
S
P
G
Site 115
S1060
R
W
S
A
R
N
P
S
P
G
T
S
A
K
N
Site 116
S1064
R
N
P
S
P
G
T
S
A
K
N
A
E
K
P
Site 117
T1078
P
N
M
Q
R
N
N
T
L
G
I
S
T
T
K
Site 118
S1096
K
I
L
M
R
G
E
S
G
E
V
T
D
D
E
Site 119
T1100
R
G
E
S
G
E
V
T
D
D
E
M
A
T
R
Site 120
S1117
K
M
H
K
E
C
R
S
R
S
G
S
D
P
Q
Site 121
S1119
H
K
E
C
R
S
R
S
G
S
D
P
Q
D
I
Site 122
S1121
E
C
R
S
R
S
G
S
D
P
Q
D
I
N
E
Site 123
S1132
D
I
N
E
Q
E
E
S
E
V
N
A
I
A
N
Site 124
S1146
N
P
P
N
P
L
P
S
R
R
A
H
S
L
T
Site 125
S1151
L
P
S
R
R
A
H
S
L
T
T
A
G
S
P
Site 126
T1153
S
R
R
A
H
S
L
T
T
A
G
S
P
N
L
Site 127
S1157
H
S
L
T
T
A
G
S
P
N
L
A
A
G
T
Site 128
S1165
P
N
L
A
A
G
T
S
S
P
I
R
P
V
S
Site 129
S1166
N
L
A
A
G
T
S
S
P
I
R
P
V
S
S
Site 130
S1172
S
S
P
I
R
P
V
S
S
P
V
L
S
S
S
Site 131
S1173
S
P
I
R
P
V
S
S
P
V
L
S
S
S
N
Site 132
S1177
P
V
S
S
P
V
L
S
S
S
N
K
S
P
S
Site 133
S1178
V
S
S
P
V
L
S
S
S
N
K
S
P
S
S
Site 134
S1179
S
S
P
V
L
S
S
S
N
K
S
P
S
S
A
Site 135
S1182
V
L
S
S
S
N
K
S
P
S
S
A
W
S
S
Site 136
S1184
S
S
S
N
K
S
P
S
S
A
W
S
S
S
S
Site 137
S1185
S
S
N
K
S
P
S
S
A
W
S
S
S
S
W
Site 138
S1188
K
S
P
S
S
A
W
S
S
S
S
W
H
G
R
Site 139
S1189
S
P
S
S
A
W
S
S
S
S
W
H
G
R
I
Site 140
S1190
P
S
S
A
W
S
S
S
S
W
H
G
R
I
K
Site 141
S1191
S
S
A
W
S
S
S
S
W
H
G
R
I
K
G
Site 142
S1205
G
G
M
K
G
F
Q
S
F
M
V
S
D
S
N
Site 143
S1211
Q
S
F
M
V
S
D
S
N
M
S
F
V
E
F
Site 144
S1224
E
F
V
E
L
F
K
S
F
S
V
R
S
R
K
Site 145
S1226
V
E
L
F
K
S
F
S
V
R
S
R
K
D
L
Site 146
Y1240
L
K
D
L
F
D
V
Y
A
V
P
C
N
R
S
Site 147
S1247
Y
A
V
P
C
N
R
S
G
S
E
S
A
P
L
Site 148
S1249
V
P
C
N
R
S
G
S
E
S
A
P
L
Y
T
Site 149
S1251
C
N
R
S
G
S
E
S
A
P
L
Y
T
N
L
Site 150
Y1255
G
S
E
S
A
P
L
Y
T
N
L
T
I
D
E
Site 151
T1259
A
P
L
Y
T
N
L
T
I
D
E
N
T
S
D
Site 152
T1275
Q
P
D
L
D
L
L
T
R
N
V
S
D
L
G
Site 153
S1287
D
L
G
L
F
I
K
S
K
Q
Q
L
S
D
N
Site 154
S1292
I
K
S
K
Q
Q
L
S
D
N
Q
R
Q
I
S
Site 155
S1299
S
D
N
Q
R
Q
I
S
D
A
I
A
A
A
S
Site 156
S1382
M
D
K
E
N
F
A
S
K
N
D
E
S
Q
E
Site 157
S1387
F
A
S
K
N
D
E
S
Q
E
N
I
K
E
L
Site 158
S1399
K
E
L
Q
L
P
L
S
Y
Y
Y
I
E
S
S
Site 159
Y1400
E
L
Q
L
P
L
S
Y
Y
Y
I
E
S
S
H
Site 160
Y1401
L
Q
L
P
L
S
Y
Y
Y
I
E
S
S
H
N
Site 161
Y1402
Q
L
P
L
S
Y
Y
Y
I
E
S
S
H
N
T
Site 162
T1409
Y
I
E
S
S
H
N
T
Y
L
T
G
H
Q
L
Site 163
Y1410
I
E
S
S
H
N
T
Y
L
T
G
H
Q
L
K
Site 164
S1421
H
Q
L
K
G
E
S
S
V
E
L
Y
S
Q
V
Site 165
Y1425
G
E
S
S
V
E
L
Y
S
Q
V
L
L
Q
G
Site 166
Y1451
D
D
G
M
P
I
I
Y
H
G
H
T
L
T
T
Site 167
S1520
F
L
F
E
T
D
F
S
D
D
P
M
L
P
S
Site 168
S1527
S
D
D
P
M
L
P
S
P
D
Q
L
R
K
K
Site 169
T1547
K
K
L
K
A
H
Q
T
P
V
D
I
L
K
Q
Site 170
Y1589
E
E
D
E
E
D
E
Y
D
Y
D
Y
E
S
L
Site 171
Y1591
D
E
E
D
E
Y
D
Y
D
Y
E
S
L
S
D
Site 172
Y1593
E
D
E
Y
D
Y
D
Y
E
S
L
S
D
D
N
Site 173
S1595
E
Y
D
Y
D
Y
E
S
L
S
D
D
N
I
L
Site 174
S1597
D
Y
D
Y
E
S
L
S
D
D
N
I
L
E
D
Site 175
S1610
E
D
R
P
E
N
K
S
C
N
D
K
L
Q
F
Site 176
S1633
R
I
K
K
A
D
N
S
A
C
N
K
G
K
V
Site 177
Y1641
A
C
N
K
G
K
V
Y
D
M
E
L
G
E
E
Site 178
T1682
V
K
F
P
G
L
S
T
L
N
A
S
G
S
S
Site 179
S1686
G
L
S
T
L
N
A
S
G
S
S
R
G
K
E
Site 180
S1688
S
T
L
N
A
S
G
S
S
R
G
K
E
R
K
Site 181
S1696
S
R
G
K
E
R
K
S
R
K
S
I
F
G
N
Site 182
S1699
K
E
R
K
S
R
K
S
I
F
G
N
N
P
G
Site 183
S1709
G
N
N
P
G
R
M
S
P
G
E
T
A
S
F
Site 184
T1713
G
R
M
S
P
G
E
T
A
S
F
N
K
T
S
Site 185
S1715
M
S
P
G
E
T
A
S
F
N
K
T
S
G
K
Site 186
T1719
E
T
A
S
F
N
K
T
S
G
K
S
S
C
E
Site 187
S1720
T
A
S
F
N
K
T
S
G
K
S
S
C
E
G
Site 188
S1724
N
K
T
S
G
K
S
S
C
E
G
I
R
Q
T
Site 189
T1731
S
C
E
G
I
R
Q
T
W
E
E
S
S
S
P
Site 190
S1735
I
R
Q
T
W
E
E
S
S
S
P
L
N
P
T
Site 191
S1737
Q
T
W
E
E
S
S
S
P
L
N
P
T
T
S
Site 192
T1743
S
S
P
L
N
P
T
T
S
L
S
A
I
I
R
Site 193
S1744
S
P
L
N
P
T
T
S
L
S
A
I
I
R
T
Site 194
S1746
L
N
P
T
T
S
L
S
A
I
I
R
T
P
K
Site 195
Y1755
I
I
R
T
P
K
C
Y
H
I
S
S
L
N
E
Site 196
S1759
P
K
C
Y
H
I
S
S
L
N
E
N
A
A
K
Site 197
Y1772
A
K
R
L
C
R
R
Y
S
Q
K
L
T
Q
H
Site 198
S1773
K
R
L
C
R
R
Y
S
Q
K
L
T
Q
H
T
Site 199
T1777
R
R
Y
S
Q
K
L
T
Q
H
T
A
C
Q
L
Site 200
Y1788
A
C
Q
L
L
R
T
Y
P
A
A
T
R
I
D
Site 201
S1796
P
A
A
T
R
I
D
S
S
N
P
N
P
L
M
Site 202
S1797
A
A
T
R
I
D
S
S
N
P
N
P
L
M
F
Site 203
T1818
L
V
A
L
N
Y
Q
T
D
D
L
P
L
H
L
Site 204
Y1853
W
D
K
N
C
P
M
Y
Q
K
F
S
P
L
E
Site 205
S1857
C
P
M
Y
Q
K
F
S
P
L
E
R
D
L
D
Site 206
S1865
P
L
E
R
D
L
D
S
M
D
P
A
V
Y
S
Site 207
S1884
S
G
Q
N
V
C
P
S
N
S
M
G
S
P
C
Site 208
S1886
Q
N
V
C
P
S
N
S
M
G
S
P
C
I
E
Site 209
S1903
V
L
G
M
P
L
D
S
C
H
F
R
T
K
P
Site 210
Y1963
L
K
A
L
K
R
G
Y
R
H
L
Q
L
R
N
Site 211
S1980
N
E
V
L
E
I
S
S
L
F
I
N
S
R
R
Site 212
S1985
I
S
S
L
F
I
N
S
R
R
M
E
E
N
S
Site 213
S1992
S
R
R
M
E
E
N
S
S
G
N
T
M
S
A
Site 214
S1993
R
R
M
E
E
N
S
S
G
N
T
M
S
A
S
Site 215
T1996
E
E
N
S
S
G
N
T
M
S
A
S
S
M
F
Site 216
S1998
N
S
S
G
N
T
M
S
A
S
S
M
F
N
T
Site 217
S2000
S
G
N
T
M
S
A
S
S
M
F
N
T
E
E
Site 218
T2005
S
A
S
S
M
F
N
T
E
E
R
K
C
L
Q
Site 219
T2013
E
E
R
K
C
L
Q
T
H
R
V
T
V
H
G
Site 220
T2017
C
L
Q
T
H
R
V
T
V
H
G
V
P
G
P
Site 221
T2056
E
Q
D
I
K
P
V
T
T
D
Y
F
L
M
E
Site 222
Y2059
I
K
P
V
T
T
D
Y
F
L
M
E
E
K
Y
Site 223
Y2066
Y
F
L
M
E
E
K
Y
F
I
S
K
E
K
N
Site 224
S2095
E
E
I
M
Q
I
L
S
S
W
F
P
E
E
G
Site 225
Y2103
S
W
F
P
E
E
G
Y
M
G
R
I
V
L
K
Site 226
T2111
M
G
R
I
V
L
K
T
Q
Q
E
N
L
E
E
Site 227
S2131
D
D
K
E
V
I
L
S
S
E
E
E
S
F
F
Site 228
S2132
D
K
E
V
I
L
S
S
E
E
E
S
F
F
V
Site 229
S2136
I
L
S
S
E
E
E
S
F
F
V
Q
V
H
D
Site 230
S2145
F
V
Q
V
H
D
V
S
P
E
Q
P
R
T
V
Site 231
T2151
V
S
P
E
Q
P
R
T
V
I
K
A
P
R
V
Site 232
T2160
I
K
A
P
R
V
S
T
A
Q
D
V
I
Q
Q
Site 233
T2168
A
Q
D
V
I
Q
Q
T
L
C
K
A
K
Y
S
Site 234
Y2174
Q
T
L
C
K
A
K
Y
S
Y
S
I
L
S
N
Site 235
S2175
T
L
C
K
A
K
Y
S
Y
S
I
L
S
N
P
Site 236
S2177
C
K
A
K
Y
S
Y
S
I
L
S
N
P
N
P
Site 237
S2180
K
Y
S
Y
S
I
L
S
N
P
N
P
S
D
Y
Site 238
S2185
I
L
S
N
P
N
P
S
D
Y
V
L
L
E
E
Site 239
Y2187
S
N
P
N
P
S
D
Y
V
L
L
E
E
V
V
Site 240
T2197
L
E
E
V
V
K
D
T
T
N
K
K
T
T
T
Site 241
T2202
K
D
T
T
N
K
K
T
T
T
P
K
S
S
Q
Site 242
T2203
D
T
T
N
K
K
T
T
T
P
K
S
S
Q
R
Site 243
T2204
T
T
N
K
K
T
T
T
P
K
S
S
Q
R
V
Site 244
S2207
K
K
T
T
T
P
K
S
S
Q
R
V
L
L
D
Site 245
S2208
K
T
T
T
P
K
S
S
Q
R
V
L
L
D
Q
Site 246
S2251
E
D
K
K
K
G
I
S
F
A
S
E
L
K
K
Site 247
T2270
T
K
Q
P
R
G
L
T
S
P
S
Q
L
L
T
Site 248
S2271
K
Q
P
R
G
L
T
S
P
S
Q
L
L
T
S
Site 249
S2273
P
R
G
L
T
S
P
S
Q
L
L
T
S
E
S
Site 250
T2277
T
S
P
S
Q
L
L
T
S
E
S
I
Q
T
K
Site 251
S2278
S
P
S
Q
L
L
T
S
E
S
I
Q
T
K
E
Site 252
S2280
S
Q
L
L
T
S
E
S
I
Q
T
K
E
E
K
Site 253
T2283
L
T
S
E
S
I
Q
T
K
E
E
K
P
V
G
Site 254
S2293
E
K
P
V
G
G
L
S
S
S
D
T
M
D
Y
Site 255
S2294
K
P
V
G
G
L
S
S
S
D
T
M
D
Y
R
Site 256
S2295
P
V
G
G
L
S
S
S
D
T
M
D
Y
R
Q
Site 257
T2297
G
G
L
S
S
S
D
T
M
D
Y
R
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation