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Updated November 2019
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Protein Info
Short Name:
PHRF1
Full Name:
PHD and RING finger domain-containing protein 1
Alias:
CTD binding SR like protein rA9; K1542; KIAA1542; PHD and ring finger domains 1; RNF221
Type:
Unknown function
Mass (Da):
178610
Number AA:
1649
UniProt ID:
Q9P1Y6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0070063
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
D
D
S
L
D
E
L
V
A
R
Site 2
S13
L
D
E
L
V
A
R
S
P
G
P
D
G
H
P
Site 3
S34
P
A
G
D
F
E
E
S
S
V
G
S
S
G
D
Site 4
S35
A
G
D
F
E
E
S
S
V
G
S
S
G
D
S
Site 5
S38
F
E
E
S
S
V
G
S
S
G
D
S
G
D
D
Site 6
S39
E
E
S
S
V
G
S
S
G
D
S
G
D
D
S
Site 7
S42
S
V
G
S
S
G
D
S
G
D
D
S
D
S
E
Site 8
S46
S
G
D
S
G
D
D
S
D
S
E
H
G
D
G
Site 9
S48
D
S
G
D
D
S
D
S
E
H
G
D
G
T
D
Site 10
T54
D
S
E
H
G
D
G
T
D
G
E
D
E
G
A
Site 11
S62
D
G
E
D
E
G
A
S
E
E
E
D
L
E
D
Site 12
S71
E
E
D
L
E
D
R
S
G
S
E
D
S
E
D
Site 13
S73
D
L
E
D
R
S
G
S
E
D
S
E
D
D
G
Site 14
S76
D
R
S
G
S
E
D
S
E
D
D
G
E
T
L
Site 15
S98
G
K
L
E
A
A
G
S
F
N
S
D
D
D
A
Site 16
S101
E
A
A
G
S
F
N
S
D
D
D
A
E
S
C
Site 17
S107
N
S
D
D
D
A
E
S
C
P
I
C
L
N
A
Site 18
T122
F
R
D
Q
A
V
G
T
P
E
N
C
A
H
Y
Site 19
T184
S
E
E
E
E
D
P
T
F
C
E
V
C
G
R
Site 20
S192
F
C
E
V
C
G
R
S
D
R
E
D
R
L
L
Site 21
T260
L
A
D
V
V
P
T
T
S
R
L
R
P
R
A
Site 22
S261
A
D
V
V
P
T
T
S
R
L
R
P
R
A
G
Site 23
T276
R
T
R
A
I
A
R
T
R
Q
S
E
R
V
R
Site 24
S279
A
I
A
R
T
R
Q
S
E
R
V
R
A
T
V
Site 25
T285
Q
S
E
R
V
R
A
T
V
N
R
N
R
I
S
Site 26
S292
T
V
N
R
N
R
I
S
T
A
R
R
V
Q
H
Site 27
T293
V
N
R
N
R
I
S
T
A
R
R
V
Q
H
T
Site 28
T300
T
A
R
R
V
Q
H
T
P
G
R
L
G
S
S
Site 29
S306
H
T
P
G
R
L
G
S
S
L
L
D
E
A
I
Site 30
S307
T
P
G
R
L
G
S
S
L
L
D
E
A
I
E
Site 31
Y325
T
G
L
S
T
A
V
Y
Q
R
P
L
T
P
R
Site 32
T330
A
V
Y
Q
R
P
L
T
P
R
T
P
A
R
R
Site 33
T333
Q
R
P
L
T
P
R
T
P
A
R
R
K
R
K
Site 34
T341
P
A
R
R
K
R
K
T
R
R
R
K
K
V
P
Site 35
T353
K
V
P
G
R
K
K
T
P
S
G
P
S
A
K
Site 36
S355
P
G
R
K
K
T
P
S
G
P
S
A
K
S
K
Site 37
S358
K
K
T
P
S
G
P
S
A
K
S
K
S
S
A
Site 38
S361
P
S
G
P
S
A
K
S
K
S
S
A
T
R
S
Site 39
S363
G
P
S
A
K
S
K
S
S
A
T
R
S
K
K
Site 40
S364
P
S
A
K
S
K
S
S
A
T
R
S
K
K
R
Site 41
T366
A
K
S
K
S
S
A
T
R
S
K
K
R
Q
H
Site 42
S368
S
K
S
S
A
T
R
S
K
K
R
Q
H
R
V
Site 43
S385
R
R
G
K
K
V
K
S
E
A
T
T
R
S
R
Site 44
T389
K
V
K
S
E
A
T
T
R
S
R
I
A
R
T
Site 45
S406
L
R
R
P
V
H
S
S
C
I
P
S
V
L
K
Site 46
Y438
L
S
L
F
G
D
P
Y
E
L
D
P
F
D
S
Site 47
S445
Y
E
L
D
P
F
D
S
S
E
E
L
S
A
N
Site 48
S446
E
L
D
P
F
D
S
S
E
E
L
S
A
N
P
Site 49
S450
F
D
S
S
E
E
L
S
A
N
P
L
S
P
L
Site 50
S455
E
L
S
A
N
P
L
S
P
L
S
A
K
R
R
Site 51
S458
A
N
P
L
S
P
L
S
A
K
R
R
A
L
S
Site 52
S465
S
A
K
R
R
A
L
S
R
S
A
L
Q
S
H
Site 53
S467
K
R
R
A
L
S
R
S
A
L
Q
S
H
Q
P
Site 54
S471
L
S
R
S
A
L
Q
S
H
Q
P
V
A
R
P
Site 55
S480
Q
P
V
A
R
P
V
S
V
G
L
S
R
R
R
Site 56
S484
R
P
V
S
V
G
L
S
R
R
R
L
P
A
A
Site 57
S530
V
I
I
H
R
D
G
S
L
S
A
K
R
A
A
Site 58
S532
I
H
R
D
G
S
L
S
A
K
R
A
A
P
V
Site 59
S540
A
K
R
A
A
P
V
S
F
Q
R
N
S
G
S
Site 60
S545
P
V
S
F
Q
R
N
S
G
S
L
S
R
G
E
Site 61
S547
S
F
Q
R
N
S
G
S
L
S
R
G
E
E
G
Site 62
S549
Q
R
N
S
G
S
L
S
R
G
E
E
G
F
K
Site 63
S566
L
Q
P
R
A
L
P
S
G
S
P
A
Q
G
P
Site 64
S568
P
R
A
L
P
S
G
S
P
A
Q
G
P
S
G
Site 65
S574
G
S
P
A
Q
G
P
S
G
N
R
P
Q
S
T
Site 66
S580
P
S
G
N
R
P
Q
S
T
G
L
S
C
Q
G
Site 67
T581
S
G
N
R
P
Q
S
T
G
L
S
C
Q
G
R
Site 68
S584
R
P
Q
S
T
G
L
S
C
Q
G
R
S
R
T
Site 69
T591
S
C
Q
G
R
S
R
T
P
A
R
T
A
G
A
Site 70
T595
R
S
R
T
P
A
R
T
A
G
A
P
V
R
L
Site 71
S617
A
V
Q
A
R
N
L
S
N
G
S
V
P
G
F
Site 72
S620
A
R
N
L
S
N
G
S
V
P
G
F
R
Q
S
Site 73
S627
S
V
P
G
F
R
Q
S
H
S
P
W
F
N
G
Site 74
S629
P
G
F
R
Q
S
H
S
P
W
F
N
G
T
N
Site 75
T639
F
N
G
T
N
K
H
T
L
P
L
A
S
A
A
Site 76
S644
K
H
T
L
P
L
A
S
A
A
S
K
I
S
S
Site 77
S647
L
P
L
A
S
A
A
S
K
I
S
S
R
D
S
Site 78
S650
A
S
A
A
S
K
I
S
S
R
D
S
K
P
P
Site 79
S651
S
A
A
S
K
I
S
S
R
D
S
K
P
P
C
Site 80
S654
S
K
I
S
S
R
D
S
K
P
P
C
R
S
V
Site 81
S660
D
S
K
P
P
C
R
S
V
V
P
G
P
P
L
Site 82
T674
L
K
P
A
P
R
R
T
D
I
S
E
L
P
R
Site 83
S677
A
P
R
R
T
D
I
S
E
L
P
R
I
P
K
Site 84
S712
E
I
P
S
A
C
I
S
R
L
T
G
R
E
G
Site 85
T715
S
A
C
I
S
R
L
T
G
R
E
G
T
G
Q
Site 86
T720
R
L
T
G
R
E
G
T
G
Q
P
G
R
G
T
Site 87
T727
T
G
Q
P
G
R
G
T
R
A
E
S
E
A
S
Site 88
S731
G
R
G
T
R
A
E
S
E
A
S
S
R
V
P
Site 89
S734
T
R
A
E
S
E
A
S
S
R
V
P
R
E
P
Site 90
S735
R
A
E
S
E
A
S
S
R
V
P
R
E
P
G
Site 91
T745
P
R
E
P
G
V
H
T
G
S
S
R
P
P
A
Site 92
S747
E
P
G
V
H
T
G
S
S
R
P
P
A
P
S
Site 93
S748
P
G
V
H
T
G
S
S
R
P
P
A
P
S
S
Site 94
S754
S
S
R
P
P
A
P
S
S
H
G
S
L
A
P
Site 95
S755
S
R
P
P
A
P
S
S
H
G
S
L
A
P
L
Site 96
S758
P
A
P
S
S
H
G
S
L
A
P
L
G
P
S
Site 97
S772
S
R
G
K
G
V
G
S
T
F
E
S
F
R
I
Site 98
T773
R
G
K
G
V
G
S
T
F
E
S
F
R
I
N
Site 99
S776
G
V
G
S
T
F
E
S
F
R
I
N
I
P
G
Site 100
S788
I
P
G
N
M
A
H
S
S
Q
L
S
S
P
G
Site 101
S789
P
G
N
M
A
H
S
S
Q
L
S
S
P
G
F
Site 102
S792
M
A
H
S
S
Q
L
S
S
P
G
F
C
N
T
Site 103
S793
A
H
S
S
Q
L
S
S
P
G
F
C
N
T
F
Site 104
T799
S
S
P
G
F
C
N
T
F
R
P
V
D
D
K
Site 105
S814
E
Q
R
K
E
N
P
S
P
L
F
S
I
K
K
Site 106
S818
E
N
P
S
P
L
F
S
I
K
K
T
K
Q
L
Site 107
T822
P
L
F
S
I
K
K
T
K
Q
L
R
S
E
V
Site 108
S827
K
K
T
K
Q
L
R
S
E
V
Y
D
P
S
D
Site 109
Y830
K
Q
L
R
S
E
V
Y
D
P
S
D
P
T
G
Site 110
S833
R
S
E
V
Y
D
P
S
D
P
T
G
S
D
S
Site 111
T836
V
Y
D
P
S
D
P
T
G
S
D
S
S
A
P
Site 112
S838
D
P
S
D
P
T
G
S
D
S
S
A
P
G
S
Site 113
S840
S
D
P
T
G
S
D
S
S
A
P
G
S
S
P
Site 114
S841
D
P
T
G
S
D
S
S
A
P
G
S
S
P
E
Site 115
S845
S
D
S
S
A
P
G
S
S
P
E
R
S
G
P
Site 116
S846
D
S
S
A
P
G
S
S
P
E
R
S
G
P
G
Site 117
S850
P
G
S
S
P
E
R
S
G
P
G
L
L
P
S
Site 118
S857
S
G
P
G
L
L
P
S
E
I
T
R
T
I
S
Site 119
T862
L
P
S
E
I
T
R
T
I
S
I
N
S
P
K
Site 120
S864
S
E
I
T
R
T
I
S
I
N
S
P
K
A
Q
Site 121
S867
T
R
T
I
S
I
N
S
P
K
A
Q
T
V
Q
Site 122
T890
T
V
E
S
I
F
G
T
E
P
E
P
P
L
G
Site 123
S899
P
E
P
P
L
G
P
S
S
A
M
S
K
L
R
Site 124
S900
E
P
P
L
G
P
S
S
A
M
S
K
L
R
G
Site 125
S915
A
V
A
A
E
G
A
S
D
T
E
R
E
E
P
Site 126
T917
A
A
E
G
A
S
D
T
E
R
E
E
P
T
E
Site 127
T923
D
T
E
R
E
E
P
T
E
S
Q
G
L
A
A
Site 128
S925
E
R
E
E
P
T
E
S
Q
G
L
A
A
R
L
Site 129
S936
A
A
R
L
R
R
P
S
P
P
E
P
W
D
E
Site 130
S948
W
D
E
E
D
G
A
S
C
S
T
F
F
G
S
Site 131
S950
E
E
D
G
A
S
C
S
T
F
F
G
S
E
E
Site 132
T951
E
D
G
A
S
C
S
T
F
F
G
S
E
E
R
Site 133
T961
G
S
E
E
R
T
V
T
C
V
T
V
V
E
P
Site 134
S973
V
E
P
E
A
P
P
S
P
D
V
L
Q
A
A
Site 135
T981
P
D
V
L
Q
A
A
T
H
R
V
V
E
L
R
Site 136
S991
V
V
E
L
R
P
P
S
R
S
R
S
T
S
S
Site 137
S993
E
L
R
P
P
S
R
S
R
S
T
S
S
S
R
Site 138
S995
R
P
P
S
R
S
R
S
T
S
S
S
R
S
R
Site 139
T996
P
P
S
R
S
R
S
T
S
S
S
R
S
R
K
Site 140
S997
P
S
R
S
R
S
T
S
S
S
R
S
R
K
K
Site 141
S998
S
R
S
R
S
T
S
S
S
R
S
R
K
K
A
Site 142
S999
R
S
R
S
T
S
S
S
R
S
R
K
K
A
K
Site 143
S1001
R
S
T
S
S
S
R
S
R
K
K
A
K
R
K
Site 144
S1011
K
A
K
R
K
R
V
S
R
E
H
G
R
T
R
Site 145
T1017
V
S
R
E
H
G
R
T
R
S
G
T
R
S
E
Site 146
S1019
R
E
H
G
R
T
R
S
G
T
R
S
E
S
R
Site 147
T1021
H
G
R
T
R
S
G
T
R
S
E
S
R
D
R
Site 148
S1023
R
T
R
S
G
T
R
S
E
S
R
D
R
S
S
Site 149
S1025
R
S
G
T
R
S
E
S
R
D
R
S
S
R
S
Site 150
S1029
R
S
E
S
R
D
R
S
S
R
S
A
S
P
S
Site 151
S1030
S
E
S
R
D
R
S
S
R
S
A
S
P
S
V
Site 152
S1032
S
R
D
R
S
S
R
S
A
S
P
S
V
G
E
Site 153
S1034
D
R
S
S
R
S
A
S
P
S
V
G
E
E
R
Site 154
S1036
S
S
R
S
A
S
P
S
V
G
E
E
R
P
R
Site 155
S1047
E
R
P
R
R
Q
R
S
K
A
K
S
R
R
S
Site 156
S1051
R
Q
R
S
K
A
K
S
R
R
S
S
S
D
R
Site 157
S1054
S
K
A
K
S
R
R
S
S
S
D
R
S
S
S
Site 158
S1055
K
A
K
S
R
R
S
S
S
D
R
S
S
S
R
Site 159
S1056
A
K
S
R
R
S
S
S
D
R
S
S
S
R
E
Site 160
S1059
R
R
S
S
S
D
R
S
S
S
R
E
R
A
K
Site 161
S1060
R
S
S
S
D
R
S
S
S
R
E
R
A
K
R
Site 162
S1061
S
S
S
D
R
S
S
S
R
E
R
A
K
R
K
Site 163
S1074
R
K
K
A
K
D
K
S
R
E
H
R
R
G
P
Site 164
S1085
R
R
G
P
W
G
H
S
R
R
T
S
R
S
R
Site 165
T1088
P
W
G
H
S
R
R
T
S
R
S
R
S
G
S
Site 166
S1089
W
G
H
S
R
R
T
S
R
S
R
S
G
S
P
Site 167
S1091
H
S
R
R
T
S
R
S
R
S
G
S
P
G
S
Site 168
S1093
R
R
T
S
R
S
R
S
G
S
P
G
S
S
S
Site 169
S1095
T
S
R
S
R
S
G
S
P
G
S
S
S
Y
E
Site 170
S1098
R
R
T
S
R
S
R
S
G
S
P
G
S
S
S
Site 171
S1099
R
S
G
S
P
G
S
S
S
Y
E
H
Y
E
S
Site 172
S1100
T
S
R
S
R
S
G
S
P
G
S
S
S
Y
E
Site 173
Y1101
G
S
P
G
S
S
S
Y
E
H
Y
E
S
R
K
Site 174
Y1104
G
S
S
S
Y
E
H
Y
E
S
R
K
K
K
K
Site 175
S1106
S
S
Y
E
H
Y
E
S
R
K
K
K
K
R
R
Site 176
S1114
R
K
K
K
K
R
R
S
A
S
R
P
R
G
R
Site 177
S1116
K
K
K
R
R
S
A
S
R
P
R
G
R
E
C
Site 178
S1124
R
P
R
G
R
E
C
S
P
T
S
S
L
E
R
Site 179
T1126
R
G
R
E
C
S
P
T
S
S
L
E
R
L
C
Site 180
S1127
G
R
E
C
S
P
T
S
S
L
E
R
L
C
R
Site 181
S1128
R
E
C
S
P
T
S
S
L
E
R
L
C
R
H
Site 182
S1142
H
K
H
Q
R
E
R
S
H
E
R
P
D
R
K
Site 183
S1151
E
R
P
D
R
K
E
S
V
A
W
P
R
D
R
Site 184
S1163
R
D
R
R
K
R
R
S
R
S
P
S
S
E
H
Site 185
S1165
R
R
K
R
R
S
R
S
P
S
S
E
H
R
A
Site 186
S1167
K
R
R
S
R
S
P
S
S
E
H
R
A
R
E
Site 187
S1168
R
R
S
R
S
P
S
S
E
H
R
A
R
E
H
Site 188
S1180
R
E
H
R
R
P
R
S
R
E
K
W
P
Q
T
Site 189
T1187
S
R
E
K
W
P
Q
T
R
S
H
S
P
E
R
Site 190
S1189
E
K
W
P
Q
T
R
S
H
S
P
E
R
K
G
Site 191
S1191
W
P
Q
T
R
S
H
S
P
E
R
K
G
A
V
Site 192
S1202
K
G
A
V
R
E
A
S
P
A
P
L
A
Q
G
Site 193
T1218
P
G
R
E
D
L
P
T
R
L
P
A
L
G
E
Site 194
S1229
A
L
G
E
A
H
V
S
P
E
V
A
T
A
D
Site 195
Y1261
P
D
D
L
D
L
D
Y
G
D
S
V
E
A
G
Site 196
S1264
L
D
L
D
Y
G
D
S
V
E
A
G
H
V
F
Site 197
S1287
F
I
Q
L
D
D
M
S
S
P
P
S
P
E
S
Site 198
S1288
I
Q
L
D
D
M
S
S
P
P
S
P
E
S
T
Site 199
S1291
D
D
M
S
S
P
P
S
P
E
S
T
D
S
S
Site 200
S1294
S
S
P
P
S
P
E
S
T
D
S
S
P
E
R
Site 201
T1295
S
P
P
S
P
E
S
T
D
S
S
P
E
R
D
Site 202
S1297
P
S
P
E
S
T
D
S
S
P
E
R
D
F
P
Site 203
S1298
S
P
E
S
T
D
S
S
P
E
R
D
F
P
L
Site 204
S1324
A
A
I
Q
R
E
V
S
L
M
H
D
E
D
P
Site 205
S1332
L
M
H
D
E
D
P
S
Q
P
P
P
L
P
E
Site 206
T1341
P
P
P
L
P
E
G
T
Q
E
P
H
L
L
R
Site 207
S1359
A
E
K
A
E
A
P
S
S
P
D
V
A
P
A
Site 208
S1360
E
K
A
E
A
P
S
S
P
D
V
A
P
A
G
Site 209
S1371
A
P
A
G
K
E
D
S
P
S
A
S
G
R
V
Site 210
S1373
A
G
K
E
D
S
P
S
A
S
G
R
V
Q
E
Site 211
S1375
K
E
D
S
P
S
A
S
G
R
V
Q
E
A
A
Site 212
S1389
A
R
P
E
E
V
V
S
Q
T
P
L
L
R
S
Site 213
T1391
P
E
E
V
V
S
Q
T
P
L
L
R
S
R
A
Site 214
T1404
R
A
L
V
K
R
V
T
W
N
L
Q
E
S
E
Site 215
S1410
V
T
W
N
L
Q
E
S
E
S
S
A
P
A
E
Site 216
S1412
W
N
L
Q
E
S
E
S
S
A
P
A
E
D
R
Site 217
S1413
N
L
Q
E
S
E
S
S
A
P
A
E
D
R
A
Site 218
S1451
T
G
V
R
Q
A
F
S
E
L
P
F
P
S
H
Site 219
S1457
F
S
E
L
P
F
P
S
H
V
L
P
E
P
G
Site 220
T1468
P
E
P
G
F
P
D
T
D
P
S
Q
V
Y
S
Site 221
S1471
G
F
P
D
T
D
P
S
Q
V
Y
S
P
G
L
Site 222
S1475
T
D
P
S
Q
V
Y
S
P
G
L
P
P
A
P
Site 223
S1486
P
P
A
P
A
Q
P
S
S
I
P
P
C
A
L
Site 224
S1529
P
A
A
L
T
P
A
S
E
P
A
S
Q
A
T
Site 225
S1533
T
P
A
S
E
P
A
S
Q
A
T
A
A
S
N
Site 226
S1539
A
S
Q
A
T
A
A
S
N
S
E
E
K
T
P
Site 227
T1545
A
S
N
S
E
E
K
T
P
A
P
R
L
A
A
Site 228
T1555
P
R
L
A
A
E
K
T
K
K
E
E
Y
M
K
Site 229
Y1582
K
L
A
I
K
P
F
Y
Q
K
R
E
V
T
K
Site 230
T1588
F
Y
Q
K
R
E
V
T
K
E
E
Y
K
D
I
Site 231
S1608
Q
K
I
C
H
S
K
S
G
E
I
N
P
V
K
Site 232
Y1623
V
A
N
L
V
K
A
Y
V
D
K
Y
R
H
M
Site 233
Y1627
V
K
A
Y
V
D
K
Y
R
H
M
R
R
H
K
Site 234
T1644
E
A
G
E
E
P
P
T
Q
G
A
E
G
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation