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Updated November 2019
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Protein Info
Short Name:
SAPAP2
Full Name:
Disks large-associated protein 2
Alias:
DAP2; DAP-2; Discs, large-associated protein 2; DLGAP2; DLGP2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2
Type:
Enzyme, kinase, metabolite
Mass (Da):
117620
Number AA:
1054
UniProt ID:
Q9P1A6
International Prot ID:
IPI00033086
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0005883
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007270
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
C
I
L
P
D
R
N
T
E
S
Q
C
T
L
C
Site 2
S25
L
P
D
R
N
T
E
S
Q
C
T
L
C
G
E
Site 3
T28
R
N
T
E
S
Q
C
T
L
C
G
E
P
E
E
Site 4
S47
D
L
V
Q
P
G
I
S
F
P
G
P
A
E
E
Site 5
Y60
E
E
D
L
D
P
Q
Y
S
W
S
P
T
Q
H
Site 6
S61
E
D
L
D
P
Q
Y
S
W
S
P
T
Q
H
F
Site 7
S63
L
D
P
Q
Y
S
W
S
P
T
Q
H
F
N
E
Site 8
S74
H
F
N
E
E
R
Y
S
P
A
P
R
S
M
K
Site 9
S79
R
Y
S
P
A
P
R
S
M
K
G
L
S
G
S
Site 10
S84
P
R
S
M
K
G
L
S
G
S
R
T
Q
P
P
Site 11
S86
S
M
K
G
L
S
G
S
R
T
Q
P
P
L
C
Site 12
T88
K
G
L
S
G
S
R
T
Q
P
P
L
C
S
G
Site 13
Y119
G
P
D
A
R
P
P
Y
L
L
S
P
A
D
S
Site 14
S122
A
R
P
P
Y
L
L
S
P
A
D
S
C
P
G
Site 15
S126
Y
L
L
S
P
A
D
S
C
P
G
G
R
H
R
Site 16
S135
P
G
G
R
H
R
C
S
P
R
S
S
V
H
S
Site 17
S138
R
H
R
C
S
P
R
S
S
V
H
S
E
C
V
Site 18
S139
H
R
C
S
P
R
S
S
V
H
S
E
C
V
M
Site 19
S142
S
P
R
S
S
V
H
S
E
C
V
M
M
P
V
Site 20
S157
V
L
G
D
H
V
S
S
S
T
F
P
R
M
H
Site 21
S158
L
G
D
H
V
S
S
S
T
F
P
R
M
H
Y
Site 22
T159
G
D
H
V
S
S
S
T
F
P
R
M
H
Y
S
Site 23
Y165
S
T
F
P
R
M
H
Y
S
S
H
Y
D
T
R
Site 24
Y169
R
M
H
Y
S
S
H
Y
D
T
R
D
D
C
A
Site 25
T208
L
H
R
D
G
F
H
T
L
Q
Y
Q
R
T
S
Site 26
Y211
D
G
F
H
T
L
Q
Y
Q
R
T
S
A
A
A
Site 27
S215
T
L
Q
Y
Q
R
T
S
A
A
A
E
Q
R
S
Site 28
S222
S
A
A
A
E
Q
R
S
E
S
P
G
R
I
R
Site 29
S224
A
A
E
Q
R
S
E
S
P
G
R
I
R
H
L
Site 30
S234
R
I
R
H
L
V
H
S
V
Q
K
L
F
T
K
Site 31
T240
H
S
V
Q
K
L
F
T
K
S
H
S
L
E
G
Site 32
S242
V
Q
K
L
F
T
K
S
H
S
L
E
G
S
S
Site 33
S244
K
L
F
T
K
S
H
S
L
E
G
S
S
K
S
Site 34
S248
K
S
H
S
L
E
G
S
S
K
S
N
A
N
G
Site 35
S251
S
L
E
G
S
S
K
S
N
A
N
G
T
K
A
Site 36
S274
H
A
H
H
A
K
H
S
K
R
S
K
S
K
E
Site 37
S279
K
H
S
K
R
S
K
S
K
E
R
K
P
E
G
Site 38
S293
G
K
P
R
P
G
M
S
S
W
W
S
S
D
D
Site 39
S294
K
P
R
P
G
M
S
S
W
W
S
S
D
D
N
Site 40
S297
P
G
M
S
S
W
W
S
S
D
D
N
L
D
S
Site 41
S298
G
M
S
S
W
W
S
S
D
D
N
L
D
S
D
Site 42
S304
S
S
D
D
N
L
D
S
D
S
T
Y
R
T
P
Site 43
S306
D
D
N
L
D
S
D
S
T
Y
R
T
P
S
V
Site 44
T307
D
N
L
D
S
D
S
T
Y
R
T
P
S
V
L
Site 45
Y308
N
L
D
S
D
S
T
Y
R
T
P
S
V
L
N
Site 46
T310
D
S
D
S
T
Y
R
T
P
S
V
L
N
R
H
Site 47
S312
D
S
T
Y
R
T
P
S
V
L
N
R
H
H
L
Site 48
Y326
L
G
P
V
A
H
C
Y
P
D
A
L
Q
S
P
Site 49
S332
C
Y
P
D
A
L
Q
S
P
F
G
D
L
S
L
Site 50
S338
Q
S
P
F
G
D
L
S
L
K
T
S
K
S
N
Site 51
S342
G
D
L
S
L
K
T
S
K
S
N
N
D
V
K
Site 52
S344
L
S
L
K
T
S
K
S
N
N
D
V
K
C
S
Site 53
T359
A
C
E
G
L
A
L
T
P
D
A
K
Y
L
K
Site 54
Y364
A
L
T
P
D
A
K
Y
L
K
R
S
S
W
S
Site 55
S369
A
K
Y
L
K
R
S
S
W
S
T
L
T
V
S
Site 56
T372
L
K
R
S
S
W
S
T
L
T
V
S
Q
A
K
Site 57
T374
R
S
S
W
S
T
L
T
V
S
Q
A
K
E
A
Site 58
S376
S
W
S
T
L
T
V
S
Q
A
K
E
A
Y
R
Site 59
S385
A
K
E
A
Y
R
K
S
S
L
N
L
D
K
P
Site 60
S386
K
E
A
Y
R
K
S
S
L
N
L
D
K
P
L
Site 61
Y407
P
A
L
R
P
C
H
Y
L
Q
V
P
Q
D
E
Site 62
Y418
P
Q
D
E
W
G
G
Y
P
T
G
G
K
D
E
Site 63
S434
I
P
C
R
R
M
R
S
G
S
Y
I
K
A
M
Site 64
S436
C
R
R
M
R
S
G
S
Y
I
K
A
M
G
D
Site 65
S446
K
A
M
G
D
E
E
S
G
E
S
D
S
S
P
Site 66
S449
G
D
E
E
S
G
E
S
D
S
S
P
K
T
S
Site 67
S451
E
E
S
G
E
S
D
S
S
P
K
T
S
P
K
Site 68
S452
E
S
G
E
S
D
S
S
P
K
T
S
P
K
S
Site 69
T455
E
S
D
S
S
P
K
T
S
P
K
S
A
I
L
Site 70
S456
S
D
S
S
P
K
T
S
P
K
S
A
I
L
P
Site 71
S459
S
P
K
T
S
P
K
S
A
I
L
P
E
P
L
Site 72
S469
L
P
E
P
L
L
K
S
I
G
Q
R
P
L
G
Site 73
Y483
G
E
H
Q
T
Q
T
Y
L
Q
A
A
S
D
V
Site 74
S488
Q
T
Y
L
Q
A
A
S
D
V
P
V
G
H
S
Site 75
Y502
S
L
D
P
A
A
N
Y
N
S
P
K
F
R
S
Site 76
S504
D
P
A
A
N
Y
N
S
P
K
F
R
S
R
N
Site 77
S509
Y
N
S
P
K
F
R
S
R
N
Q
S
Y
M
R
Site 78
S513
K
F
R
S
R
N
Q
S
Y
M
R
A
V
S
T
Site 79
Y514
F
R
S
R
N
Q
S
Y
M
R
A
V
S
T
L
Site 80
S519
Q
S
Y
M
R
A
V
S
T
L
S
Q
A
S
C
Site 81
S531
A
S
C
V
S
Q
V
S
E
A
E
I
N
G
Q
Site 82
S541
E
I
N
G
Q
F
E
S
V
C
E
S
V
F
S
Site 83
S545
Q
F
E
S
V
C
E
S
V
F
S
E
V
E
S
Site 84
S552
S
V
F
S
E
V
E
S
Q
A
M
D
A
L
D
Site 85
T566
D
L
P
G
C
F
R
T
R
S
H
S
Y
L
R
Site 86
S568
P
G
C
F
R
T
R
S
H
S
Y
L
R
A
I
Site 87
S570
C
F
R
T
R
S
H
S
Y
L
R
A
I
Q
A
Site 88
Y571
R
S
T
A
A
V
S
Y
T
N
Y
K
K
T
P
Site 89
S580
R
A
I
Q
A
G
Y
S
Q
D
D
E
C
I
P
Site 90
T590
D
E
C
I
P
M
M
T
P
S
D
I
T
S
T
Site 91
S596
M
T
P
S
D
I
T
S
T
I
R
S
T
A
A
Site 92
T597
T
P
S
D
I
T
S
T
I
R
S
T
A
A
V
Site 93
S600
D
I
T
S
T
I
R
S
T
A
A
V
S
Y
T
Site 94
T601
I
T
S
T
I
R
S
T
A
A
V
S
Y
T
N
Site 95
Y609
A
A
V
S
Y
T
N
Y
K
K
T
P
P
P
V
Site 96
T612
S
Y
T
N
Y
K
K
T
P
P
P
V
P
P
R
Site 97
T620
P
P
P
V
P
P
R
T
T
S
K
P
L
I
S
Site 98
T621
P
P
V
P
P
R
T
T
S
K
P
L
I
S
V
Site 99
S622
P
V
P
P
R
T
T
S
K
P
L
I
S
V
T
Site 100
S627
T
T
S
K
P
L
I
S
V
T
A
Q
S
S
T
Site 101
T629
S
K
P
L
I
S
V
T
A
Q
S
S
T
E
S
Site 102
S632
L
I
S
V
T
A
Q
S
S
T
E
S
T
Q
D
Site 103
S633
I
S
V
T
A
Q
S
S
T
E
S
T
Q
D
A
Site 104
T634
S
V
T
A
Q
S
S
T
E
S
T
Q
D
A
Y
Site 105
S636
T
A
Q
S
S
T
E
S
T
Q
D
A
Y
Q
D
Site 106
T637
A
Q
S
S
T
E
S
T
Q
D
A
Y
Q
D
S
Site 107
Y641
T
E
S
T
Q
D
A
Y
Q
D
S
R
A
Q
R
Site 108
S644
T
Q
D
A
Y
Q
D
S
R
A
Q
R
M
S
P
Site 109
S650
D
S
R
A
Q
R
M
S
P
W
P
Q
D
S
R
Site 110
S656
M
S
P
W
P
Q
D
S
R
G
L
Y
N
S
T
Site 111
Y660
P
Q
D
S
R
G
L
Y
N
S
T
D
S
L
D
Site 112
S662
D
S
R
G
L
Y
N
S
T
D
S
L
D
S
N
Site 113
S665
G
L
Y
N
S
T
D
S
L
D
S
N
K
A
M
Site 114
S688
A
Q
R
H
L
P
E
S
Q
S
S
S
V
R
T
Site 115
S690
R
H
L
P
E
S
Q
S
S
S
V
R
T
S
D
Site 116
S691
H
L
P
E
S
Q
S
S
S
V
R
T
S
D
K
Site 117
S692
L
P
E
S
Q
S
S
S
V
R
T
S
D
K
A
Site 118
T695
S
Q
S
S
S
V
R
T
S
D
K
A
I
L
V
Site 119
S696
Q
S
S
S
V
R
T
S
D
K
A
I
L
V
S
Site 120
S703
S
D
K
A
I
L
V
S
K
A
E
E
L
L
K
Site 121
S711
K
A
E
E
L
L
K
S
R
C
S
S
I
G
I
Site 122
S714
E
L
L
K
S
R
C
S
S
I
G
I
Q
D
S
Site 123
S715
L
L
K
S
R
C
S
S
I
G
I
Q
D
S
E
Site 124
S721
S
S
I
G
I
Q
D
S
E
F
P
E
H
Q
P
Site 125
Y729
E
F
P
E
H
Q
P
Y
P
R
S
D
V
E
T
Site 126
S732
E
H
Q
P
Y
P
R
S
D
V
E
T
A
T
D
Site 127
T736
Y
P
R
S
D
V
E
T
A
T
D
S
D
T
E
Site 128
T738
R
S
D
V
E
T
A
T
D
S
D
T
E
S
R
Site 129
S740
D
V
E
T
A
T
D
S
D
T
E
S
R
G
L
Site 130
T742
E
T
A
T
D
S
D
T
E
S
R
G
L
R
E
Site 131
S744
A
T
D
S
D
T
E
S
R
G
L
R
E
Y
H
Site 132
Y750
E
S
R
G
L
R
E
Y
H
S
V
G
V
Q
V
Site 133
S752
R
G
L
R
E
Y
H
S
V
G
V
Q
V
E
D
Site 134
S771
G
R
F
K
R
S
N
S
V
T
A
A
V
Q
A
Site 135
T773
F
K
R
S
N
S
V
T
A
A
V
Q
A
D
L
Site 136
T790
E
G
F
P
G
H
I
T
T
E
D
K
G
L
Q
Site 137
T791
G
F
P
G
H
I
T
T
E
D
K
G
L
Q
F
Site 138
S800
D
K
G
L
Q
F
G
S
S
F
Q
R
H
S
E
Site 139
S801
K
G
L
Q
F
G
S
S
F
Q
R
H
S
E
P
Site 140
S806
G
S
S
F
Q
R
H
S
E
P
S
T
P
T
Q
Site 141
S809
F
Q
R
H
S
E
P
S
T
P
T
Q
Y
S
A
Site 142
T810
Q
R
H
S
E
P
S
T
P
T
Q
Y
S
A
V
Site 143
S815
P
S
T
P
T
Q
Y
S
A
V
R
T
V
R
T
Site 144
T819
T
Q
Y
S
A
V
R
T
V
R
T
Q
G
L
F
Site 145
T822
S
A
V
R
T
V
R
T
Q
G
L
F
S
Y
R
Site 146
S827
V
R
T
Q
G
L
F
S
Y
R
E
D
Y
R
T
Site 147
Y828
R
T
Q
G
L
F
S
Y
R
E
D
Y
R
T
Q
Site 148
Y832
L
F
S
Y
R
E
D
Y
R
T
Q
V
D
T
S
Site 149
T834
S
Y
R
E
D
Y
R
T
Q
V
D
T
S
T
L
Site 150
T838
D
Y
R
T
Q
V
D
T
S
T
L
P
P
P
D
Site 151
S839
Y
R
T
Q
V
D
T
S
T
L
P
P
P
D
P
Site 152
T840
R
T
Q
V
D
T
S
T
L
P
P
P
D
P
W
Site 153
T854
W
L
E
P
A
I
D
T
V
E
T
G
R
M
S
Site 154
T857
P
A
I
D
T
V
E
T
G
R
M
S
P
C
R
Site 155
S861
T
V
E
T
G
R
M
S
P
C
R
R
D
G
S
Site 156
S868
S
P
C
R
R
D
G
S
W
F
L
K
L
L
H
Site 157
T878
L
K
L
L
H
A
E
T
K
R
M
E
G
W
C
Site 158
S898
E
A
E
E
N
D
L
S
E
E
I
L
G
K
I
Site 159
S917
G
S
A
Q
L
L
M
S
Q
K
F
Q
Q
F
Y
Site 160
S934
C
Q
Q
N
M
D
P
S
A
M
P
R
P
T
S
Site 161
T940
P
S
A
M
P
R
P
T
S
Q
D
L
A
G
Y
Site 162
S941
S
A
M
P
R
P
T
S
Q
D
L
A
G
Y
W
Site 163
S978
N
D
W
K
M
M
E
S
P
E
R
K
E
E
R
Site 164
T1003
P
K
G
K
F
P
I
T
R
E
K
S
L
D
L
Site 165
S1007
F
P
I
T
R
E
K
S
L
D
L
P
D
R
Q
Site 166
S1030
M
A
A
K
R
A
A
S
F
R
Q
N
S
A
S
Site 167
S1035
A
A
S
F
R
Q
N
S
A
S
E
R
A
D
S
Site 168
S1037
S
F
R
Q
N
S
A
S
E
R
A
D
S
I
E
Site 169
S1042
S
A
S
E
R
A
D
S
I
E
I
Y
I
P
E
Site 170
Y1046
R
A
D
S
I
E
I
Y
I
P
E
A
Q
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation