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Updated November 2019
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Protein Info
Short Name:
CACNA1I
Full Name:
Voltage-dependent T-type calcium channel subunit alpha-1I
Alias:
Type:
Mass (Da):
245103
Number AA:
2223
UniProt ID:
Q9P0X4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
E
S
A
S
P
P
S
S
S
A
A
Site 2
S10
E
S
A
S
P
P
S
S
S
A
A
A
P
A
A
Site 3
S11
S
A
S
P
P
S
S
S
A
A
A
P
A
A
E
Site 4
T22
P
A
A
E
P
G
V
T
T
E
Q
P
G
P
R
Site 5
S30
T
E
Q
P
G
P
R
S
P
P
S
S
P
P
G
Site 6
S33
P
G
P
R
S
P
P
S
S
P
P
G
L
E
E
Site 7
S34
G
P
R
S
P
P
S
S
P
P
G
L
E
E
P
Site 8
Y145
G
I
F
G
K
K
C
Y
L
G
D
T
W
N
R
Site 9
Y256
G
D
V
A
L
P
P
Y
Y
Q
P
E
E
D
D
Site 10
Y257
D
V
A
L
P
P
Y
Y
Q
P
E
E
D
D
E
Site 11
S270
D
E
M
P
F
I
C
S
L
S
G
D
N
G
I
Site 12
Y301
C
L
S
K
D
D
V
Y
D
F
G
A
G
R
Q
Site 13
T328
R
Y
Y
N
V
C
R
T
G
S
A
N
P
H
K
Site 14
S330
Y
N
V
C
R
T
G
S
A
N
P
H
K
G
A
Site 15
Y419
M
L
E
Q
R
Q
R
Y
L
S
S
S
T
V
A
Site 16
S421
E
Q
R
Q
R
Y
L
S
S
S
T
V
A
S
Y
Site 17
S423
R
Q
R
Y
L
S
S
S
T
V
A
S
Y
A
E
Site 18
S427
L
S
S
S
T
V
A
S
Y
A
E
P
G
D
C
Site 19
Y428
S
S
S
T
V
A
S
Y
A
E
P
G
D
C
Y
Site 20
Y435
Y
A
E
P
G
D
C
Y
E
E
I
F
Q
Y
V
Site 21
Y441
C
Y
E
E
I
F
Q
Y
V
C
H
I
L
R
K
Site 22
Y457
K
R
R
A
L
G
L
Y
Q
A
L
Q
S
R
R
Site 23
S462
G
L
Y
Q
A
L
Q
S
R
R
Q
A
L
G
P
Site 24
Y487
H
A
K
E
P
R
H
Y
H
G
K
T
K
G
Q
Site 25
T508
L
G
S
R
H
C
Q
T
L
H
G
P
A
S
P
Site 26
S514
Q
T
L
H
G
P
A
S
P
G
N
D
H
S
G
Site 27
S520
A
S
P
G
N
D
H
S
G
R
E
L
C
P
Q
Site 28
S529
R
E
L
C
P
Q
H
S
P
L
D
A
T
P
H
Site 29
T534
Q
H
S
P
L
D
A
T
P
H
T
L
V
Q
P
Site 30
S552
T
L
A
S
D
P
A
S
C
P
C
C
Q
H
E
Site 31
S565
H
E
D
G
R
R
P
S
G
L
G
S
T
D
S
Site 32
S569
R
R
P
S
G
L
G
S
T
D
S
G
Q
E
G
Site 33
S572
S
G
L
G
S
T
D
S
G
Q
E
G
S
G
S
Site 34
S577
T
D
S
G
Q
E
G
S
G
S
G
S
S
A
G
Site 35
S579
S
G
Q
E
G
S
G
S
G
S
S
A
G
G
E
Site 36
S581
Q
E
G
S
G
S
G
S
S
A
G
G
E
D
E
Site 37
S596
A
D
G
D
G
A
R
S
S
E
D
G
A
S
S
Site 38
S597
D
G
D
G
A
R
S
S
E
D
G
A
S
S
E
Site 39
S602
R
S
S
E
D
G
A
S
S
E
L
G
K
E
E
Site 40
S603
S
S
E
D
G
A
S
S
E
L
G
K
E
E
E
Site 41
T629
C
G
D
V
W
R
E
T
R
A
K
L
R
G
I
Site 42
S639
K
L
R
G
I
V
D
S
K
Y
F
N
R
G
I
Site 43
Y641
R
G
I
V
D
S
K
Y
F
N
R
G
I
M
M
Site 44
Y704
F
D
Y
L
R
N
P
Y
N
I
F
D
S
I
I
Site 45
T794
K
F
S
L
R
T
D
T
G
D
T
V
P
D
R
Site 46
T797
L
R
T
D
T
G
D
T
V
P
D
R
K
N
F
Site 47
S806
P
D
R
K
N
F
D
S
L
L
W
A
I
V
T
Site 48
Y828
E
D
W
N
V
V
L
Y
N
G
M
A
S
T
S
Site 49
S835
Y
N
G
M
A
S
T
S
P
W
A
S
L
Y
F
Site 50
S874
A
E
G
D
A
N
R
S
Y
S
D
E
D
Q
S
Site 51
Y875
E
G
D
A
N
R
S
Y
S
D
E
D
Q
S
S
Site 52
S876
G
D
A
N
R
S
Y
S
D
E
D
Q
S
S
S
Site 53
S881
S
Y
S
D
E
D
Q
S
S
S
N
I
E
E
F
Site 54
S882
Y
S
D
E
D
Q
S
S
S
N
I
E
E
F
D
Site 55
S883
S
D
E
D
Q
S
S
S
N
I
E
E
F
D
K
Site 56
S897
K
L
Q
E
G
L
D
S
S
G
D
P
K
L
C
Site 57
S898
L
Q
E
G
L
D
S
S
G
D
P
K
L
C
P
Site 58
T909
K
L
C
P
I
P
M
T
P
N
G
H
L
D
P
Site 59
S917
P
N
G
H
L
D
P
S
L
P
L
G
G
H
L
Site 60
S937
A
G
P
A
P
R
L
S
L
Q
P
D
P
M
L
Site 61
S952
V
A
L
G
S
R
K
S
S
V
M
S
L
G
R
Site 62
S953
A
L
G
S
R
K
S
S
V
M
S
L
G
R
M
Site 63
S956
S
R
K
S
S
V
M
S
L
G
R
M
S
Y
D
Site 64
S961
V
M
S
L
G
R
M
S
Y
D
Q
R
S
L
S
Site 65
Y962
M
S
L
G
R
M
S
Y
D
Q
R
S
L
S
S
Site 66
S966
R
M
S
Y
D
Q
R
S
L
S
S
S
R
S
S
Site 67
S968
S
Y
D
Q
R
S
L
S
S
S
R
S
S
Y
Y
Site 68
S969
Y
D
Q
R
S
L
S
S
S
R
S
S
Y
Y
G
Site 69
S970
D
Q
R
S
L
S
S
S
R
S
S
Y
Y
G
P
Site 70
S972
R
S
L
S
S
S
R
S
S
Y
Y
G
P
W
G
Site 71
S973
S
L
S
S
S
R
S
S
Y
Y
G
P
W
G
R
Site 72
Y974
L
S
S
S
R
S
S
Y
Y
G
P
W
G
R
S
Site 73
Y975
S
S
S
R
S
S
Y
Y
G
P
W
G
R
S
A
Site 74
S986
G
R
S
A
A
W
A
S
R
R
S
S
W
N
S
Site 75
S989
A
A
W
A
S
R
R
S
S
W
N
S
L
K
H
Site 76
S990
A
W
A
S
R
R
S
S
W
N
S
L
K
H
K
Site 77
S993
S
R
R
S
S
W
N
S
L
K
H
K
P
P
S
Site 78
S1000
S
L
K
H
K
P
P
S
A
E
H
E
S
L
L
Site 79
S1005
P
P
S
A
E
H
E
S
L
L
S
A
E
R
G
Site 80
S1008
A
E
H
E
S
L
L
S
A
E
R
G
G
G
A
Site 81
T1034
P
R
A
A
P
L
H
T
P
H
A
H
H
I
H
Site 82
T1056
R
H
R
H
H
R
R
T
L
S
L
D
N
R
D
Site 83
S1058
R
H
H
R
R
T
L
S
L
D
N
R
D
S
V
Site 84
S1064
L
S
L
D
N
R
D
S
V
D
L
A
E
L
V
Site 85
S1100
D
C
N
G
R
M
P
S
I
A
K
D
V
F
T
Site 86
T1107
S
I
A
K
D
V
F
T
K
M
G
D
R
G
D
Site 87
Y1124
E
D
E
E
E
I
D
Y
T
L
C
F
R
V
R
Site 88
T1125
D
E
E
E
I
D
Y
T
L
C
F
R
V
R
K
Site 89
Y1137
V
R
K
M
I
D
V
Y
K
P
D
W
C
E
V
Site 90
Y1151
V
R
E
D
W
S
V
Y
L
F
S
P
E
N
R
Site 91
S1154
D
W
S
V
Y
L
F
S
P
E
N
R
F
R
V
Site 92
Y1235
L
Y
F
G
E
Q
A
Y
L
R
S
S
W
N
V
Site 93
S1239
E
Q
A
Y
L
R
S
S
W
N
V
L
D
G
F
Site 94
Y1333
Q
L
F
K
G
K
F
Y
H
C
L
G
V
D
T
Site 95
T1344
G
V
D
T
R
N
I
T
N
R
S
D
C
M
A
Site 96
Y1469
R
K
A
Q
R
L
P
Y
Y
A
T
Y
C
H
T
Site 97
Y1470
K
A
Q
R
L
P
Y
Y
A
T
Y
C
H
T
R
Site 98
Y1509
V
T
M
S
L
E
H
Y
N
Q
P
T
S
L
E
Site 99
S1514
E
H
Y
N
Q
P
T
S
L
E
T
A
L
K
Y
Site 100
Y1521
S
L
E
T
A
L
K
Y
C
N
Y
M
F
T
T
Site 101
T1660
E
G
M
S
R
H
A
T
F
E
N
F
G
M
A
Site 102
T1692
K
D
T
L
R
D
C
T
H
D
E
R
S
C
L
Site 103
S1697
D
C
T
H
D
E
R
S
C
L
S
S
L
Q
F
Site 104
S1701
D
E
R
S
C
L
S
S
L
Q
F
V
S
P
L
Site 105
S1736
L
M
K
H
L
D
D
S
N
K
E
A
Q
E
D
Site 106
T1766
G
P
G
P
R
L
P
T
G
S
P
G
A
P
G
Site 107
S1768
G
P
R
L
P
T
G
S
P
G
A
P
G
R
G
Site 108
T1785
G
A
G
G
G
G
D
T
E
G
G
L
C
R
R
Site 109
Y1794
G
G
L
C
R
R
C
Y
S
P
A
Q
E
N
L
Site 110
S1795
G
L
C
R
R
C
Y
S
P
A
Q
E
N
L
W
Site 111
S1805
Q
E
N
L
W
L
D
S
V
S
L
I
I
K
D
Site 112
T1819
D
S
L
E
G
E
L
T
I
I
D
N
L
S
G
Site 113
S1827
I
I
D
N
L
S
G
S
I
F
H
H
Y
S
S
Site 114
Y1832
S
G
S
I
F
H
H
Y
S
S
P
A
G
C
K
Site 115
S1833
G
S
I
F
H
H
Y
S
S
P
A
G
C
K
K
Site 116
T1853
Q
E
V
Q
L
A
E
T
E
A
F
S
L
N
S
Site 117
S1857
L
A
E
T
E
A
F
S
L
N
S
D
R
S
S
Site 118
S1860
T
E
A
F
S
L
N
S
D
R
S
S
S
I
L
Site 119
S1863
F
S
L
N
S
D
R
S
S
S
I
L
L
G
D
Site 120
S1864
S
L
N
S
D
R
S
S
S
I
L
L
G
D
D
Site 121
S1865
L
N
S
D
R
S
S
S
I
L
L
G
D
D
L
Site 122
T1878
D
L
S
L
E
D
P
T
A
C
P
P
G
R
K
Site 123
S1887
C
P
P
G
R
K
D
S
K
G
E
L
D
P
P
Site 124
S1915
P
L
S
S
T
A
V
S
P
D
P
E
N
F
L
Site 125
S1935
I
P
F
N
P
V
R
S
W
L
K
H
D
S
S
Site 126
S1941
R
S
W
L
K
H
D
S
S
Q
A
P
P
S
P
Site 127
S1942
S
W
L
K
H
D
S
S
Q
A
P
P
S
P
F
Site 128
S1947
D
S
S
Q
A
P
P
S
P
F
S
P
D
A
S
Site 129
S1950
Q
A
P
P
S
P
F
S
P
D
A
S
S
P
L
Site 130
S1954
S
P
F
S
P
D
A
S
S
P
L
L
P
M
P
Site 131
S1955
P
F
S
P
D
A
S
S
P
L
L
P
M
P
A
Site 132
S1970
E
F
F
H
P
A
V
S
A
S
Q
K
G
P
E
Site 133
S1972
F
H
P
A
V
S
A
S
Q
K
G
P
E
K
G
Site 134
T1984
E
K
G
T
G
T
G
T
L
P
K
I
A
L
Q
Site 135
S1993
P
K
I
A
L
Q
G
S
W
A
S
L
R
S
P
Site 136
S1996
A
L
Q
G
S
W
A
S
L
R
S
P
R
V
N
Site 137
S1999
G
S
W
A
S
L
R
S
P
R
V
N
C
T
L
Site 138
T2005
R
S
P
R
V
N
C
T
L
L
R
Q
A
T
G
Site 139
T2011
C
T
L
L
R
Q
A
T
G
S
D
T
S
L
D
Site 140
S2013
L
L
R
Q
A
T
G
S
D
T
S
L
D
A
S
Site 141
T2015
R
Q
A
T
G
S
D
T
S
L
D
A
S
P
S
Site 142
S2016
Q
A
T
G
S
D
T
S
L
D
A
S
P
S
S
Site 143
S2020
S
D
T
S
L
D
A
S
P
S
S
S
A
G
S
Site 144
S2022
T
S
L
D
A
S
P
S
S
S
A
G
S
L
Q
Site 145
S2023
S
L
D
A
S
P
S
S
S
A
G
S
L
Q
T
Site 146
S2024
L
D
A
S
P
S
S
S
A
G
S
L
Q
T
T
Site 147
S2027
S
P
S
S
S
A
G
S
L
Q
T
T
L
E
D
Site 148
T2031
S
A
G
S
L
Q
T
T
L
E
D
S
L
T
L
Site 149
S2035
L
Q
T
T
L
E
D
S
L
T
L
S
D
S
P
Site 150
T2037
T
T
L
E
D
S
L
T
L
S
D
S
P
R
R
Site 151
S2039
L
E
D
S
L
T
L
S
D
S
P
R
R
A
L
Site 152
S2041
D
S
L
T
L
S
D
S
P
R
R
A
L
G
P
Site 153
S2060
P
G
P
R
A
G
L
S
P
A
A
R
R
R
L
Site 154
S2068
P
A
A
R
R
R
L
S
L
R
G
R
G
L
F
Site 155
S2076
L
R
G
R
G
L
F
S
L
R
G
L
R
A
H
Site 156
S2086
G
L
R
A
H
Q
R
S
H
S
S
G
G
S
T
Site 157
S2088
R
A
H
Q
R
S
H
S
S
G
G
S
T
S
P
Site 158
S2089
A
H
Q
R
S
H
S
S
G
G
S
T
S
P
G
Site 159
S2092
R
S
H
S
S
G
G
S
T
S
P
G
C
T
H
Site 160
T2093
S
H
S
S
G
G
S
T
S
P
G
C
T
H
H
Site 161
S2094
H
S
S
G
G
S
T
S
P
G
C
T
H
H
D
Site 162
T2098
G
S
T
S
P
G
C
T
H
H
D
S
M
D
P
Site 163
S2102
P
G
C
T
H
H
D
S
M
D
P
S
D
E
E
Site 164
S2106
H
H
D
S
M
D
P
S
D
E
E
G
R
G
G
Site 165
S2121
A
G
G
G
G
A
G
S
E
H
S
E
T
L
S
Site 166
S2124
G
G
A
G
S
E
H
S
E
T
L
S
S
L
S
Site 167
T2126
A
G
S
E
H
S
E
T
L
S
S
L
S
L
T
Site 168
S2128
S
E
H
S
E
T
L
S
S
L
S
L
T
S
L
Site 169
S2129
E
H
S
E
T
L
S
S
L
S
L
T
S
L
F
Site 170
T2148
P
P
P
A
P
G
L
T
P
A
R
K
F
S
S
Site 171
S2154
L
T
P
A
R
K
F
S
S
T
S
S
L
A
A
Site 172
S2155
T
P
A
R
K
F
S
S
T
S
S
L
A
A
P
Site 173
T2156
P
A
R
K
F
S
S
T
S
S
L
A
A
P
G
Site 174
S2158
R
K
F
S
S
T
S
S
L
A
A
P
G
R
P
Site 175
S2177
L
A
H
G
L
A
R
S
P
S
W
A
A
D
R
Site 176
S2179
H
G
L
A
R
S
P
S
W
A
A
D
R
S
K
Site 177
S2185
P
S
W
A
A
D
R
S
K
D
P
P
G
R
A
Site 178
S2219
L
E
P
G
D
A
A
S
K
R
K
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation