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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3BP4
Full Name:
SH3 domain-binding protein 4
Alias:
BOG25; SH3 domain-binding protein 4: Transferrin receptor-trafficking protein: EH-binding protein 10: SH3 domain-binding protein 4: Transferrin receptor-trafficking protein: EH-binding protein 10: Putative uncharacterized protein SH3BP4; SH3B4; SH3-domain binding protein 4; Transferrin receptor trafficking protein; TTP
Type:
Cell cycle regulation; Vesicle protein
Mass (Da):
107496
Number AA:
963
UniProt ID:
Q9P0V3
International Prot ID:
IPI00005030
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030136
GO:0005905
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
N
G
L
P
R
C
K
S
E
G
T
L
I
D
L
Site 2
T22
P
R
C
K
S
E
G
T
L
I
D
L
S
E
G
Site 3
S27
E
G
T
L
I
D
L
S
E
G
F
S
E
T
S
Site 4
S31
I
D
L
S
E
G
F
S
E
T
S
F
N
D
I
Site 5
S34
S
E
G
F
S
E
T
S
F
N
D
I
K
V
P
Site 6
S42
F
N
D
I
K
V
P
S
P
S
A
L
L
V
D
Site 7
S44
D
I
K
V
P
S
P
S
A
L
L
V
D
N
P
Site 8
T52
A
L
L
V
D
N
P
T
P
F
G
N
A
K
E
Site 9
T73
Y
C
P
T
N
F
T
T
L
K
F
S
K
G
D
Site 10
Y83
F
S
K
G
D
H
L
Y
V
L
D
T
S
G
G
Site 11
Y103
H
N
T
T
E
M
G
Y
I
P
S
S
Y
V
Q
Site 12
S106
T
E
M
G
Y
I
P
S
S
Y
V
Q
P
L
N
Site 13
Y108
M
G
Y
I
P
S
S
Y
V
Q
P
L
N
Y
R
Site 14
Y114
S
Y
V
Q
P
L
N
Y
R
N
S
T
L
S
D
Site 15
S117
Q
P
L
N
Y
R
N
S
T
L
S
D
S
G
M
Site 16
T118
P
L
N
Y
R
N
S
T
L
S
D
S
G
M
I
Site 17
S120
N
Y
R
N
S
T
L
S
D
S
G
M
I
D
N
Site 18
S122
R
N
S
T
L
S
D
S
G
M
I
D
N
L
P
Site 19
S131
M
I
D
N
L
P
D
S
P
D
E
V
A
K
E
Site 20
T146
L
E
L
L
G
G
W
T
D
D
K
K
V
P
G
Site 21
Y156
K
K
V
P
G
R
M
Y
S
N
N
P
F
W
N
Site 22
S200
L
L
F
D
A
G
T
S
S
F
T
E
S
S
S
Site 23
S201
L
F
D
A
G
T
S
S
F
T
E
S
S
S
A
Site 24
T203
D
A
G
T
S
S
F
T
E
S
S
S
A
T
T
Site 25
S205
G
T
S
S
F
T
E
S
S
S
A
T
T
N
S
Site 26
S206
T
S
S
F
T
E
S
S
S
A
T
T
N
S
T
Site 27
S207
S
S
F
T
E
S
S
S
A
T
T
N
S
T
G
Site 28
T209
F
T
E
S
S
S
A
T
T
N
S
T
G
N
I
Site 29
T210
T
E
S
S
S
A
T
T
N
S
T
G
N
I
F
Site 30
T223
I
F
D
E
L
P
V
T
N
G
L
H
A
E
P
Site 31
S241
R
D
N
P
F
F
R
S
K
R
S
Y
S
L
S
Site 32
S244
P
F
F
R
S
K
R
S
Y
S
L
S
E
L
S
Site 33
Y245
F
F
R
S
K
R
S
Y
S
L
S
E
L
S
V
Site 34
S246
F
R
S
K
R
S
Y
S
L
S
E
L
S
V
L
Site 35
S248
S
K
R
S
Y
S
L
S
E
L
S
V
L
Q
A
Site 36
S251
S
Y
S
L
S
E
L
S
V
L
Q
A
K
S
D
Site 37
S257
L
S
V
L
Q
A
K
S
D
A
P
T
S
S
S
Site 38
T261
Q
A
K
S
D
A
P
T
S
S
S
F
F
T
G
Site 39
S262
A
K
S
D
A
P
T
S
S
S
F
F
T
G
L
Site 40
S263
K
S
D
A
P
T
S
S
S
F
F
T
G
L
K
Site 41
S264
S
D
A
P
T
S
S
S
F
F
T
G
L
K
S
Site 42
T267
P
T
S
S
S
F
F
T
G
L
K
S
P
A
P
Site 43
S271
S
F
F
T
G
L
K
S
P
A
P
E
Q
F
Q
Site 44
S279
P
A
P
E
Q
F
Q
S
R
E
D
F
R
T
A
Site 45
T285
Q
S
R
E
D
F
R
T
A
W
L
N
H
R
K
Site 46
S296
N
H
R
K
L
A
R
S
C
H
D
L
D
L
L
Site 47
S306
D
L
D
L
L
G
Q
S
P
G
W
G
Q
T
Q
Site 48
S368
D
P
P
L
E
L
N
S
D
R
S
C
S
I
S
Site 49
S371
L
E
L
N
S
D
R
S
C
S
I
S
P
V
L
Site 50
S373
L
N
S
D
R
S
C
S
I
S
P
V
L
E
V
Site 51
S375
S
D
R
S
C
S
I
S
P
V
L
E
V
K
L
Site 52
S383
P
V
L
E
V
K
L
S
N
L
E
V
K
T
S
Site 53
S407
E
I
K
N
D
L
F
S
K
S
T
V
G
L
Q
Site 54
S409
K
N
D
L
F
S
K
S
T
V
G
L
Q
C
L
Site 55
T410
N
D
L
F
S
K
S
T
V
G
L
Q
C
L
R
Site 56
S418
V
G
L
Q
C
L
R
S
D
S
K
E
G
P
Y
Site 57
S420
L
Q
C
L
R
S
D
S
K
E
G
P
Y
V
S
Site 58
Y425
S
D
S
K
E
G
P
Y
V
S
V
P
L
N
C
Site 59
S427
S
K
E
G
P
Y
V
S
V
P
L
N
C
S
C
Site 60
T465
P
S
I
L
Y
P
S
T
V
W
D
F
I
N
K
Site 61
T475
D
F
I
N
K
K
V
T
V
G
L
Y
G
P
K
Site 62
Y479
K
K
V
T
V
G
L
Y
G
P
K
H
I
H
P
Site 63
S487
G
P
K
H
I
H
P
S
F
K
T
V
V
T
I
Site 64
T493
P
S
F
K
T
V
V
T
I
F
G
H
D
C
A
Site 65
S532
G
K
H
Q
F
V
L
S
R
P
Q
D
L
K
V
Site 66
Y548
M
F
S
N
M
T
N
Y
E
V
K
A
S
E
Q
Site 67
T577
S
R
L
I
F
P
I
T
S
Q
N
P
N
E
L
Site 68
S578
R
L
I
F
P
I
T
S
Q
N
P
N
E
L
S
Site 69
S585
S
Q
N
P
N
E
L
S
D
F
T
L
R
V
Q
Site 70
T588
P
N
E
L
S
D
F
T
L
R
V
Q
V
K
D
Site 71
T602
D
D
Q
E
A
I
L
T
Q
F
C
V
Q
T
P
Site 72
T608
L
T
Q
F
C
V
Q
T
P
Q
P
P
P
K
S
Site 73
S615
T
P
Q
P
P
P
K
S
A
I
K
P
S
G
Q
Site 74
S620
P
K
S
A
I
K
P
S
G
Q
R
R
F
L
K
Site 75
S637
E
V
G
K
I
I
L
S
P
F
A
T
T
T
K
Site 76
T643
L
S
P
F
A
T
T
T
K
Y
P
T
F
Q
D
Site 77
Y645
P
F
A
T
T
T
K
Y
P
T
F
Q
D
R
P
Site 78
T647
A
T
T
T
K
Y
P
T
F
Q
D
R
P
V
S
Site 79
S654
T
F
Q
D
R
P
V
S
S
L
K
F
G
K
L
Site 80
S655
F
Q
D
R
P
V
S
S
L
K
F
G
K
L
L
Site 81
T664
K
F
G
K
L
L
K
T
V
V
R
Q
N
K
N
Site 82
Y677
K
N
H
Y
L
L
E
Y
K
K
G
D
G
I
A
Site 83
S687
G
D
G
I
A
L
L
S
E
E
R
V
R
L
R
Site 84
Y706
T
K
E
W
Y
I
G
Y
Y
Q
G
R
V
G
L
Site 85
Y707
K
E
W
Y
I
G
Y
Y
Q
G
R
V
G
L
V
Site 86
S731
R
A
R
P
S
L
C
S
G
P
E
L
S
T
S
Site 87
S736
L
C
S
G
P
E
L
S
T
S
V
L
L
E
Q
Site 88
Y753
R
P
C
K
F
L
T
Y
I
Y
A
S
V
R
T
Site 89
S767
T
L
L
M
E
N
I
S
S
W
R
S
F
A
D
Site 90
S768
L
L
M
E
N
I
S
S
W
R
S
F
A
D
A
Site 91
S771
E
N
I
S
S
W
R
S
F
A
D
A
L
G
Y
Site 92
S793
F
C
R
A
E
L
D
S
E
P
E
R
V
A
S
Site 93
S800
S
E
P
E
R
V
A
S
V
L
E
K
L
K
E
Site 94
S819
T
E
N
K
E
R
K
S
F
Q
K
E
L
V
M
Site 95
Y875
S
K
Q
Q
M
D
A
Y
E
S
P
H
R
D
R
Site 96
S877
Q
Q
M
D
A
Y
E
S
P
H
R
D
R
N
G
Site 97
S888
D
R
N
G
V
V
D
S
E
A
M
W
K
P
A
Site 98
Y896
E
A
M
W
K
P
A
Y
D
F
L
L
T
W
S
Site 99
Y910
S
H
Q
I
G
D
S
Y
R
D
V
I
Q
E
L
Site 100
T936
T
K
R
W
K
H
L
T
G
T
L
I
L
V
N
Site 101
S954
V
L
R
A
A
A
F
S
P
A
D
Q
D
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation