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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP1
Full Name:
Sentrin-specific protease 1
Alias:
Sentrin/SUMO-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SuPr-2
Type:
EC 3.4.22.-; Protease; Nuclear receptor co-regulator
Mass (Da):
73481
Number AA:
644
UniProt ID:
Q9P0U3
International Prot ID:
IPI00005101
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0008233
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006508
GO:0006512
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
R
M
D
A
G
E
V
T
L
V
N
H
N
S
V
Site 2
T26
N
H
N
S
V
F
K
T
H
L
L
P
Q
T
G
Site 3
T32
K
T
H
L
L
P
Q
T
G
F
P
E
D
Q
L
Site 4
S40
G
F
P
E
D
Q
L
S
L
S
D
Q
Q
I
L
Site 5
S42
P
E
D
Q
L
S
L
S
D
Q
Q
I
L
S
S
Site 6
S48
L
S
D
Q
Q
I
L
S
S
R
Q
G
H
L
D
Site 7
S57
R
Q
G
H
L
D
R
S
F
T
C
S
T
R
S
Site 8
T59
G
H
L
D
R
S
F
T
C
S
T
R
S
A
A
Site 9
S61
L
D
R
S
F
T
C
S
T
R
S
A
A
Y
N
Site 10
S64
S
F
T
C
S
T
R
S
A
A
Y
N
P
S
Y
Site 11
S70
R
S
A
A
Y
N
P
S
Y
Y
S
D
N
P
S
Site 12
Y71
S
A
A
Y
N
P
S
Y
Y
S
D
N
P
S
S
Site 13
Y72
A
A
Y
N
P
S
Y
Y
S
D
N
P
S
S
D
Site 14
S73
A
Y
N
P
S
Y
Y
S
D
N
P
S
S
D
S
Site 15
S77
S
Y
Y
S
D
N
P
S
S
D
S
F
L
G
S
Site 16
S78
Y
Y
S
D
N
P
S
S
D
S
F
L
G
S
G
Site 17
S80
S
D
N
P
S
S
D
S
F
L
G
S
G
D
L
Site 18
S84
S
S
D
S
F
L
G
S
G
D
L
R
T
F
G
Site 19
T89
L
G
S
G
D
L
R
T
F
G
Q
S
A
N
G
Site 20
S93
D
L
R
T
F
G
Q
S
A
N
G
Q
W
R
N
Site 21
S101
A
N
G
Q
W
R
N
S
T
P
S
S
S
S
S
Site 22
T102
N
G
Q
W
R
N
S
T
P
S
S
S
S
S
L
Site 23
S104
Q
W
R
N
S
T
P
S
S
S
S
S
L
Q
K
Site 24
S105
W
R
N
S
T
P
S
S
S
S
S
L
Q
K
S
Site 25
S106
R
N
S
T
P
S
S
S
S
S
L
Q
K
S
R
Site 26
S107
N
S
T
P
S
S
S
S
S
L
Q
K
S
R
N
Site 27
S108
S
T
P
S
S
S
S
S
L
Q
K
S
R
N
S
Site 28
S112
S
S
S
S
L
Q
K
S
R
N
S
R
S
L
Y
Site 29
S115
S
L
Q
K
S
R
N
S
R
S
L
Y
L
E
T
Site 30
S117
Q
K
S
R
N
S
R
S
L
Y
L
E
T
R
K
Site 31
Y119
S
R
N
S
R
S
L
Y
L
E
T
R
K
T
S
Site 32
T122
S
R
S
L
Y
L
E
T
R
K
T
S
S
G
L
Site 33
T125
L
Y
L
E
T
R
K
T
S
S
G
L
S
N
S
Site 34
S126
Y
L
E
T
R
K
T
S
S
G
L
S
N
S
F
Site 35
S130
R
K
T
S
S
G
L
S
N
S
F
A
G
K
S
Site 36
S132
T
S
S
G
L
S
N
S
F
A
G
K
S
N
H
Site 37
Y146
H
H
C
H
V
S
A
Y
E
K
S
F
P
I
K
Site 38
S149
H
V
S
A
Y
E
K
S
F
P
I
K
P
V
P
Site 39
S157
F
P
I
K
P
V
P
S
P
S
W
S
G
S
C
Site 40
S159
I
K
P
V
P
S
P
S
W
S
G
S
C
R
R
Site 41
S161
P
V
P
S
P
S
W
S
G
S
C
R
R
S
L
Site 42
S163
P
S
P
S
W
S
G
S
C
R
R
S
L
L
S
Site 43
S167
W
S
G
S
C
R
R
S
L
L
S
P
K
K
T
Site 44
S170
S
C
R
R
S
L
L
S
P
K
K
T
Q
R
R
Site 45
T174
S
L
L
S
P
K
K
T
Q
R
R
H
V
S
T
Site 46
S180
K
T
Q
R
R
H
V
S
T
A
E
E
T
V
Q
Site 47
T181
T
Q
R
R
H
V
S
T
A
E
E
T
V
Q
E
Site 48
Y194
Q
E
E
E
R
E
I
Y
R
Q
L
L
Q
M
V
Site 49
T202
R
Q
L
L
Q
M
V
T
G
K
Q
F
T
I
A
Site 50
S220
T
H
F
P
L
H
L
S
R
C
L
S
S
S
K
Site 51
S224
L
H
L
S
R
C
L
S
S
S
K
N
T
L
K
Site 52
S226
L
S
R
C
L
S
S
S
K
N
T
L
K
D
S
Site 53
T229
C
L
S
S
S
K
N
T
L
K
D
S
L
F
K
Site 54
S233
S
K
N
T
L
K
D
S
L
F
K
N
G
N
S
Site 55
S240
S
L
F
K
N
G
N
S
C
A
S
Q
I
I
G
Site 56
S243
K
N
G
N
S
C
A
S
Q
I
I
G
S
D
T
Site 57
S248
C
A
S
Q
I
I
G
S
D
T
S
S
S
G
S
Site 58
T250
S
Q
I
I
G
S
D
T
S
S
S
G
S
A
S
Site 59
S251
Q
I
I
G
S
D
T
S
S
S
G
S
A
S
I
Site 60
S253
I
G
S
D
T
S
S
S
G
S
A
S
I
L
T
Site 61
S255
S
D
T
S
S
S
G
S
A
S
I
L
T
N
Q
Site 62
S257
T
S
S
S
G
S
A
S
I
L
T
N
Q
E
Q
Site 63
T260
S
G
S
A
S
I
L
T
N
Q
E
Q
L
S
H
Site 64
S266
L
T
N
Q
E
Q
L
S
H
S
V
Y
S
L
S
Site 65
S268
N
Q
E
Q
L
S
H
S
V
Y
S
L
S
S
Y
Site 66
Y270
E
Q
L
S
H
S
V
Y
S
L
S
S
Y
T
P
Site 67
S271
Q
L
S
H
S
V
Y
S
L
S
S
Y
T
P
D
Site 68
S273
S
H
S
V
Y
S
L
S
S
Y
T
P
D
V
A
Site 69
S274
H
S
V
Y
S
L
S
S
Y
T
P
D
V
A
F
Site 70
S283
T
P
D
V
A
F
G
S
K
D
S
G
T
L
H
Site 71
S286
V
A
F
G
S
K
D
S
G
T
L
H
H
P
H
Site 72
T288
F
G
S
K
D
S
G
T
L
H
H
P
H
H
H
Site 73
S308
Q
P
D
N
L
A
A
S
N
T
Q
S
E
G
S
Site 74
T310
D
N
L
A
A
S
N
T
Q
S
E
G
S
D
S
Site 75
S312
L
A
A
S
N
T
Q
S
E
G
S
D
S
V
I
Site 76
S315
S
N
T
Q
S
E
G
S
D
S
V
I
L
L
K
Site 77
S317
T
Q
S
E
G
S
D
S
V
I
L
L
K
V
K
Site 78
S326
I
L
L
K
V
K
D
S
Q
T
P
T
P
S
S
Site 79
T328
L
K
V
K
D
S
Q
T
P
T
P
S
S
T
F
Site 80
T330
V
K
D
S
Q
T
P
T
P
S
S
T
F
F
Q
Site 81
S332
D
S
Q
T
P
T
P
S
S
T
F
F
Q
A
E
Site 82
S333
S
Q
T
P
T
P
S
S
T
F
F
Q
A
E
L
Site 83
T334
Q
T
P
T
P
S
S
T
F
F
Q
A
E
L
W
Site 84
S347
L
W
I
K
E
L
T
S
V
Y
D
S
R
A
R
Site 85
Y349
I
K
E
L
T
S
V
Y
D
S
R
A
R
E
R
Site 86
S351
E
L
T
S
V
Y
D
S
R
A
R
E
R
L
R
Site 87
S381
R
L
Q
E
R
E
H
S
V
H
D
S
V
E
L
Site 88
S385
R
E
H
S
V
H
D
S
V
E
L
H
L
R
V
Site 89
T401
L
E
K
E
I
P
V
T
V
V
Q
E
T
Q
K
Site 90
S416
K
G
H
K
L
T
D
S
E
D
E
F
P
E
I
Site 91
S445
G
N
Q
D
E
V
L
S
E
A
F
R
L
T
I
Site 92
T451
L
S
E
A
F
R
L
T
I
T
R
K
D
I
Q
Site 93
T459
I
T
R
K
D
I
Q
T
L
N
H
L
N
W
L
Site 94
Y474
N
D
E
I
I
N
F
Y
M
N
M
L
M
E
R
Site 95
S489
S
K
E
K
G
L
P
S
V
H
A
F
N
T
F
Site 96
Y506
T
K
L
K
T
A
G
Y
Q
A
V
K
R
W
T
Site 97
T513
Y
Q
A
V
K
R
W
T
K
K
V
D
V
F
S
Site 98
Y548
F
R
K
K
N
I
T
Y
Y
D
S
M
G
G
I
Site 99
Y549
R
K
K
N
I
T
Y
Y
D
S
M
G
G
I
N
Site 100
Y566
A
C
R
I
L
L
Q
Y
L
K
Q
E
S
I
D
Site 101
T581
K
K
R
K
E
F
D
T
N
G
W
Q
L
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation