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Updated November 2019
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Protein Info
Short Name:
ARHGEF12
Full Name:
Rho guanine nucleotide exchange factor 12
Alias:
ARHGC; KIAA0382; LARG; Leukemia-associated RhoGEF; Rho guanine nucleotide exchange factor (GEF) 12; RHO guanine nucleotide exchange factor (GEF) 12 (LARG)
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
173232
Number AA:
1544
UniProt ID:
Q9NZN5
International Prot ID:
IPI00022164
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0001664
GO:0005096
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
S
G
T
Q
S
T
I
T
D
R
F
P
L
K
K
Site 2
S22
K
K
P
I
R
H
G
S
I
L
N
R
E
S
P
Site 3
S28
G
S
I
L
N
R
E
S
P
T
D
K
K
Q
K
Site 4
S41
Q
K
V
E
R
I
A
S
H
D
F
D
P
T
D
Site 5
T47
A
S
H
D
F
D
P
T
D
S
S
S
K
K
T
Site 6
S49
H
D
F
D
P
T
D
S
S
S
K
K
T
K
S
Site 7
S50
D
F
D
P
T
D
S
S
S
K
K
T
K
S
S
Site 8
S51
F
D
P
T
D
S
S
S
K
K
T
K
S
S
S
Site 9
T54
T
D
S
S
S
K
K
T
K
S
S
S
E
E
S
Site 10
S56
S
S
S
K
K
T
K
S
S
S
E
E
S
R
S
Site 11
S57
S
S
K
K
T
K
S
S
S
E
E
S
R
S
E
Site 12
S58
S
K
K
T
K
S
S
S
E
E
S
R
S
E
I
Site 13
S61
T
K
S
S
S
E
E
S
R
S
E
I
Y
G
L
Site 14
S63
S
S
S
E
E
S
R
S
E
I
Y
G
L
V
Q
Site 15
T85
D
D
N
G
F
G
L
T
V
S
G
D
N
P
V
Site 16
T120
R
I
I
K
V
N
G
T
L
V
T
H
S
N
H
Site 17
Y139
K
L
I
K
S
G
S
Y
V
A
L
T
V
Q
G
Site 18
T143
S
G
S
Y
V
A
L
T
V
Q
G
R
P
P
G
Site 19
S151
V
Q
G
R
P
P
G
S
P
Q
I
P
L
A
D
Site 20
S164
A
D
S
E
V
E
P
S
V
I
G
H
M
S
P
Site 21
S170
P
S
V
I
G
H
M
S
P
I
M
T
S
P
H
Site 22
T174
G
H
M
S
P
I
M
T
S
P
H
S
P
G
A
Site 23
S175
H
M
S
P
I
M
T
S
P
H
S
P
G
A
S
Site 24
S178
P
I
M
T
S
P
H
S
P
G
A
S
G
N
M
Site 25
S182
S
P
H
S
P
G
A
S
G
N
M
E
R
I
T
Site 26
T189
S
G
N
M
E
R
I
T
S
P
V
L
M
G
E
Site 27
S190
G
N
M
E
R
I
T
S
P
V
L
M
G
E
E
Site 28
Y227
L
Q
L
L
Q
E
D
Y
N
R
T
P
A
Q
R
Site 29
T230
L
Q
E
D
Y
N
R
T
P
A
Q
R
L
L
K
Site 30
S254
P
Q
L
Q
E
Q
L
S
K
A
T
G
S
A
Q
Site 31
T267
A
Q
D
G
A
V
V
T
P
S
R
P
L
G
D
Site 32
S269
D
G
A
V
V
T
P
S
R
P
L
G
D
T
L
Site 33
T275
P
S
R
P
L
G
D
T
L
T
V
S
E
A
E
Site 34
T277
R
P
L
G
D
T
L
T
V
S
E
A
E
T
D
Site 35
S279
L
G
D
T
L
T
V
S
E
A
E
T
D
P
G
Site 36
T283
L
T
V
S
E
A
E
T
D
P
G
D
V
L
G
Site 37
T292
P
G
D
V
L
G
R
T
D
C
S
S
G
D
A
Site 38
S295
V
L
G
R
T
D
C
S
S
G
D
A
S
R
P
Site 39
S296
L
G
R
T
D
C
S
S
G
D
A
S
R
P
S
Site 40
S300
D
C
S
S
G
D
A
S
R
P
S
S
D
N
A
Site 41
S303
S
G
D
A
S
R
P
S
S
D
N
A
D
S
P
Site 42
S304
G
D
A
S
R
P
S
S
D
N
A
D
S
P
K
Site 43
S309
P
S
S
D
N
A
D
S
P
K
S
G
P
K
E
Site 44
S312
D
N
A
D
S
P
K
S
G
P
K
E
R
I
Y
Site 45
Y319
S
G
P
K
E
R
I
Y
L
E
E
N
P
E
K
Site 46
S327
L
E
E
N
P
E
K
S
E
T
I
Q
D
T
D
Site 47
T329
E
N
P
E
K
S
E
T
I
Q
D
T
D
T
Q
Site 48
T333
K
S
E
T
I
Q
D
T
D
T
Q
S
L
V
G
Site 49
T335
E
T
I
Q
D
T
D
T
Q
S
L
V
G
S
P
Site 50
S337
I
Q
D
T
D
T
Q
S
L
V
G
S
P
S
T
Site 51
S341
D
T
Q
S
L
V
G
S
P
S
T
R
I
A
P
Site 52
S343
Q
S
L
V
G
S
P
S
T
R
I
A
P
H
I
Site 53
T360
A
E
D
D
D
F
G
T
E
H
E
Q
I
N
G
Site 54
S374
G
Q
C
S
C
F
Q
S
I
E
L
L
K
S
R
Site 55
S380
Q
S
I
E
L
L
K
S
R
P
A
H
L
A
V
Site 56
Y410
C
Y
L
Y
S
D
L
Y
K
H
T
N
S
K
E
Site 57
S439
R
S
A
H
L
K
V
S
V
P
D
E
M
S
A
Site 58
S445
V
S
V
P
D
E
M
S
A
D
L
E
K
R
R
Site 59
Y464
P
E
D
L
H
R
H
Y
I
Q
T
M
Q
E
R
Site 60
T492
Q
K
R
S
M
G
L
T
L
A
E
S
E
L
T
Site 61
T511
E
R
D
K
D
R
L
T
L
E
K
E
R
T
C
Site 62
T517
L
T
L
E
K
E
R
T
C
A
E
Q
I
V
A
Site 63
T532
K
I
E
E
V
L
M
T
A
Q
A
V
E
E
D
Site 64
S541
Q
A
V
E
E
D
K
S
S
T
M
Q
Y
V
I
Site 65
S542
A
V
E
E
D
K
S
S
T
M
Q
Y
V
I
L
Site 66
Y546
D
K
S
S
T
M
Q
Y
V
I
L
M
Y
M
K
Site 67
Y551
M
Q
Y
V
I
L
M
Y
M
K
H
L
G
V
K
Site 68
S599
G
K
R
R
G
F
P
S
I
L
G
P
P
R
R
Site 69
S608
L
G
P
P
R
R
P
S
R
H
D
N
S
A
I
Site 70
S631
A
R
H
P
K
H
L
S
T
P
S
S
V
S
P
Site 71
T632
R
H
P
K
H
L
S
T
P
S
S
V
S
P
E
Site 72
S634
P
K
H
L
S
T
P
S
S
V
S
P
E
P
Q
Site 73
S635
K
H
L
S
T
P
S
S
V
S
P
E
P
Q
D
Site 74
S637
L
S
T
P
S
S
V
S
P
E
P
Q
D
S
A
Site 75
S643
V
S
P
E
P
Q
D
S
A
K
L
R
Q
S
G
Site 76
S649
D
S
A
K
L
R
Q
S
G
L
A
N
E
G
T
Site 77
T656
S
G
L
A
N
E
G
T
D
A
G
Y
L
P
A
Site 78
Y660
N
E
G
T
D
A
G
Y
L
P
A
N
S
M
S
Site 79
S667
Y
L
P
A
N
S
M
S
S
V
A
S
G
A
S
Site 80
S671
N
S
M
S
S
V
A
S
G
A
S
F
S
Q
E
Site 81
S674
S
S
V
A
S
G
A
S
F
S
Q
E
G
G
K
Site 82
S676
V
A
S
G
A
S
F
S
Q
E
G
G
K
E
N
Site 83
T685
E
G
G
K
E
N
D
T
G
S
K
Q
V
G
E
Site 84
S687
G
K
E
N
D
T
G
S
K
Q
V
G
E
T
S
Site 85
S694
S
K
Q
V
G
E
T
S
A
P
G
D
T
L
D
Site 86
T699
E
T
S
A
P
G
D
T
L
D
G
T
P
R
T
Site 87
T703
P
G
D
T
L
D
G
T
P
R
T
L
N
T
V
Site 88
T706
T
L
D
G
T
P
R
T
L
N
T
V
F
D
F
Site 89
T709
G
T
P
R
T
L
N
T
V
F
D
F
P
P
P
Site 90
T732
E
C
E
V
E
R
V
T
E
H
G
T
P
K
P
Site 91
T736
E
R
V
T
E
H
G
T
P
K
P
F
R
K
F
Site 92
S745
K
P
F
R
K
F
D
S
V
A
F
G
E
S
Q
Site 93
Y797
E
V
I
N
E
L
F
Y
T
E
R
A
H
V
R
Site 94
T798
V
I
N
E
L
F
Y
T
E
R
A
H
V
R
T
Site 95
T805
T
E
R
A
H
V
R
T
L
K
V
L
D
Q
V
Site 96
Y814
K
V
L
D
Q
V
F
Y
Q
R
V
S
R
E
G
Site 97
S818
Q
V
F
Y
Q
R
V
S
R
E
G
I
L
S
P
Site 98
S824
V
S
R
E
G
I
L
S
P
S
E
L
R
K
I
Site 99
S826
R
E
G
I
L
S
P
S
E
L
R
K
I
F
S
Site 100
S833
S
E
L
R
K
I
F
S
N
L
E
D
I
L
Q
Site 101
T858
A
V
R
K
R
N
E
T
S
V
I
D
Q
I
G
Site 102
T870
Q
I
G
E
D
L
L
T
W
F
S
G
P
G
E
Site 103
S873
E
D
L
L
T
W
F
S
G
P
G
E
E
K
L
Site 104
T886
K
L
K
H
A
A
A
T
F
C
S
N
Q
P
F
Site 105
S900
F
A
L
E
M
I
K
S
R
Q
K
K
D
S
R
Site 106
S906
K
S
R
Q
K
K
D
S
R
F
Q
T
F
V
Q
Site 107
T910
K
K
D
S
R
F
Q
T
F
V
Q
D
A
E
S
Site 108
T938
P
T
Q
M
Q
R
L
T
K
Y
P
L
L
L
D
Site 109
Y940
Q
M
Q
R
L
T
K
Y
P
L
L
L
D
N
I
Site 110
Y950
L
L
D
N
I
A
K
Y
T
E
W
P
T
E
R
Site 111
Y973
H
C
R
Q
I
L
N
Y
V
N
Q
A
V
K
E
Site 112
Y990
N
K
Q
R
L
E
D
Y
Q
R
R
L
D
T
S
Site 113
T996
D
Y
Q
R
R
L
D
T
S
S
L
K
L
S
E
Site 114
S997
Y
Q
R
R
L
D
T
S
S
L
K
L
S
E
Y
Site 115
S998
Q
R
R
L
D
T
S
S
L
K
L
S
E
Y
P
Site 116
S1002
D
T
S
S
L
K
L
S
E
Y
P
N
V
E
E
Site 117
Y1004
S
S
L
K
L
S
E
Y
P
N
V
E
E
L
R
Site 118
T1016
E
L
R
N
L
D
L
T
K
R
K
M
I
H
E
Site 119
T1035
W
K
V
N
R
D
K
T
I
D
L
Y
T
L
L
Site 120
Y1039
R
D
K
T
I
D
L
Y
T
L
L
L
E
D
I
Site 121
S1068
C
H
S
K
I
L
A
S
T
A
D
S
K
H
T
Site 122
S1072
I
L
A
S
T
A
D
S
K
H
T
F
S
P
V
Site 123
T1075
S
T
A
D
S
K
H
T
F
S
P
V
I
K
L
Site 124
S1077
A
D
S
K
H
T
F
S
P
V
I
K
L
S
T
Site 125
S1101
N
K
A
L
F
V
I
S
M
S
D
N
G
A
Q
Site 126
Y1110
S
D
N
G
A
Q
I
Y
E
L
V
A
Q
T
V
Site 127
T1121
A
Q
T
V
S
E
K
T
V
W
Q
D
L
I
C
Site 128
S1138
A
A
S
V
K
E
Q
S
T
K
P
I
P
L
P
Site 129
S1147
K
P
I
P
L
P
Q
S
T
P
G
E
G
D
N
Site 130
T1148
P
I
P
L
P
Q
S
T
P
G
E
G
D
N
D
Site 131
S1160
D
N
D
E
E
D
P
S
K
L
K
E
E
Q
H
Site 132
S1170
K
E
E
Q
H
G
I
S
V
T
G
L
Q
S
P
Site 133
T1172
E
Q
H
G
I
S
V
T
G
L
Q
S
P
D
R
Site 134
S1176
I
S
V
T
G
L
Q
S
P
D
R
D
L
G
L
Site 135
S1185
D
R
D
L
G
L
E
S
T
L
I
S
S
K
P
Site 136
T1186
R
D
L
G
L
E
S
T
L
I
S
S
K
P
Q
Site 137
S1189
G
L
E
S
T
L
I
S
S
K
P
Q
S
H
S
Site 138
S1190
L
E
S
T
L
I
S
S
K
P
Q
S
H
S
L
Site 139
S1194
L
I
S
S
K
P
Q
S
H
S
L
S
T
S
G
Site 140
S1196
S
S
K
P
Q
S
H
S
L
S
T
S
G
K
S
Site 141
S1198
K
P
Q
S
H
S
L
S
T
S
G
K
S
E
V
Site 142
S1200
Q
S
H
S
L
S
T
S
G
K
S
E
V
R
D
Site 143
S1203
S
L
S
T
S
G
K
S
E
V
R
D
L
F
V
Site 144
T1224
K
E
Q
H
T
D
G
T
L
K
E
V
G
E
D
Site 145
Y1232
L
K
E
V
G
E
D
Y
Q
I
A
I
P
D
S
Site 146
S1239
Y
Q
I
A
I
P
D
S
H
L
P
V
S
E
E
Site 147
S1244
P
D
S
H
L
P
V
S
E
E
R
W
A
L
D
Site 148
S1273
Q
L
G
L
T
E
K
S
V
Q
E
D
W
Q
H
Site 149
Y1284
D
W
Q
H
F
P
R
Y
R
T
A
S
Q
G
P
Site 150
T1286
Q
H
F
P
R
Y
R
T
A
S
Q
G
P
Q
T
Site 151
S1288
F
P
R
Y
R
T
A
S
Q
G
P
Q
T
D
S
Site 152
T1293
T
A
S
Q
G
P
Q
T
D
S
V
I
Q
N
S
Site 153
S1295
S
Q
G
P
Q
T
D
S
V
I
Q
N
S
E
N
Site 154
Y1306
N
S
E
N
I
K
A
Y
H
S
G
E
G
H
M
Site 155
T1319
H
M
P
F
R
T
G
T
G
D
I
A
T
C
Y
Site 156
T1324
T
G
T
G
D
I
A
T
C
Y
S
P
R
T
S
Site 157
Y1326
T
G
D
I
A
T
C
Y
S
P
R
T
S
T
E
Site 158
S1327
G
D
I
A
T
C
Y
S
P
R
T
S
T
E
S
Site 159
T1330
A
T
C
Y
S
P
R
T
S
T
E
S
F
A
P
Site 160
S1331
T
C
Y
S
P
R
T
S
T
E
S
F
A
P
R
Site 161
T1332
C
Y
S
P
R
T
S
T
E
S
F
A
P
R
D
Site 162
S1334
S
P
R
T
S
T
E
S
F
A
P
R
D
S
V
Site 163
S1340
E
S
F
A
P
R
D
S
V
G
L
A
P
Q
D
Site 164
T1362
V
M
D
H
M
I
M
T
P
E
M
P
T
M
E
Site 165
T1367
I
M
T
P
E
M
P
T
M
E
P
E
G
G
L
Site 166
S1377
P
E
G
G
L
D
D
S
G
E
H
F
F
D
A
Site 167
S1389
F
D
A
R
E
A
H
S
D
E
N
P
S
E
G
Site 168
S1412
K
D
V
N
L
R
I
S
G
N
Y
L
I
L
D
Site 169
Y1415
N
L
R
I
S
G
N
Y
L
I
L
D
G
Y
D
Site 170
Y1421
N
Y
L
I
L
D
G
Y
D
P
V
Q
E
S
S
Site 171
S1435
S
T
D
E
E
V
A
S
S
L
T
L
Q
P
M
Site 172
S1436
T
D
E
E
V
A
S
S
L
T
L
Q
P
M
T
Site 173
S1450
T
G
I
P
A
V
E
S
T
H
Q
Q
Q
H
S
Site 174
S1457
S
T
H
Q
Q
Q
H
S
P
Q
N
T
H
S
D
Site 175
T1461
Q
Q
H
S
P
Q
N
T
H
S
D
G
A
I
S
Site 176
S1463
H
S
P
Q
N
T
H
S
D
G
A
I
S
P
F
Site 177
S1468
T
H
S
D
G
A
I
S
P
F
T
P
E
F
L
Site 178
T1471
D
G
A
I
S
P
F
T
P
E
F
L
V
Q
Q
Site 179
S1492
Y
S
C
F
E
I
Q
S
P
S
S
C
A
D
S
Site 180
S1494
C
F
E
I
Q
S
P
S
S
C
A
D
S
Q
S
Site 181
S1495
F
E
I
Q
S
P
S
S
C
A
D
S
Q
S
Q
Site 182
S1499
S
P
S
S
C
A
D
S
Q
S
Q
I
M
E
Y
Site 183
S1501
S
S
C
A
D
S
Q
S
Q
I
M
E
Y
I
H
Site 184
Y1506
S
Q
S
Q
I
M
E
Y
I
H
K
I
E
A
D
Site 185
T1525
K
K
V
E
E
S
Y
T
I
L
C
Q
R
L
A
Site 186
S1541
S
A
L
T
D
K
H
S
D
K
S
_
_
_
_
Site 187
S1544
T
D
K
H
S
D
K
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation