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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF224
Full Name:
Zinc finger protein 224
Alias:
BMZF2; BMZF-2; Bone marrow zinc finger 2; KOX22; Z255; Zinc finger 224; Zinc finger 233; Zinc finger 27; Zinc finger KOX22; Zinc finger protein 255; ZN255; ZNF255; ZNF27
Type:
Transcription factor
Mass (Da):
82248
Number AA:
707
UniProt ID:
Q9NZL3
International Prot ID:
IPI00396331
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
D
L
A
Q
R
K
L
Y
R
D
V
M
L
E
N
Site 2
S46
E
N
F
R
N
L
L
S
V
G
H
Q
A
F
H
Site 3
T88
K
I
Q
T
E
M
E
T
V
S
E
A
G
T
H
Site 4
S90
Q
T
E
M
E
T
V
S
E
A
G
T
H
Q
E
Site 5
T94
E
T
V
S
E
A
G
T
H
Q
E
W
S
F
Q
Site 6
S109
Q
I
W
E
K
I
A
S
D
L
T
R
S
Q
D
Site 7
T112
E
K
I
A
S
D
L
T
R
S
Q
D
L
V
I
Site 8
S114
I
A
S
D
L
T
R
S
Q
D
L
V
I
N
S
Site 9
S121
S
Q
D
L
V
I
N
S
S
Q
F
S
K
E
G
Site 10
S122
Q
D
L
V
I
N
S
S
Q
F
S
K
E
G
D
Site 11
S125
V
I
N
S
S
Q
F
S
K
E
G
D
F
P
C
Site 12
S139
C
Q
T
E
A
G
L
S
V
I
H
T
R
Q
K
Site 13
T143
A
G
L
S
V
I
H
T
R
Q
K
S
S
Q
G
Site 14
S147
V
I
H
T
R
Q
K
S
S
Q
G
N
G
Y
K
Site 15
Y153
K
S
S
Q
G
N
G
Y
K
P
S
F
S
D
V
Site 16
S156
Q
G
N
G
Y
K
P
S
F
S
D
V
S
H
F
Site 17
S158
N
G
Y
K
P
S
F
S
D
V
S
H
F
D
F
Site 18
S161
K
P
S
F
S
D
V
S
H
F
D
F
H
Q
Q
Site 19
S171
D
F
H
Q
Q
L
H
S
G
E
K
S
H
T
C
Site 20
S175
Q
L
H
S
G
E
K
S
H
T
C
D
E
C
G
Site 21
T177
H
S
G
E
K
S
H
T
C
D
E
C
G
K
N
Site 22
Y187
E
C
G
K
N
F
C
Y
I
S
A
L
R
I
H
Site 23
Y204
V
H
M
G
E
K
C
Y
K
C
D
V
C
G
K
Site 24
S214
D
V
C
G
K
E
F
S
Q
S
S
H
L
Q
T
Site 25
S216
C
G
K
E
F
S
Q
S
S
H
L
Q
T
H
Q
Site 26
S217
G
K
E
F
S
Q
S
S
H
L
Q
T
H
Q
R
Site 27
T221
S
Q
S
S
H
L
Q
T
H
Q
R
V
H
T
G
Site 28
T227
Q
T
H
Q
R
V
H
T
G
E
K
P
F
K
C
Site 29
S242
V
E
C
G
K
G
F
S
R
R
S
A
L
N
V
Site 30
S245
G
K
G
F
S
R
R
S
A
L
N
V
H
H
K
Site 31
T255
N
V
H
H
K
L
H
T
G
E
K
P
Y
N
C
Site 32
Y260
L
H
T
G
E
K
P
Y
N
C
E
E
C
G
K
Site 33
S273
G
K
A
F
I
H
D
S
Q
L
Q
E
H
Q
R
Site 34
T283
Q
E
H
Q
R
I
H
T
G
E
K
P
F
K
C
Site 35
S301
G
K
S
F
C
G
R
S
R
L
N
R
H
S
M
Site 36
S307
R
S
R
L
N
R
H
S
M
V
H
T
A
E
K
Site 37
T311
N
R
H
S
M
V
H
T
A
E
K
P
F
R
C
Site 38
T320
E
K
P
F
R
C
D
T
C
D
K
S
F
R
Q
Site 39
S324
R
C
D
T
C
D
K
S
F
R
Q
R
S
A
L
Site 40
S329
D
K
S
F
R
Q
R
S
A
L
N
S
H
R
M
Site 41
S333
R
Q
R
S
A
L
N
S
H
R
M
I
H
T
G
Site 42
T339
N
S
H
R
M
I
H
T
G
E
K
P
Y
K
C
Site 43
T367
Y
T
H
H
M
V
H
T
G
E
K
P
Y
N
C
Site 44
Y372
V
H
T
G
E
K
P
Y
N
C
K
E
C
G
K
Site 45
S385
G
K
S
F
R
W
A
S
C
L
L
K
H
Q
R
Site 46
S395
L
K
H
Q
R
V
H
S
G
E
K
P
F
K
C
Site 47
S421
Q
C
Y
S
H
Q
R
S
H
S
G
E
K
P
Y
Site 48
S423
Y
S
H
Q
R
S
H
S
G
E
K
P
Y
K
C
Site 49
Y428
S
H
S
G
E
K
P
Y
K
C
V
E
C
G
K
Site 50
Y437
C
V
E
C
G
K
G
Y
K
R
R
L
D
L
D
Site 51
T451
D
F
H
Q
R
V
H
T
G
E
K
L
Y
N
C
Site 52
Y456
V
H
T
G
E
K
L
Y
N
C
K
E
C
G
K
Site 53
S464
N
C
K
E
C
G
K
S
F
S
R
A
P
C
L
Site 54
S466
K
E
C
G
K
S
F
S
R
A
P
C
L
L
K
Site 55
S479
L
K
H
E
R
L
H
S
G
E
K
P
F
Q
C
Site 56
T494
E
E
C
G
K
R
F
T
Q
N
S
H
L
H
S
Site 57
S497
G
K
R
F
T
Q
N
S
H
L
H
S
H
Q
R
Site 58
S501
T
Q
N
S
H
L
H
S
H
Q
R
V
H
T
G
Site 59
T507
H
S
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 60
Y521
C
E
K
C
G
K
G
Y
N
S
K
F
N
L
D
Site 61
T535
D
M
H
Q
K
V
H
T
G
E
R
P
Y
N
C
Site 62
Y540
V
H
T
G
E
R
P
Y
N
C
K
E
C
G
K
Site 63
S553
G
K
S
F
G
W
A
S
C
L
L
K
H
Q
R
Site 64
S563
L
K
H
Q
R
L
H
S
G
E
K
P
F
K
C
Site 65
T578
E
E
C
G
K
R
F
T
Q
N
S
Q
L
H
S
Site 66
S581
G
K
R
F
T
Q
N
S
Q
L
H
S
H
Q
R
Site 67
S585
T
Q
N
S
Q
L
H
S
H
Q
R
V
H
T
G
Site 68
Y596
V
H
T
G
E
K
P
Y
K
C
D
E
C
G
K
Site 69
S606
D
E
C
G
K
G
F
S
W
S
S
T
R
L
T
Site 70
S608
C
G
K
G
F
S
W
S
S
T
R
L
T
H
Q
Site 71
S609
G
K
G
F
S
W
S
S
T
R
L
T
H
Q
R
Site 72
T610
K
G
F
S
W
S
S
T
R
L
T
H
Q
R
R
Site 73
T613
S
W
S
S
T
R
L
T
H
Q
R
R
H
S
R
Site 74
S619
L
T
H
Q
R
R
H
S
R
E
T
P
L
K
C
Site 75
T622
Q
R
R
H
S
R
E
T
P
L
K
C
E
Q
H
Site 76
S637
G
K
N
I
V
Q
N
S
F
S
K
V
Q
E
K
Site 77
S647
K
V
Q
E
K
V
H
S
V
E
K
P
Y
K
C
Site 78
Y661
C
E
D
C
G
K
G
Y
N
R
R
L
N
L
D
Site 79
S690
R
E
C
D
M
C
F
S
Q
A
S
S
L
R
L
Site 80
S694
M
C
F
S
Q
A
S
S
L
R
L
H
Q
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation