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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DTL
Full Name:
Denticleless protein homolog
Alias:
Ddb1- and Cul4-associated factor 2; Denticleless; FLJ20735; L2DTL; Lethal(2) denticleless; Lethal(2) denticleless protein homologue; RA-regulated nuclear matrix-associated protein; Retinoic acid-regulated nuclear matrix-associated protein
Type:
Nuclear membrane, Membrane, Cytoplasm, Nucleus protein
Mass (Da):
79441
Number AA:
730
UniProt ID:
Q9NZJ0
International Prot ID:
IPI00643808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
G
V
L
R
N
G
W
S
S
Q
Y
P
L
Q
S
Site 2
S21
V
L
R
N
G
W
S
S
Q
Y
P
L
Q
S
L
Site 3
Y23
R
N
G
W
S
S
Q
Y
P
L
Q
S
L
L
T
Site 4
S27
S
S
Q
Y
P
L
Q
S
L
L
T
G
Y
Q
C
Site 5
Y32
L
Q
S
L
L
T
G
Y
Q
C
S
G
N
D
E
Site 6
S35
L
L
T
G
Y
Q
C
S
G
N
D
E
H
T
S
Site 7
T41
C
S
G
N
D
E
H
T
S
Y
G
E
T
G
V
Site 8
S42
S
G
N
D
E
H
T
S
Y
G
E
T
G
V
P
Site 9
Y43
G
N
D
E
H
T
S
Y
G
E
T
G
V
P
V
Site 10
T46
E
H
T
S
Y
G
E
T
G
V
P
V
P
P
F
Site 11
S58
P
P
F
G
C
T
F
S
S
A
P
N
M
E
H
Site 12
Y79
E
E
G
F
V
R
L
Y
N
T
E
S
Q
S
F
Site 13
T81
G
F
V
R
L
Y
N
T
E
S
Q
S
F
R
K
Site 14
S83
V
R
L
Y
N
T
E
S
Q
S
F
R
K
K
C
Site 15
S85
L
Y
N
T
E
S
Q
S
F
R
K
K
C
F
K
Site 16
T135
K
A
G
E
L
I
G
T
C
K
G
H
Q
C
S
Site 17
S142
T
C
K
G
H
Q
C
S
L
K
S
V
A
F
S
Site 18
S145
G
H
Q
C
S
L
K
S
V
A
F
S
K
F
E
Site 19
Y179
C
N
K
K
D
G
F
Y
R
Q
V
N
Q
I
S
Site 20
T191
Q
I
S
G
A
H
N
T
S
D
K
Q
T
P
S
Site 21
S192
I
S
G
A
H
N
T
S
D
K
Q
T
P
S
K
Site 22
T196
H
N
T
S
D
K
Q
T
P
S
K
P
K
K
K
Site 23
S198
T
S
D
K
Q
T
P
S
K
P
K
K
K
Q
N
Site 24
S206
K
P
K
K
K
Q
N
S
K
G
L
A
P
S
V
Site 25
S212
N
S
K
G
L
A
P
S
V
D
F
Q
Q
S
V
Site 26
Y249
V
W
D
L
R
K
N
Y
T
A
Y
R
Q
E
P
Site 27
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Site 28
S261
Q
E
P
I
A
S
K
S
F
L
Y
P
G
S
S
Site 29
Y264
I
A
S
K
S
F
L
Y
P
G
S
S
T
R
K
Site 30
S267
K
S
F
L
Y
P
G
S
S
T
R
K
L
G
Y
Site 31
S268
S
F
L
Y
P
G
S
S
T
R
K
L
G
Y
S
Site 32
S275
S
T
R
K
L
G
Y
S
S
L
I
L
D
S
T
Site 33
S276
T
R
K
L
G
Y
S
S
L
I
L
D
S
T
G
Site 34
T318
F
N
G
H
Q
N
S
T
F
Y
V
K
S
S
L
Site 35
Y320
G
H
Q
N
S
T
F
Y
V
K
S
S
L
S
P
Site 36
S324
S
T
F
Y
V
K
S
S
L
S
P
D
D
Q
F
Site 37
S326
F
Y
V
K
S
S
L
S
P
D
D
Q
F
L
V
Site 38
S334
P
D
D
Q
F
L
V
S
G
S
S
D
E
A
A
Site 39
T348
A
Y
I
W
K
V
S
T
P
W
Q
P
P
T
V
Site 40
T354
S
T
P
W
Q
P
P
T
V
L
L
G
H
S
Q
Site 41
S380
F
T
K
I
A
T
C
S
D
D
N
T
L
K
I
Site 42
S404
K
P
G
G
D
K
L
S
T
V
G
W
A
S
Q
Site 43
T405
P
G
G
D
K
L
S
T
V
G
W
A
S
Q
K
Site 44
S410
L
S
T
V
G
W
A
S
Q
K
K
K
E
S
R
Site 45
S416
A
S
Q
K
K
K
E
S
R
P
G
L
V
T
V
Site 46
T422
E
S
R
P
G
L
V
T
V
T
S
S
Q
S
T
Site 47
T424
R
P
G
L
V
T
V
T
S
S
Q
S
T
P
A
Site 48
S425
P
G
L
V
T
V
T
S
S
Q
S
T
P
A
K
Site 49
S426
G
L
V
T
V
T
S
S
Q
S
T
P
A
K
A
Site 50
S428
V
T
V
T
S
S
Q
S
T
P
A
K
A
P
R
Site 51
T429
T
V
T
S
S
Q
S
T
P
A
K
A
P
R
A
Site 52
S441
P
R
A
K
C
N
P
S
N
S
S
P
S
S
A
Site 53
S443
A
K
C
N
P
S
N
S
S
P
S
S
A
A
C
Site 54
S444
K
C
N
P
S
N
S
S
P
S
S
A
A
C
A
Site 55
S447
P
S
N
S
S
P
S
S
A
A
C
A
P
S
C
Site 56
S462
A
G
D
L
P
L
P
S
N
T
P
T
F
S
I
Site 57
T464
D
L
P
L
P
S
N
T
P
T
F
S
I
K
T
Site 58
T466
P
L
P
S
N
T
P
T
F
S
I
K
T
S
P
Site 59
S468
P
S
N
T
P
T
F
S
I
K
T
S
P
A
K
Site 60
S472
P
T
F
S
I
K
T
S
P
A
K
A
R
S
P
Site 61
S478
T
S
P
A
K
A
R
S
P
I
N
R
R
G
S
Site 62
S485
S
P
I
N
R
R
G
S
V
S
S
V
S
P
K
Site 63
S487
I
N
R
R
G
S
V
S
S
V
S
P
K
P
P
Site 64
S488
N
R
R
G
S
V
S
S
V
S
P
K
P
P
S
Site 65
S490
R
G
S
V
S
S
V
S
P
K
P
P
S
S
F
Site 66
S495
S
V
S
P
K
P
P
S
S
F
K
M
S
I
R
Site 67
S496
V
S
P
K
P
P
S
S
F
K
M
S
I
R
N
Site 68
S500
P
P
S
S
F
K
M
S
I
R
N
W
V
T
R
Site 69
T506
M
S
I
R
N
W
V
T
R
T
P
S
S
S
P
Site 70
T508
I
R
N
W
V
T
R
T
P
S
S
S
P
P
I
Site 71
S510
N
W
V
T
R
T
P
S
S
S
P
P
I
T
P
Site 72
S511
W
V
T
R
T
P
S
S
S
P
P
I
T
P
P
Site 73
S512
V
T
R
T
P
S
S
S
P
P
I
T
P
P
A
Site 74
T516
P
S
S
S
P
P
I
T
P
P
A
S
E
T
K
Site 75
S520
P
P
I
T
P
P
A
S
E
T
K
I
M
S
P
Site 76
T522
I
T
P
P
A
S
E
T
K
I
M
S
P
R
K
Site 77
S526
A
S
E
T
K
I
M
S
P
R
K
A
L
I
P
Site 78
S535
R
K
A
L
I
P
V
S
Q
K
S
S
Q
A
E
Site 79
S538
L
I
P
V
S
Q
K
S
S
Q
A
E
A
C
S
Site 80
S539
I
P
V
S
Q
K
S
S
Q
A
E
A
C
S
E
Site 81
S545
S
S
Q
A
E
A
C
S
E
S
R
N
R
V
K
Site 82
S557
R
V
K
R
R
L
D
S
S
C
L
E
S
V
K
Site 83
S558
V
K
R
R
L
D
S
S
C
L
E
S
V
K
Q
Site 84
S562
L
D
S
S
C
L
E
S
V
K
Q
K
C
V
K
Site 85
S599
A
G
N
Q
E
D
L
S
K
D
S
L
G
P
T
Site 86
S602
Q
E
D
L
S
K
D
S
L
G
P
T
K
S
S
Site 87
T606
S
K
D
S
L
G
P
T
K
S
S
K
I
E
G
Site 88
S608
D
S
L
G
P
T
K
S
S
K
I
E
G
A
G
Site 89
T616
S
K
I
E
G
A
G
T
S
I
S
E
P
P
S
Site 90
S617
K
I
E
G
A
G
T
S
I
S
E
P
P
S
P
Site 91
S619
E
G
A
G
T
S
I
S
E
P
P
S
P
I
S
Site 92
S623
T
S
I
S
E
P
P
S
P
I
S
P
Y
A
S
Site 93
S626
S
E
P
P
S
P
I
S
P
Y
A
S
E
S
C
Site 94
Y628
P
P
S
P
I
S
P
Y
A
S
E
S
C
G
T
Site 95
S630
S
P
I
S
P
Y
A
S
E
S
C
G
T
L
P
Site 96
T635
Y
A
S
E
S
C
G
T
L
P
L
P
L
R
P
Site 97
S647
L
R
P
C
G
E
G
S
E
M
V
G
K
E
N
Site 98
S655
E
M
V
G
K
E
N
S
S
P
E
N
K
N
W
Site 99
S656
M
V
G
K
E
N
S
S
P
E
N
K
N
W
L
Site 100
S676
K
R
K
A
E
N
P
S
P
R
S
P
S
S
Q
Site 101
S679
A
E
N
P
S
P
R
S
P
S
S
Q
T
P
N
Site 102
S681
N
P
S
P
R
S
P
S
S
Q
T
P
N
S
R
Site 103
S682
P
S
P
R
S
P
S
S
Q
T
P
N
S
R
R
Site 104
T684
P
R
S
P
S
S
Q
T
P
N
S
R
R
Q
S
Site 105
S687
P
S
S
Q
T
P
N
S
R
R
Q
S
G
K
T
Site 106
S691
T
P
N
S
R
R
Q
S
G
K
T
L
P
S
P
Site 107
T694
S
R
R
Q
S
G
K
T
L
P
S
P
V
T
I
Site 108
S697
Q
S
G
K
T
L
P
S
P
V
T
I
T
P
S
Site 109
T700
K
T
L
P
S
P
V
T
I
T
P
S
S
M
R
Site 110
T702
L
P
S
P
V
T
I
T
P
S
S
M
R
K
I
Site 111
S704
S
P
V
T
I
T
P
S
S
M
R
K
I
C
T
Site 112
S705
P
V
T
I
T
P
S
S
M
R
K
I
C
T
Y
Site 113
Y712
S
M
R
K
I
C
T
Y
F
H
R
K
S
Q
E
Site 114
S717
C
T
Y
F
H
R
K
S
Q
E
D
F
C
G
P
Site 115
S727
D
F
C
G
P
E
H
S
T
E
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation