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Updated November 2019
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Protein Info
Short Name:
formin 2
Full Name:
Formin-2
Alias:
FMN2
Type:
Uncharacterized protein found almost exclusively in the developing and mature central nervous system
Mass (Da):
180106
Number AA:
1722
UniProt ID:
Q9NZ56
International Prot ID:
IPI00742944
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0051295
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
Q
D
G
K
L
K
R
S
A
G
D
A
L
H
E
Site 2
T35
G
P
R
D
V
E
A
T
K
K
G
S
G
G
K
Site 3
S61
G
G
G
G
G
G
E
S
G
K
K
K
S
K
S
Site 4
S66
G
E
S
G
K
K
K
S
K
S
D
S
R
A
S
Site 5
S68
S
G
K
K
K
S
K
S
D
S
R
A
S
V
F
Site 6
S70
K
K
K
S
K
S
D
S
R
A
S
V
F
S
N
Site 7
S73
S
K
S
D
S
R
A
S
V
F
S
N
L
R
I
Site 8
S76
D
S
R
A
S
V
F
S
N
L
R
I
R
K
N
Site 9
S85
L
R
I
R
K
N
L
S
K
G
K
G
A
G
G
Site 10
S93
K
G
K
G
A
G
G
S
R
E
D
V
L
D
S
Site 11
S100
S
R
E
D
V
L
D
S
Q
A
L
Q
T
G
E
Site 12
S110
L
Q
T
G
E
L
D
S
A
H
S
L
L
T
K
Site 13
S113
G
E
L
D
S
A
H
S
L
L
T
K
T
P
D
Site 14
T116
D
S
A
H
S
L
L
T
K
T
P
D
L
S
L
Site 15
T118
A
H
S
L
L
T
K
T
P
D
L
S
L
S
A
Site 16
S122
L
T
K
T
P
D
L
S
L
S
A
D
E
A
G
Site 17
S124
K
T
P
D
L
S
L
S
A
D
E
A
G
L
S
Site 18
S131
S
A
D
E
A
G
L
S
D
T
E
C
A
D
P
Site 19
T133
D
E
A
G
L
S
D
T
E
C
A
D
P
F
E
Site 20
T165
P
I
A
E
D
V
E
T
A
A
G
A
Q
D
G
Site 21
T175
G
A
Q
D
G
Q
R
T
S
S
G
S
D
T
D
Site 22
S176
A
Q
D
G
Q
R
T
S
S
G
S
D
T
D
I
Site 23
S177
Q
D
G
Q
R
T
S
S
G
S
D
T
D
I
Y
Site 24
S179
G
Q
R
T
S
S
G
S
D
T
D
I
Y
S
F
Site 25
T181
R
T
S
S
G
S
D
T
D
I
Y
S
F
H
S
Site 26
Y184
S
G
S
D
T
D
I
Y
S
F
H
S
A
T
E
Site 27
S185
G
S
D
T
D
I
Y
S
F
H
S
A
T
E
Q
Site 28
S197
T
E
Q
E
D
L
L
S
D
I
Q
Q
A
I
R
Site 29
T237
E
E
P
A
A
P
P
T
A
V
S
P
Q
P
G
Site 30
S266
G
A
G
E
A
P
G
S
P
D
T
E
Q
A
L
Site 31
T269
E
A
P
G
S
P
D
T
E
Q
A
L
S
A
L
Site 32
S274
P
D
T
E
Q
A
L
S
A
L
S
D
L
P
E
Site 33
S277
E
Q
A
L
S
A
L
S
D
L
P
E
S
L
A
Site 34
S282
A
L
S
D
L
P
E
S
L
A
A
E
P
R
E
Site 35
S295
R
E
P
Q
Q
P
P
S
P
G
G
L
P
V
S
Site 36
S302
S
P
G
G
L
P
V
S
E
A
P
S
L
P
A
Site 37
S317
A
Q
P
A
A
K
D
S
P
S
S
T
A
F
P
Site 38
S319
P
A
A
K
D
S
P
S
S
T
A
F
P
F
P
Site 39
S320
A
A
K
D
S
P
S
S
T
A
F
P
F
P
E
Site 40
T321
A
K
D
S
P
S
S
T
A
F
P
F
P
E
A
Site 41
T345
P
V
R
G
A
G
D
T
D
E
E
G
E
E
D
Site 42
S361
F
E
D
A
P
R
G
S
P
G
E
E
W
A
P
Site 43
S396
P
D
A
P
A
A
A
S
L
P
G
S
P
A
P
Site 44
S400
A
A
A
S
L
P
G
S
P
A
P
S
Q
R
C
Site 45
S404
L
P
G
S
P
A
P
S
Q
R
C
F
K
P
Y
Site 46
Y411
S
Q
R
C
F
K
P
Y
P
L
I
T
P
C
Y
Site 47
Y418
Y
P
L
I
T
P
C
Y
I
K
T
T
T
R
Q
Site 48
T421
I
T
P
C
Y
I
K
T
T
T
R
Q
L
S
S
Site 49
T422
T
P
C
Y
I
K
T
T
T
R
Q
L
S
S
P
Site 50
T423
P
C
Y
I
K
T
T
T
R
Q
L
S
S
P
N
Site 51
S427
K
T
T
T
R
Q
L
S
S
P
N
H
S
P
S
Site 52
S428
T
T
T
R
Q
L
S
S
P
N
H
S
P
S
Q
Site 53
S432
Q
L
S
S
P
N
H
S
P
S
Q
S
P
N
Q
Site 54
S434
S
S
P
N
H
S
P
S
Q
S
P
N
Q
S
P
Site 55
S436
P
N
H
S
P
S
Q
S
P
N
Q
S
P
R
I
Site 56
S440
P
S
Q
S
P
N
Q
S
P
R
I
K
R
R
P
Site 57
S450
I
K
R
R
P
E
P
S
L
S
R
G
S
R
T
Site 58
S452
R
R
P
E
P
S
L
S
R
G
S
R
T
A
L
Site 59
S455
E
P
S
L
S
R
G
S
R
T
A
L
A
S
V
Site 60
S461
G
S
R
T
A
L
A
S
V
A
A
P
A
K
K
Site 61
S480
G
G
L
A
A
G
L
S
R
S
A
D
W
T
E
Site 62
S482
L
A
A
G
L
S
R
S
A
D
W
T
E
E
L
Site 63
T486
L
S
R
S
A
D
W
T
E
E
L
G
A
R
T
Site 64
T493
T
E
E
L
G
A
R
T
P
R
V
G
G
S
A
Site 65
S499
R
T
P
R
V
G
G
S
A
H
L
L
E
R
G
Site 66
S509
L
L
E
R
G
V
A
S
D
S
G
G
G
V
S
Site 67
S511
E
R
G
V
A
S
D
S
G
G
G
V
S
P
A
Site 68
S516
S
D
S
G
G
G
V
S
P
A
L
A
A
K
A
Site 69
T538
D
G
F
Q
N
V
F
T
G
R
T
L
L
E
K
Site 70
S548
T
L
L
E
K
L
F
S
Q
Q
E
N
G
P
P
Site 71
S563
E
E
A
E
K
F
C
S
R
I
I
A
M
G
L
Site 72
S575
M
G
L
L
L
P
F
S
D
C
F
R
E
P
C
Site 73
S592
N
A
Q
T
N
A
A
S
F
D
Q
D
Q
L
Y
Site 74
Y599
S
F
D
Q
D
Q
L
Y
T
W
A
A
V
S
Q
Site 75
S605
L
Y
T
W
A
A
V
S
Q
P
T
H
S
L
D
Site 76
S610
A
V
S
Q
P
T
H
S
L
D
Y
S
E
G
Q
Site 77
Y613
Q
P
T
H
S
L
D
Y
S
E
G
Q
F
P
R
Site 78
S614
P
T
H
S
L
D
Y
S
E
G
Q
F
P
R
R
Site 79
S624
Q
F
P
R
R
V
P
S
M
G
P
P
S
K
P
Site 80
S629
V
P
S
M
G
P
P
S
K
P
P
D
E
E
H
Site 81
T643
H
R
L
E
D
A
E
T
E
S
Q
S
A
V
S
Site 82
S645
L
E
D
A
E
T
E
S
Q
S
A
V
S
E
T
Site 83
S647
D
A
E
T
E
S
Q
S
A
V
S
E
T
P
Q
Site 84
T652
S
Q
S
A
V
S
E
T
P
Q
K
R
S
D
A
Site 85
S657
S
E
T
P
Q
K
R
S
D
A
V
Q
K
E
V
Site 86
S669
K
E
V
V
D
M
K
S
E
G
Q
A
T
V
I
Site 87
T674
M
K
S
E
G
Q
A
T
V
I
Q
Q
L
E
Q
Site 88
T688
Q
T
I
E
D
L
R
T
K
I
A
E
L
E
R
Site 89
Y697
I
A
E
L
E
R
Q
Y
P
A
L
D
T
E
V
Site 90
T702
R
Q
Y
P
A
L
D
T
E
V
A
S
G
H
Q
Site 91
S743
H
R
I
L
E
A
K
S
I
Q
T
S
P
T
E
Site 92
S747
E
A
K
S
I
Q
T
S
P
T
E
E
G
G
V
Site 93
S775
P
C
P
P
G
A
E
S
G
P
Q
T
K
F
C
Site 94
T779
G
A
E
S
G
P
Q
T
K
F
C
S
E
I
S
Site 95
S786
T
K
F
C
S
E
I
S
L
I
V
S
P
R
R
Site 96
S795
I
V
S
P
R
R
I
S
V
Q
L
D
S
H
Q
Site 97
S800
R
I
S
V
Q
L
D
S
H
Q
P
T
Q
S
I
Site 98
T804
Q
L
D
S
H
Q
P
T
Q
S
I
S
Q
P
P
Site 99
S806
D
S
H
Q
P
T
Q
S
I
S
Q
P
P
P
P
Site 100
S808
H
Q
P
T
Q
S
I
S
Q
P
P
P
P
P
S
Site 101
S815
S
Q
P
P
P
P
P
S
L
L
W
S
A
G
Q
Site 102
S819
P
P
P
S
L
L
W
S
A
G
Q
G
Q
P
G
Site 103
S827
A
G
Q
G
Q
P
G
S
Q
P
P
H
S
I
S
Site 104
S832
P
G
S
Q
P
P
H
S
I
S
T
E
F
Q
T
Site 105
S834
S
Q
P
P
H
S
I
S
T
E
F
Q
T
S
H
Site 106
S840
I
S
T
E
F
Q
T
S
H
E
H
S
V
S
S
Site 107
S844
F
Q
T
S
H
E
H
S
V
S
S
A
F
K
N
Site 108
S846
T
S
H
E
H
S
V
S
S
A
F
K
N
S
C
Site 109
S847
S
H
E
H
S
V
S
S
A
F
K
N
S
C
N
Site 110
S852
V
S
S
A
F
K
N
S
C
N
I
P
S
P
P
Site 111
S857
K
N
S
C
N
I
P
S
P
P
P
L
P
C
T
Site 112
T864
S
P
P
P
L
P
C
T
E
S
S
S
S
M
P
Site 113
S866
P
P
L
P
C
T
E
S
S
S
S
M
P
G
L
Site 114
S867
P
L
P
C
T
E
S
S
S
S
M
P
G
L
G
Site 115
S868
L
P
C
T
E
S
S
S
S
M
P
G
L
G
M
Site 116
S869
P
C
T
E
S
S
S
S
M
P
G
L
G
M
V
Site 117
T887
P
P
P
L
P
G
M
T
V
P
T
L
P
S
T
Site 118
T894
T
V
P
T
L
P
S
T
A
I
P
Q
P
P
P
Site 119
T1230
P
P
L
P
P
P
G
T
G
I
P
P
P
P
L
Site 120
S1251
P
L
L
P
Q
V
G
S
S
T
L
P
T
P
Q
Site 121
Y1297
C
R
P
M
K
P
L
Y
W
T
R
I
Q
L
H
Site 122
S1305
W
T
R
I
Q
L
H
S
K
R
D
S
S
T
S
Site 123
S1309
Q
L
H
S
K
R
D
S
S
T
S
L
I
W
E
Site 124
S1310
L
H
S
K
R
D
S
S
T
S
L
I
W
E
K
Site 125
S1312
S
K
R
D
S
S
T
S
L
I
W
E
K
I
E
Site 126
S1333
H
E
F
E
E
L
F
S
K
T
A
V
K
E
R
Site 127
S1345
K
E
R
K
K
P
I
S
D
T
I
S
K
T
K
Site 128
T1347
R
K
K
P
I
S
D
T
I
S
K
T
K
A
K
Site 129
S1349
K
P
I
S
D
T
I
S
K
T
K
A
K
Q
V
Site 130
S1361
K
Q
V
V
K
L
L
S
N
K
R
S
Q
A
V
Site 131
Y1403
L
E
T
L
Q
A
L
Y
E
N
R
A
Q
S
D
Site 132
S1409
L
Y
E
N
R
A
Q
S
D
E
L
E
K
I
E
Site 133
S1422
I
E
K
H
G
R
S
S
K
D
K
E
N
A
K
Site 134
S1430
K
D
K
E
N
A
K
S
L
D
K
P
E
Q
F
Site 135
Y1439
D
K
P
E
Q
F
L
Y
E
L
S
L
I
P
N
Site 136
S1442
E
Q
F
L
Y
E
L
S
L
I
P
N
F
S
E
Site 137
S1463
F
Q
S
T
F
S
E
S
I
C
S
I
R
R
K
Site 138
S1466
T
F
S
E
S
I
C
S
I
R
R
K
L
E
L
Site 139
T1480
L
L
Q
K
L
C
E
T
L
K
N
G
P
G
V
Site 140
S1527
P
K
L
K
D
V
K
S
S
D
N
S
R
S
L
Site 141
S1531
D
V
K
S
S
D
N
S
R
S
L
L
S
Y
I
Site 142
S1533
K
S
S
D
N
S
R
S
L
L
S
Y
I
V
S
Site 143
S1536
D
N
S
R
S
L
L
S
Y
I
V
S
Y
Y
L
Site 144
Y1537
N
S
R
S
L
L
S
Y
I
V
S
Y
Y
L
R
Site 145
Y1542
L
S
Y
I
V
S
Y
Y
L
R
N
F
D
E
D
Site 146
S1569
P
Q
D
L
F
Q
A
S
Q
M
K
F
E
D
F
Site 147
Y1598
E
V
E
A
G
K
V
Y
Q
V
S
S
K
E
H
Site 148
S1602
G
K
V
Y
Q
V
S
S
K
E
H
M
Q
P
F
Site 149
S1630
D
Q
E
A
E
E
N
S
L
T
E
T
H
K
C
Site 150
T1632
E
A
E
E
N
S
L
T
E
T
H
K
C
F
L
Site 151
T1634
E
E
N
S
L
T
E
T
H
K
C
F
L
E
T
Site 152
S1657
K
L
G
E
K
E
V
S
P
N
A
F
F
S
I
Site 153
S1702
C
R
Q
K
K
G
K
S
L
Y
K
I
K
P
R
Site 154
S1712
K
I
K
P
R
H
D
S
G
I
K
A
K
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation