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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Plk2
Full Name:
Serine/threonine-protein kinase PLK2
Alias:
EC 2.7.11.21; Polo-like kinase 2; Serine/threonine-protein kinase SNK; Serum inducible kinase; Serum-inducible kinase; SNK
Type:
EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family
Mass (Da):
78237
Number AA:
685
UniProt ID:
Q9NYY3
International Prot ID:
IPI00302787
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042801
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0043123
GO:0006468
GO:0000074
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
L
L
R
T
I
T
Y
Q
P
A
A
S
T
Site 2
Y9
E
L
L
R
T
I
T
Y
Q
P
A
A
S
T
K
Site 3
S30
G
K
G
C
G
A
D
S
K
K
K
R
P
P
Q
Site 4
S42
P
P
Q
P
P
E
E
S
Q
P
P
Q
S
Q
A
Site 5
S47
E
E
S
Q
P
P
Q
S
Q
A
Q
V
P
P
A
Site 6
S65
H
H
H
H
H
S
H
S
G
P
E
I
S
R
I
Site 7
T77
S
R
I
I
V
D
P
T
T
G
K
R
Y
C
R
Site 8
T78
R
I
I
V
D
P
T
T
G
K
R
Y
C
R
G
Site 9
Y82
D
P
T
T
G
K
R
Y
C
R
G
K
V
L
G
Site 10
Y97
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
Site 11
T100
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Site 12
T103
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
Site 13
Y108
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
Site 14
S116
A
A
K
I
I
P
H
S
R
V
A
K
P
H
Q
Site 15
Y148
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Site 16
Y156
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
Site 17
S166
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
Site 18
T178
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
Site 19
Y184
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
Site 20
Y185
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
Site 21
S191
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Site 22
Y195
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
Site 23
T239
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
Site 24
T243
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
Site 25
Y246
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
Site 26
S248
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
Site 27
T282
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
Site 28
Y297
R
C
I
R
E
A
R
Y
T
M
P
S
S
L
L
Site 29
S301
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
Site 30
S302
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
Site 31
S324
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
Site 32
T339
D
F
F
L
Q
G
F
T
P
D
R
L
S
S
S
Site 33
S344
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
Site 34
S345
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
Site 35
S346
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
Site 36
S357
T
V
P
D
F
H
L
S
S
P
A
K
N
F
F
Site 37
S358
V
P
D
F
H
L
S
S
P
A
K
N
F
F
K
Site 38
T384
D
K
A
R
Y
I
D
T
H
N
R
V
S
K
E
Site 39
S389
I
D
T
H
N
R
V
S
K
E
D
E
D
I
Y
Site 40
Y396
S
K
E
D
E
D
I
Y
K
L
R
H
D
L
K
Site 41
S406
R
H
D
L
K
K
T
S
I
T
Q
Q
P
S
K
Site 42
T408
D
L
K
K
T
S
I
T
Q
Q
P
S
K
H
R
Site 43
T416
Q
Q
P
S
K
H
R
T
D
E
E
L
Q
P
P
Site 44
T425
E
E
L
Q
P
P
T
T
T
V
A
R
S
G
T
Site 45
T426
E
L
Q
P
P
T
T
T
V
A
R
S
G
T
P
Site 46
T432
T
T
V
A
R
S
G
T
P
A
V
E
N
K
Q
Site 47
S455
I
V
R
G
T
L
G
S
C
S
S
S
S
E
C
Site 48
S457
R
G
T
L
G
S
C
S
S
S
S
E
C
L
E
Site 49
S458
G
T
L
G
S
C
S
S
S
S
E
C
L
E
D
Site 50
S459
T
L
G
S
C
S
S
S
S
E
C
L
E
D
S
Site 51
S460
L
G
S
C
S
S
S
S
E
C
L
E
D
S
T
Site 52
S466
S
S
E
C
L
E
D
S
T
M
G
S
V
A
D
Site 53
S470
L
E
D
S
T
M
G
S
V
A
D
T
V
A
R
Site 54
S500
P
K
E
Q
L
S
T
S
F
Q
W
V
T
K
W
Site 55
Y510
W
V
T
K
W
V
D
Y
S
N
K
Y
G
F
G
Site 56
Y518
S
N
K
Y
G
F
G
Y
Q
L
S
D
H
T
V
Site 57
T524
G
Y
Q
L
S
D
H
T
V
G
V
L
F
N
N
Site 58
S536
F
N
N
G
A
H
M
S
L
L
P
D
K
K
T
Site 59
T543
S
L
L
P
D
K
K
T
V
H
Y
Y
A
E
L
Site 60
Y546
P
D
K
K
T
V
H
Y
Y
A
E
L
G
Q
C
Site 61
Y547
D
K
K
T
V
H
Y
Y
A
E
L
G
Q
C
S
Site 62
S567
D
A
P
E
Q
F
I
S
Q
V
T
V
L
K
Y
Site 63
Y574
S
Q
V
T
V
L
K
Y
F
S
H
Y
M
E
E
Site 64
Y578
V
L
K
Y
F
S
H
Y
M
E
E
N
L
M
D
Site 65
S591
M
D
G
G
D
L
P
S
V
T
D
I
R
R
P
Site 66
T593
G
G
D
L
P
S
V
T
D
I
R
R
P
R
L
Site 67
Y601
D
I
R
R
P
R
L
Y
L
L
Q
W
L
K
S
Site 68
T644
Q
N
E
E
Y
L
L
T
Y
I
N
E
D
R
I
Site 69
S652
Y
I
N
E
D
R
I
S
T
T
F
R
L
T
T
Site 70
T653
I
N
E
D
R
I
S
T
T
F
R
L
T
T
L
Site 71
T654
N
E
D
R
I
S
T
T
F
R
L
T
T
L
L
Site 72
S667
L
L
M
S
G
C
S
S
E
L
K
N
R
M
E
Site 73
Y675
E
L
K
N
R
M
E
Y
A
L
N
M
L
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation