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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEK2
Full Name:
Pleckstrin-2
Alias:
Type:
Cytoplasm, Plasma membrane, Nucleus, Cell projection, Cytoskeleton protein
Mass (Da):
39971
Number AA:
353
UniProt ID:
Q9NYT0
International Prot ID:
IPI00009302
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042995
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
W
F
I
L
R
Q
N
T
L
V
Y
Y
K
L
E
Site 2
Y35
L
R
Q
N
T
L
V
Y
Y
K
L
E
G
G
R
Site 3
Y36
R
Q
N
T
L
V
Y
Y
K
L
E
G
G
R
R
Site 4
T45
L
E
G
G
R
R
V
T
P
P
K
G
R
I
L
Site 5
T76
P
L
L
I
K
L
K
T
Q
T
S
T
E
Y
F
Site 6
S79
I
K
L
K
T
Q
T
S
T
E
Y
F
L
E
A
Site 7
Y82
K
T
Q
T
S
T
E
Y
F
L
E
A
C
S
R
Site 8
S116
G
K
V
Q
Q
L
H
S
L
R
N
S
F
K
L
Site 9
S120
Q
L
H
S
L
R
N
S
F
K
L
P
P
H
I
Site 10
S128
F
K
L
P
P
H
I
S
L
H
R
I
V
D
K
Site 11
S139
I
V
D
K
M
H
D
S
N
T
G
I
R
S
S
Site 12
T141
D
K
M
H
D
S
N
T
G
I
R
S
S
P
N
Site 13
S146
S
N
T
G
I
R
S
S
P
N
M
E
Q
G
S
Site 14
S153
S
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
Site 15
T154
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
Site 16
Y155
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
S
Site 17
T158
Q
G
S
T
Y
K
K
T
F
L
G
S
S
L
V
Site 18
S163
K
K
T
F
L
G
S
S
L
V
D
W
L
I
S
Site 19
S172
V
D
W
L
I
S
N
S
F
T
A
S
R
L
E
Site 20
S206
R
S
M
G
A
I
R
S
G
D
L
A
E
Q
F
Site 21
S217
A
E
Q
F
L
D
D
S
T
A
L
Y
T
F
A
Site 22
T218
E
Q
F
L
D
D
S
T
A
L
Y
T
F
A
E
Site 23
Y221
L
D
D
S
T
A
L
Y
T
F
A
E
S
Y
K
Site 24
T222
D
D
S
T
A
L
Y
T
F
A
E
S
Y
K
K
Site 25
S232
E
S
Y
K
K
K
I
S
P
K
E
E
I
S
L
Site 26
S238
I
S
P
K
E
E
I
S
L
S
T
V
E
L
S
Site 27
S240
P
K
E
E
I
S
L
S
T
V
E
L
S
G
T
Site 28
T241
K
E
E
I
S
L
S
T
V
E
L
S
G
T
V
Site 29
T247
S
T
V
E
L
S
G
T
V
V
K
Q
G
Y
L
Site 30
Y253
G
T
V
V
K
Q
G
Y
L
A
K
Q
G
H
K
Site 31
Y280
K
D
P
A
F
L
H
Y
Y
D
P
S
K
E
E
Site 32
Y281
D
P
A
F
L
H
Y
Y
D
P
S
K
E
E
N
Site 33
S284
F
L
H
Y
Y
D
P
S
K
E
E
N
R
P
V
Site 34
S295
N
R
P
V
G
G
F
S
L
R
G
S
L
V
S
Site 35
T326
G
N
L
F
K
V
I
T
K
D
D
T
H
Y
Y
Site 36
T330
K
V
I
T
K
D
D
T
H
Y
Y
I
Q
A
S
Site 37
Y332
I
T
K
D
D
T
H
Y
Y
I
Q
A
S
S
K
Site 38
Y333
T
K
D
D
T
H
Y
Y
I
Q
A
S
S
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation