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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCA66
Full Name:
U3 small nucleolar RNA-associated protein 6 homolog
Alias:
C17orf40; HC66; Hepatocellular carcinoma associated antigen 66; Hepatocellular carcinoma-associated antigen 66; U3 small nucleolar RNA-associated protein 6; UTP6; UTP6, small subunit (SSU) processome component
Type:
Uncharacterized protein
Mass (Da):
70194
Number AA:
597
UniProt ID:
Q9NYH9
International Prot ID:
IPI00020128
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006364
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
K
K
A
S
D
L
E
Y
K
I
Q
R
R
T
L
Site 2
T48
E
Y
K
I
Q
R
R
T
L
F
K
E
D
F
I
Site 3
Y57
F
K
E
D
F
I
N
Y
V
Q
Y
E
I
N
L
Site 4
T73
E
L
I
Q
R
R
R
T
R
I
G
Y
S
F
K
Site 5
Y77
R
R
R
T
R
I
G
Y
S
F
K
K
D
E
I
Site 6
S78
R
R
T
R
I
G
Y
S
F
K
K
D
E
I
E
Site 7
S87
K
K
D
E
I
E
N
S
I
V
H
R
V
Q
G
Site 8
S100
Q
G
V
F
Q
R
A
S
A
K
W
K
D
D
V
Site 9
T122
A
F
C
K
K
W
A
T
K
T
R
L
S
K
V
Site 10
S138
S
A
M
L
A
I
H
S
N
K
P
A
L
W
I
Site 11
S157
W
E
M
E
D
R
L
S
S
E
S
A
R
Q
L
Site 12
S158
E
M
E
D
R
L
S
S
E
S
A
R
Q
L
F
Site 13
S160
E
D
R
L
S
S
E
S
A
R
Q
L
F
L
R
Site 14
Y179
H
P
E
C
P
K
L
Y
K
E
Y
F
R
M
E
Site 15
Y182
C
P
K
L
Y
K
E
Y
F
R
M
E
L
M
H
Site 16
S204
K
E
E
F
E
K
A
S
M
D
V
E
N
P
D
Site 17
Y212
M
D
V
E
N
P
D
Y
S
E
E
I
L
K
G
Site 18
S213
D
V
E
N
P
D
Y
S
E
E
I
L
K
G
E
Site 19
Y260
K
D
L
Q
K
E
I
Y
D
D
L
Q
A
L
H
Site 20
T268
D
D
L
Q
A
L
H
T
D
D
P
L
T
W
D
Site 21
T273
L
H
T
D
D
P
L
T
W
D
Y
V
A
R
R
Site 22
Y276
D
D
P
L
T
W
D
Y
V
A
R
R
E
L
E
Site 23
S286
R
R
E
L
E
I
E
S
Q
T
E
E
Q
P
T
Site 24
T293
S
Q
T
E
E
Q
P
T
T
K
Q
A
K
A
V
Site 25
T294
Q
T
E
E
Q
P
T
T
K
Q
A
K
A
V
E
Site 26
Y313
E
E
R
C
C
A
V
Y
E
E
A
V
K
T
L
Site 27
T319
V
Y
E
E
A
V
K
T
L
P
T
E
A
M
W
Site 28
T338
T
F
C
L
E
R
F
T
K
K
S
N
S
G
F
Site 29
S341
L
E
R
F
T
K
K
S
N
S
G
F
L
R
G
Site 30
S343
R
F
T
K
K
S
N
S
G
F
L
R
G
K
R
Site 31
T354
R
G
K
R
L
E
R
T
M
T
V
F
R
K
A
Site 32
T356
K
R
L
E
R
T
M
T
V
F
R
K
A
H
E
Site 33
Y372
K
L
L
S
E
C
Q
Y
K
Q
L
S
V
S
L
Site 34
S402
G
T
E
L
F
R
D
S
G
T
M
W
Q
L
K
Site 35
S453
E
W
S
E
G
A
K
S
Q
E
D
T
E
A
V
Site 36
T457
G
A
K
S
Q
E
D
T
E
A
V
F
K
K
A
Site 37
S473
L
A
V
I
G
A
D
S
V
T
L
K
N
K
Y
Site 38
T475
V
I
G
A
D
S
V
T
L
K
N
K
Y
L
D
Site 39
Y480
S
V
T
L
K
N
K
Y
L
D
W
A
Y
R
S
Site 40
Y485
N
K
Y
L
D
W
A
Y
R
S
G
G
Y
K
K
Site 41
S499
K
A
R
A
V
F
K
S
L
Q
E
S
R
P
F
Site 42
S503
V
F
K
S
L
Q
E
S
R
P
F
S
V
D
F
Site 43
S507
L
Q
E
S
R
P
F
S
V
D
F
F
R
K
M
Site 44
Y532
N
M
A
N
I
R
E
Y
Y
E
R
A
L
R
E
Site 45
Y533
M
A
N
I
R
E
Y
Y
E
R
A
L
R
E
F
Site 46
S542
R
A
L
R
E
F
G
S
A
D
S
D
L
W
M
Site 47
Y551
D
S
D
L
W
M
D
Y
M
K
E
E
L
N
H
Site 48
S581
M
K
M
L
Q
G
E
S
A
E
A
F
V
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation