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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNK4
Full Name:
Potassium channel subfamily K member 4
Alias:
TWIK-related arachidonic acid-stimulated potassium channel protein;Two pore potassium channel KT4.1
Type:
Mass (Da):
42704
Number AA:
393
UniProt ID:
Q9NYG8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T77
G
G
G
A
D
P
E
T
N
S
T
S
N
S
S
Site 2
S79
G
A
D
P
E
T
N
S
T
S
N
S
S
H
S
Site 3
T80
A
D
P
E
T
N
S
T
S
N
S
S
H
S
A
Site 4
S81
D
P
E
T
N
S
T
S
N
S
S
H
S
A
W
Site 5
S83
E
T
N
S
T
S
N
S
S
H
S
A
W
D
L
Site 6
S84
T
N
S
T
S
N
S
S
H
S
A
W
D
L
G
Site 7
S86
S
T
S
N
S
S
H
S
A
W
D
L
G
S
A
Site 8
S144
G
V
G
D
R
L
G
S
S
L
R
H
G
I
G
Site 9
S145
V
G
D
R
L
G
S
S
L
R
H
G
I
G
H
Site 10
Y218
T
T
V
G
F
G
D
Y
V
A
G
A
D
P
R
Site 11
S228
G
A
D
P
R
Q
D
S
P
A
Y
Q
P
L
V
Site 12
Y231
P
R
Q
D
S
P
A
Y
Q
P
L
V
W
F
W
Site 13
S261
G
N
W
L
R
V
V
S
R
R
T
R
A
E
M
Site 14
T264
L
R
V
V
S
R
R
T
R
A
E
M
G
G
L
Site 15
T281
Q
A
A
S
W
T
G
T
V
T
A
R
V
T
Q
Site 16
T283
A
S
W
T
G
T
V
T
A
R
V
T
Q
R
A
Site 17
T287
G
T
V
T
A
R
V
T
Q
R
A
G
P
A
A
Site 18
S319
Q
P
L
G
R
P
R
S
P
S
P
P
E
K
A
Site 19
S321
L
G
R
P
R
S
P
S
P
P
E
K
A
Q
P
Site 20
S330
P
E
K
A
Q
P
P
S
P
P
T
A
S
A
L
Site 21
S335
P
P
S
P
P
T
A
S
A
L
D
Y
P
S
E
Site 22
Y339
P
T
A
S
A
L
D
Y
P
S
E
N
L
A
F
Site 23
S350
N
L
A
F
I
D
E
S
S
D
T
Q
S
E
R
Site 24
S351
L
A
F
I
D
E
S
S
D
T
Q
S
E
R
G
Site 25
T353
F
I
D
E
S
S
D
T
Q
S
E
R
G
C
P
Site 26
S355
D
E
S
S
D
T
Q
S
E
R
G
C
P
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation