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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DACT1
Full Name:
Dapper homolog 1
Alias:
Hepatocellular carcinoma novel gene 3 protein
Type:
Mass (Da):
90174
Number AA:
836
UniProt ID:
Q9NYF0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
P
A
R
G
E
Q
R
T
A
E
P
E
G
R
W
Site 2
T39
R
E
K
G
E
A
D
T
E
R
Q
R
T
R
E
Site 3
T44
A
D
T
E
R
Q
R
T
R
E
R
Q
E
A
T
Site 4
Y60
A
G
L
A
E
L
E
Y
L
R
Q
R
Q
E
L
Site 5
S137
Q
E
L
D
K
Q
I
S
D
L
R
L
D
V
E
Site 6
T146
L
R
L
D
V
E
K
T
S
E
E
H
L
E
T
Site 7
S147
R
L
D
V
E
K
T
S
E
E
H
L
E
T
D
Site 8
T153
T
S
E
E
H
L
E
T
D
S
R
P
S
S
G
Site 9
S155
E
E
H
L
E
T
D
S
R
P
S
S
G
F
Y
Site 10
S158
L
E
T
D
S
R
P
S
S
G
F
Y
E
L
S
Site 11
S159
E
T
D
S
R
P
S
S
G
F
Y
E
L
S
D
Site 12
Y162
S
R
P
S
S
G
F
Y
E
L
S
D
G
A
S
Site 13
S165
S
S
G
F
Y
E
L
S
D
G
A
S
G
S
L
Site 14
S169
Y
E
L
S
D
G
A
S
G
S
L
S
N
S
S
Site 15
S171
L
S
D
G
A
S
G
S
L
S
N
S
S
N
S
Site 16
S173
D
G
A
S
G
S
L
S
N
S
S
N
S
V
F
Site 17
S175
A
S
G
S
L
S
N
S
S
N
S
V
F
S
E
Site 18
S176
S
G
S
L
S
N
S
S
N
S
V
F
S
E
C
Site 19
S178
S
L
S
N
S
S
N
S
V
F
S
E
C
L
S
Site 20
S181
N
S
S
N
S
V
F
S
E
C
L
S
S
C
H
Site 21
S189
E
C
L
S
S
C
H
S
S
T
C
F
C
S
P
Site 22
S202
S
P
L
E
A
T
L
S
L
S
D
G
C
P
K
Site 23
S204
L
E
A
T
L
S
L
S
D
G
C
P
K
S
A
Site 24
S229
G
H
C
E
D
Q
A
S
G
A
V
C
R
S
L
Site 25
S235
A
S
G
A
V
C
R
S
L
S
T
P
Q
F
N
Site 26
S237
G
A
V
C
R
S
L
S
T
P
Q
F
N
S
L
Site 27
T238
A
V
C
R
S
L
S
T
P
Q
F
N
S
L
D
Site 28
Y254
I
A
D
V
N
P
K
Y
Q
C
D
L
V
S
K
Site 29
Y267
S
K
N
G
N
D
V
Y
R
Y
P
S
P
L
H
Site 30
Y269
N
G
N
D
V
Y
R
Y
P
S
P
L
H
A
V
Site 31
S271
N
D
V
Y
R
Y
P
S
P
L
H
A
V
A
V
Site 32
S303
D
R
L
G
N
H
A
S
D
I
C
G
G
S
E
Site 33
T316
S
E
L
D
A
V
K
T
D
S
S
L
P
S
P
Site 34
S318
L
D
A
V
K
T
D
S
S
L
P
S
P
S
S
Site 35
S319
D
A
V
K
T
D
S
S
L
P
S
P
S
S
L
Site 36
S322
K
T
D
S
S
L
P
S
P
S
S
L
W
S
A
Site 37
S324
D
S
S
L
P
S
P
S
S
L
W
S
A
S
H
Site 38
S325
S
S
L
P
S
P
S
S
L
W
S
A
S
H
P
Site 39
S328
P
S
P
S
S
L
W
S
A
S
H
P
S
S
S
Site 40
S330
P
S
S
L
W
S
A
S
H
P
S
S
S
K
K
Site 41
S333
L
W
S
A
S
H
P
S
S
S
K
K
M
D
G
Site 42
S334
W
S
A
S
H
P
S
S
S
K
K
M
D
G
Y
Site 43
S335
S
A
S
H
P
S
S
S
K
K
M
D
G
Y
I
Site 44
Y341
S
S
K
K
M
D
G
Y
I
L
S
L
V
Q
K
Site 45
S344
K
M
D
G
Y
I
L
S
L
V
Q
K
K
T
H
Site 46
T350
L
S
L
V
Q
K
K
T
H
P
V
R
T
N
K
Site 47
T355
K
K
T
H
P
V
R
T
N
K
P
R
T
S
V
Site 48
T360
V
R
T
N
K
P
R
T
S
V
N
A
D
P
T
Site 49
S361
R
T
N
K
P
R
T
S
V
N
A
D
P
T
K
Site 50
T367
T
S
V
N
A
D
P
T
K
G
L
L
R
N
G
Site 51
S375
K
G
L
L
R
N
G
S
V
C
V
R
A
P
G
Site 52
S385
V
R
A
P
G
G
V
S
Q
G
N
S
V
N
L
Site 53
S389
G
G
V
S
Q
G
N
S
V
N
L
K
N
S
K
Site 54
S402
S
K
Q
A
C
L
P
S
G
G
I
P
S
L
N
Site 55
S407
L
P
S
G
G
I
P
S
L
N
N
G
T
F
S
Site 56
T412
I
P
S
L
N
N
G
T
F
S
P
P
K
Q
W
Site 57
S414
S
L
N
N
G
T
F
S
P
P
K
Q
W
S
K
Site 58
S420
F
S
P
P
K
Q
W
S
K
E
S
K
A
E
Q
Site 59
S430
S
K
A
E
Q
A
E
S
K
R
V
P
L
P
E
Site 60
S441
P
L
P
E
G
C
P
S
G
A
A
S
D
L
Q
Site 61
S445
G
C
P
S
G
A
A
S
D
L
Q
S
K
H
L
Site 62
S449
G
A
A
S
D
L
Q
S
K
H
L
P
K
T
A
Site 63
T455
Q
S
K
H
L
P
K
T
A
K
P
A
S
Q
E
Site 64
S460
P
K
T
A
K
P
A
S
Q
E
H
A
R
C
S
Site 65
S467
S
Q
E
H
A
R
C
S
A
I
G
T
G
E
S
Site 66
T471
A
R
C
S
A
I
G
T
G
E
S
P
K
E
S
Site 67
S474
S
A
I
G
T
G
E
S
P
K
E
S
A
Q
L
Site 68
S478
T
G
E
S
P
K
E
S
A
Q
L
S
G
A
S
Site 69
S482
P
K
E
S
A
Q
L
S
G
A
S
P
K
E
S
Site 70
S485
S
A
Q
L
S
G
A
S
P
K
E
S
P
S
R
Site 71
S489
S
G
A
S
P
K
E
S
P
S
R
G
P
A
P
Site 72
S491
A
S
P
K
E
S
P
S
R
G
P
A
P
P
Q
Site 73
S510
V
Q
P
L
K
K
M
S
Q
K
N
S
L
Q
G
Site 74
S514
K
K
M
S
Q
K
N
S
L
Q
G
V
P
P
A
Site 75
T528
A
T
P
P
L
L
S
T
A
F
P
V
E
E
R
Site 76
S542
R
P
A
L
D
F
K
S
E
G
S
S
Q
S
L
Site 77
S546
D
F
K
S
E
G
S
S
Q
S
L
E
E
A
H
Site 78
S548
K
S
E
G
S
S
Q
S
L
E
E
A
H
L
V
Site 79
S566
F
I
P
G
Q
Q
P
S
V
R
L
H
R
G
H
Site 80
S582
N
M
G
V
V
K
N
S
S
L
K
H
R
G
P
Site 81
S583
M
G
V
V
K
N
S
S
L
K
H
R
G
P
A
Site 82
T600
G
L
E
N
G
L
P
T
V
R
E
K
T
R
A
Site 83
T605
L
P
T
V
R
E
K
T
R
A
G
S
K
K
C
Site 84
S609
R
E
K
T
R
A
G
S
K
K
C
R
F
P
D
Site 85
T620
R
F
P
D
D
L
D
T
N
K
K
L
K
K
A
Site 86
S629
K
K
L
K
K
A
S
S
K
G
R
K
S
G
G
Site 87
S634
A
S
S
K
G
R
K
S
G
G
G
P
E
A
G
Site 88
S655
G
G
G
H
R
A
G
S
R
A
H
G
H
G
R
Site 89
T674
A
K
P
K
H
K
R
T
D
Y
R
R
W
K
S
Site 90
Y676
P
K
H
K
R
T
D
Y
R
R
W
K
S
S
A
Site 91
S681
T
D
Y
R
R
W
K
S
S
A
E
I
S
Y
E
Site 92
S682
D
Y
R
R
W
K
S
S
A
E
I
S
Y
E
E
Site 93
S686
W
K
S
S
A
E
I
S
Y
E
E
A
L
R
R
Site 94
Y705
R
R
E
N
V
G
L
Y
P
A
P
V
P
L
P
Site 95
Y717
P
L
P
Y
A
S
P
Y
A
Y
V
A
S
D
S
Site 96
Y719
P
Y
A
S
P
Y
A
Y
V
A
S
D
S
E
Y
Site 97
S722
S
P
Y
A
Y
V
A
S
D
S
E
Y
S
A
E
Site 98
S724
Y
A
Y
V
A
S
D
S
E
Y
S
A
E
C
E
Site 99
Y726
Y
V
A
S
D
S
E
Y
S
A
E
C
E
S
L
Site 100
S727
V
A
S
D
S
E
Y
S
A
E
C
E
S
L
F
Site 101
S732
E
Y
S
A
E
C
E
S
L
F
H
S
T
V
V
Site 102
S736
E
C
E
S
L
F
H
S
T
V
V
D
T
S
E
Site 103
T737
C
E
S
L
F
H
S
T
V
V
D
T
S
E
D
Site 104
S742
H
S
T
V
V
D
T
S
E
D
E
Q
S
N
Y
Site 105
Y749
S
E
D
E
Q
S
N
Y
T
T
N
C
F
G
D
Site 106
T751
D
E
Q
S
N
Y
T
T
N
C
F
G
D
S
E
Site 107
S757
T
T
N
C
F
G
D
S
E
S
S
V
S
E
G
Site 108
S759
N
C
F
G
D
S
E
S
S
V
S
E
G
E
F
Site 109
S760
C
F
G
D
S
E
S
S
V
S
E
G
E
F
V
Site 110
S762
G
D
S
E
S
S
V
S
E
G
E
F
V
G
E
Site 111
S770
E
G
E
F
V
G
E
S
T
T
T
S
D
S
E
Site 112
T772
E
F
V
G
E
S
T
T
T
S
D
S
E
E
S
Site 113
T773
F
V
G
E
S
T
T
T
S
D
S
E
E
S
G
Site 114
S774
V
G
E
S
T
T
T
S
D
S
E
E
S
G
G
Site 115
S776
E
S
T
T
T
S
D
S
E
E
S
G
G
L
I
Site 116
T808
L
H
N
H
P
A
K
T
F
V
K
I
K
A
S
Site 117
S827
K
K
I
L
R
F
R
S
G
S
L
K
L
M
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation