KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MTMR4
Full Name:
Myotubularin-related protein 4
Alias:
EC 3.1.3.48; FYVE-DSP2, zinc finger, FYVE domain containing 11; KIAA0647; ZFYVE11
Type:
Protein phosphatase, Myotubularin related
Mass (Da):
133339
Number AA:
1195
UniProt ID:
Q9NYA4
International Prot ID:
IPI00292693
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0004725
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
E
E
G
P
P
S
L
E
Y
I
Q
A
K
Site 2
Y11
E
G
P
P
S
L
E
Y
I
Q
A
K
D
L
F
Site 3
S56
A
D
A
L
I
A
I
S
N
Y
R
L
H
I
K
Site 4
Y58
A
L
I
A
I
S
N
Y
R
L
H
I
K
F
K
Site 5
S67
L
H
I
K
F
K
D
S
V
I
N
V
P
L
R
Site 6
S78
V
P
L
R
M
I
D
S
V
E
S
R
D
M
F
Site 7
S112
K
Q
C
Q
E
W
L
S
R
L
S
R
A
T
A
Site 8
S115
Q
E
W
L
S
R
L
S
R
A
T
A
R
P
A
Site 9
T118
L
S
R
L
S
R
A
T
A
R
P
A
K
P
E
Site 10
T146
L
T
E
E
D
Q
H
T
H
L
C
Q
P
G
E
Site 11
S188
S
N
Y
K
L
C
P
S
Y
P
Q
K
L
L
V
Site 12
Y189
N
Y
K
L
C
P
S
Y
P
Q
K
L
L
V
P
Site 13
S209
K
E
L
E
N
V
A
S
F
R
S
W
K
R
I
Site 14
S212
E
N
V
A
S
F
R
S
W
K
R
I
P
V
V
Site 15
Y250
W
R
N
A
D
D
E
Y
L
V
T
S
I
A
K
Site 16
T268
L
D
P
G
T
R
A
T
G
G
S
L
S
T
G
Site 17
S271
G
T
R
A
T
G
G
S
L
S
T
G
N
N
D
Site 18
S273
R
A
T
G
G
S
L
S
T
G
N
N
D
T
S
Site 19
S280
S
T
G
N
N
D
T
S
E
A
C
D
A
D
F
Site 20
T292
A
D
F
D
S
S
L
T
A
C
S
G
V
E
S
Site 21
S299
T
A
C
S
G
V
E
S
T
A
A
P
Q
K
L
Site 22
Y314
L
I
L
D
A
R
S
Y
T
A
A
V
A
N
R
Site 23
Y332
G
G
C
E
C
E
E
Y
Y
P
N
C
E
V
V
Site 24
Y355
A
I
R
N
S
F
Q
Y
L
R
A
V
C
S
Q
Site 25
S361
Q
Y
L
R
A
V
C
S
Q
M
P
D
P
S
N
Site 26
S367
C
S
Q
M
P
D
P
S
N
W
L
S
A
L
E
Site 27
S371
P
D
P
S
N
W
L
S
A
L
E
S
T
K
W
Site 28
T414
C
S
D
G
W
D
R
T
P
Q
I
V
A
L
A
Site 29
Y428
A
K
I
L
L
D
P
Y
Y
R
T
L
E
G
F
Site 30
Y429
K
I
L
L
D
P
Y
Y
R
T
L
E
G
F
Q
Site 31
Y524
E
R
E
K
R
N
I
Y
K
R
T
C
S
V
W
Site 32
Y546
K
N
F
H
N
F
L
Y
T
P
S
S
D
M
V
Site 33
T547
N
F
H
N
F
L
Y
T
P
S
S
D
M
V
L
Site 34
S549
H
N
F
L
Y
T
P
S
S
D
M
V
L
H
P
Site 35
T578
L
P
A
S
S
P
C
T
L
G
E
E
N
M
D
Site 36
Y587
G
E
E
N
M
D
L
Y
L
S
P
V
A
Q
S
Site 37
S589
E
N
M
D
L
Y
L
S
P
V
A
Q
S
Q
E
Site 38
S594
Y
L
S
P
V
A
Q
S
Q
E
F
S
G
R
S
Site 39
S598
V
A
Q
S
Q
E
F
S
G
R
S
L
D
R
L
Site 40
S601
S
Q
E
F
S
G
R
S
L
D
R
L
P
K
T
Site 41
T608
S
L
D
R
L
P
K
T
R
S
M
D
D
L
L
Site 42
S610
D
R
L
P
K
T
R
S
M
D
D
L
L
S
A
Site 43
S616
R
S
M
D
D
L
L
S
A
C
D
T
S
S
P
Site 44
T620
D
L
L
S
A
C
D
T
S
S
P
L
T
R
T
Site 45
S622
L
S
A
C
D
T
S
S
P
L
T
R
T
S
S
Site 46
T625
C
D
T
S
S
P
L
T
R
T
S
S
D
P
N
Site 47
S628
S
S
P
L
T
R
T
S
S
D
P
N
L
N
N
Site 48
S629
S
P
L
T
R
T
S
S
D
P
N
L
N
N
H
Site 49
S649
V
G
L
E
P
W
H
S
N
P
E
G
S
E
T
Site 50
T656
S
N
P
E
G
S
E
T
S
F
V
D
S
G
V
Site 51
S657
N
P
E
G
S
E
T
S
F
V
D
S
G
V
G
Site 52
S661
S
E
T
S
F
V
D
S
G
V
G
G
P
Q
Q
Site 53
T669
G
V
G
G
P
Q
Q
T
V
G
E
V
G
L
P
Site 54
S681
G
L
P
P
P
L
P
S
S
Q
K
D
Y
L
S
Site 55
S682
L
P
P
P
L
P
S
S
Q
K
D
Y
L
S
N
Site 56
Y686
L
P
S
S
Q
K
D
Y
L
S
N
K
P
F
K
Site 57
S688
S
S
Q
K
D
Y
L
S
N
K
P
F
K
S
H
Site 58
S694
L
S
N
K
P
F
K
S
H
K
S
C
S
P
S
Site 59
S697
K
P
F
K
S
H
K
S
C
S
P
S
Y
K
L
Site 60
S699
F
K
S
H
K
S
C
S
P
S
Y
K
L
L
N
Site 61
S701
S
H
K
S
C
S
P
S
Y
K
L
L
N
T
A
Site 62
T707
P
S
Y
K
L
L
N
T
A
V
P
R
E
M
K
Site 63
T717
P
R
E
M
K
S
N
T
S
D
P
E
I
K
V
Site 64
S736
K
G
P
A
P
D
P
S
A
Q
D
E
L
G
R
Site 65
T744
A
Q
D
E
L
G
R
T
L
D
G
I
G
E
P
Site 66
T758
P
P
E
H
C
P
E
T
E
A
V
S
A
L
S
Site 67
S781
G
V
C
N
F
P
E
S
S
Q
N
S
P
T
G
Site 68
S782
V
C
N
F
P
E
S
S
Q
N
S
P
T
G
T
Site 69
S785
F
P
E
S
S
Q
N
S
P
T
G
T
P
Q
Q
Site 70
T787
E
S
S
Q
N
S
P
T
G
T
P
Q
Q
A
Q
Site 71
T789
S
Q
N
S
P
T
G
T
P
Q
Q
A
Q
P
D
Site 72
S797
P
Q
Q
A
Q
P
D
S
M
L
G
V
P
S
K
Site 73
S803
D
S
M
L
G
V
P
S
K
C
V
L
D
H
S
Site 74
S810
S
K
C
V
L
D
H
S
L
S
T
V
C
N
P
Site 75
S819
S
T
V
C
N
P
P
S
A
A
C
Q
T
P
L
Site 76
T824
P
P
S
A
A
C
Q
T
P
L
D
P
S
T
D
Site 77
T830
Q
T
P
L
D
P
S
T
D
F
L
N
Q
D
P
Site 78
S838
D
F
L
N
Q
D
P
S
G
S
V
A
S
I
S
Site 79
S840
L
N
Q
D
P
S
G
S
V
A
S
I
S
H
Q
Site 80
S845
S
G
S
V
A
S
I
S
H
Q
E
Q
L
S
S
Site 81
S851
I
S
H
Q
E
Q
L
S
S
V
P
D
L
T
H
Site 82
S852
S
H
Q
E
Q
L
S
S
V
P
D
L
T
H
G
Site 83
T857
L
S
S
V
P
D
L
T
H
G
E
E
D
I
G
Site 84
S893
E
L
V
R
K
P
I
S
Q
S
Q
I
S
E
F
Site 85
S895
V
R
K
P
I
S
Q
S
Q
I
S
E
F
S
F
Site 86
S898
P
I
S
Q
S
Q
I
S
E
F
S
F
L
G
S
Site 87
S901
Q
S
Q
I
S
E
F
S
F
L
G
S
N
W
D
Site 88
S905
S
E
F
S
F
L
G
S
N
W
D
S
F
Q
G
Site 89
S909
F
L
G
S
N
W
D
S
F
Q
G
M
V
T
S
Site 90
T915
D
S
F
Q
G
M
V
T
S
F
P
S
G
E
A
Site 91
S916
S
F
Q
G
M
V
T
S
F
P
S
G
E
A
T
Site 92
T923
S
F
P
S
G
E
A
T
P
R
R
L
L
S
Y
Site 93
S929
A
T
P
R
R
L
L
S
Y
G
C
C
S
K
R
Site 94
Y930
T
P
R
R
L
L
S
Y
G
C
C
S
K
R
P
Site 95
S934
L
L
S
Y
G
C
C
S
K
R
P
N
S
K
Q
Site 96
S939
C
C
S
K
R
P
N
S
K
Q
M
R
A
T
G
Site 97
T945
N
S
K
Q
M
R
A
T
G
P
C
F
G
G
Q
Site 98
S961
A
Q
R
E
G
V
K
S
P
V
C
S
S
H
S
Site 99
S965
G
V
K
S
P
V
C
S
S
H
S
N
G
H
C
Site 100
S966
V
K
S
P
V
C
S
S
H
S
N
G
H
C
T
Site 101
S968
S
P
V
C
S
S
H
S
N
G
H
C
T
G
P
Site 102
S984
G
K
N
Q
M
W
L
S
S
H
P
K
Q
V
S
Site 103
S985
K
N
Q
M
W
L
S
S
H
P
K
Q
V
S
S
Site 104
S991
S
S
H
P
K
Q
V
S
S
T
K
P
V
P
L
Site 105
S992
S
H
P
K
Q
V
S
S
T
K
P
V
P
L
N
Site 106
S1002
P
V
P
L
N
C
P
S
P
V
P
P
L
Y
L
Site 107
Y1008
P
S
P
V
P
P
L
Y
L
D
D
D
G
L
P
Site 108
Y1066
P
A
E
P
P
M
D
Y
E
D
D
F
T
C
L
Site 109
T1071
M
D
Y
E
D
D
F
T
C
L
K
E
S
D
G
Site 110
S1076
D
F
T
C
L
K
E
S
D
G
S
D
T
E
D
Site 111
S1079
C
L
K
E
S
D
G
S
D
T
E
D
F
G
S
Site 112
T1081
K
E
S
D
G
S
D
T
E
D
F
G
S
D
H
Site 113
S1086
S
D
T
E
D
F
G
S
D
H
S
E
D
C
L
Site 114
S1089
E
D
F
G
S
D
H
S
E
D
C
L
S
E
A
Site 115
S1094
D
H
S
E
D
C
L
S
E
A
S
W
E
P
V
Site 116
S1097
E
D
C
L
S
E
A
S
W
E
P
V
D
K
K
Site 117
Y1160
P
I
P
D
Q
Q
L
Y
D
P
V
L
V
C
N
Site 118
S1183
S
R
A
R
E
L
M
S
Q
Q
L
K
K
P
I
Site 119
S1194
K
K
P
I
A
T
A
S
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation