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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMPD3
Full Name:
Sphingomyelin phosphodiesterase 3
Alias:
Neutral sphingomyelinase 2;Neutral sphingomyelinase II
Type:
Mass (Da):
71081
Number AA:
655
UniProt ID:
Q9NY59
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
L
A
A
S
F
I
P
T
T
Y
E
K
R
Q
R
Site 2
T42
A
A
S
F
I
P
T
T
Y
E
K
R
Q
R
A
Site 3
Y43
A
S
F
I
P
T
T
Y
E
K
R
Q
R
A
D
Site 4
Y95
L
Q
S
A
R
R
P
Y
I
Y
S
R
L
E
D
Site 5
Y97
S
A
R
R
P
Y
I
Y
S
R
L
E
D
K
G
Site 6
S98
A
R
R
P
Y
I
Y
S
R
L
E
D
K
G
L
Site 7
S113
A
G
G
A
A
L
L
S
E
W
K
G
T
G
P
Site 8
T118
L
L
S
E
W
K
G
T
G
P
G
K
S
F
C
Site 9
S123
K
G
T
G
P
G
K
S
F
C
F
A
T
A
N
Site 10
Y170
A
R
P
Q
I
K
I
Y
I
D
S
P
T
N
T
Site 11
S173
Q
I
K
I
Y
I
D
S
P
T
N
T
S
I
S
Site 12
T175
K
I
Y
I
D
S
P
T
N
T
S
I
S
A
A
Site 13
T177
Y
I
D
S
P
T
N
T
S
I
S
A
A
S
F
Site 14
S178
I
D
S
P
T
N
T
S
I
S
A
A
S
F
S
Site 15
S180
S
P
T
N
T
S
I
S
A
A
S
F
S
S
L
Site 16
S183
N
T
S
I
S
A
A
S
F
S
S
L
V
S
P
Site 17
S185
S
I
S
A
A
S
F
S
S
L
V
S
P
Q
G
Site 18
S186
I
S
A
A
S
F
S
S
L
V
S
P
Q
G
G
Site 19
T207
V
P
G
S
I
K
R
T
A
S
V
E
Y
K
G
Site 20
S209
G
S
I
K
R
T
A
S
V
E
Y
K
G
D
G
Site 21
S230
E
A
A
N
G
P
A
S
G
D
P
V
D
S
S
Site 22
S236
A
S
G
D
P
V
D
S
S
S
P
E
D
A
C
Site 23
S237
S
G
D
P
V
D
S
S
S
P
E
D
A
C
I
Site 24
S238
G
D
P
V
D
S
S
S
P
E
D
A
C
I
V
Site 25
T279
G
G
G
P
R
G
Q
T
P
N
H
N
Q
Q
D
Site 26
S289
H
N
Q
Q
D
G
D
S
G
S
L
G
S
P
S
Site 27
S291
Q
Q
D
G
D
S
G
S
L
G
S
P
S
A
S
Site 28
S294
G
D
S
G
S
L
G
S
P
S
A
S
R
E
S
Site 29
S296
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Site 30
S298
S
L
G
S
P
S
A
S
R
E
S
L
V
K
G
Site 31
S301
S
P
S
A
S
R
E
S
L
V
K
G
R
A
G
Site 32
T311
K
G
R
A
G
P
D
T
S
A
S
G
E
P
G
Site 33
S312
G
R
A
G
P
D
T
S
A
S
G
E
P
G
A
Site 34
S314
A
G
P
D
T
S
A
S
G
E
P
G
A
N
S
Site 35
Y325
G
A
N
S
K
L
L
Y
K
A
S
V
V
K
K
Site 36
S328
S
K
L
L
Y
K
A
S
V
V
K
K
A
A
A
Site 37
T372
V
F
D
K
R
A
A
T
K
L
K
E
Q
L
H
Site 38
Y381
L
K
E
Q
L
H
G
Y
F
E
Y
I
L
Y
D
Site 39
T447
L
K
V
Q
V
G
S
T
P
Q
D
Q
R
I
V
Site 40
S469
L
H
A
P
Q
E
D
S
A
I
R
C
G
Q
L
Site 41
S489
W
L
A
D
F
R
K
S
T
S
S
S
S
A
A
Site 42
T490
L
A
D
F
R
K
S
T
S
S
S
S
A
A
N
Site 43
S491
A
D
F
R
K
S
T
S
S
S
S
A
A
N
P
Site 44
S492
D
F
R
K
S
T
S
S
S
S
A
A
N
P
E
Site 45
S493
F
R
K
S
T
S
S
S
S
A
A
N
P
E
E
Site 46
S517
D
F
N
F
D
N
C
S
S
D
D
K
L
E
Q
Site 47
S518
F
N
F
D
N
C
S
S
D
D
K
L
E
Q
Q
Site 48
S527
D
K
L
E
Q
Q
H
S
L
F
T
H
Y
R
D
Site 49
Y532
Q
H
S
L
F
T
H
Y
R
D
P
C
R
L
G
Site 50
Y558
L
L
D
T
N
G
L
Y
D
E
D
V
C
T
P
Site 51
T564
L
Y
D
E
D
V
C
T
P
D
N
L
Q
K
V
Site 52
S574
N
L
Q
K
V
L
E
S
E
E
G
R
R
E
Y
Site 53
Y581
S
E
E
G
R
R
E
Y
L
A
F
P
T
S
K
Site 54
T586
R
E
Y
L
A
F
P
T
S
K
S
S
G
Q
K
Site 55
S587
E
Y
L
A
F
P
T
S
K
S
S
G
Q
K
G
Site 56
S589
L
A
F
P
T
S
K
S
S
G
Q
K
G
R
K
Site 57
Y608
G
N
G
R
R
I
D
Y
M
L
H
A
E
E
G
Site 58
S628
K
A
E
V
E
E
F
S
F
I
T
Q
L
S
G
Site 59
S650
A
M
R
L
M
V
S
S
G
E
E
E
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation