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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN3A
Full Name:
Sodium channel protein type 3 subunit alpha
Alias:
KIAA1356; NAC3
Type:
Membrane protein
Mass (Da):
226294
Number AA:
2000
UniProt ID:
Q9NY46
International Prot ID:
IPI00020692
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
V
P
P
G
P
E
S
F
R
L
F
T
R
E
Site 2
T18
P
E
S
F
R
L
F
T
R
E
S
L
A
A
I
Site 3
S21
F
R
L
F
T
R
E
S
L
A
A
I
E
K
R
Site 4
S53
E
N
K
P
K
P
N
S
D
L
E
A
G
K
N
Site 5
Y65
G
K
N
L
P
F
I
Y
G
D
I
P
P
E
M
Site 6
Y83
P
L
E
D
L
D
P
Y
Y
I
N
K
K
T
F
Site 7
Y84
L
E
D
L
D
P
Y
Y
I
N
K
K
T
F
I
Site 8
T154
L
S
N
P
P
D
W
T
K
N
V
E
Y
T
F
Site 9
Y159
D
W
T
K
N
V
E
Y
T
F
T
G
I
Y
T
Site 10
T162
K
N
V
E
Y
T
F
T
G
I
Y
T
F
E
S
Site 11
S283
K
C
L
Q
W
P
P
S
D
S
A
F
E
T
N
Site 12
T289
P
S
D
S
A
F
E
T
N
T
T
S
Y
F
N
Site 13
T292
S
A
F
E
T
N
T
T
S
Y
F
N
G
T
M
Site 14
Y294
F
E
T
N
T
T
S
Y
F
N
G
T
M
D
S
Site 15
T304
G
T
M
D
S
N
G
T
F
V
N
V
T
M
S
Site 16
Y318
S
T
F
N
W
K
D
Y
I
G
D
D
S
H
F
Site 17
Y326
I
G
D
D
S
H
F
Y
V
L
D
G
Q
K
D
Site 18
S341
P
L
L
C
G
N
G
S
D
A
G
Q
C
P
E
Site 19
Y350
A
G
Q
C
P
E
G
Y
I
C
V
K
A
G
R
Site 20
Y361
K
A
G
R
N
P
N
Y
G
Y
T
S
F
D
T
Site 21
Y363
G
R
N
P
N
Y
G
Y
T
S
F
D
T
F
S
Site 22
T381
L
S
L
F
R
L
M
T
Q
D
Y
W
E
N
L
Site 23
Y384
F
R
L
M
T
Q
D
Y
W
E
N
L
Y
Q
L
Site 24
S466
A
Q
A
V
A
A
A
S
A
A
S
R
D
F
S
Site 25
S473
S
A
A
S
R
D
F
S
G
I
G
G
L
G
E
Site 26
S484
G
L
G
E
L
L
E
S
S
S
E
A
S
K
L
Site 27
S485
L
G
E
L
L
E
S
S
S
E
A
S
K
L
S
Site 28
S486
G
E
L
L
E
S
S
S
E
A
S
K
L
S
S
Site 29
S489
L
E
S
S
S
E
A
S
K
L
S
S
K
S
A
Site 30
S492
S
S
E
A
S
K
L
S
S
K
S
A
K
E
W
Site 31
S493
S
E
A
S
K
L
S
S
K
S
A
K
E
W
R
Site 32
S522
N
N
K
G
E
R
D
S
F
P
K
S
E
S
E
Site 33
S526
E
R
D
S
F
P
K
S
E
S
E
D
S
V
K
Site 34
S528
D
S
F
P
K
S
E
S
E
D
S
V
K
R
S
Site 35
S531
P
K
S
E
S
E
D
S
V
K
R
S
S
F
L
Site 36
S535
S
E
D
S
V
K
R
S
S
F
L
F
S
M
D
Site 37
S536
E
D
S
V
K
R
S
S
F
L
F
S
M
D
G
Site 38
S540
K
R
S
S
F
L
F
S
M
D
G
N
R
L
T
Site 39
T547
S
M
D
G
N
R
L
T
S
D
K
K
F
C
S
Site 40
S548
M
D
G
N
R
L
T
S
D
K
K
F
C
S
P
Site 41
S554
T
S
D
K
K
F
C
S
P
H
Q
S
L
L
S
Site 42
S558
K
F
C
S
P
H
Q
S
L
L
S
I
R
G
S
Site 43
S561
S
P
H
Q
S
L
L
S
I
R
G
S
L
F
S
Site 44
S565
S
L
L
S
I
R
G
S
L
F
S
P
R
R
N
Site 45
S568
S
I
R
G
S
L
F
S
P
R
R
N
S
K
T
Site 46
S573
L
F
S
P
R
R
N
S
K
T
S
I
F
S
F
Site 47
T575
S
P
R
R
N
S
K
T
S
I
F
S
F
R
G
Site 48
S576
P
R
R
N
S
K
T
S
I
F
S
F
R
G
R
Site 49
S579
N
S
K
T
S
I
F
S
F
R
G
R
A
K
D
Site 50
S589
G
R
A
K
D
V
G
S
E
N
D
F
A
D
D
Site 51
S599
D
F
A
D
D
E
H
S
T
F
E
D
S
E
S
Site 52
T600
F
A
D
D
E
H
S
T
F
E
D
S
E
S
R
Site 53
S604
E
H
S
T
F
E
D
S
E
S
R
R
D
S
L
Site 54
S606
S
T
F
E
D
S
E
S
R
R
D
S
L
F
V
Site 55
S610
D
S
E
S
R
R
D
S
L
F
V
P
H
R
H
Site 56
S623
R
H
G
E
R
R
N
S
N
V
S
Q
A
S
M
Site 57
S626
E
R
R
N
S
N
V
S
Q
A
S
M
S
S
R
Site 58
S629
N
S
N
V
S
Q
A
S
M
S
S
R
M
V
P
Site 59
S631
N
V
S
Q
A
S
M
S
S
R
M
V
P
G
L
Site 60
S632
V
S
Q
A
S
M
S
S
R
M
V
P
G
L
P
Site 61
S646
P
A
N
G
K
M
H
S
T
V
D
C
N
G
V
Site 62
T647
A
N
G
K
M
H
S
T
V
D
C
N
G
V
V
Site 63
S665
G
G
P
S
A
L
T
S
P
T
G
Q
L
P
P
Site 64
T677
L
P
P
E
G
T
T
T
E
T
E
V
R
K
R
Site 65
S687
E
V
R
K
R
R
L
S
S
Y
Q
I
S
M
E
Site 66
S688
V
R
K
R
R
L
S
S
Y
Q
I
S
M
E
M
Site 67
Y689
R
K
R
R
L
S
S
Y
Q
I
S
M
E
M
L
Site 68
S692
R
L
S
S
Y
Q
I
S
M
E
M
L
E
D
S
Site 69
S699
S
M
E
M
L
E
D
S
S
G
R
Q
R
A
V
Site 70
S700
M
E
M
L
E
D
S
S
G
R
Q
R
A
V
S
Site 71
S707
S
G
R
Q
R
A
V
S
I
A
S
I
L
T
N
Site 72
T715
I
A
S
I
L
T
N
T
M
E
E
L
E
E
S
Site 73
S722
T
M
E
E
L
E
E
S
R
Q
K
C
P
P
C
Site 74
Y782
L
F
M
A
M
E
H
Y
P
M
T
E
Q
F
S
Site 75
T785
A
M
E
H
Y
P
M
T
E
Q
F
S
S
V
L
Site 76
Y817
K
I
I
A
M
D
P
Y
Y
Y
F
Q
E
G
W
Site 77
Y1017
R
M
Q
K
G
I
D
Y
V
K
N
K
M
R
E
Site 78
Y1063
E
I
S
K
E
L
N
Y
L
R
D
G
N
G
T
Site 79
T1070
Y
L
R
D
G
N
G
T
T
S
G
V
G
T
G
Site 80
S1072
R
D
G
N
G
T
T
S
G
V
G
T
G
S
S
Site 81
T1076
G
T
T
S
G
V
G
T
G
S
S
V
E
K
Y
Site 82
S1079
S
G
V
G
T
G
S
S
V
E
K
Y
V
I
D
Site 83
Y1083
T
G
S
S
V
E
K
Y
V
I
D
E
N
D
Y
Site 84
Y1090
Y
V
I
D
E
N
D
Y
M
S
F
I
N
N
P
Site 85
T1117
S
D
F
E
N
L
N
T
E
E
F
S
S
E
S
Site 86
S1122
L
N
T
E
E
F
S
S
E
S
E
L
E
E
S
Site 87
S1129
S
E
S
E
L
E
E
S
K
E
K
L
N
A
T
Site 88
T1136
S
K
E
K
L
N
A
T
S
S
S
E
G
S
T
Site 89
S1137
K
E
K
L
N
A
T
S
S
S
E
G
S
T
V
Site 90
S1138
E
K
L
N
A
T
S
S
S
E
G
S
T
V
D
Site 91
S1139
K
L
N
A
T
S
S
S
E
G
S
T
V
D
V
Site 92
T1143
T
S
S
S
E
G
S
T
V
D
V
V
L
P
R
Site 93
T1157
R
E
G
E
Q
A
E
T
E
P
E
E
D
L
K
Site 94
T1170
L
K
P
E
A
C
F
T
E
G
C
I
K
K
F
Site 95
S1183
K
F
P
F
C
Q
V
S
T
E
E
G
K
G
K
Site 96
Y1229
A
L
A
F
E
D
I
Y
I
E
Q
R
K
T
I
Site 97
T1235
I
Y
I
E
Q
R
K
T
I
K
T
M
L
E
Y
Site 98
T1238
E
Q
R
K
T
I
K
T
M
L
E
Y
A
D
K
Site 99
S1316
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 100
S1376
T
G
N
M
F
D
I
S
D
V
N
N
L
S
D
Site 101
S1382
I
S
D
V
N
N
L
S
D
C
Q
A
L
G
K
Site 102
Y1424
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
D
Site 103
Y1438
D
V
K
L
Q
P
V
Y
E
E
N
L
Y
M
Y
Site 104
T1486
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 105
Y1492
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 106
Y1553
E
T
D
D
Q
G
K
Y
M
T
L
V
L
S
R
Site 107
T1555
D
D
Q
G
K
Y
M
T
L
V
L
S
R
I
N
Site 108
S1559
K
Y
M
T
L
V
L
S
R
I
N
L
V
F
I
Site 109
T1570
L
V
F
I
V
L
F
T
G
E
F
V
L
K
L
Site 110
Y1583
K
L
V
S
L
R
H
Y
Y
F
T
I
G
W
N
Site 111
Y1613
L
A
E
M
I
E
K
Y
F
V
S
P
T
L
F
Site 112
S1616
M
I
E
K
Y
F
V
S
P
T
L
F
R
V
I
Site 113
T1730
P
P
D
C
D
P
D
T
I
H
P
G
S
S
V
Site 114
S1735
P
D
T
I
H
P
G
S
S
V
K
G
D
C
G
Site 115
S1736
D
T
I
H
P
G
S
S
V
K
G
D
C
G
N
Site 116
S1781
F
S
V
A
T
E
E
S
A
E
P
L
S
E
D
Site 117
S1786
E
E
S
A
E
P
L
S
E
D
D
F
E
M
F
Site 118
Y1794
E
D
D
F
E
M
F
Y
E
V
W
E
K
F
D
Site 119
T1805
E
K
F
D
P
D
A
T
Q
F
I
E
F
S
K
Site 120
S1864
T
K
R
V
L
G
E
S
G
E
M
D
A
L
R
Site 121
S1881
M
E
D
R
F
M
A
S
N
P
S
K
V
S
Y
Site 122
S1884
R
F
M
A
S
N
P
S
K
V
S
Y
E
P
I
Site 123
S1887
A
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
Site 124
Y1888
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
L
Site 125
T1893
V
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
Site 126
T1894
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
E
Site 127
Y1914
I
Q
R
N
F
R
C
Y
L
L
K
Q
R
L
K
Site 128
S1924
K
Q
R
L
K
N
I
S
S
N
Y
N
K
E
A
Site 129
S1925
Q
R
L
K
N
I
S
S
N
Y
N
K
E
A
I
Site 130
Y1927
L
K
N
I
S
S
N
Y
N
K
E
A
I
K
G
Site 131
T1954
D
K
L
N
G
N
S
T
P
E
K
T
D
G
S
Site 132
T1958
G
N
S
T
P
E
K
T
D
G
S
S
S
T
T
Site 133
S1961
T
P
E
K
T
D
G
S
S
S
T
T
S
P
P
Site 134
S1962
P
E
K
T
D
G
S
S
S
T
T
S
P
P
S
Site 135
S1963
E
K
T
D
G
S
S
S
T
T
S
P
P
S
Y
Site 136
T1964
K
T
D
G
S
S
S
T
T
S
P
P
S
Y
D
Site 137
T1965
T
D
G
S
S
S
T
T
S
P
P
S
Y
D
S
Site 138
S1966
D
G
S
S
S
T
T
S
P
P
S
Y
D
S
V
Site 139
S1969
S
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
Site 140
Y1970
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
D
Site 141
S1972
T
S
P
P
S
Y
D
S
V
T
K
P
D
K
E
Site 142
T1974
P
P
S
Y
D
S
V
T
K
P
D
K
E
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation