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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMPD4
Full Name:
Sphingomyelin phosphodiesterase 4
Alias:
FLJ20297; FLJ20756; KIAA1418; NET13; Neutral sphingomyelinase 3; Neutral sphingomyelinase III; Neutral sphingomyelinase-3; NSMA3; NSMase- 3; NSMASE3; NSMase-3; Sphingomyelin phosphodiesterase 4, neutral membrane; Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Type:
Endoplasmic reticulum; Phosphodiesterase; Lipid Metabolism - sphingolipid; EC 3.1.4.12
Mass (Da):
93352
Number AA:
827
UniProt ID:
Q9NXE4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0005802
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0005515
GO:0050290
PhosphoSite+
KinaseNET
Biological Process:
GO:0006685
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y105
Y
K
L
Q
A
E
D
Y
K
F
D
F
P
V
S
Site 2
S112
Y
K
F
D
F
P
V
S
Y
L
P
G
P
V
K
Site 3
Y113
K
F
D
F
P
V
S
Y
L
P
G
P
V
K
A
Site 4
S130
Q
E
C
I
L
P
D
S
P
L
Y
H
N
K
V
Site 5
Y133
I
L
P
D
S
P
L
Y
H
N
K
V
Q
F
T
Site 6
T140
Y
H
N
K
V
Q
F
T
P
T
G
G
L
G
L
Site 7
S174
T
Q
K
P
L
P
V
S
L
H
V
R
T
S
D
Site 8
S201
W
F
L
P
T
E
G
S
V
P
P
P
L
S
S
Site 9
S207
G
S
V
P
P
P
L
S
S
S
P
G
G
T
S
Site 10
S208
S
V
P
P
P
L
S
S
S
P
G
G
T
S
P
Site 11
S209
V
P
P
P
L
S
S
S
P
G
G
T
S
P
S
Site 12
T213
L
S
S
S
P
G
G
T
S
P
S
P
P
P
R
Site 13
S214
S
S
S
P
G
G
T
S
P
S
P
P
P
R
T
Site 14
S216
S
P
G
G
T
S
P
S
P
P
P
R
T
P
A
Site 15
T221
S
P
S
P
P
P
R
T
P
A
I
P
F
A
S
Site 16
S228
T
P
A
I
P
F
A
S
Y
G
L
H
H
T
S
Site 17
Y229
P
A
I
P
F
A
S
Y
G
L
H
H
T
S
L
Site 18
S235
S
Y
G
L
H
H
T
S
L
L
K
R
H
I
S
Site 19
S242
S
L
L
K
R
H
I
S
H
Q
T
S
V
N
A
Site 20
S246
R
H
I
S
H
Q
T
S
V
N
A
D
P
A
S
Site 21
S253
S
V
N
A
D
P
A
S
H
E
I
W
R
S
E
Site 22
S259
A
S
H
E
I
W
R
S
E
T
L
L
Q
V
F
Site 23
T261
H
E
I
W
R
S
E
T
L
L
Q
V
F
V
E
Site 24
Y279
H
H
Y
S
L
E
M
Y
Q
K
M
Q
S
P
H
Site 25
S284
E
M
Y
Q
K
M
Q
S
P
H
A
K
L
E
V
Site 26
S297
E
V
L
H
Y
R
L
S
V
S
S
A
L
Y
S
Site 27
S300
H
Y
R
L
S
V
S
S
A
L
Y
S
P
A
Q
Site 28
S304
S
V
S
S
A
L
Y
S
P
A
Q
P
S
L
Q
Site 29
S309
L
Y
S
P
A
Q
P
S
L
Q
A
L
H
A
Y
Site 30
Y316
S
L
Q
A
L
H
A
Y
Q
E
S
F
T
P
T
Site 31
S319
A
L
H
A
Y
Q
E
S
F
T
P
T
E
E
H
Site 32
T321
H
A
Y
Q
E
S
F
T
P
T
E
E
H
V
L
Site 33
T323
Y
Q
E
S
F
T
P
T
E
E
H
V
L
V
V
Site 34
S350
S
L
K
P
E
Q
A
S
P
S
A
H
S
H
A
Site 35
S352
K
P
E
Q
A
S
P
S
A
H
S
H
A
T
S
Site 36
S355
Q
A
S
P
S
A
H
S
H
A
T
S
P
L
E
Site 37
S359
S
A
H
S
H
A
T
S
P
L
E
E
F
K
R
Site 38
Y404
V
L
E
M
W
L
S
Y
L
Q
P
W
R
Y
A
Site 39
Y410
S
Y
L
Q
P
W
R
Y
A
P
D
K
Q
A
P
Site 40
S419
P
D
K
Q
A
P
G
S
D
S
Q
P
R
C
V
Site 41
S421
K
Q
A
P
G
S
D
S
Q
P
R
C
V
S
E
Site 42
S427
D
S
Q
P
R
C
V
S
E
K
W
A
P
F
V
Site 43
T455
F
L
N
R
A
L
R
T
D
L
V
S
P
K
H
Site 44
S459
A
L
R
T
D
L
V
S
P
K
H
A
L
M
V
Site 45
T505
H
R
Q
H
R
L
F
T
A
P
T
F
T
G
S
Site 46
S512
T
A
P
T
F
T
G
S
F
L
S
P
W
P
P
Site 47
S525
P
P
A
V
T
D
A
S
F
K
V
K
S
H
V
Site 48
S530
D
A
S
F
K
V
K
S
H
V
Y
S
L
E
G
Site 49
S534
K
V
K
S
H
V
Y
S
L
E
G
Q
D
C
K
Site 50
Y542
L
E
G
Q
D
C
K
Y
T
P
M
F
G
P
E
Site 51
T543
E
G
Q
D
C
K
Y
T
P
M
F
G
P
E
A
Site 52
T562
L
R
L
A
Q
L
I
T
Q
A
K
H
T
A
K
Site 53
S570
Q
A
K
H
T
A
K
S
I
S
D
Q
C
A
E
Site 54
S572
K
H
T
A
K
S
I
S
D
Q
C
A
E
S
P
Site 55
S578
I
S
D
Q
C
A
E
S
P
A
G
H
S
F
L
Site 56
S592
L
S
W
L
G
F
S
S
M
D
T
N
G
S
Y
Site 57
T595
L
G
F
S
S
M
D
T
N
G
S
Y
T
A
N
Site 58
S598
S
S
M
D
T
N
G
S
Y
T
A
N
D
L
D
Site 59
S611
L
D
E
M
G
Q
D
S
V
R
K
T
D
E
Y
Site 60
T615
G
Q
D
S
V
R
K
T
D
E
Y
L
E
K
A
Site 61
Y618
S
V
R
K
T
D
E
Y
L
E
K
A
L
E
Y
Site 62
Y625
Y
L
E
K
A
L
E
Y
L
R
Q
I
F
R
L
Site 63
S633
L
R
Q
I
F
R
L
S
E
A
Q
L
R
Q
F
Site 64
T641
E
A
Q
L
R
Q
F
T
L
A
L
G
T
T
Q
Site 65
T646
Q
F
T
L
A
L
G
T
T
Q
D
E
N
G
K
Site 66
T669
G
E
D
G
L
I
L
T
P
L
G
R
Y
Q
I
Site 67
Y687
L
R
R
F
E
I
E
Y
Q
G
D
P
E
L
Q
Site 68
S698
P
E
L
Q
P
I
R
S
Y
E
I
A
S
L
V
Site 69
Y699
E
L
Q
P
I
R
S
Y
E
I
A
S
L
V
R
Site 70
S712
V
R
T
L
F
R
L
S
S
A
I
N
H
R
F
Site 71
S713
R
T
L
F
R
L
S
S
A
I
N
H
R
F
A
Site 72
S728
G
Q
M
A
A
L
C
S
R
D
D
F
L
G
S
Site 73
S735
S
R
D
D
F
L
G
S
F
C
R
Y
H
L
T
Site 74
T742
S
F
C
R
Y
H
L
T
E
P
G
L
A
S
R
Site 75
S753
L
A
S
R
H
L
L
S
P
V
G
R
R
Q
V
Site 76
T764
R
R
Q
V
A
G
H
T
R
G
P
R
L
S
L
Site 77
S770
H
T
R
G
P
R
L
S
L
R
F
L
G
S
Y
Site 78
T819
A
S
A
M
T
L
L
T
E
R
G
K
L
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation