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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF446
Full Name:
Zinc finger protein 446
Alias:
Zinc finger protein with KRAB and SCAN domains 20
Type:
Mass (Da):
48957
Number AA:
450
UniProt ID:
Q9NWS9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
L
P
V
M
D
P
E
T
T
L
E
E
P
E
T
Site 2
T24
T
T
L
E
E
P
E
T
A
R
L
R
F
R
G
Site 3
Y34
L
R
F
R
G
F
C
Y
Q
E
V
A
G
P
R
Site 4
S93
V
R
G
Q
R
P
G
S
P
E
E
A
A
A
L
Site 5
T131
V
L
P
A
A
Q
K
T
E
E
P
L
G
S
P
Site 6
S137
K
T
E
E
P
L
G
S
P
H
P
S
G
T
V
Site 7
S141
P
L
G
S
P
H
P
S
G
T
V
E
S
P
G
Site 8
T143
G
S
P
H
P
S
G
T
V
E
S
P
G
E
G
Site 9
S146
H
P
S
G
T
V
E
S
P
G
E
G
P
Q
D
Site 10
T154
P
G
E
G
P
Q
D
T
R
I
E
G
S
V
Q
Site 11
S159
Q
D
T
R
I
E
G
S
V
Q
L
S
C
S
V
Site 12
S163
I
E
G
S
V
Q
L
S
C
S
V
K
E
E
P
Site 13
S165
G
S
V
Q
L
S
C
S
V
K
E
E
P
N
V
Site 14
S180
D
G
Q
E
V
A
P
S
S
P
P
L
A
A
Q
Site 15
S181
G
Q
E
V
A
P
S
S
P
P
L
A
A
Q
S
Site 16
S188
S
P
P
L
A
A
Q
S
P
E
G
N
H
G
H
Site 17
S200
H
G
H
Q
E
P
A
S
T
S
F
H
P
P
R
Site 18
T201
G
H
Q
E
P
A
S
T
S
F
H
P
P
R
I
Site 19
S202
H
Q
E
P
A
S
T
S
F
H
P
P
R
I
Q
Site 20
S218
E
W
G
L
L
D
R
S
Q
K
E
L
Y
W
D
Site 21
Y223
D
R
S
Q
K
E
L
Y
W
D
A
M
L
E
K
Site 22
S236
E
K
Y
G
T
V
V
S
L
G
L
P
P
H
Q
Site 23
S264
T
G
T
G
V
C
R
S
L
R
S
G
N
E
S
Site 24
S267
G
V
C
R
S
L
R
S
G
N
E
S
E
G
P
Site 25
S271
S
L
R
S
G
N
E
S
E
G
P
P
G
C
P
Site 26
T299
E
G
L
S
G
A
A
T
P
A
P
T
V
R
P
Site 27
T303
G
A
A
T
P
A
P
T
V
R
P
G
T
P
P
Site 28
T308
A
P
T
V
R
P
G
T
P
P
V
P
T
Q
P
Site 29
T316
P
P
V
P
T
Q
P
T
P
A
E
T
R
L
E
Site 30
T327
T
R
L
E
P
A
A
T
P
R
K
P
Y
T
C
Site 31
Y332
A
A
T
P
R
K
P
Y
T
C
E
Q
C
G
R
Site 32
T333
A
T
P
R
K
P
Y
T
C
E
Q
C
G
R
G
Site 33
T353
V
F
V
I
H
H
R
T
H
T
S
G
P
G
V
Site 34
T355
V
I
H
H
R
T
H
T
S
G
P
G
V
Q
S
Site 35
S362
T
S
G
P
G
V
Q
S
P
G
L
A
T
G
E
Site 36
S370
P
G
L
A
T
G
E
S
T
E
K
P
P
Q
G
Site 37
S388
F
P
H
H
P
R
R
S
L
T
G
P
R
S
Y
Site 38
T390
H
H
P
R
R
S
L
T
G
P
R
S
Y
P
C
Site 39
S394
R
S
L
T
G
P
R
S
Y
P
C
E
E
C
G
Site 40
Y395
S
L
T
G
P
R
S
Y
P
C
E
E
C
G
C
Site 41
S416
Q
L
V
I
H
R
K
S
H
T
G
Q
R
R
H
Site 42
S436
G
R
A
F
D
W
K
S
Q
L
V
I
H
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation