KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NLE1
Full Name:
Notchless protein homolog 1
Alias:
FLJ10458; Nle; Notchless 1; Notchless gene; Notchless gene homologue variant; Notchless homolog 1
Type:
Mass (Da):
53266
Number AA:
485
UniProt ID:
Q9NVX2
International Prot ID:
IPI00018196
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0001826
GO:0007154
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
E
G
G
Q
L
L
G
S
P
F
D
V
P
V
D
Site 2
T40
F
D
V
P
V
D
I
T
P
D
R
L
Q
L
V
Site 3
S72
H
D
A
E
I
V
S
S
L
G
K
T
L
E
S
Site 4
S79
S
L
G
K
T
L
E
S
Q
A
V
E
T
E
K
Site 5
T107
V
R
A
V
T
R
C
T
S
S
L
E
G
H
S
Site 6
S108
R
A
V
T
R
C
T
S
S
L
E
G
H
S
E
Site 7
S109
A
V
T
R
C
T
S
S
L
E
G
H
S
E
A
Site 8
Y128
A
F
S
P
T
G
K
Y
L
A
S
G
S
G
D
Site 9
S131
P
T
G
K
Y
L
A
S
G
S
G
D
T
T
V
Site 10
S133
G
K
Y
L
A
S
G
S
G
D
T
T
V
R
F
Site 11
T136
L
A
S
G
S
G
D
T
T
V
R
F
W
D
L
Site 12
T137
A
S
G
S
G
D
T
T
V
R
F
W
D
L
S
Site 13
T145
V
R
F
W
D
L
S
T
E
T
P
H
F
T
C
Site 14
T147
F
W
D
L
S
T
E
T
P
H
F
T
C
K
G
Site 15
S161
G
H
R
H
W
V
L
S
I
S
W
S
P
D
G
Site 16
S163
R
H
W
V
L
S
I
S
W
S
P
D
G
K
K
Site 17
S165
W
V
L
S
I
S
W
S
P
D
G
K
K
L
A
Site 18
S173
P
D
G
K
K
L
A
S
G
C
K
N
G
Q
I
Site 19
S186
Q
I
L
L
W
D
P
S
T
G
K
Q
V
G
R
Site 20
T187
I
L
L
W
D
P
S
T
G
K
Q
V
G
R
T
Site 21
T194
T
G
K
Q
V
G
R
T
L
A
G
H
S
K
W
Site 22
S199
G
R
T
L
A
G
H
S
K
W
I
T
G
L
S
Site 23
T203
A
G
H
S
K
W
I
T
G
L
S
W
E
P
L
Site 24
S206
S
K
W
I
T
G
L
S
W
E
P
L
H
A
N
Site 25
Y218
H
A
N
P
E
C
R
Y
V
A
S
S
S
K
D
Site 26
S221
P
E
C
R
Y
V
A
S
S
S
K
D
G
S
V
Site 27
S222
E
C
R
Y
V
A
S
S
S
K
D
G
S
V
R
Site 28
S223
C
R
Y
V
A
S
S
S
K
D
G
S
V
R
I
Site 29
S227
A
S
S
S
K
D
G
S
V
R
I
W
D
T
T
Site 30
T233
G
S
V
R
I
W
D
T
T
A
G
R
C
E
R
Site 31
T234
S
V
R
I
W
D
T
T
A
G
R
C
E
R
I
Site 32
T243
G
R
C
E
R
I
L
T
G
H
T
Q
S
V
T
Site 33
S248
I
L
T
G
H
T
Q
S
V
T
C
L
R
W
G
Site 34
T250
T
G
H
T
Q
S
V
T
C
L
R
W
G
G
D
Site 35
Y261
W
G
G
D
G
L
L
Y
S
A
S
Q
D
R
T
Site 36
S262
G
G
D
G
L
L
Y
S
A
S
Q
D
R
T
I
Site 37
S264
D
G
L
L
Y
S
A
S
Q
D
R
T
I
K
V
Site 38
T268
Y
S
A
S
Q
D
R
T
I
K
V
W
R
A
H
Site 39
S312
A
F
E
P
A
E
A
S
V
N
P
Q
D
L
Q
Site 40
S331
E
L
K
E
R
A
L
S
R
Y
N
L
V
R
G
Site 41
Y333
K
E
R
A
L
S
R
Y
N
L
V
R
G
Q
G
Site 42
S346
Q
G
P
E
R
L
V
S
G
S
D
D
F
T
L
Site 43
S348
P
E
R
L
V
S
G
S
D
D
F
T
L
F
L
Site 44
S357
D
F
T
L
F
L
W
S
P
A
E
D
K
K
P
Site 45
T366
A
E
D
K
K
P
L
T
R
M
T
G
H
Q
A
Site 46
T369
K
K
P
L
T
R
M
T
G
H
Q
A
L
I
N
Site 47
S381
L
I
N
Q
V
L
F
S
P
D
S
R
I
V
A
Site 48
S384
Q
V
L
F
S
P
D
S
R
I
V
A
S
A
S
Site 49
S389
P
D
S
R
I
V
A
S
A
S
F
D
K
S
I
Site 50
S395
A
S
A
S
F
D
K
S
I
K
L
W
D
G
R
Site 51
T403
I
K
L
W
D
G
R
T
G
K
Y
L
A
S
L
Site 52
Y406
W
D
G
R
T
G
K
Y
L
A
S
L
R
G
H
Site 53
S409
R
T
G
K
Y
L
A
S
L
R
G
H
V
A
A
Site 54
S431
A
D
S
R
L
L
V
S
G
S
S
D
S
T
L
Site 55
S433
S
R
L
L
V
S
G
S
S
D
S
T
L
K
V
Site 56
S434
R
L
L
V
S
G
S
S
D
S
T
L
K
V
W
Site 57
T437
V
S
G
S
S
D
S
T
L
K
V
W
D
V
K
Site 58
Y460
P
G
H
A
D
E
V
Y
A
V
D
W
S
P
D
Site 59
S465
E
V
Y
A
V
D
W
S
P
D
G
Q
R
V
A
Site 60
S473
P
D
G
Q
R
V
A
S
G
G
K
D
K
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation