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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS10
Full Name:
Integrator complex subunit 10
Alias:
C8orf35; FLJ10569; Int10
Type:
Unknown function
Mass (Da):
82236
Number AA:
710
UniProt ID:
Q9NVR2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032039
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016180
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y44
P
A
D
F
N
I
Q
Y
E
M
Y
T
I
E
R
Site 2
T58
R
N
A
E
R
T
A
T
A
G
R
L
L
Y
D
Site 3
T84
W
R
E
I
S
I
I
T
S
A
L
R
N
D
S
Site 4
S85
R
E
I
S
I
I
T
S
A
L
R
N
D
S
Q
Site 5
S91
T
S
A
L
R
N
D
S
Q
D
K
Q
T
Q
F
Site 6
T96
N
D
S
Q
D
K
Q
T
Q
F
L
R
S
L
F
Site 7
S101
K
Q
T
Q
F
L
R
S
L
F
E
T
L
P
G
Site 8
T125
V
T
E
Q
C
F
N
T
L
E
R
S
E
M
L
Site 9
S165
E
T
I
E
E
Q
E
S
P
V
N
C
F
R
K
Site 10
Y198
P
A
N
L
L
Y
K
Y
L
N
K
A
A
E
F
Site 11
Y209
A
A
E
F
Y
I
N
Y
V
T
R
S
T
Q
I
Site 12
S227
H
Q
G
A
Q
D
T
S
D
L
M
S
P
S
K
Site 13
S231
Q
D
T
S
D
L
M
S
P
S
K
R
S
S
Q
Site 14
S233
T
S
D
L
M
S
P
S
K
R
S
S
Q
K
Y
Site 15
S237
M
S
P
S
K
R
S
S
Q
K
Y
I
I
E
G
Site 16
Y240
S
K
R
S
S
Q
K
Y
I
I
E
G
L
T
E
Site 17
T246
K
Y
I
I
E
G
L
T
E
K
S
S
Q
I
V
Site 18
S249
I
E
G
L
T
E
K
S
S
Q
I
V
D
P
W
Site 19
S250
E
G
L
T
E
K
S
S
Q
I
V
D
P
W
E
Site 20
S280
Q
M
D
K
G
R
R
S
Y
G
D
I
L
H
R
Site 21
Y281
M
D
K
G
R
R
S
Y
G
D
I
L
H
R
M
Site 22
Y294
R
M
K
D
L
C
R
Y
M
N
N
F
D
S
E
Site 23
S300
R
Y
M
N
N
F
D
S
E
A
H
A
K
Y
K
Site 24
Y306
D
S
E
A
H
A
K
Y
K
N
Q
V
V
Y
S
Site 25
Y312
K
Y
K
N
Q
V
V
Y
S
T
M
L
V
F
F
Site 26
Y325
F
F
K
N
A
F
Q
Y
V
N
S
I
Q
P
S
Site 27
S328
N
A
F
Q
Y
V
N
S
I
Q
P
S
L
F
Q
Site 28
S332
Y
V
N
S
I
Q
P
S
L
F
Q
G
P
N
A
Site 29
Y355
L
E
D
V
S
N
V
Y
G
D
V
E
I
D
R
Site 30
T379
L
A
E
G
R
E
K
T
M
S
S
D
D
E
D
Site 31
S381
E
G
R
E
K
T
M
S
S
D
D
E
D
C
S
Site 32
S382
G
R
E
K
T
M
S
S
D
D
E
D
C
S
A
Site 33
S388
S
S
D
D
E
D
C
S
A
K
G
R
N
R
H
Site 34
S406
N
K
A
E
L
A
N
S
T
E
V
L
E
S
F
Site 35
S412
N
S
T
E
V
L
E
S
F
K
L
A
R
E
S
Site 36
S419
S
F
K
L
A
R
E
S
W
E
L
L
Y
S
L
Site 37
Y424
R
E
S
W
E
L
L
Y
S
L
E
F
L
D
K
Site 38
S425
E
S
W
E
L
L
Y
S
L
E
F
L
D
K
E
Site 39
S480
A
A
L
Q
G
S
I
S
Q
P
Q
I
T
G
Q
Site 40
T512
A
L
G
E
Y
R
M
T
C
E
K
V
L
D
L
Site 41
S533
P
I
Q
D
G
G
K
S
Q
E
E
P
S
K
V
Site 42
S548
K
P
K
F
R
K
G
S
D
L
K
L
L
P
C
Site 43
Y625
Q
Y
E
N
F
F
N
Y
V
T
N
I
D
M
L
Site 44
Y637
D
M
L
E
E
F
A
Y
L
R
T
Q
E
G
G
Site 45
T662
G
M
L
I
K
H
H
T
V
T
R
G
I
T
K
Site 46
T668
H
T
V
T
R
G
I
T
K
G
V
K
E
D
F
Site 47
S684
L
A
M
E
R
Q
V
S
R
C
G
E
N
L
M
Site 48
T708
E
K
I
L
L
L
Q
T
L
T
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation