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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMLHE
Full Name:
Trimethyllysine dioxygenase, mitochondrial
Alias:
Epsilon-trimethyllysine 2-oxoglutarate dioxygenase;Epsilon-trimethyllysine hydroxylase;TML hydroxylase;TML-alpha-ketoglutarate dioxygenase
Type:
Mass (Da):
49518
Number AA:
421
UniProt ID:
Q9NVH6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
H
R
L
S
H
L
H
S
R
L
Q
D
L
L
K
Site 2
T44
L
A
V
H
W
H
H
T
A
S
K
S
L
T
C
Site 3
Y64
E
D
H
F
E
L
K
Y
A
N
T
V
M
R
F
Site 4
S84
R
D
H
C
R
S
A
S
C
Y
N
S
K
T
H
Site 5
Y86
H
C
R
S
A
S
C
Y
N
S
K
T
H
Q
R
Site 6
S88
R
S
A
S
C
Y
N
S
K
T
H
Q
R
S
L
Site 7
T90
A
S
C
Y
N
S
K
T
H
Q
R
S
L
D
T
Site 8
S94
N
S
K
T
H
Q
R
S
L
D
T
A
S
V
D
Site 9
T97
T
H
Q
R
S
L
D
T
A
S
V
D
L
C
I
Site 10
S99
Q
R
S
L
D
T
A
S
V
D
L
C
I
K
P
Site 11
T108
D
L
C
I
K
P
K
T
I
R
L
D
E
T
T
Site 12
T114
K
T
I
R
L
D
E
T
T
L
F
F
T
W
P
Site 13
T115
T
I
R
L
D
E
T
T
L
F
F
T
W
P
D
Site 14
Y128
P
D
G
H
V
T
K
Y
D
L
N
W
L
V
K
Site 15
S164
Y
Q
Q
A
Q
V
P
S
V
D
C
Q
S
F
L
Site 16
S169
V
P
S
V
D
C
Q
S
F
L
E
T
N
E
G
Site 17
T173
D
C
Q
S
F
L
E
T
N
E
G
L
K
K
F
Site 18
S210
E
K
L
A
E
R
I
S
L
I
R
E
T
I
Y
Site 19
Y217
S
L
I
R
E
T
I
Y
G
R
M
W
Y
F
T
Site 20
Y222
T
I
Y
G
R
M
W
Y
F
T
S
D
F
S
R
Site 21
T232
S
D
F
S
R
G
D
T
A
Y
T
K
L
A
L
Site 22
Y234
F
S
R
G
D
T
A
Y
T
K
L
A
L
D
R
Site 23
T243
K
L
A
L
D
R
H
T
D
T
T
Y
F
Q
E
Site 24
T245
A
L
D
R
H
T
D
T
T
Y
F
Q
E
P
C
Site 25
Y247
D
R
H
T
D
T
T
Y
F
Q
E
P
C
G
I
Site 26
T265
H
C
L
K
H
E
G
T
G
G
R
T
L
L
V
Site 27
S293
P
E
E
F
E
L
L
S
K
V
P
L
K
H
E
Site 28
Y301
K
V
P
L
K
H
E
Y
I
E
D
V
G
E
C
Site 29
Y322
I
G
P
V
L
N
I
Y
P
W
N
K
E
L
Y
Site 30
Y329
Y
P
W
N
K
E
L
Y
L
I
R
Y
N
N
Y
Site 31
Y333
K
E
L
Y
L
I
R
Y
N
N
Y
D
R
A
V
Site 32
Y336
Y
L
I
R
Y
N
N
Y
D
R
A
V
I
N
T
Site 33
T343
Y
D
R
A
V
I
N
T
V
P
Y
D
V
V
H
Site 34
Y353
Y
D
V
V
H
R
W
Y
T
A
H
R
T
L
T
Site 35
T358
R
W
Y
T
A
H
R
T
L
T
I
E
L
R
R
Site 36
T360
Y
T
A
H
R
T
L
T
I
E
L
R
R
P
E
Site 37
Y397
G
R
E
C
F
T
G
Y
R
Q
L
C
G
C
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation