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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXD2
Full Name:
Exonuclease 3'-5' domain-containing protein 2
Alias:
Exonuclease 3'-5' domain-like-containing protein 2
Type:
Mass (Da):
56346
Number AA:
496
UniProt ID:
Q9NVH0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
V
G
C
S
E
D
A
S
K
L
L
Q
D
Y
G
Site 2
Y66
R
G
C
L
D
L
R
Y
L
A
M
R
Q
R
N
Site 3
S103
K
S
L
L
L
R
C
S
N
W
D
A
E
T
L
Site 4
S138
H
L
L
G
Y
P
F
S
R
N
S
P
G
E
K
Site 5
S141
G
Y
P
F
S
R
N
S
P
G
E
K
N
D
D
Site 6
S150
G
E
K
N
D
D
H
S
S
W
R
K
V
L
E
Site 7
S151
E
K
N
D
D
H
S
S
W
R
K
V
L
E
K
Site 8
S169
V
V
D
I
P
F
R
S
K
G
M
S
R
L
G
Site 9
S173
P
F
R
S
K
G
M
S
R
L
G
E
E
V
N
Site 10
S186
V
N
G
E
A
T
E
S
Q
Q
K
P
R
N
K
Site 11
S195
Q
K
P
R
N
K
K
S
K
M
D
G
M
V
P
Site 12
Y222
R
K
P
L
G
V
G
Y
S
A
R
K
S
P
L
Site 13
S223
K
P
L
G
V
G
Y
S
A
R
K
S
P
L
Y
Site 14
S227
V
G
Y
S
A
R
K
S
P
L
Y
D
N
C
F
Site 15
Y230
S
A
R
K
S
P
L
Y
D
N
C
F
L
H
A
Site 16
T245
P
D
G
Q
P
L
C
T
C
D
R
R
K
A
Q
Site 17
Y254
D
R
R
K
A
Q
W
Y
L
D
K
G
I
G
E
Site 18
S282
E
P
A
G
R
P
E
S
P
G
D
Y
Y
L
M
Site 19
Y286
R
P
E
S
P
G
D
Y
Y
L
M
V
K
E
N
Site 20
Y287
P
E
S
P
G
D
Y
Y
L
M
V
K
E
N
L
Site 21
S303
V
V
C
G
K
R
D
S
Y
I
R
K
N
V
I
Site 22
Y304
V
C
G
K
R
D
S
Y
I
R
K
N
V
I
P
Site 23
Y314
K
N
V
I
P
H
E
Y
R
K
H
F
P
I
E
Site 24
Y343
S
C
H
A
I
S
N
Y
Y
D
N
H
L
K
Q
Site 25
S362
E
F
Q
A
P
I
G
S
E
E
G
L
R
L
L
Site 26
S379
P
E
R
R
Q
V
R
S
G
A
R
A
L
L
N
Site 27
S389
R
A
L
L
N
A
E
S
L
P
T
Q
R
K
E
Site 28
T392
L
N
A
E
S
L
P
T
Q
R
K
E
E
L
L
Site 29
Y406
L
Q
A
L
R
E
F
Y
N
T
D
V
V
T
E
Site 30
T408
A
L
R
E
F
Y
N
T
D
V
V
T
E
E
M
Site 31
S421
E
M
L
Q
E
A
A
S
L
E
T
R
I
S
N
Site 32
S427
A
S
L
E
T
R
I
S
N
E
N
Y
V
P
H
Site 33
Y431
T
R
I
S
N
E
N
Y
V
P
H
G
L
K
V
Site 34
S443
L
K
V
V
Q
C
H
S
Q
G
G
L
R
S
L
Site 35
S449
H
S
Q
G
G
L
R
S
L
M
Q
L
E
S
R
Site 36
S455
R
S
L
M
Q
L
E
S
R
W
R
Q
H
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation