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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP40
Full Name:
Ubiquitin carboxyl-terminal hydrolase 40
Alias:
Deubiquitinating enzyme 40;Ubiquitin thiolesterase 40;Ubiquitin-specific-processing protease 40
Type:
Mass (Da):
140130
Number AA:
1235
UniProt ID:
Q9NVE5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
G
D
L
F
E
E
E
Y
S
T
V
S
N
N
Q
Site 2
S11
D
L
F
E
E
E
Y
S
T
V
S
N
N
Q
Y
Site 3
T12
L
F
E
E
E
Y
S
T
V
S
N
N
Q
Y
G
Site 4
S14
E
E
E
Y
S
T
V
S
N
N
Q
Y
G
K
G
Site 5
Y18
S
T
V
S
N
N
Q
Y
G
K
G
K
K
L
K
Site 6
T26
G
K
G
K
K
L
K
T
K
A
L
E
P
P
A
Site 7
T38
P
P
A
P
R
E
F
T
N
L
S
G
I
R
N
Site 8
S41
P
R
E
F
T
N
L
S
G
I
R
N
Q
G
G
Site 9
T49
G
I
R
N
Q
G
G
T
C
Y
L
N
S
L
L
Site 10
Y51
R
N
Q
G
G
T
C
Y
L
N
S
L
L
Q
T
Site 11
S71
E
F
R
E
A
L
F
S
L
G
P
E
E
L
G
Site 12
T114
L
D
Q
E
A
A
S
T
A
D
L
T
D
S
F
Site 13
T118
A
A
S
T
A
D
L
T
D
S
F
G
W
T
S
Site 14
S120
S
T
A
D
L
T
D
S
F
G
W
T
S
N
E
Site 15
T124
L
T
D
S
F
G
W
T
S
N
E
E
M
R
Q
Site 16
Y159
T
S
G
H
D
L
I
Y
R
L
Y
H
G
T
I
Site 17
Y162
H
D
L
I
Y
R
L
Y
H
G
T
I
V
N
Q
Site 18
S179
C
K
E
C
K
N
V
S
E
R
Q
E
D
F
L
Site 19
Y206
E
D
A
L
W
N
M
Y
V
E
E
E
V
F
D
Site 20
S232
R
L
V
K
A
A
K
S
A
K
L
R
K
L
P
Site 21
Y259
D
F
V
K
C
E
R
Y
K
E
T
S
C
Y
T
Site 22
Y265
R
Y
K
E
T
S
C
Y
T
F
P
L
R
I
N
Site 23
T266
Y
K
E
T
S
C
Y
T
F
P
L
R
I
N
L
Site 24
Y287
S
E
L
D
D
L
E
Y
I
Y
D
L
F
S
V
Site 25
Y306
G
G
C
Y
G
G
H
Y
H
V
Y
I
K
D
V
Site 26
Y309
Y
G
G
H
Y
H
V
Y
I
K
D
V
D
H
L
Site 27
S337
V
N
L
K
D
L
Q
S
E
E
E
I
D
H
P
Site 28
Y380
G
I
S
W
N
K
K
Y
R
K
Q
H
G
P
L
Site 29
S401
H
S
Q
I
F
L
L
S
S
D
E
S
T
V
R
Site 30
S405
F
L
L
S
S
D
E
S
T
V
R
L
L
K
N
Site 31
T406
L
L
S
S
D
E
S
T
V
R
L
L
K
N
S
Site 32
S413
T
V
R
L
L
K
N
S
S
L
Q
A
E
S
D
Site 33
S414
V
R
L
L
K
N
S
S
L
Q
A
E
S
D
F
Site 34
S436
F
K
M
L
P
P
E
S
P
G
L
N
N
S
I
Site 35
S482
Y
M
L
F
Y
R
K
S
Q
L
Q
R
P
P
E
Site 36
Y496
E
A
R
A
N
P
R
Y
G
V
P
C
H
L
L
Site 37
S522
T
K
R
A
E
C
D
S
A
N
N
T
F
E
L
Site 38
T526
E
C
D
S
A
N
N
T
F
E
L
H
L
H
L
Site 39
Y537
H
L
H
L
G
P
Q
Y
H
F
F
N
G
A
L
Site 40
S549
G
A
L
H
P
V
V
S
Q
T
E
S
V
W
D
Site 41
S553
P
V
V
S
Q
T
E
S
V
W
D
L
T
F
D
Site 42
T558
T
E
S
V
W
D
L
T
F
D
K
R
K
T
L
Site 43
T564
L
T
F
D
K
R
K
T
L
G
D
L
R
Q
S
Site 44
S571
T
L
G
D
L
R
Q
S
I
F
Q
L
L
E
F
Site 45
Y598
V
P
A
G
L
H
I
Y
Q
S
L
G
G
D
E
Site 46
S600
A
G
L
H
I
Y
Q
S
L
G
G
D
E
L
T
Site 47
T634
V
G
G
V
H
I
Q
T
G
I
D
C
E
P
L
Site 48
T650
L
N
V
L
H
L
D
T
S
S
D
G
E
K
C
Site 49
S651
N
V
L
H
L
D
T
S
S
D
G
E
K
C
C
Site 50
S652
V
L
H
L
D
T
S
S
D
G
E
K
C
C
Q
Site 51
T711
P
K
E
D
M
R
K
T
F
R
E
Q
G
L
R
Site 52
S721
E
Q
G
L
R
N
G
S
S
I
L
I
Q
D
S
Site 53
S722
Q
G
L
R
N
G
S
S
I
L
I
Q
D
S
H
Site 54
S728
S
S
I
L
I
Q
D
S
H
D
D
N
S
L
L
Site 55
S733
Q
D
S
H
D
D
N
S
L
L
T
K
E
E
K
Site 56
S761
K
N
L
C
Q
L
E
S
E
E
K
Q
V
K
I
Site 57
S797
M
K
E
L
A
D
N
S
C
L
R
P
I
D
R
Site 58
S815
L
L
C
P
V
P
D
S
Y
T
L
K
E
A
E
Site 59
Y816
L
C
P
V
P
D
S
Y
T
L
K
E
A
E
L
Site 60
T817
C
P
V
P
D
S
Y
T
L
K
E
A
E
L
K
Site 61
S827
E
A
E
L
K
M
G
S
S
L
G
L
C
L
G
Site 62
S828
A
E
L
K
M
G
S
S
L
G
L
C
L
G
K
Site 63
S850
F
L
F
F
A
M
G
S
D
V
Q
P
G
T
E
Site 64
S879
L
K
L
M
L
K
K
S
G
L
Q
G
D
A
W
Site 65
Y895
L
R
K
M
D
W
C
Y
E
A
G
E
P
L
C
Site 66
Y939
L
K
V
P
I
W
W
Y
Q
L
Q
G
P
S
G
Site 67
T968
W
G
R
V
W
R
A
T
S
S
Q
G
A
S
G
Site 68
S969
G
R
V
W
R
A
T
S
S
Q
G
A
S
G
N
Site 69
S970
R
V
W
R
A
T
S
S
Q
G
A
S
G
N
E
Site 70
S974
A
T
S
S
Q
G
A
S
G
N
E
P
A
Q
V
Site 71
S992
Y
L
G
D
I
E
I
S
E
D
A
T
L
A
E
Site 72
T996
I
E
I
S
E
D
A
T
L
A
E
L
K
S
Q
Site 73
T1025
P
A
H
L
R
A
W
T
V
E
R
K
R
P
G
Site 74
T1037
R
P
G
R
L
L
R
T
D
R
Q
P
L
R
E
Site 75
Y1045
D
R
Q
P
L
R
E
Y
K
L
G
R
R
I
E
Site 76
T1073
P
Q
D
V
L
L
R
T
Q
V
R
I
P
G
E
Site 77
T1082
V
R
I
P
G
E
R
T
Y
A
P
A
L
D
L
Site 78
Y1083
R
I
P
G
E
R
T
Y
A
P
A
L
D
L
V
Site 79
S1101
A
Q
G
G
T
A
G
S
L
R
Q
R
V
A
D
Site 80
Y1110
R
Q
R
V
A
D
F
Y
R
L
P
V
E
K
I
Site 81
Y1122
E
K
I
E
I
A
K
Y
F
P
E
K
F
E
W
Site 82
T1140
S
S
W
N
Q
Q
I
T
K
R
K
K
K
K
K
Site 83
Y1150
K
K
K
K
K
Q
D
Y
L
Q
G
A
P
Y
Y
Site 84
Y1156
D
Y
L
Q
G
A
P
Y
Y
L
K
D
G
D
T
Site 85
Y1157
Y
L
Q
G
A
P
Y
Y
L
K
D
G
D
T
I
Site 86
T1163
Y
Y
L
K
D
G
D
T
I
G
V
K
N
L
L
Site 87
S1178
I
D
D
D
D
D
F
S
T
I
R
D
D
T
G
Site 88
T1179
D
D
D
D
D
F
S
T
I
R
D
D
T
G
K
Site 89
T1184
F
S
T
I
R
D
D
T
G
K
E
K
Q
K
Q
Site 90
S1199
R
A
L
G
R
R
K
S
Q
E
A
L
H
E
Q
Site 91
S1207
Q
E
A
L
H
E
Q
S
S
Y
I
L
S
S
A
Site 92
S1208
E
A
L
H
E
Q
S
S
Y
I
L
S
S
A
E
Site 93
Y1209
A
L
H
E
Q
S
S
Y
I
L
S
S
A
E
T
Site 94
S1212
E
Q
S
S
Y
I
L
S
S
A
E
T
P
A
R
Site 95
T1216
Y
I
L
S
S
A
E
T
P
A
R
P
R
A
P
Site 96
S1226
R
P
R
A
P
E
T
S
L
S
I
H
V
G
S
Site 97
S1228
R
A
P
E
T
S
L
S
I
H
V
G
S
F
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation