KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SETD4
Full Name:
SET domain-containing protein 4
Alias:
SET domain-containing 4
Type:
Mass (Da):
50416
Number AA:
440
UniProt ID:
Q9NVD3
International Prot ID:
IPI00019322
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Q
K
G
K
G
R
T
S
R
I
R
R
R
K
L
Site 2
S19
R
R
R
K
L
C
G
S
S
E
S
R
G
V
N
Site 3
S20
R
R
K
L
C
G
S
S
E
S
R
G
V
N
E
Site 4
S28
E
S
R
G
V
N
E
S
H
K
S
E
F
I
E
Site 5
S31
G
V
N
E
S
H
K
S
E
F
I
E
L
R
K
Site 6
S48
K
A
R
K
F
Q
D
S
N
L
A
P
A
C
F
Site 7
T58
A
P
A
C
F
P
G
T
G
R
G
L
M
S
Q
Site 8
S64
G
T
G
R
G
L
M
S
Q
T
S
L
Q
E
G
Site 9
S67
R
G
L
M
S
Q
T
S
L
Q
E
G
Q
M
I
Site 10
Y92
T
D
T
V
I
R
S
Y
L
G
A
Y
I
T
K
Site 11
T98
S
Y
L
G
A
Y
I
T
K
W
K
P
P
P
S
Site 12
S105
T
K
W
K
P
P
P
S
P
L
L
A
L
C
T
Site 13
S124
E
K
H
A
G
H
R
S
L
W
K
P
Y
L
E
Site 14
Y129
H
R
S
L
W
K
P
Y
L
E
I
L
P
K
A
Site 15
S154
V
V
N
L
L
P
K
S
L
K
A
K
A
E
E
Site 16
S172
H
V
Q
E
F
F
A
S
S
R
D
F
F
S
S
Site 17
S173
V
Q
E
F
F
A
S
S
R
D
F
F
S
S
L
Site 18
S179
S
S
R
D
F
F
S
S
L
Q
P
L
F
A
E
Site 19
Y210
T
V
N
T
R
A
V
Y
L
R
P
R
Q
R
E
Site 20
S220
P
R
Q
R
E
C
L
S
A
E
P
D
T
C
A
Site 21
Y231
D
T
C
A
L
A
P
Y
L
D
L
L
N
H
S
Site 22
S238
Y
L
D
L
L
N
H
S
P
H
V
Q
V
K
A
Site 23
S253
A
F
N
E
E
T
H
S
Y
E
I
R
T
T
S
Site 24
Y254
F
N
E
E
T
H
S
Y
E
I
R
T
T
S
R
Site 25
T259
H
S
Y
E
I
R
T
T
S
R
W
R
K
H
E
Site 26
S260
S
Y
E
I
R
T
T
S
R
W
R
K
H
E
E
Site 27
Y284
N
Q
R
L
F
L
E
Y
G
F
V
S
V
H
N
Site 28
Y306
S
R
E
I
L
V
K
Y
L
P
S
T
D
K
Q
Site 29
Y326
S
I
L
K
D
H
G
Y
I
E
N
L
T
F
G
Site 30
S368
V
L
L
G
E
V
I
S
D
T
N
E
K
T
S
Site 31
T370
L
G
E
V
I
S
D
T
N
E
K
T
S
L
D
Site 32
Y384
D
I
A
Q
K
I
C
Y
Y
F
I
E
E
T
N
Site 33
S434
A
S
A
E
T
L
H
S
L
Q
T
A
F
T
_
Site 34
T437
E
T
L
H
S
L
Q
T
A
F
T
_
_
_
_
Site 35
T440
H
S
L
Q
T
A
F
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation